emodin has been researched along with Pancreatitis in 32 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Numerous preclinical investigations have exhibited the beneficial impact of emodin (EMO) on the management of severe acute pancreatitis (SAP)-associated acute lung injury (ALI)." | 8.31 | Emodin Ameliorates Severe Acute Pancreatitis-Associated Acute Lung Injury in Rats by Modulating Exosome-Specific miRNA Expression Profiles. ( Cao, Y; Chen, H; Ge, P; Lan, B; Liu, J; Luo, Y; Sun, Z; Wen, H; Yang, Q; Yuan, H; Zhang, G; Zhang, L, 2023) |
| " Both emodin and dexamethasone (DEX) have been used for treating severe acute pancreatitis-associated acute lung injury (SAP-ALI)." | 8.02 | Effect of emodin on long non-coding RNA-mRNA networks in rats with severe acute pancreatitis-induced acute lung injury. ( Chen, H; Jiang, L; Li, L; Li, Z; Luo, Y; Ntim, M; Quan, W; Shang, D; Xu, C; Xu, Q; Zhang, G; Zhang, J, 2021) |
| "The aim of this study was to investigate the effects of emodin on attenuating autophagy response in acute pancreatitis (AP) models." | 7.88 | Emodin Attenuates Autophagy Response to Protect the Pancreas From Acute Pancreatitis Failure. ( Chi, C; Cui, L; Guo, Y; Li, C; Liu, R; Liu, X; Song, H; Wang, X; Yin, C; Yu, X, 2018) |
| "Emodin, a traditional Chinese medicine, has a therapeutic effect on severe acute pancreatitis (SAP), whereas the underlying mechanism is still unclear." | 7.85 | Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition. ( Gu, ML; Ji, F; Ning, JW; Usman, A; Xu, J; Yu, MS; Zhang, Y, 2017) |
| "The present study aimed to evaluate the protective effects of emodin on severe acute pancreatitis (SAP)‑associated acute lung injury (ALI), and investigated the possible mechanism involved." | 7.85 | Emodin alleviates severe acute pancreatitis-associated acute lung injury by decreasing pre-B-cell colony-enhancing factor expression and promoting polymorphonuclear neutrophil apoptosis. ( Chen, H; Cui, H; Li, S; Sun, Z; Xu, C; Zhang, J, 2017) |
| "The present study investigates the ameliorating effects of emodin on acute lung injury (ALI) induced by severe acute pancreatitis (SAP)." | 7.83 | Emodin ameliorates acute lung injury induced by severe acute pancreatitis through the up-regulated expressions of AQP1 and AQP5 in lung. ( Fan, R; Gao, Z; Huang, B; Tong, C; Wang, Y; Xie, P; Xu, J, 2016) |
| "Emodin is the main active constituent of rhubarb and is often used in Chinese herbal medicine for the treatment of systemic inflammatory response syndrome (SIRS)." | 7.80 | In vitro effects of emodin on peritoneal macrophages that express membrane-bound CD14 protein in a rat model of severe acute pancreatitis/systemic inflammatory response syndrome. ( Chen, G; Ni, Q; Shang, D; Sun, K, 2014) |
| "To investigate the effect of emodin on pancreatic claudin-5 and occludin expression, and pancreatic paracellular permeability in acute pancreatitis (AP)." | 7.78 | Emodin promoted pancreatic claudin-5 and occludin expression in experimental acute pancreatitis rats. ( Li, BK; Ruan, HL; Xia, XM; Xing, SM, 2012) |
| "To investigate the effect of emodin on expression of claudin-4, claudin-5 and occludin, as well as the alveolar epithelial barrier in rats with pancreatitis induced by sodium taurocholate." | 7.76 | Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis. ( Lu, H; Wan, HJ; Wang, FY; Wang, ZK; Xia, XM; Xu, WA, 2010) |
| "To investigate the therapeutic effects of emodin in combination with baicalein on severe acute pancreatitis (SAP) rats and to explore the mechanism of SAP." | 7.73 | Effects of emodin and baicalein on rats with severe acute pancreatitis. ( Li, ZF; Liu, XG; Wang, JX; Wang, KM; Wu, YT; Zhang, XP; Zhou, YF, 2005) |
| "The mechanism of emodin in treating acute pancreatitis might be by way of enhancing cytokine TGF beta 1 gene expression, regulating cell growth and differentiation, stimulating the formation of extracellular matrix components, increasing DNA synthesis and protein content, and to take part in pancreatic repairing and remodeling." | 7.71 | [Study on effect of emodin on TGF beta 1 expression in pancreatic tissue of rats suffering from acute pancreatitis]. ( Gong, ZH; Lou, KX; Yuan, YZ, 2001) |
| "To investigate mechanisms of the Chinese herb emodin and somatostatin analogs (SSa; Sandostatin) in acute pancreatitis of rats by analyzing the changes in pancreatic tissue cytokine transforming growth factor beta1 (TGFbeta1) and epidermal growth factor (EGF) gene expression, DNA synthesis, total protein content, and the relations between them." | 7.71 | Mechanisms of Chinese herb emodin and somatostatin analogs on pancreatic regeneration in acute pancreatitis in rats. ( Gong, Z; Lou, K; Tu, S; Xu, J; Yuan, Y; Zhai, Z, 2002) |
| "Emodin is a natural product, which can alleviate the symptoms of AP." | 5.62 | Emodin inhibits the progression of acute pancreatitis via regulation of lncRNA TUG1 and exosomal lncRNA TUG1. ( Chen, Z; He, B; Tang, X; Wang, B; Wen, X, 2021) |
| "Lung injury is a common complication of acute pancreatitis (AP), which leads to the development of acute respiratory distress syndrome and causes high mortality." | 5.56 | Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling. ( Dong, X; Fan, R; Gao, Z; Qu, W; Sui, J; Sun, D, 2020) |
| "There is no specific drug to treat severe acute pancreatitis (SAP), which induces substantial medical and social burden." | 5.51 | Emodin Attenuates Severe Acute Pancreatitis via Antioxidant and Anti-inflammatory Activity. ( Liu, H; Ni, Y; Shang, D; Sui, H; Xia, S; Xiang, H; Zhou, Q, 2019) |
| "Emodin is a major component of the Chinese herb rhubarb, which has been widely used in the treatment of numerous diseases, including inflammation and cancer." | 5.42 | Emodin has a protective effect in cases of severe acute pancreatitis via inhibition of nuclear factor‑κB activation resulting in antioxidation. ( Qian, AH; Qiao, MM; Yang, SL; Yao, WY; Yuan, YZ; Zhai, ZK; Zhang, YP; Zhou, YF, 2015) |
| "Severe acute pancreatitis (SAP) characterized by atrocious progression and numerous complications often leads to a high mortality rate due to hypermetabolism, systemic inflammatory response syndrome (SIRS), and multiple organs dysfunction syndrome (MODS)." | 5.34 | The effect of emodin-assisted early enteral nutrition on severe acute pancreatitis and secondary hepatic injury. ( Gao, Y; Jiang, HC; Meng, QH; Sun, B; Wang, G, 2007) |
| "Numerous preclinical investigations have exhibited the beneficial impact of emodin (EMO) on the management of severe acute pancreatitis (SAP)-associated acute lung injury (ALI)." | 4.31 | Emodin Ameliorates Severe Acute Pancreatitis-Associated Acute Lung Injury in Rats by Modulating Exosome-Specific miRNA Expression Profiles. ( Cao, Y; Chen, H; Ge, P; Lan, B; Liu, J; Luo, Y; Sun, Z; Wen, H; Yang, Q; Yuan, H; Zhang, G; Zhang, L, 2023) |
| "CQCQD ameliorated cerulein-induced AP and its associated pain via inhibiting neuron activation-mediated pancreatic acinar cell SP-NK1R signaling pathways and its active compounds baicalin, emodin, and magnolol contributed to this effect." | 4.02 | Chaiqin chengqi decoction ameliorates acute pancreatitis in mice via inhibition of neuron activation-mediated acinar cell SP/NK1R signaling pathways. ( Deng, L; Du, D; Fu, X; Han, C; Hong, J; Huang, W; Jiang, K; Jin, T; Li, J; Liu, T; Mukherjee, R; Phillips, AR; Shi, N; Sutton, R; Wang, R; Wen, Y; Windsor, JA; Xia, Q; Yang, J, 2021) |
| " Both emodin and dexamethasone (DEX) have been used for treating severe acute pancreatitis-associated acute lung injury (SAP-ALI)." | 4.02 | Effect of emodin on long non-coding RNA-mRNA networks in rats with severe acute pancreatitis-induced acute lung injury. ( Chen, H; Jiang, L; Li, L; Li, Z; Luo, Y; Ntim, M; Quan, W; Shang, D; Xu, C; Xu, Q; Zhang, G; Zhang, J, 2021) |
| "The aim of this study was to investigate the effects of emodin on attenuating autophagy response in acute pancreatitis (AP) models." | 3.88 | Emodin Attenuates Autophagy Response to Protect the Pancreas From Acute Pancreatitis Failure. ( Chi, C; Cui, L; Guo, Y; Li, C; Liu, R; Liu, X; Song, H; Wang, X; Yin, C; Yu, X, 2018) |
| "To investigate the effects of combined use of emodin and baicalein (CEB) at the cellular and organism levels in severe acute pancreatitis (SAP) and explore the underlying mechanism." | 3.88 | Emodin and baicalein inhibit sodium taurocholate-induced vacuole formation in pancreatic acinar cells. ( Bie, BB; Chen, HY; Guo, Y; Huang, N; Li, J; Li, ZF; Shi, MJ; Yang, J; Zhang, J; Zhou, R, 2018) |
| "The present study aimed to evaluate the protective effects of emodin on severe acute pancreatitis (SAP)‑associated acute lung injury (ALI), and investigated the possible mechanism involved." | 3.85 | Emodin alleviates severe acute pancreatitis-associated acute lung injury by decreasing pre-B-cell colony-enhancing factor expression and promoting polymorphonuclear neutrophil apoptosis. ( Chen, H; Cui, H; Li, S; Sun, Z; Xu, C; Zhang, J, 2017) |
| "Emodin, a traditional Chinese medicine, has a therapeutic effect on severe acute pancreatitis (SAP), whereas the underlying mechanism is still unclear." | 3.85 | Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition. ( Gu, ML; Ji, F; Ning, JW; Usman, A; Xu, J; Yu, MS; Zhang, Y, 2017) |
| "The present study investigates the ameliorating effects of emodin on acute lung injury (ALI) induced by severe acute pancreatitis (SAP)." | 3.83 | Emodin ameliorates acute lung injury induced by severe acute pancreatitis through the up-regulated expressions of AQP1 and AQP5 in lung. ( Fan, R; Gao, Z; Huang, B; Tong, C; Wang, Y; Xie, P; Xu, J, 2016) |
| "Emodin is the main active constituent of rhubarb and is often used in Chinese herbal medicine for the treatment of systemic inflammatory response syndrome (SIRS)." | 3.80 | In vitro effects of emodin on peritoneal macrophages that express membrane-bound CD14 protein in a rat model of severe acute pancreatitis/systemic inflammatory response syndrome. ( Chen, G; Ni, Q; Shang, D; Sun, K, 2014) |
| "To investigate the effect of emodin on pancreatic claudin-5 and occludin expression, and pancreatic paracellular permeability in acute pancreatitis (AP)." | 3.78 | Emodin promoted pancreatic claudin-5 and occludin expression in experimental acute pancreatitis rats. ( Li, BK; Ruan, HL; Xia, XM; Xing, SM, 2012) |
| "To investigate the effect of emodin on expression of claudin-4, claudin-5 and occludin, as well as the alveolar epithelial barrier in rats with pancreatitis induced by sodium taurocholate." | 3.76 | Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis. ( Lu, H; Wan, HJ; Wang, FY; Wang, ZK; Xia, XM; Xu, WA, 2010) |
| "To investigate the therapeutic effects of emodin in combination with baicalein on severe acute pancreatitis (SAP) rats and to explore the mechanism of SAP." | 3.73 | Effects of emodin and baicalein on rats with severe acute pancreatitis. ( Li, ZF; Liu, XG; Wang, JX; Wang, KM; Wu, YT; Zhang, XP; Zhou, YF, 2005) |
| "To investigate mechanisms of the Chinese herb emodin and somatostatin analogs (SSa; Sandostatin) in acute pancreatitis of rats by analyzing the changes in pancreatic tissue cytokine transforming growth factor beta1 (TGFbeta1) and epidermal growth factor (EGF) gene expression, DNA synthesis, total protein content, and the relations between them." | 3.71 | Mechanisms of Chinese herb emodin and somatostatin analogs on pancreatic regeneration in acute pancreatitis in rats. ( Gong, Z; Lou, K; Tu, S; Xu, J; Yuan, Y; Zhai, Z, 2002) |
| "The mechanism of emodin in treating acute pancreatitis might be by way of enhancing cytokine TGF beta 1 gene expression, regulating cell growth and differentiation, stimulating the formation of extracellular matrix components, increasing DNA synthesis and protein content, and to take part in pancreatic repairing and remodeling." | 3.71 | [Study on effect of emodin on TGF beta 1 expression in pancreatic tissue of rats suffering from acute pancreatitis]. ( Gong, ZH; Lou, KX; Yuan, YZ, 2001) |
| "Emodin is an anthraquinone compound extracted from rhubarb that can alleviate the damage to pancreatic ductal epithelial cells induced by adenosine triphosphate, but whether it has a similar protective effect on sodium taurocholate (STC)-stimulated pancreatic ductal cells and the underlying mechanism has not yet been reported." | 1.72 | Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Ductal Cell Damage by Inhibiting the S100A9/VNN1 Signaling Pathway. ( Chen, M; Guo, F; Wu, Y; Xiang, H; Zhao, L; Zhou, Q, 2022) |
| "Emodin is a natural product, which can alleviate the symptoms of AP." | 1.62 | Emodin inhibits the progression of acute pancreatitis via regulation of lncRNA TUG1 and exosomal lncRNA TUG1. ( Chen, Z; He, B; Tang, X; Wang, B; Wen, X, 2021) |
| "Lung injury is a common complication of acute pancreatitis (AP), which leads to the development of acute respiratory distress syndrome and causes high mortality." | 1.56 | Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling. ( Dong, X; Fan, R; Gao, Z; Qu, W; Sui, J; Sun, D, 2020) |
| "There is no specific drug to treat severe acute pancreatitis (SAP), which induces substantial medical and social burden." | 1.51 | Emodin Attenuates Severe Acute Pancreatitis via Antioxidant and Anti-inflammatory Activity. ( Liu, H; Ni, Y; Shang, D; Sui, H; Xia, S; Xiang, H; Zhou, Q, 2019) |
| "Severe acute pancreatitis (SAP) results in high mortality." | 1.43 | Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca ( Chen, HL; Liu, JJ; Shang, D; Sun, FL; Teng, YS; Wang, GJ; Wang, Y; Xia, SL; Xiang, H; Zhang, GX, 2016) |
| "Emodin is a major component of the Chinese herb rhubarb, which has been widely used in the treatment of numerous diseases, including inflammation and cancer." | 1.42 | Emodin has a protective effect in cases of severe acute pancreatitis via inhibition of nuclear factor‑κB activation resulting in antioxidation. ( Qian, AH; Qiao, MM; Yang, SL; Yao, WY; Yuan, YZ; Zhai, ZK; Zhang, YP; Zhou, YF, 2015) |
| " The peak concentration and area under curve of all three components were much higher in the AP group than those in the normal group with MLHP in external application for 48 h (P<0." | 1.42 | Effect of acute pancreatitis on the pharmacokinetics of Chinese herbal micron Liuhe Pill ointment in rats. ( Chen, GY; Chen, WW; Li, J; Liu, YL; Tang, WF; Wan, MH; Zhao, XL, 2015) |
| "Aloe emodin was found in all pancreas from acute pancreatitis models while only one in normal group." | 1.39 | Effect of acute pancreatitis on the pharmacokinetics of Chinese herbal ointment Liu-He-Dan in anaesthetized rats. ( Chen, GY; Chen, WW; Tang, WF; Wan, MH; Xiang, J; Yu, Q; Zhao, XL, 2013) |
| "Severe acute pancreatitis (SAP) characterized by atrocious progression and numerous complications often leads to a high mortality rate due to hypermetabolism, systemic inflammatory response syndrome (SIRS), and multiple organs dysfunction syndrome (MODS)." | 1.34 | The effect of emodin-assisted early enteral nutrition on severe acute pancreatitis and secondary hepatic injury. ( Gao, Y; Jiang, HC; Meng, QH; Sun, B; Wang, G, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (21.88) | 29.6817 |
| 2010's | 16 (50.00) | 24.3611 |
| 2020's | 9 (28.13) | 2.80 |
| Authors | Studies |
|---|---|
| Wen, X | 1 |
| He, B | 1 |
| Tang, X | 1 |
| Wang, B | 1 |
| Chen, Z | 1 |
| Zhou, Q | 5 |
| Xiang, H | 6 |
| Liu, H | 2 |
| Qi, B | 1 |
| Shi, X | 1 |
| Guo, W | 1 |
| Zou, J | 1 |
| Wan, X | 1 |
| Wu, W | 1 |
| Wang, Z | 2 |
| Liu, W | 1 |
| Xia, S | 3 |
| Shang, D | 6 |
| Guo, F | 3 |
| Wu, Y | 3 |
| Chen, M | 3 |
| Zhao, L | 3 |
| Yang, Q | 1 |
| Luo, Y | 3 |
| Ge, P | 1 |
| Lan, B | 1 |
| Liu, J | 3 |
| Wen, H | 1 |
| Cao, Y | 1 |
| Sun, Z | 2 |
| Zhang, G | 3 |
| Yuan, H | 1 |
| Zhang, L | 1 |
| Chen, H | 4 |
| Ni, Y | 1 |
| Sui, H | 1 |
| Xu, C | 3 |
| Zhang, J | 6 |
| Li, Z | 3 |
| Liu, Z | 1 |
| Xu, Q | 2 |
| Wang, M | 1 |
| Wang, F | 1 |
| Gao, Z | 2 |
| Sui, J | 1 |
| Fan, R | 2 |
| Qu, W | 1 |
| Dong, X | 1 |
| Sun, D | 1 |
| Wen, Y | 2 |
| Han, C | 2 |
| Liu, T | 2 |
| Wang, R | 2 |
| Cai, W | 1 |
| Yang, J | 3 |
| Liang, G | 1 |
| Yao, L | 1 |
| Shi, N | 2 |
| Fu, X | 2 |
| Deng, L | 2 |
| Sutton, R | 2 |
| Windsor, JA | 2 |
| Hong, J | 2 |
| Phillips, AR | 2 |
| Du, D | 2 |
| Huang, W | 2 |
| Xia, Q | 2 |
| Ntim, M | 1 |
| Quan, W | 1 |
| Jiang, L | 1 |
| Li, L | 1 |
| Li, J | 5 |
| Jin, T | 1 |
| Jiang, K | 1 |
| Mukherjee, R | 1 |
| Zhang, S | 3 |
| Zhou, R | 3 |
| Li, ZF | 4 |
| Ning, JW | 1 |
| Zhang, Y | 1 |
| Yu, MS | 1 |
| Gu, ML | 1 |
| Xu, J | 3 |
| Usman, A | 1 |
| Ji, F | 1 |
| Cui, H | 1 |
| Li, S | 1 |
| Bie, BB | 1 |
| Huang, N | 1 |
| Guo, Y | 2 |
| Chen, HY | 1 |
| Shi, MJ | 1 |
| Yu, X | 1 |
| Li, C | 1 |
| Song, H | 2 |
| Wang, X | 1 |
| Cui, L | 1 |
| Liu, X | 1 |
| Chi, C | 1 |
| Liu, R | 1 |
| Yin, C | 1 |
| Zhang, Q | 1 |
| Tao, X | 1 |
| Qu, J | 1 |
| Li, H | 1 |
| Ni, Q | 1 |
| Sun, K | 1 |
| Chen, G | 1 |
| Yao, WY | 1 |
| Zhou, YF | 2 |
| Qian, AH | 1 |
| Zhang, YP | 1 |
| Qiao, MM | 1 |
| Zhai, ZK | 1 |
| Yuan, YZ | 2 |
| Yang, SL | 1 |
| Liu, YL | 1 |
| Zhao, XL | 3 |
| Wan, MH | 2 |
| Chen, GY | 2 |
| Chen, WW | 2 |
| Tang, WF | 3 |
| Huang, B | 1 |
| Wang, Y | 2 |
| Tong, C | 1 |
| Xie, P | 1 |
| Wang, GJ | 1 |
| Teng, YS | 1 |
| Sun, FL | 1 |
| Liu, JJ | 1 |
| Xia, SL | 1 |
| Zhang, GX | 1 |
| Chen, HL | 1 |
| Zhang, YM | 1 |
| Ren, HY | 1 |
| Li, JY | 1 |
| Wu, FS | 1 |
| Su, H | 1 |
| Xia, XM | 3 |
| Huang, C | 1 |
| Zhang, AJ | 1 |
| Wan, L | 1 |
| Zhou, L | 1 |
| Wang, FY | 1 |
| Wang, ZK | 1 |
| Wan, HJ | 1 |
| Xu, WA | 1 |
| Lu, H | 1 |
| Li, BK | 1 |
| Xing, SM | 1 |
| Ruan, HL | 1 |
| Xiang, J | 1 |
| Yu, Q | 1 |
| Gong, Z | 1 |
| Yuan, Y | 1 |
| Lou, K | 1 |
| Tu, S | 1 |
| Zhai, Z | 1 |
| Lou, KX | 1 |
| Gong, ZH | 1 |
| Zhang, XP | 1 |
| Liu, XG | 1 |
| Wu, YT | 1 |
| Wang, JX | 1 |
| Wang, KM | 1 |
| Wang, G | 1 |
| Sun, B | 1 |
| Gao, Y | 1 |
| Meng, QH | 1 |
| Jiang, HC | 1 |
| Xia, X | 1 |
| Zhang, A | 1 |
| Bo, W | 1 |
1 review available for emodin and Pancreatitis
| Article | Year |
|---|---|
Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Apigenin; Artemisinins; Drugs, Chinese Herbal; Emo | 2017 |
31 other studies available for emodin and Pancreatitis
| Article | Year |
|---|---|
Emodin inhibits the progression of acute pancreatitis via regulation of lncRNA TUG1 and exosomal lncRNA TUG1.
Topics: Acinar Cells; Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Emodin; Exosomes; Humans; Mal | 2021 |
Emodin Alleviates Intestinal Barrier Dysfunction by Inhibiting Apoptosis and Regulating the Immune Response in Severe Acute Pancreatitis.
Topics: Animals; Apoptosis; Disease Models, Animal; Emodin; Intestinal Mucosa; Mice; Pancreatitis | 2021 |
Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Ductal Cell Damage by Inhibiting the S100A9/VNN1 Signaling Pathway.
Topics: Acute Disease; Emodin; Epithelial Cells; Glutamate-Cysteine Ligase; Glutathione; Humans; Pancreatiti | 2022 |
Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Ductal Cell Damage by Inhibiting the S100A9/VNN1 Signaling Pathway.
Topics: Acute Disease; Emodin; Epithelial Cells; Glutamate-Cysteine Ligase; Glutathione; Humans; Pancreatiti | 2022 |
Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Ductal Cell Damage by Inhibiting the S100A9/VNN1 Signaling Pathway.
Topics: Acute Disease; Emodin; Epithelial Cells; Glutamate-Cysteine Ligase; Glutathione; Humans; Pancreatiti | 2022 |
Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Ductal Cell Damage by Inhibiting the S100A9/VNN1 Signaling Pathway.
Topics: Acute Disease; Emodin; Epithelial Cells; Glutamate-Cysteine Ligase; Glutathione; Humans; Pancreatiti | 2022 |
Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Ductal Cell Damage by Inhibiting the S100A9/VNN1 Signaling Pathway.
Topics: Acute Disease; Emodin; Epithelial Cells; Glutamate-Cysteine Ligase; Glutathione; Humans; Pancreatiti | 2022 |
Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Ductal Cell Damage by Inhibiting the S100A9/VNN1 Signaling Pathway.
Topics: Acute Disease; Emodin; Epithelial Cells; Glutamate-Cysteine Ligase; Glutathione; Humans; Pancreatiti | 2022 |
Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Ductal Cell Damage by Inhibiting the S100A9/VNN1 Signaling Pathway.
Topics: Acute Disease; Emodin; Epithelial Cells; Glutamate-Cysteine Ligase; Glutathione; Humans; Pancreatiti | 2022 |
Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Ductal Cell Damage by Inhibiting the S100A9/VNN1 Signaling Pathway.
Topics: Acute Disease; Emodin; Epithelial Cells; Glutamate-Cysteine Ligase; Glutathione; Humans; Pancreatiti | 2022 |
Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Ductal Cell Damage by Inhibiting the S100A9/VNN1 Signaling Pathway.
Topics: Acute Disease; Emodin; Epithelial Cells; Glutamate-Cysteine Ligase; Glutathione; Humans; Pancreatiti | 2022 |
Emodin Ameliorates Severe Acute Pancreatitis-Associated Acute Lung Injury in Rats by Modulating Exosome-Specific miRNA Expression Profiles.
Topics: Acute Disease; Acute Lung Injury; Animals; Emodin; Exosomes; MicroRNAs; Pancreatitis; Rats | 2023 |
Emodin Attenuates Severe Acute Pancreatitis via Antioxidant and Anti-inflammatory Activity.
Topics: Amylases; Animals; Anti-Inflammatory Agents; Antioxidants; Emodin; Humans; Inflammasomes; Interleuki | 2019 |
Proteomic analysis reveals the protective effects of emodin on severe acute pancreatitis induced lung injury by inhibiting neutrophil proteases activity.
Topics: Acute Disease; Animals; Emodin; Lung; Neutrophils; Pancreatitis; Peptide Hydrolases; Proteomics; Rat | 2020 |
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Topics: Acute Disease; Acute Lung Injury; Administration, Oral; Animals; Cell Proliferation; Cells, Cultured | 2020 |
Chaiqin chengqi decoction alleviates severity of acute pancreatitis via inhibition of TLR4 and NLRP3 inflammasome: Identification of bioactive ingredients via pharmacological sub-network analysis and experimental validation.
Topics: Acinar Cells; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ceruletide; Drugs, Chinese Herbal; E | 2020 |
Effect of emodin on long non-coding RNA-mRNA networks in rats with severe acute pancreatitis-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Biomarkers; Biopsy; Computational Biology; Cytokines; Disease Models, An | 2021 |
Chaiqin chengqi decoction ameliorates acute pancreatitis in mice via inhibition of neuron activation-mediated acinar cell SP/NK1R signaling pathways.
Topics: Acinar Cells; Analgesics; Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Ceruletide; Drugs, | 2021 |
Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition.
Topics: Acute Disease; Animals; Caspase 1; Caspase Inhibitors; Disease Models, Animal; Emodin; Inflammation | 2017 |
Emodin alleviates severe acute pancreatitis-associated acute lung injury by decreasing pre-B-cell colony-enhancing factor expression and promoting polymorphonuclear neutrophil apoptosis.
Topics: Acute Disease; Acute Lung Injury; Amylases; Animals; Apoptosis; Cytokines; Dexamethasone; Emodin; Ge | 2017 |
Emodin and baicalein inhibit sodium taurocholate-induced vacuole formation in pancreatic acinar cells.
Topics: Acinar Cells; Acute Disease; Animals; Calcium; Calcium Signaling; Cell Survival; Cells, Cultured; Di | 2018 |
Emodin Attenuates Autophagy Response to Protect the Pancreas From Acute Pancreatitis Failure.
Topics: Acute Disease; Animals; Autophagy; Beclin-1; Emodin; Gene Expression; Male; Microtubule-Associated P | 2018 |
Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway.
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Emodin; Humans; Male; NLR Family, Pyrin Doma | 2019 |
In vitro effects of emodin on peritoneal macrophages that express membrane-bound CD14 protein in a rat model of severe acute pancreatitis/systemic inflammatory response syndrome.
Topics: Acute Disease; Animals; Dexamethasone; Disease Models, Animal; Emodin; Lipopolysaccharide Receptors; | 2014 |
Emodin has a protective effect in cases of severe acute pancreatitis via inhibition of nuclear factor‑κB activation resulting in antioxidation.
Topics: Acute Disease; Amylases; Animals; Antioxidants; Disease Models, Animal; Drugs, Chinese Herbal; Emodi | 2015 |
Effect of acute pancreatitis on the pharmacokinetics of Chinese herbal micron Liuhe Pill ointment in rats.
Topics: Acute Disease; Animals; Anthraquinones; Drugs, Chinese Herbal; Emodin; Male; Ointments; Pancreatitis | 2015 |
Emodin ameliorates acute lung injury induced by severe acute pancreatitis through the up-regulated expressions of AQP1 and AQP5 in lung.
Topics: Acute Lung Injury; Animals; Aquaporin 1; Aquaporin 5; Emodin; Gene Expression; Male; Pancreatitis; R | 2016 |
Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca
Topics: Acrylates; Animals; Apoptosis; Calcium; Calpain; Caspase 12; Caspase 3; Emodin; Gene Expression Regu | 2016 |
Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis.
Topics: Acute Disease; Alanine Transaminase; Animals; Anthraquinones; Aspartate Aminotransferases; Biphenyl | 2017 |
Emodin and baicalein inhibit pancreatic stromal derived factor-1 expression in rats with acute pancreatitis.
Topics: Acute Disease; Animals; Chemokine CXCL12; Emodin; Flavanones; Immunohistochemistry; Interleukin-6; M | 2009 |
Protecting effects of emodin on multiorgan failure of rats with severe acute pancreatitis.
Topics: Acute Disease; Animals; Emodin; Intestine, Small; Liver; Lung; Multiple Organ Failure; Pancreas; Pan | 2009 |
Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis.
Topics: Animals; Blood-Air Barrier; Claudin-4; Claudin-5; Emodin; Lung; Male; Membrane Proteins; Occludin; P | 2010 |
Emodin promoted pancreatic claudin-5 and occludin expression in experimental acute pancreatitis rats.
Topics: Acute Disease; Animals; Claudin-5; Claudins; Cytokines; Emodin; Male; Membrane Proteins; Occludin; P | 2012 |
Effect of acute pancreatitis on the pharmacokinetics of Chinese herbal ointment Liu-He-Dan in anaesthetized rats.
Topics: Administration, Cutaneous; Amylases; Animals; Anthraquinones; Arginine; Disease Models, Animal; Drug | 2013 |
Mechanisms of Chinese herb emodin and somatostatin analogs on pancreatic regeneration in acute pancreatitis in rats.
Topics: Acute Disease; Amylases; Animals; DNA; Drugs, Chinese Herbal; Emodin; Enzyme Inhibitors; Epidermal G | 2002 |
[Study on effect of emodin on TGF beta 1 expression in pancreatic tissue of rats suffering from acute pancreatitis].
Topics: Acute Disease; Animals; DNA; Emodin; Male; Pancreas; Pancreatitis; Random Allocation; Rats; Rats, Wi | 2001 |
Effects of emodin and baicalein on rats with severe acute pancreatitis.
Topics: Acute Disease; Animals; Drug Therapy, Combination; Emodin; Enzyme Inhibitors; Flavanones; Male; Panc | 2005 |
The effect of emodin-assisted early enteral nutrition on severe acute pancreatitis and secondary hepatic injury.
Topics: Acute Disease; Animals; Ascites; Cathartics; Edema; Emodin; Enteral Nutrition; Humans; Inflammation; | 2007 |
Up-regulation of Toll-like receptor 4 was suppressed by emodin and baicalin in the setting of acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Therapy, Co | 2009 |