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emodin and Muscle Contraction

emodin has been researched along with Muscle Contraction in 14 studies

Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.

Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

Research Excerpts

ExcerptRelevanceReference
"[3H]-ryanodine binding was dose-dependently potentiated by emodin in a biphasic manner."5.30Emodin-induced muscle contraction of mouse diaphragm and the involvement of Ca2+ influx and Ca2+ release from sarcoplasmic reticulum. ( Cheng, YW; Kang, JJ, 1998)
"(1) Emodin inhibited the tension and amplitude of jejunum smooth muscle contraction in a dose-dependent manner (P < 0."3.80[The effect of emodin on the contraction of isolated jejunum smooth muscle of rats]. ( Gao, L; Guo, Z; Han, X; Hu, P; Jiang, LL; Ma, HJ; Yang, J; Zhang, Y, 2014)
"To observe the effect of emodin on motility signal transduction and calcium ion in colonic smooth muscle cells (SMC) in rats with bacterial peritonitis caused multiple organ dysfunction syndrome (MODS)."3.72[Effect of emodin on motility signal transduction in colonic smooth muscle cells in rats with multiple organ dysfunction syndrome]. ( Chen, ZY; Jian, X; Ma, T; Qi, QH, 2004)
"Emodin has a direct contractile effect on colonic smooth muscle cell."1.32Signal pathways involved in emodin-induced contraction of smooth muscle cells from rat colon. ( Dong, ZL; Ma, T; Qi, QH; Xu, J; Yang, WX, 2004)
" Depletion of endogenous ACh in the presence of HC-3 was achieved by construction of an ACh dose-response curve, using exogenous ACh, prior to re-testing the effects of emodin in the presence of HC-3."1.32The stimulant cathartic, emodin, contracts the rat isolated ileum by triggering release of endogenous acetylcholine. ( Ali, S; Osborne, RH; Watson, MS, 2004)
"[3H]-ryanodine binding was dose-dependently potentiated by emodin in a biphasic manner."1.30Emodin-induced muscle contraction of mouse diaphragm and the involvement of Ca2+ influx and Ca2+ release from sarcoplasmic reticulum. ( Cheng, YW; Kang, JJ, 1998)
"Emodin is an active principle of Rheum palmatum."1.29[Study on effect of emodin on the isolated intestinal smooth muscle of guinea-pigs]. ( Jin, ZH; Lin, XZ; Ma, DL, 1994)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (28.57)18.2507
2000's7 (50.00)29.6817
2010's2 (14.29)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Chung, MI1
Gan, KH1
Lin, CN1
Ko, FN1
Teng, CM1
Qiu, JY1
Ma, LQ1
Liu, BB1
Zhang, WJ1
Liu, MS1
Wang, GG1
Zhao, XX1
Luo, X1
Wang, Q1
Xu, H1
Zang, DA1
Shen, J1
Peng, YB1
Zhao, P1
Xue, L1
Yu, MF1
Chen, W1
Dai, J1
Liu, QH1
Hu, P1
Yang, J1
Gao, L1
Han, X1
Jiang, LL1
Ma, HJ1
Guo, Z1
Zhang, Y1
Wu, ZX2
Yu, BP2
Xia, H2
Xu, L2
Yang, WX2
Wang, J2
Li, JY1
Chen, D1
Xiong, Y1
Wang, L1
Lv, B1
Lin, Y1
Ma, T2
Qi, QH2
Xu, J2
Dong, ZL1
Ali, S1
Watson, MS1
Osborne, RH1
Chen, ZY1
Jian, X1
Zheyu, C1
Qinghui, QI1
Lixin, L1
Tao, MA1
Zhang, L1
Lunan, Y1
Jin, ZH1
Ma, DL1
Lin, XZ1
Cheng, YW1
Kang, JJ1
Li, J1
Yang, W1
Hu, W1
Jin, Z1
Wang, X1
Xu, W1

Other Studies

14 other studies available for emodin and Muscle Contraction

ArticleYear
Antiplatelet effects and vasorelaxing action of some constituents of Formosan plants.
    Journal of natural products, 1993, Volume: 56, Issue:6

    Topics: Animals; Anthraquinones; Aorta, Thoracic; Female; In Vitro Techniques; Male; Muscle Contraction; Mus

1993
Folium Sennae and emodin reverse airway smooth muscle contraction.
    Cell biology international, 2020, Volume: 44, Issue:9

    Topics: Acetylcholine; Animals; Bronchodilator Agents; Emodin; Lung; Male; Mice; Mice, Inbred BALB C; Muscle

2020
[The effect of emodin on the contraction of isolated jejunum smooth muscle of rats].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2014, Volume: 30, Issue:1

    Topics: Animals; Calcium Signaling; Emodin; Glyburide; Jejunum; Muscle Contraction; Muscle, Smooth; NG-Nitro

2014
Emodin increases Ca(2+) influx through L-type Ca(2+) channel in guinea pig gallbladder smooth muscle.
    European journal of pharmacology, 2008, Oct-24, Volume: 595, Issue:1-3

    Topics: Animals; Calcium Channel Agonists; Calcium Channels, L-Type; Calcium Signaling; Dose-Response Relati

2008
Emodin inhibits voltage-dependent potassium current in guinea pig gallbladder smooth muscle.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Emodin; Female; Gallbladder; Guinea Pigs; In Vitro Techni

2009
[Effects of emodin on cytoplasmic adenine nucleotide content in guinea pig taenia coli cells].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2001, Volume: 17, Issue:3

    Topics: Adenine Nucleotides; Animals; Colon; Cytoplasm; Emodin; Guinea Pigs; Muscle Contraction; Muscle, Smo

2001
Characteristics of emodin on modulating the contractility of jejunal smooth muscle.
    Canadian journal of physiology and pharmacology, 2012, Volume: 90, Issue:4

    Topics: Animals; Atropine; Constipation; Diarrhea; Diphenhydramine; Disease Models, Animal; Dose-Response Re

2012
Signal pathways involved in emodin-induced contraction of smooth muscle cells from rat colon.
    World journal of gastroenterology, 2004, May-15, Volume: 10, Issue:10

    Topics: Animals; Azepines; Calcium; Calcium Signaling; Colon; Emodin; Enzyme Inhibitors; Muscle Contraction;

2004
The stimulant cathartic, emodin, contracts the rat isolated ileum by triggering release of endogenous acetylcholine.
    Autonomic & autacoid pharmacology, 2004, Volume: 24, Issue:4

    Topics: Acetylcholine; Animals; Atropine; Catecholamines; Cathartics; Dose-Response Relationship, Drug; Emod

2004
[Effect of emodin on motility signal transduction in colonic smooth muscle cells in rats with multiple organ dysfunction syndrome].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2004, Volume: 24, Issue:12

    Topics: Animals; Calcium; Colon; Emodin; Enzyme Inhibitors; Gastrointestinal Motility; In Vitro Techniques;

2004
Effects of emodin on Ca2+ signal transduction of smooth muscle cells in multiple organ dysfunction syndrome.
    The Journal of surgical research, 2006, Volume: 131, Issue:1

    Topics: Animals; Calcium Signaling; Colon; Emodin; Enzyme Inhibitors; Male; Multiple Organ Failure; Muscle C

2006
[Study on effect of emodin on the isolated intestinal smooth muscle of guinea-pigs].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1994, Volume: 14, Issue:7

    Topics: Animals; Calcium Chloride; Colon; Dose-Response Relationship, Drug; Emodin; Guinea Pigs; Ileum; In V

1994
Emodin-induced muscle contraction of mouse diaphragm and the involvement of Ca2+ influx and Ca2+ release from sarcoplasmic reticulum.
    British journal of pharmacology, 1998, Volume: 123, Issue:5

    Topics: Animals; Calcium; Diaphragm; Emodin; Female; Ion Transport; Male; Mice; Mice, Inbred ICR; Muscle Con

1998
[Effects of emodin on the activity of K channel in guinea pig taenia coli smooth muscle cells].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1998, Volume: 33, Issue:5

    Topics: Animals; Cromakalim; Dose-Response Relationship, Drug; Emodin; Female; Guinea Pigs; Male; Membrane P

1998