Page last updated: 2024-10-26

emodin and Obesity

emodin has been researched along with Obesity in 13 studies

Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
"Emodin has a protective effect on asthma."8.12Emodin inhibits NF-κB signaling pathway to protect obese asthmatic rats from pathological damage via Visfatin. ( Cai, W; He, X; Hu, J; Miao, J, 2022)
"Emodin is a natural anthraquinone derivative that exhibits variety of pharmacologic effects including lowering lipids and regulating glucose utilization."5.62Emodin Improves Glucose and Lipid Metabolism Disorders in Obese Mice ( Cheng, L; Dong, S; He, R; Huang, Z; Ning, Y; Shang, F; Sun, J; Zhang, S, 2021)
"Emodin has been shown to exert strong anti-inflammatory property via acting on macrophages in a range of disease models."5.62Emodin inhibits lipid accumulation and inflammation in adipose tissue of high-fat diet-fed mice by inducing M2 polarization of adipose tissue macrophages. ( Peng, J; Wang, F; Wang, X; Xu, X; Yu, F; Yu, N; Zhang, L; Zhao, Y; Zhou, J, 2021)
"After 8-week treatment, body weight, wet weight of visceral fat and the percentage of body fat (PBF) were measured."5.40Preparation of a nano emodin transfersome and study on its anti-obesity mechanism in adipose tissue of diet-induced obese rats. ( Chang, X; Chao, J; Han, S; Huang, Q; Lin, H; Lu, K; Qu, S; Shen, C; Song, X; Tan, M; Wang, C; Xie, S; Xu, L; Yuan, Q; Zhang, J, 2014)
"Emodin is an active herbal component traditionally used in China for treating a variety of diseases."5.38Emodin protects against high-fat diet-induced obesity via regulation of AMP-activated protein kinase pathways in white adipose tissue. ( Chang, CJ; Liou, SS; Liu, IM; Lu, HJ; Tzeng, TF, 2012)
"Emodin has a protective effect on asthma."4.12Emodin inhibits NF-κB signaling pathway to protect obese asthmatic rats from pathological damage via Visfatin. ( Cai, W; He, X; Hu, J; Miao, J, 2022)
" The ability of emodin to inhibit prednisone- or dexamethasone-induced insulin resistance was investigated in C57BL/6J mice and its effect on metabolic abnormalities was observed in DIO mice."3.76Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice. ( Chen, JH; Dou, W; Feng, Y; Huang, SL; Leng, Y; Shen, JH; Shen, Y; Zhang, S, 2010)
"Emodin is a natural anthraquinone derivative that exhibits variety of pharmacologic effects including lowering lipids and regulating glucose utilization."1.62Emodin Improves Glucose and Lipid Metabolism Disorders in Obese Mice ( Cheng, L; Dong, S; He, R; Huang, Z; Ning, Y; Shang, F; Sun, J; Zhang, S, 2021)
"Emodin has been shown to exert strong anti-inflammatory property via acting on macrophages in a range of disease models."1.62Emodin inhibits lipid accumulation and inflammation in adipose tissue of high-fat diet-fed mice by inducing M2 polarization of adipose tissue macrophages. ( Peng, J; Wang, F; Wang, X; Xu, X; Yu, F; Yu, N; Zhang, L; Zhao, Y; Zhou, J, 2021)
"Emodin was admixed to high fat-food of obese mice at two doses (2 and 5g/kg; daily emodin uptake 103 and 229mg/kg)."1.46Emodin, a compound with putative antidiabetic potential, deteriorates glucose tolerance in rodents. ( Abu Eid, S; Adams, M; Fürnsinn, C; Hackl, MT; Kaplanian, M; Luger, A; Riedl, R; Scherer, T; Torres-Gómez, H, 2017)
"Currently, obesity has become a worldwide epidemic associated with Type 2 diabetes, dyslipidemia, cardiovascular disease and chronic metabolic diseases."1.43Emodin improves lipid and glucose metabolism in high fat diet-induced obese mice through regulating SREBP pathway. ( Ding, L; Li, J; Qi, M; Song, B; Tang, X; Wang, Z; Xiao, X; Yang, L; Yang, Q, 2016)
"After 8-week treatment, body weight, wet weight of visceral fat and the percentage of body fat (PBF) were measured."1.40Preparation of a nano emodin transfersome and study on its anti-obesity mechanism in adipose tissue of diet-induced obese rats. ( Chang, X; Chao, J; Han, S; Huang, Q; Lin, H; Lu, K; Qu, S; Shen, C; Song, X; Tan, M; Wang, C; Xie, S; Xu, L; Yuan, Q; Zhang, J, 2014)
"Emodin is an active herbal component traditionally used in China for treating a variety of diseases."1.38Emodin protects against high-fat diet-induced obesity via regulation of AMP-activated protein kinase pathways in white adipose tissue. ( Chang, CJ; Liou, SS; Liu, IM; Lu, HJ; Tzeng, TF, 2012)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's9 (69.23)24.3611
2020's4 (30.77)2.80

Authors

AuthorsStudies
Miao, J1
He, X1
Hu, J1
Cai, W1
Otoo, A1
Czika, A1
Lamptey, J1
Yang, JP1
Feng, Q1
Wang, MJ1
Wang, YX1
Ding, YB1
Cheng, L1
Zhang, S2
Shang, F1
Ning, Y1
Huang, Z1
He, R1
Sun, J1
Dong, S1
Yu, F1
Yu, N1
Peng, J1
Zhao, Y1
Zhang, L1
Wang, X1
Xu, X1
Zhou, J1
Wang, F2
Washington, K1
Wason, J1
Thein, MS1
Lavery, LA1
Hamblin, MR1
Gordon, IL1
Nong, F1
Zhao, Z1
Luo, X1
Liu, C1
Li, H1
Liu, Q1
Wen, B1
Zhou, L1
Buddeberg, BS1
Sharma, R1
O'Driscoll, JM1
Kaelin Agten, A1
Khalil, A1
Thilaganathan, B1
Wakabayashi, H1
Osawa, M1
Koga, S1
Li, K1
Sakaue, H1
Sengoku, Y1
Takagi, H1
Kim, SW1
Son, Y2
Choi, K1
Kim, SI1
Park, J1
Lee, JH1
Jang, JH1
Brailsford, AD1
Majidin, WNM1
Wojek, N1
Cowan, DA1
Walker, C1
Kim, JH1
Phi, JH1
Lee, JY1
Kim, KH1
Park, SH1
Choi, YH1
Cho, BK1
Kim, SK1
Kim, HJ1
Pei, M1
Ko, JS1
Ma, MH1
Park, GE1
Baek, J1
Yang, H1
Cho, MJ1
Choi, DH1
Reyes-Garcia, JG1
Rodríguez-Flores, M1
Kaufer-Horwitz, M1
García-García, E1
Lu, K1
Xie, S1
Han, S1
Zhang, J1
Chang, X1
Chao, J1
Huang, Q1
Yuan, Q1
Lin, H1
Xu, L1
Shen, C1
Tan, M1
Qu, S1
Wang, C1
Song, X1
Li, J1
Ding, L1
Song, B1
Xiao, X1
Qi, M1
Yang, Q2
Tang, X1
Wang, Z1
Yang, L1
Ma, F1
Hu, L1
Yu, M1
Abu Eid, S1
Adams, M1
Scherer, T1
Torres-Gómez, H1
Hackl, MT1
Kaplanian, M1
Riedl, R1
Luger, A1
Fürnsinn, C1
Feng, Y1
Huang, SL1
Dou, W1
Chen, JH1
Shen, Y1
Shen, JH1
Leng, Y1
Tzeng, TF1
Lu, HJ1
Liou, SS1
Chang, CJ1
Liu, IM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Efficacy of Chinese Herbal Medicine in Patients With Obesity: a Retrospective Study[NCT04481464]500 participants (Anticipated)Observational2020-11-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

13 other studies available for emodin and Obesity

ArticleYear
Emodin inhibits NF-κB signaling pathway to protect obese asthmatic rats from pathological damage via Visfatin.
    Tissue & cell, 2022, Volume: 74

    Topics: Animals; Asthma; Cytokines; Disease Models, Animal; Emodin; Male; NF-kappa B; Nicotinamide Phosphori

2022
Emodin improves glucose metabolism and ovarian function in PCOS mice via the HMGB1/TLR4/NF-κB molecular pathway.
    Reproduction (Cambridge, England), 2023, 11-01, Volume: 166, Issue:5

    Topics: Animals; Emodin; Female; Glucose; HMGB1 Protein; Humans; Mice; NF-kappa B; Obesity; Polycystic Ovary

2023
Emodin Improves Glucose and Lipid Metabolism Disorders in Obese Mice
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Body Weight; Diet, High-Fat; Emodin; Lipid Me

2021
Emodin inhibits lipid accumulation and inflammation in adipose tissue of high-fat diet-fed mice by inducing M2 polarization of adipose tissue macrophages.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:7

    Topics: 3T3-L1 Cells; Adipogenesis; Adipose Tissue; Animals; Cell Line; Diet, High-Fat; Emodin; Inflammation

2021
    Journal of textile science & engineering, 2018, Volume: 8, Issue:2

    Topics: Adult; Anabolic Agents; Androgens; Animals; Anthraquinones; Birth Weight; Body Mass Index; Carbon Is

2018
Safety of drug combinations based on psychoactive agents in the treatment of obesity (A reply by the authors).
    International journal of clinical pharmacology and therapeutics, 2019, Volume: 57, Issue:5

    Topics: Atropine; Diazepam; Drug Combinations; Emodin; Humans; Obesity; Phenylpropanolamine; Psychotropic Dr

2019
Safety of drug combinations based on psychoactive agents in the treatment of obesity.
    International journal of clinical pharmacology and therapeutics, 2019, Volume: 57, Issue:5

    Topics: Atropine; Diazepam; Drug Combinations; Emodin; Humans; Obesity; Phenylpropanolamine; Psychotropic Dr

2019
Preparation of a nano emodin transfersome and study on its anti-obesity mechanism in adipose tissue of diet-induced obese rats.
    Journal of translational medicine, 2014, Mar-19, Volume: 12

    Topics: Adipose Tissue; Animals; Anti-Obesity Agents; Body Weight; Cell Cycle Proteins; Emodin; Lipase; Lipo

2014
Emodin improves lipid and glucose metabolism in high fat diet-induced obese mice through regulating SREBP pathway.
    European journal of pharmacology, 2016, Jan-05, Volume: 770

    Topics: Adipose Tissue; Animals; Cell Line; Diet, High-Fat; Down-Regulation; Emodin; Glucose; Humans; Insuli

2016
Emodin Decreases Hepatic Hypoxia-Inducible Factor-1[Formula: see text] by Inhibiting its Biosynthesis.
    The American journal of Chinese medicine, 2016, Volume: 44, Issue:5

    Topics: Animals; Emodin; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1; Liver; Male; Mice; Mice, Inbred C

2016
Emodin, a compound with putative antidiabetic potential, deteriorates glucose tolerance in rodents.
    European journal of pharmacology, 2017, Mar-05, Volume: 798

    Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Dose-Response Relationship, Drug; Eating; Emodi

2017
Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice.
    British journal of pharmacology, 2010, Volume: 161, Issue:1

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adrenal Cortex Hormones; Animals; Cell Line; Dexamethas

2010
Emodin protects against high-fat diet-induced obesity via regulation of AMP-activated protein kinase pathways in white adipose tissue.
    Planta medica, 2012, Volume: 78, Issue:10

    Topics: 3T3-L1 Cells; Adipocytes, White; Adipose Tissue, White; AMP-Activated Protein Kinases; Animals; Anti

2012