Page last updated: 2024-10-26

emodin and Renal Insufficiency

emodin has been researched along with Renal Insufficiency in 3 studies

Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.

Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.

Research Excerpts

ExcerptRelevanceReference
"Treatment with emodin significantly turns down the accelerated cell cycle and proliferation of MCs cultured in high glucose (HG) via inhibiting cFLIP."5.40Emodin suppresses hyperglycemia-induced proliferation and fibronectin expression in mesangial cells via inhibiting cFLIP. ( Cao, S; Gao, J; Guo, C; Su, Z; Wang, F; Wang, W, 2014)
"Treatment with emodin significantly turns down the accelerated cell cycle and proliferation of MCs cultured in high glucose (HG) via inhibiting cFLIP."1.40Emodin suppresses hyperglycemia-induced proliferation and fibronectin expression in mesangial cells via inhibiting cFLIP. ( Cao, S; Gao, J; Guo, C; Su, Z; Wang, F; Wang, W, 2014)
"Emodin treatment markedly and significantly mitigated all these effects."1.39Abrogation of cisplatin-induced nephrotoxicity by emodin in rats. ( Al Husseini, IS; Al-Lawati, I; Al-Salam, S; Ali, BH; Fahim, M; Nemmar, A; Waly, M; Yasin, J, 2013)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Xing, M1
Ma, X1
Wang, X1
Wang, H1
Xie, M1
Zhang, Z1
Zhou, J1
Gao, J1
Wang, F1
Wang, W1
Su, Z1
Guo, C1
Cao, S1
Ali, BH1
Al-Salam, S1
Al Husseini, IS1
Al-Lawati, I1
Waly, M1
Yasin, J1
Fahim, M1
Nemmar, A1

Other Studies

3 other studies available for emodin and Renal Insufficiency

ArticleYear
Emodin disrupts the Notch1/Nrf2/GPX4 antioxidant system and promotes renal cell ferroptosis.
    Journal of applied toxicology : JAT, 2023, Volume: 43, Issue:11

    Topics: Animals; Antioxidants; Emodin; Ferroptosis; Kidney; Mice; NF-E2-Related Factor 2; Phospholipid Hydro

2023
Emodin suppresses hyperglycemia-induced proliferation and fibronectin expression in mesangial cells via inhibiting cFLIP.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Animals; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Cycle Checkpoints; Cell P

2014
Abrogation of cisplatin-induced nephrotoxicity by emodin in rats.
    Fundamental & clinical pharmacology, 2013, Volume: 27, Issue:2

    Topics: Acetylglucosaminidase; Animals; Cisplatin; Creatinine; Drug Interactions; Emodin; Glutathione; Kidne

2013