Page last updated: 2024-10-26

emodin and Neoplasms

emodin has been researched along with Neoplasms in 41 studies

Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
" In addition, characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome."4.80Human UDP-glucuronosyltransferases: metabolism, expression, and disease. ( Strassburg, CP; Tukey, RH, 2000)
"Cancer is the second leading cause of death in the world."2.72Potential Role of Natural Products to Combat Radiotherapy and Their Future Perspectives. ( Akter, R; Bibi, P; Hassan, SSU; Mubin, S; Najda, A; Rahman, MH; Saeeda, S; Shah, M; Wesołowska, S, 2021)
"In this paper we mainly report the anti-cancer effects of emodin according to the studies of the past five years, including four parts such as inhibit tumor growth, inhibit migration and invasion, enhance the efficacy of combination therapy, increase chemosensitivity and attenuated side effects."2.52[Research progress in anti-tumor effect of emodin]. ( Lin, WF; Ling, CQ; Wang, C, 2015)
"Emodin is a pleiotropic molecule capable of interacting with several major molecular targets including NF-κB, casein kinase II, HER2/neu, HIF-1α, AKT/mTOR, STAT3, CXCR4, topoisomerase II, p53, p21, and androgen receptors which are involved in inflammation and cancer."2.49Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer. ( Ahn, KS; Kumar, AP; Sethi, G; Shanmugam, MK; Shrimali, D; Tan, BK; Zhang, J, 2013)
"Emodin was identified as one of the best candidates, showing a great G4-binding potential."1.51Combined treatment with emodin and a telomerase inhibitor induces significant telomere damage/dysfunction and cell death. ( Geng, X; Liu, J; Liu, R; Liu, Y; Wang, F; Wang, S; Wang, Y; Zhang, T, 2019)
"Emodin was coordinated with Mn(II) through the 9-C=O and 1-OH, and the general formula of the complex was Mn(II) (emodin)2·2H2O."1.40Synthesis, characterization, and anti-cancer activity of emodin-Mn(II) metal complex. ( Tan, J; Wang, BC; Yang, L; Zhu, LC, 2014)
"Besides cardiovascular diseases, cancer represents the major cause of death in developed countries."1.36A FRET-based microplate assay for human protein kinase CK2, a target in neoplastic disease. ( Götz, C; Gratz, A; Jose, J, 2010)
"Emodin is a natural anthraquinone derivative that exhibits anti-proliferative effects in various cancer cell lines by efficient induction of apoptosis."1.34Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action. ( Bjørling-Poulsen, M; Guerra, B; Olsen, BB, 2007)
"In vivo study showed that tumors exposed to the arsenic/emodin cotreatment had dramatically smaller sizes and weaker antioxidant capacity, compared with arsenic alone."1.33Alteration of subcellular redox equilibrium and the consequent oxidative modification of nuclear factor kappaB are critical for anticancer cytotoxicity by emodin, a reactive oxygen species-producing agent. ( Chen, Y; Hu, Q; Jing, Y; Li, H; Shi, G; Tang, X; Wang, Y; Yang, J; Yi, J, 2006)
" Taken together, these results suggest an innovative and safe chemotherapeutic strategy that uses natural anthraquinone derivatives as ROS generators to increase the susceptibility of tumor cells to cytotoxic therapeutic agents."1.32Anthraquinones sensitize tumor cells to arsenic cytotoxicity in vitro and in vivo via reactive oxygen species-mediated dual regulation of apoptosis. ( Chen, YY; Guo, QS; Hu, QS; Kang, XL; Li, H; Lu, Y; Shi, GY; Tang, XM; Wang, XJ; Yang, J; Yi, J, 2004)
"Emodin is a naturally occurring anthraquinone which is widely used as a laxative and has other versatile biological activities."1.31Generation of free radicals by emodic acid and its [D-Lys6]GnRH-conjugate. ( Barbosa, F; Bilkis, I; Fridkin, M; Gescheidt, G; Koch, Y; Mazur, Y; Péron, V; Rahimipour, S; Weiner, L, 2001)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.44)18.7374
1990's0 (0.00)18.2507
2000's11 (26.83)29.6817
2010's21 (51.22)24.3611
2020's8 (19.51)2.80

Authors

AuthorsStudies
Tukey, RH1
Strassburg, CP1
Fang, X1
Shao, L1
Zhang, H1
Wang, S3
Diamandis, P1
Wildenhain, J1
Clarke, ID1
Sacher, AG1
Graham, J1
Bellows, DS1
Ling, EK1
Ward, RJ1
Jamieson, LG1
Tyers, M1
Dirks, PB1
Song, G1
Liu, H1
Zhang, W1
Geng, M1
Li, Y2
Han, YM1
Lee, SK1
Jeong, DG1
Ryu, SE1
Han, DC1
Kim, DK1
Kwon, BM1
Lin, R1
Elf, S1
Shan, C1
Kang, HB1
Ji, Q1
Zhou, L1
Hitosugi, T1
Zhang, L1
Zhang, S1
Seo, JH1
Xie, J1
Tucker, M1
Gu, TL1
Sudderth, J1
Jiang, L1
Mitsche, M1
DeBerardinis, RJ1
Wu, S1
Mao, H1
Chen, PR1
Wang, D2
Chen, GZ1
Hurwitz, SJ1
Lonial, S1
Arellano, ML1
Khoury, HJ1
Khuri, FR1
Lee, BH1
Lei, Q1
Brat, DJ1
Ye, K1
Boggon, TJ1
He, C1
Kang, S1
Fan, J1
Chen, J1
Golonko, A1
Pienkowski, T1
Swislocka, R1
Lazny, R1
Roszko, M1
Lewandowski, W1
Stompor-Gorący, M1
Yiu, CY1
Chiu, YJ1
Lin, TP1
Akter, R1
Najda, A1
Rahman, MH1
Shah, M1
Wesołowska, S1
Hassan, SSU1
Mubin, S1
Bibi, P1
Saeeda, S1
Wu, M3
Ling, W3
Wei, J3
Liao, R3
Sun, H3
Li, D3
Zhao, Y3
Zhao, L3
Liang, W1
Fan, Y1
Liu, Y3
Fang, T1
Zhang, J3
Xu, Y1
Li, J1
Adnan, M1
Rasul, A1
Hussain, G1
Shah, MA1
Sarfraz, I1
Nageen, B1
Riaz, A1
Khalid, R1
Asrar, M1
Selamoglu, Z1
Adem, Ş1
Sarker, SD1
Tuli, HS1
Aggarwal, V1
Tuorkey, M1
Aggarwal, D1
Parashar, NC1
Varol, M1
Savla, R1
Kaur, G1
Mittal, S1
Sak, K1
Pecere, T1
Ponterio, E1
Di Iorio, E1
Carli, M1
Fassan, M1
Santoro, L1
Bissaro, M1
Bernabè, G1
Moro, S1
Castagliuolo, I1
Palù, G1
Dumit, VI1
Zerbes, RM1
Kaeser-Pebernard, S1
Rackiewicz, M1
Wall, MT1
Gretzmeier, C1
Küttner, V1
van der Laan, M1
Braun, RJ1
Dengjel, J1
Gibson, SA1
Benveniste, EN1
Geng, C1
Zhang, Y1
Hidru, TH1
Zhi, L1
Tao, M1
Zou, L1
Chen, C1
Li, H3
Chen, KC1
Juang, SH1
Lien, JC1
Liu, R1
Liu, J1
Wang, Y3
Zhang, T1
Geng, X1
Wang, F2
Shrimali, D1
Shanmugam, MK1
Kumar, AP1
Tan, BK1
Ahn, KS1
Sethi, G1
Wei, WT1
Lin, SZ1
Liu, DL1
Wang, ZH1
Chen, R1
Hu, Y1
Chen, M1
Yang, L1
Tan, J1
Wang, BC1
Zhu, LC1
Xing, JY1
Song, GP1
Deng, JP1
Jiang, LZ1
Xiong, P1
Yang, BJ1
Liu, SS1
Lin, WF1
Wang, C1
Ling, CQ1
Ku, HJ1
Kwon, OS1
Kang, BS1
Lee, DS1
Lee, HS1
Park, JW1
Xia, QS1
Sun, RY1
Xiu, RJ1
Gratz, A1
Götz, C1
Jose, J1
Bačkorová, M1
Bačkor, M1
Mikeš, J1
Jendželovský, R1
Fedoročko, P1
Lin, ML1
Lu, YC1
Su, HL1
Lin, HT1
Lee, CC1
Kang, SE1
Lai, TC1
Chung, JG1
Chen, SS1
Liu, A1
Chen, H1
Wei, W1
Ye, S1
Liao, W1
Gong, J1
Jiang, Z1
Wang, L1
Lin, S1
Yan, YY1
Zheng, LS1
Zhang, X1
Chen, LK1
Singh, S1
Zhang, JY1
Liang, YJ1
Dai, CL1
Gu, LQ1
Zeng, MS1
Talele, TT1
Chen, ZS1
Fu, LW1
Yang, J2
Chen, YY1
Wang, XJ1
Shi, GY1
Hu, QS1
Kang, XL1
Lu, Y1
Tang, XM1
Guo, QS1
Yi, J2
Huang, Q1
Shen, HM1
Shui, G1
Wenk, MR1
Ong, CN1
Jing, Y1
Chen, Y1
Hu, Q1
Shi, G1
Tang, X1
Olsen, BB1
Bjørling-Poulsen, M1
Guerra, B1
Song, Y1
Zeng, Y1
Su, L1
Zhang, Z1
Braumann, C1
Tangermann, J1
Jacobi, CA1
Müller, JM1
Dubiel, W1
Ueno, Y1
Rahimipour, S1
Bilkis, I1
Péron, V1
Gescheidt, G1
Barbosa, F1
Mazur, Y1
Koch, Y1
Weiner, L1
Fridkin, M1

Reviews

16 reviews available for emodin and Neoplasms

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia;

2000
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms;

2015
Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system.
    European journal of medicinal chemistry, 2019, Apr-01, Volume: 167

    Topics: Animals; Diet; Humans; Neoplasms; Phenols; Polyphenols; Proteasome Endopeptidase Complex; Ubiquitin

2019
The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb-A Summary Update.
    International journal of molecular sciences, 2021, Sep-01, Volume: 22, Issue:17

    Topics: Emodin; Humans; Infections; Inflammation; Neoplasms; Rheum

2021
Potential Role of Natural Products to Combat Radiotherapy and Their Future Perspectives.
    Molecules (Basel, Switzerland), 2021, Oct-02, Volume: 26, Issue:19

    Topics: Berberine; Biological Products; Curcumin; Emodin; Genistein; Humans; Neoplasms; Pentacyclic Triterpe

2021
Physcion and Physcion 8-O-β-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities.
    Current drug targets, 2021, Volume: 22, Issue:5

    Topics: Antineoplastic Agents; Emodin; Glucosides; Humans; Neoplasms; Signal Transduction

2021
Emodin: A metabolite that exhibits anti-neoplastic activities by modulating multiple oncogenic targets.
    Toxicology in vitro : an international journal published in association with BIBRA, 2021, Volume: 73

    Topics: Animals; Antineoplastic Agents; Drug Delivery Systems; Drug Synergism; Emodin; Humans; Intestinal Ab

2021
Sonodynamic therapy: A potential treatment for atherosclerosis.
    Life sciences, 2018, Aug-15, Volume: 207

    Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Atherosclerosis; Berberine; Cell Death; Chal

2018
Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.
    Cancer letters, 2013, Dec-01, Volume: 341, Issue:2

    Topics: Emodin; Humans; Inflammation; Models, Biological; Neoplasms; NF-kappa B; Protein Kinase Inhibitors;

2013
The distinct mechanisms of the antitumor activity of emodin in different types of cancer (Review).
    Oncology reports, 2013, Volume: 30, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Combined Modality Therapy; Drug Synergism; Emodin; Humans; Neoplas

2013
Potential antineoplastic effects of Aloe-emodin: a comprehensive review.
    The American journal of Chinese medicine, 2014, Volume: 42, Issue:2

    Topics: Aloe; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Transformation,

2014
[Research progress in anti-tumor effect of emodin].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2015, Volume: 40, Issue:20

    Topics: Animals; Antineoplastic Agents, Phytogenic; Emodin; Humans; Neoplasms

2015
[Progress of research on molecular mechanisms in antitumor effect of emodin].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2009, Volume: 29, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; Drug Resistance, Neoplasm; Emodin;

2009
[Advance of study on apoptosis inducer of several types of natural drug].
    Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2007, Volume: 24, Issue:3

    Topics: Abietanes; Antineoplastic Agents; Apoptosis; Emodin; Flavones; Humans; Neoplasms; Phenanthrenes; Sap

2007
Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets.
    Mini reviews in medicinal chemistry, 2008, Volume: 8, Issue:5

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; COP9 Signalosome Complex; Curcumin; Drug Sc

2008
[Mycotoxins as a tool for the analysis of biological function].
    Nihon saikingaku zasshi. Japanese journal of bacteriology, 1983, Volume: 38, Issue:5

    Topics: Aflatoxins; Animals; Chemical and Drug Induced Liver Injury; Cytochalasins; Cytochrome P-450 Enzyme

1983

Other Studies

25 other studies available for emodin and Neoplasms

ArticleYear
CHMIS-C: a comprehensive herbal medicine information system for cancer.
    Journal of medicinal chemistry, 2005, Mar-10, Volume: 48, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Databases, Factual; Internet; National Institutes of Health (U.S.

2005
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic

2007
Synthesis and biological evaluation of cytotoxic activity of novel anthracene L-rhamnopyranosides.
    Bioorganic & medicinal chemistry, 2010, Jul-15, Volume: 18, Issue:14

    Topics: Anthracenes; Cell Line, Tumor; Cytotoxins; DNA; DNA Topoisomerases, Type II; Humans; Monosaccharides

2010
Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity.
    Bioorganic & medicinal chemistry letters, 2012, Jan-01, Volume: 22, Issue:1

    Topics: Anthraquinones; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Collagen; Colonic Neoplasms;

2012
The Ethyl Acetate Subfraction of Polygonum cuspidatum Root Containing Emodin Affect EBV Gene Expression and Induce EBV-Positive Cells Apoptosis.
    Biological & pharmaceutical bulletin, 2021, Dec-01, Volume: 44, Issue:12

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Burkitt Lymphoma; Cell Line, Tumor; Emodin; Epstein-Ba

2021
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
    Journal of controlled release : official journal of the Controlled Release Society, 2022, Volume: 352

    Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen

2022
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
    Journal of controlled release : official journal of the Controlled Release Society, 2022, Volume: 352

    Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen

2022
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
    Journal of controlled release : official journal of the Controlled Release Society, 2022, Volume: 352

    Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen

2022
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
    Journal of controlled release : official journal of the Controlled Release Society, 2022, Volume: 352

    Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen

2022
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
    Journal of controlled release : official journal of the Controlled Release Society, 2022, Volume: 352

    Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen

2022
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
    Journal of controlled release : official journal of the Controlled Release Society, 2022, Volume: 352

    Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen

2022
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
    Journal of controlled release : official journal of the Controlled Release Society, 2022, Volume: 352

    Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen

2022
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
    Journal of controlled release : official journal of the Controlled Release Society, 2022, Volume: 352

    Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen

2022
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
    Journal of controlled release : official journal of the Controlled Release Society, 2022, Volume: 352

    Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen

2022
ROS/pH dual-sensitive emodin-chlorambucil co-loaded micelles enhance anti-tumor effect through combining oxidative damage and chemotherapy.
    International journal of pharmaceutics, 2023, Nov-25, Volume: 647

    Topics: Chlorambucil; Emodin; Glutathione; Humans; Hydrogen-Ion Concentration; Micelles; Neoplasms; Oxidativ

2023
On the mechanism of tumor cell entry of aloe-emodin, a natural compound endowed with anticancer activity.
    International journal of cancer, 2021, 09-01, Volume: 149, Issue:5

    Topics: Aloe; Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Emodin; H

2021
Respiratory status determines the effect of emodin on cell viability.
    Oncotarget, 2017, Jun-06, Volume: 8, Issue:23

    Topics: A549 Cells; Caco-2 Cells; Cell Proliferation; Cell Survival; Cells, Cultured; Emodin; Fibroblasts; H

2017
Protein Kinase CK2: An Emerging Regulator of Immunity.
    Trends in immunology, 2018, Volume: 39, Issue:2

    Topics: Animals; Autoimmune Diseases; Casein Kinase II; Clinical Trials as Topic; Emodin; Humans; Immunity;

2018
Identification of antiproliferative emodin analogues as inhibitors of epidermal growth factor receptor in cancer.
    International journal of molecular medicine, 2019, Volume: 43, Issue:3

    Topics: Binding Sites; Emodin; ErbB Receptors; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interac

2019
Combined treatment with emodin and a telomerase inhibitor induces significant telomere damage/dysfunction and cell death.
    Cell death & disease, 2019, 07-11, Volume: 10, Issue:7

    Topics: Aminobenzoates; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor

2019
Synthesis, characterization, and anti-cancer activity of emodin-Mn(II) metal complex.
    Chinese journal of natural medicines, 2014, Volume: 12, Issue:12

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Emodin; HeLa Cells; Hep G2 Cells; Humans;

2014
Antitumor Effects and Mechanism of Novel Emodin Rhamnoside Derivatives against Human Cancer Cells In Vitro.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationsh

2015
IDH2 knockdown sensitizes tumor cells to emodin cytotoxicity in vitro and in vivo.
    Free radical research, 2016, Volume: 50, Issue:10

    Topics: Animals; Apoptosis; Cell Line, Tumor; Emodin; Isocitrate Dehydrogenase; Mice; Neoplasms; Oxidation-R

2016
A FRET-based microplate assay for human protein kinase CK2, a target in neoplastic disease.
    Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:2

    Topics: Casein Kinase II; Emodin; Enzyme Assays; Fluorescence; Fluorescence Resonance Energy Transfer; Human

2010
Variable responses of different human cancer cells to the lichen compounds parietin, atranorin, usnic acid and gyrophoric acid.
    Toxicology in vitro : an international journal published in association with BIBRA, 2011, Volume: 25, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Benzoates; Benzofurans; Cell Adhesion; Cell Line, Tumor; Cell Nucl

2011
Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells.
    Journal of cellular biochemistry, 2011, Volume: 112, Issue:4

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Carrier Proteins; Caspase 8; C

2011
Antiproliferative and antimetastatic effects of emodin on human pancreatic cancer.
    Oncology reports, 2011, Volume: 26, Issue:1

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Emodi

2011
Blockade of Her2/neu binding to Hsp90 by emodin azide methyl anthraquinone derivative induces proteasomal degradation of Her2/neu.
    Molecular pharmaceutics, 2011, Oct-03, Volume: 8, Issue:5

    Topics: Animals; Anthraquinones; Antineoplastic Agents, Phytogenic; Azides; Cell Line, Tumor; Emodin; Female

2011
Anthraquinones sensitize tumor cells to arsenic cytotoxicity in vitro and in vivo via reactive oxygen species-mediated dual regulation of apoptosis.
    Free radical biology & medicine, 2004, Dec-15, Volume: 37, Issue:12

    Topics: Animals; Anthraquinones; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; Caspase 3; Caspase 9

2004
Emodin inhibits tumor cell adhesion through disruption of the membrane lipid Raft-associated integrin signaling pathway.
    Cancer research, 2006, Jun-01, Volume: 66, Issue:11

    Topics: Cell Adhesion; Cell Line, Tumor; Cholesterol; Emodin; Focal Adhesion Protein-Tyrosine Kinases; Focal

2006
Alteration of subcellular redox equilibrium and the consequent oxidative modification of nuclear factor kappaB are critical for anticancer cytotoxicity by emodin, a reactive oxygen species-producing agent.
    Free radical biology & medicine, 2006, Jun-15, Volume: 40, Issue:12

    Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cell Nucleus; DNA, Neoplasm; Emodin; HeLa Cells

2006
Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action.
    The international journal of biochemistry & cell biology, 2007, Volume: 39, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Casein Kinase II; Emodin; Enzyme Inhibitors; Gene Expression Regu

2007
Generation of free radicals by emodic acid and its [D-Lys6]GnRH-conjugate.
    Photochemistry and photobiology, 2001, Volume: 74, Issue:2

    Topics: Antineoplastic Agents; Emodin; Free Radicals; Gonadotropin-Releasing Hormone; Humans; Neoplasms; Pho

2001