emodin and Neoplasms
emodin has been researched along with Neoplasms in 41 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " In addition, characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome." | 4.80 | Human UDP-glucuronosyltransferases: metabolism, expression, and disease. ( Strassburg, CP; Tukey, RH, 2000) |
| "Cancer is the second leading cause of death in the world." | 2.72 | Potential Role of Natural Products to Combat Radiotherapy and Their Future Perspectives. ( Akter, R; Bibi, P; Hassan, SSU; Mubin, S; Najda, A; Rahman, MH; Saeeda, S; Shah, M; Wesołowska, S, 2021) |
| "In this paper we mainly report the anti-cancer effects of emodin according to the studies of the past five years, including four parts such as inhibit tumor growth, inhibit migration and invasion, enhance the efficacy of combination therapy, increase chemosensitivity and attenuated side effects." | 2.52 | [Research progress in anti-tumor effect of emodin]. ( Lin, WF; Ling, CQ; Wang, C, 2015) |
| "Emodin is a pleiotropic molecule capable of interacting with several major molecular targets including NF-κB, casein kinase II, HER2/neu, HIF-1α, AKT/mTOR, STAT3, CXCR4, topoisomerase II, p53, p21, and androgen receptors which are involved in inflammation and cancer." | 2.49 | Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer. ( Ahn, KS; Kumar, AP; Sethi, G; Shanmugam, MK; Shrimali, D; Tan, BK; Zhang, J, 2013) |
| "Emodin was identified as one of the best candidates, showing a great G4-binding potential." | 1.51 | Combined treatment with emodin and a telomerase inhibitor induces significant telomere damage/dysfunction and cell death. ( Geng, X; Liu, J; Liu, R; Liu, Y; Wang, F; Wang, S; Wang, Y; Zhang, T, 2019) |
| "Emodin was coordinated with Mn(II) through the 9-C=O and 1-OH, and the general formula of the complex was Mn(II) (emodin)2·2H2O." | 1.40 | Synthesis, characterization, and anti-cancer activity of emodin-Mn(II) metal complex. ( Tan, J; Wang, BC; Yang, L; Zhu, LC, 2014) |
| "Besides cardiovascular diseases, cancer represents the major cause of death in developed countries." | 1.36 | A FRET-based microplate assay for human protein kinase CK2, a target in neoplastic disease. ( Götz, C; Gratz, A; Jose, J, 2010) |
| "Emodin is a natural anthraquinone derivative that exhibits anti-proliferative effects in various cancer cell lines by efficient induction of apoptosis." | 1.34 | Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action. ( Bjørling-Poulsen, M; Guerra, B; Olsen, BB, 2007) |
| "In vivo study showed that tumors exposed to the arsenic/emodin cotreatment had dramatically smaller sizes and weaker antioxidant capacity, compared with arsenic alone." | 1.33 | Alteration of subcellular redox equilibrium and the consequent oxidative modification of nuclear factor kappaB are critical for anticancer cytotoxicity by emodin, a reactive oxygen species-producing agent. ( Chen, Y; Hu, Q; Jing, Y; Li, H; Shi, G; Tang, X; Wang, Y; Yang, J; Yi, J, 2006) |
| " Taken together, these results suggest an innovative and safe chemotherapeutic strategy that uses natural anthraquinone derivatives as ROS generators to increase the susceptibility of tumor cells to cytotoxic therapeutic agents." | 1.32 | Anthraquinones sensitize tumor cells to arsenic cytotoxicity in vitro and in vivo via reactive oxygen species-mediated dual regulation of apoptosis. ( Chen, YY; Guo, QS; Hu, QS; Kang, XL; Li, H; Lu, Y; Shi, GY; Tang, XM; Wang, XJ; Yang, J; Yi, J, 2004) |
| "Emodin is a naturally occurring anthraquinone which is widely used as a laxative and has other versatile biological activities." | 1.31 | Generation of free radicals by emodic acid and its [D-Lys6]GnRH-conjugate. ( Barbosa, F; Bilkis, I; Fridkin, M; Gescheidt, G; Koch, Y; Mazur, Y; Péron, V; Rahimipour, S; Weiner, L, 2001) |
Research
Studies (41)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.44) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (26.83) | 29.6817 |
| 2010's | 21 (51.22) | 24.3611 |
| 2020's | 8 (19.51) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Tukey, RH | 1 |
| Strassburg, CP | 1 |
| Fang, X | 1 |
| Shao, L | 1 |
| Zhang, H | 1 |
| Wang, S | 3 |
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Song, G | 1 |
| Liu, H | 1 |
| Zhang, W | 1 |
| Geng, M | 1 |
| Li, Y | 2 |
| Han, YM | 1 |
| Lee, SK | 1 |
| Jeong, DG | 1 |
| Ryu, SE | 1 |
| Han, DC | 1 |
| Kim, DK | 1 |
| Kwon, BM | 1 |
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 2 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Golonko, A | 1 |
| Pienkowski, T | 1 |
| Swislocka, R | 1 |
| Lazny, R | 1 |
| Roszko, M | 1 |
| Lewandowski, W | 1 |
| Stompor-Gorący, M | 1 |
| Yiu, CY | 1 |
| Chiu, YJ | 1 |
| Lin, TP | 1 |
| Akter, R | 1 |
| Najda, A | 1 |
| Rahman, MH | 1 |
| Shah, M | 1 |
| Wesołowska, S | 1 |
| Hassan, SSU | 1 |
| Mubin, S | 1 |
| Bibi, P | 1 |
| Saeeda, S | 1 |
| Wu, M | 3 |
| Ling, W | 3 |
| Wei, J | 3 |
| Liao, R | 3 |
| Sun, H | 3 |
| Li, D | 3 |
| Zhao, Y | 3 |
| Zhao, L | 3 |
| Liang, W | 1 |
| Fan, Y | 1 |
| Liu, Y | 3 |
| Fang, T | 1 |
| Zhang, J | 3 |
| Xu, Y | 1 |
| Li, J | 1 |
| Adnan, M | 1 |
| Rasul, A | 1 |
| Hussain, G | 1 |
| Shah, MA | 1 |
| Sarfraz, I | 1 |
| Nageen, B | 1 |
| Riaz, A | 1 |
| Khalid, R | 1 |
| Asrar, M | 1 |
| Selamoglu, Z | 1 |
| Adem, Ş | 1 |
| Sarker, SD | 1 |
| Tuli, HS | 1 |
| Aggarwal, V | 1 |
| Tuorkey, M | 1 |
| Aggarwal, D | 1 |
| Parashar, NC | 1 |
| Varol, M | 1 |
| Savla, R | 1 |
| Kaur, G | 1 |
| Mittal, S | 1 |
| Sak, K | 1 |
| Pecere, T | 1 |
| Ponterio, E | 1 |
| Di Iorio, E | 1 |
| Carli, M | 1 |
| Fassan, M | 1 |
| Santoro, L | 1 |
| Bissaro, M | 1 |
| Bernabè, G | 1 |
| Moro, S | 1 |
| Castagliuolo, I | 1 |
| Palù, G | 1 |
| Dumit, VI | 1 |
| Zerbes, RM | 1 |
| Kaeser-Pebernard, S | 1 |
| Rackiewicz, M | 1 |
| Wall, MT | 1 |
| Gretzmeier, C | 1 |
| Küttner, V | 1 |
| van der Laan, M | 1 |
| Braun, RJ | 1 |
| Dengjel, J | 1 |
| Gibson, SA | 1 |
| Benveniste, EN | 1 |
| Geng, C | 1 |
| Zhang, Y | 1 |
| Hidru, TH | 1 |
| Zhi, L | 1 |
| Tao, M | 1 |
| Zou, L | 1 |
| Chen, C | 1 |
| Li, H | 3 |
| Chen, KC | 1 |
| Juang, SH | 1 |
| Lien, JC | 1 |
| Liu, R | 1 |
| Liu, J | 1 |
| Wang, Y | 3 |
| Zhang, T | 1 |
| Geng, X | 1 |
| Wang, F | 2 |
| Shrimali, D | 1 |
| Shanmugam, MK | 1 |
| Kumar, AP | 1 |
| Tan, BK | 1 |
| Ahn, KS | 1 |
| Sethi, G | 1 |
| Wei, WT | 1 |
| Lin, SZ | 1 |
| Liu, DL | 1 |
| Wang, ZH | 1 |
| Chen, R | 1 |
| Hu, Y | 1 |
| Chen, M | 1 |
| Yang, L | 1 |
| Tan, J | 1 |
| Wang, BC | 1 |
| Zhu, LC | 1 |
| Xing, JY | 1 |
| Song, GP | 1 |
| Deng, JP | 1 |
| Jiang, LZ | 1 |
| Xiong, P | 1 |
| Yang, BJ | 1 |
| Liu, SS | 1 |
| Lin, WF | 1 |
| Wang, C | 1 |
| Ling, CQ | 1 |
| Ku, HJ | 1 |
| Kwon, OS | 1 |
| Kang, BS | 1 |
| Lee, DS | 1 |
| Lee, HS | 1 |
| Park, JW | 1 |
| Xia, QS | 1 |
| Sun, RY | 1 |
| Xiu, RJ | 1 |
| Gratz, A | 1 |
| Götz, C | 1 |
| Jose, J | 1 |
| Bačkorová, M | 1 |
| Bačkor, M | 1 |
| Mikeš, J | 1 |
| Jendželovský, R | 1 |
| Fedoročko, P | 1 |
| Lin, ML | 1 |
| Lu, YC | 1 |
| Su, HL | 1 |
| Lin, HT | 1 |
| Lee, CC | 1 |
| Kang, SE | 1 |
| Lai, TC | 1 |
| Chung, JG | 1 |
| Chen, SS | 1 |
| Liu, A | 1 |
| Chen, H | 1 |
| Wei, W | 1 |
| Ye, S | 1 |
| Liao, W | 1 |
| Gong, J | 1 |
| Jiang, Z | 1 |
| Wang, L | 1 |
| Lin, S | 1 |
| Yan, YY | 1 |
| Zheng, LS | 1 |
| Zhang, X | 1 |
| Chen, LK | 1 |
| Singh, S | 1 |
| Zhang, JY | 1 |
| Liang, YJ | 1 |
| Dai, CL | 1 |
| Gu, LQ | 1 |
| Zeng, MS | 1 |
| Talele, TT | 1 |
| Chen, ZS | 1 |
| Fu, LW | 1 |
| Yang, J | 2 |
| Chen, YY | 1 |
| Wang, XJ | 1 |
| Shi, GY | 1 |
| Hu, QS | 1 |
| Kang, XL | 1 |
| Lu, Y | 1 |
| Tang, XM | 1 |
| Guo, QS | 1 |
| Yi, J | 2 |
| Huang, Q | 1 |
| Shen, HM | 1 |
| Shui, G | 1 |
| Wenk, MR | 1 |
| Ong, CN | 1 |
| Jing, Y | 1 |
| Chen, Y | 1 |
| Hu, Q | 1 |
| Shi, G | 1 |
| Tang, X | 1 |
| Olsen, BB | 1 |
| Bjørling-Poulsen, M | 1 |
| Guerra, B | 1 |
| Song, Y | 1 |
| Zeng, Y | 1 |
| Su, L | 1 |
| Zhang, Z | 1 |
| Braumann, C | 1 |
| Tangermann, J | 1 |
| Jacobi, CA | 1 |
| Müller, JM | 1 |
| Dubiel, W | 1 |
| Ueno, Y | 1 |
| Rahimipour, S | 1 |
| Bilkis, I | 1 |
| Péron, V | 1 |
| Gescheidt, G | 1 |
| Barbosa, F | 1 |
| Mazur, Y | 1 |
| Koch, Y | 1 |
| Weiner, L | 1 |
| Fridkin, M | 1 |
Reviews
16 reviews available for emodin and Neoplasms
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; | 2000 |
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system.
Topics: Animals; Diet; Humans; Neoplasms; Phenols; Polyphenols; Proteasome Endopeptidase Complex; Ubiquitin | 2019 |
The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb-A Summary Update.
Topics: Emodin; Humans; Infections; Inflammation; Neoplasms; Rheum | 2021 |
Potential Role of Natural Products to Combat Radiotherapy and Their Future Perspectives.
Topics: Berberine; Biological Products; Curcumin; Emodin; Genistein; Humans; Neoplasms; Pentacyclic Triterpe | 2021 |
Physcion and Physcion 8-O-β-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities.
Topics: Antineoplastic Agents; Emodin; Glucosides; Humans; Neoplasms; Signal Transduction | 2021 |
Emodin: A metabolite that exhibits anti-neoplastic activities by modulating multiple oncogenic targets.
Topics: Animals; Antineoplastic Agents; Drug Delivery Systems; Drug Synergism; Emodin; Humans; Intestinal Ab | 2021 |
Sonodynamic therapy: A potential treatment for atherosclerosis.
Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Atherosclerosis; Berberine; Cell Death; Chal | 2018 |
Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.
Topics: Emodin; Humans; Inflammation; Models, Biological; Neoplasms; NF-kappa B; Protein Kinase Inhibitors; | 2013 |
The distinct mechanisms of the antitumor activity of emodin in different types of cancer (Review).
Topics: Antineoplastic Agents; Apoptosis; Combined Modality Therapy; Drug Synergism; Emodin; Humans; Neoplas | 2013 |
Potential antineoplastic effects of Aloe-emodin: a comprehensive review.
Topics: Aloe; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Transformation, | 2014 |
[Research progress in anti-tumor effect of emodin].
Topics: Animals; Antineoplastic Agents, Phytogenic; Emodin; Humans; Neoplasms | 2015 |
[Progress of research on molecular mechanisms in antitumor effect of emodin].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; Drug Resistance, Neoplasm; Emodin; | 2009 |
[Advance of study on apoptosis inducer of several types of natural drug].
Topics: Abietanes; Antineoplastic Agents; Apoptosis; Emodin; Flavones; Humans; Neoplasms; Phenanthrenes; Sap | 2007 |
Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; COP9 Signalosome Complex; Curcumin; Drug Sc | 2008 |
[Mycotoxins as a tool for the analysis of biological function].
Topics: Aflatoxins; Animals; Chemical and Drug Induced Liver Injury; Cytochalasins; Cytochrome P-450 Enzyme | 1983 |
Other Studies
25 other studies available for emodin and Neoplasms
| Article | Year |
|---|---|
CHMIS-C: a comprehensive herbal medicine information system for cancer.
Topics: Antineoplastic Agents, Phytogenic; Databases, Factual; Internet; National Institutes of Health (U.S. | 2005 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Synthesis and biological evaluation of cytotoxic activity of novel anthracene L-rhamnopyranosides.
Topics: Anthracenes; Cell Line, Tumor; Cytotoxins; DNA; DNA Topoisomerases, Type II; Humans; Monosaccharides | 2010 |
Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity.
Topics: Anthraquinones; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Collagen; Colonic Neoplasms; | 2012 |
The Ethyl Acetate Subfraction of Polygonum cuspidatum Root Containing Emodin Affect EBV Gene Expression and Induce EBV-Positive Cells Apoptosis.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Burkitt Lymphoma; Cell Line, Tumor; Emodin; Epstein-Ba | 2021 |
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen | 2022 |
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen | 2022 |
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen | 2022 |
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen | 2022 |
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen | 2022 |
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen | 2022 |
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen | 2022 |
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen | 2022 |
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment.
Topics: Biomimetics; Emodin; Ferritins; Ferroptosis; Nanoparticles; Neoplasms; Oxygen; Photosensitizing Agen | 2022 |
ROS/pH dual-sensitive emodin-chlorambucil co-loaded micelles enhance anti-tumor effect through combining oxidative damage and chemotherapy.
Topics: Chlorambucil; Emodin; Glutathione; Humans; Hydrogen-Ion Concentration; Micelles; Neoplasms; Oxidativ | 2023 |
On the mechanism of tumor cell entry of aloe-emodin, a natural compound endowed with anticancer activity.
Topics: Aloe; Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Emodin; H | 2021 |
Respiratory status determines the effect of emodin on cell viability.
Topics: A549 Cells; Caco-2 Cells; Cell Proliferation; Cell Survival; Cells, Cultured; Emodin; Fibroblasts; H | 2017 |
Protein Kinase CK2: An Emerging Regulator of Immunity.
Topics: Animals; Autoimmune Diseases; Casein Kinase II; Clinical Trials as Topic; Emodin; Humans; Immunity; | 2018 |
Identification of antiproliferative emodin analogues as inhibitors of epidermal growth factor receptor in cancer.
Topics: Binding Sites; Emodin; ErbB Receptors; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interac | 2019 |
Combined treatment with emodin and a telomerase inhibitor induces significant telomere damage/dysfunction and cell death.
Topics: Aminobenzoates; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor | 2019 |
Synthesis, characterization, and anti-cancer activity of emodin-Mn(II) metal complex.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Emodin; HeLa Cells; Hep G2 Cells; Humans; | 2014 |
Antitumor Effects and Mechanism of Novel Emodin Rhamnoside Derivatives against Human Cancer Cells In Vitro.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationsh | 2015 |
IDH2 knockdown sensitizes tumor cells to emodin cytotoxicity in vitro and in vivo.
Topics: Animals; Apoptosis; Cell Line, Tumor; Emodin; Isocitrate Dehydrogenase; Mice; Neoplasms; Oxidation-R | 2016 |
A FRET-based microplate assay for human protein kinase CK2, a target in neoplastic disease.
Topics: Casein Kinase II; Emodin; Enzyme Assays; Fluorescence; Fluorescence Resonance Energy Transfer; Human | 2010 |
Variable responses of different human cancer cells to the lichen compounds parietin, atranorin, usnic acid and gyrophoric acid.
Topics: Antineoplastic Agents; Apoptosis; Benzoates; Benzofurans; Cell Adhesion; Cell Line, Tumor; Cell Nucl | 2011 |
Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Carrier Proteins; Caspase 8; C | 2011 |
Antiproliferative and antimetastatic effects of emodin on human pancreatic cancer.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Emodi | 2011 |
Blockade of Her2/neu binding to Hsp90 by emodin azide methyl anthraquinone derivative induces proteasomal degradation of Her2/neu.
Topics: Animals; Anthraquinones; Antineoplastic Agents, Phytogenic; Azides; Cell Line, Tumor; Emodin; Female | 2011 |
Anthraquinones sensitize tumor cells to arsenic cytotoxicity in vitro and in vivo via reactive oxygen species-mediated dual regulation of apoptosis.
Topics: Animals; Anthraquinones; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; Caspase 3; Caspase 9 | 2004 |
Emodin inhibits tumor cell adhesion through disruption of the membrane lipid Raft-associated integrin signaling pathway.
Topics: Cell Adhesion; Cell Line, Tumor; Cholesterol; Emodin; Focal Adhesion Protein-Tyrosine Kinases; Focal | 2006 |
Alteration of subcellular redox equilibrium and the consequent oxidative modification of nuclear factor kappaB are critical for anticancer cytotoxicity by emodin, a reactive oxygen species-producing agent.
Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cell Nucleus; DNA, Neoplasm; Emodin; HeLa Cells | 2006 |
Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action.
Topics: Antineoplastic Agents, Phytogenic; Casein Kinase II; Emodin; Enzyme Inhibitors; Gene Expression Regu | 2007 |
Generation of free radicals by emodic acid and its [D-Lys6]GnRH-conjugate.
Topics: Antineoplastic Agents; Emodin; Free Radicals; Gonadotropin-Releasing Hormone; Humans; Neoplasms; Pho | 2001 |