Page last updated: 2024-10-26

emodin and Lung Neoplasms

emodin has been researched along with Lung Neoplasms in 42 studies

Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.

Lung Neoplasms: Tumors or cancer of the LUNG.

Research Excerpts

ExcerptRelevanceReference
"This study suggests a novel function of emodin, whereby it selectively suppresses N2 neutrophils to prevent hypercoagulation and lung carcinogenesis."7.91Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis. ( Du, G; Duan, Y; Li, Z; Lin, H; Lin, Y; Tong, Q; Wang, M; Wang, Y; Yan, G; Zhang, M; Zhang, S; Zhou, L, 2019)
"This study investigated the mechanism of the cytotoxic effect of emodin, an active anthraquinone, on human lung adenocarcinoma A549 cells."7.80Emodin elicits cytotoxicity in human lung adenocarcinoma A549 cells through inducing apoptosis. ( Chan, SW; Guo, DJ; Guo, ZD; Kwan, YW; Lee, SM; Leung, GP; Li, WY; Ng, YF; Yu, PH; Zhang, H, 2014)
"To investigate the anti-tumor mechanisms of emodin on human lung adenocarcinoma cell line Anip973 (LACC)."7.73[Inhibitory effect of emodin on proliferation of human lung adenocarcinoma cells in vitro]. ( Bao, Y; Li, JN; Lu, FZ; Xiao, JL, 2005)
"To study the suppressive role of emodin on the growth and its effect on the proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line Anip 973."7.73[Effects of emodin on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line Anip 973]. ( Li, JN; Lv, FZ; Xiao, JL, 2006)
"Lung adenocarcinoma is the most common type of lung cancer."5.91The ethyl acetate extract of Wenxia Changfu Formula inhibits the carcinogenesis of lung adenocarcinoma by regulating PI3K-AKT signaling pathway. ( Han, X; Li, H; Lv, C; Wang, L; Wang, M, 2023)
"Emodin is an anthraquinone derivative originally isolated from Chinese rhubarb, possesses anticancer properties."5.46Emodin Inhibits ATP-Induced Proliferation and Migration by Suppressing P2Y Receptors in Human Lung Adenocarcinoma Cells. ( Guan, R; Li, L; Shen, L; Song, N; Wang, X; Zhu, D, 2017)
"In the present study, we used breast cancer MDA-MB-231 cells and a mouse xenograft model to demonstrate the effect of emodin on the migration, invasion and metastasis of human breast cancer MDA-MB-231 cells and the related mechanisms."5.42Inhibitory effect of emodin on migration, invasion and metastasis of human breast cancer MDA-MB-231 cells in vitro and in vivo. ( Chen, Q; Lu, Y; Su, S; Sun, Y; Wang, X; Zhang, H; Zhao, M; Zhou, Q, 2015)
"Emodin (EMD) is an anthraquinone derivative extracted from the root and rhizome of Rheum palmatum L."5.42The anthraquinone derivative Emodin inhibits angiogenesis and metastasis through downregulating Runx2 activity in breast cancer. ( Chen, B; Fu, J; Ke, X; Liu, T; Liu, Z; Lu, H; Ma, J; Wang, S, 2015)
"Emodin has been found to exert anti-tumor effects through promoting cell cycle arrest and apoptosis, and inhibiting angiogenesis, but its effects on tumor-associated macrophages during cancer metastasis have not been investigated."5.40Emodin suppresses pulmonary metastasis of breast cancer accompanied with decreased macrophage recruitment and M2 polarization in the lungs. ( Fan, D; Hu, J; Iwanowycz, S; Jia, X; Saaoud, F; Wang, J; Wang, Q; Wang, Y; Yu, F, 2014)
"The emodin treatment induced P450s 1A1 and 1B1 mRNA in human lung carcinoma NCI-H322 and breast cancer MCF-7 cells."5.31Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5. ( Chen, TL; Ueng, TH; Wang, HW; Yang, PC, 2001)
"This study suggests a novel function of emodin, whereby it selectively suppresses N2 neutrophils to prevent hypercoagulation and lung carcinogenesis."3.91Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis. ( Du, G; Duan, Y; Li, Z; Lin, H; Lin, Y; Tong, Q; Wang, M; Wang, Y; Yan, G; Zhang, M; Zhang, S; Zhou, L, 2019)
"This study investigated the mechanism of the cytotoxic effect of emodin, an active anthraquinone, on human lung adenocarcinoma A549 cells."3.80Emodin elicits cytotoxicity in human lung adenocarcinoma A549 cells through inducing apoptosis. ( Chan, SW; Guo, DJ; Guo, ZD; Kwan, YW; Lee, SM; Leung, GP; Li, WY; Ng, YF; Yu, PH; Zhang, H, 2014)
"To investigate the anti-tumor mechanisms of emodin on human lung adenocarcinoma cell line Anip973 (LACC)."3.73[Inhibitory effect of emodin on proliferation of human lung adenocarcinoma cells in vitro]. ( Bao, Y; Li, JN; Lu, FZ; Xiao, JL, 2005)
"To study the suppressive role of emodin on the growth and its effect on the proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line Anip 973."3.73[Effects of emodin on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line Anip 973]. ( Li, JN; Lv, FZ; Xiao, JL, 2006)
"Lung adenocarcinoma is the most common type of lung cancer."1.91The ethyl acetate extract of Wenxia Changfu Formula inhibits the carcinogenesis of lung adenocarcinoma by regulating PI3K-AKT signaling pathway. ( Han, X; Li, H; Lv, C; Wang, L; Wang, M, 2023)
"Emodin is a Chinese herb-derived compound extracted from the roots of Rheum officinale that exhibits numerous pharmacological characteristics."1.72Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-IIa. ( Fan, XX; Guan, XX; Leung, EL; Li, JX; Li, RZ; Liang, TL; Liu, L; Meng, WY; Pan, HD; Wang, XR; Wu, QB; Xu, C; Yao, XJ; Zhang, FY, 2022)
"Lung cancer is one of the most common causes of cancer related mortality."1.51Physcion 8-O-β-Glucopyranoside Exerts Anti-Tumor Activity Against Non-Small Cell Lung Cancer by Targeting PPARγ. ( Du, Y; Li, Y; Lv, Z; Sun, D; Sun, L; Zhou, J, 2019)
"Emodin is an anthraquinone derivative originally isolated from Chinese rhubarb, possesses anticancer properties."1.46Emodin Inhibits ATP-Induced Proliferation and Migration by Suppressing P2Y Receptors in Human Lung Adenocarcinoma Cells. ( Guan, R; Li, L; Shen, L; Song, N; Wang, X; Zhu, D, 2017)
"Given the aggressive properties of breast cancer, the current study suggests that PG can serve as a safe therapeutic agent for suppressing breast cancer metastasis, although additional data is necessitated."1.46Physcion 8-O-β-glucopyranoside suppresses the metastasis of breast cancer in vitro and in vivo by modulating DNMT1. ( Chen, X; Fan, D; Guo, H; Li, F, 2017)
"Emodin is a phytochemical with potent anticancer activities against various human malignant cancer types, including lung cancer; however, the molecular mechanisms underlying the effects of emodin remain unclear."1.46Emodin induces apoptosis of lung cancer cells through ER stress and the TRIB3/NF-κB pathway. ( Cai, H; Liu, Z; Qu, J; Su, J; Xue, X; Yan, Y, 2017)
"Emodin has anti-neoplastic activities on multiple tumors."1.46Emodin Increases Expression of Insulin-Like Growth Factor Binding Protein 1 through Activation of MEK/ERK/AMPKα and Interaction of PPARγ and Sp1 in Lung Cancer. ( Chen, Y; Hann, SS; Tang, Q; Wu, J; Zheng, F, 2017)
" Their biodistribution and pharmacokinetic properties were determined in rat models of induced necrosis."1.43Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones. ( Feng, Y; Gao, M; Huang, D; Jiang, C; Ni, Y; Shao, H; Sun, Z; Wang, X; Yang, S; Yin, Z; Zhang, D; Zhang, J, 2016)
"In the present study, we used breast cancer MDA-MB-231 cells and a mouse xenograft model to demonstrate the effect of emodin on the migration, invasion and metastasis of human breast cancer MDA-MB-231 cells and the related mechanisms."1.42Inhibitory effect of emodin on migration, invasion and metastasis of human breast cancer MDA-MB-231 cells in vitro and in vivo. ( Chen, Q; Lu, Y; Su, S; Sun, Y; Wang, X; Zhang, H; Zhao, M; Zhou, Q, 2015)
"Emodin (EMD) is an anthraquinone derivative extracted from the root and rhizome of Rheum palmatum L."1.42The anthraquinone derivative Emodin inhibits angiogenesis and metastasis through downregulating Runx2 activity in breast cancer. ( Chen, B; Fu, J; Ke, X; Liu, T; Liu, Z; Lu, H; Ma, J; Wang, S, 2015)
"Emodin has been found to exert anti-tumor effects through promoting cell cycle arrest and apoptosis, and inhibiting angiogenesis, but its effects on tumor-associated macrophages during cancer metastasis have not been investigated."1.40Emodin suppresses pulmonary metastasis of breast cancer accompanied with decreased macrophage recruitment and M2 polarization in the lungs. ( Fan, D; Hu, J; Iwanowycz, S; Jia, X; Saaoud, F; Wang, J; Wang, Q; Wang, Y; Yu, F, 2014)
"In emodin- and MMC-cotreated cells, ERK1/2 phosphorylation was enhanced by constitutively active MKK1/2 (MKK1/2-CA), thus increasing Rad51 protein levels and protein stability."1.36Role of Rad51 down-regulation and extracellular signal-regulated kinases 1 and 2 inactivation in emodin and mitomycin C-induced synergistic cytotoxicity in human non-small-cell lung cancer cells. ( Cheng, CM; Chiu, YF; Kuo, YH; Lin, ST; Lin, YW; Su, YJ; Tsai, MS, 2010)
"Emodin has been shown to exhibit an anti-cancer effect."1.34Effects of emodin on gene expression profile in small cell lung cancer NCI-H446 cells. ( Fu, ZY; Han, JX; Huang, HY, 2007)
"The emodin treatment induced P450s 1A1 and 1B1 mRNA in human lung carcinoma NCI-H322 and breast cancer MCF-7 cells."1.31Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5. ( Chen, TL; Ueng, TH; Wang, HW; Yang, PC, 2001)
"Aloe-emodin-treated CH27 cells had an increased relative abundance of cytochrome c in the cytosolic fraction."1.31Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma. ( Hsu, SL; Lee, HZ; Liu, MC; Wu, CH, 2001)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.38)18.2507
2000's11 (26.19)29.6817
2010's23 (54.76)24.3611
2020's7 (16.67)2.80

Authors

AuthorsStudies
Zhang, FY1
Li, RZ1
Xu, C1
Fan, XX1
Li, JX1
Meng, WY1
Wang, XR1
Liang, TL1
Guan, XX1
Pan, HD1
Liu, L1
Yao, XJ1
Wu, QB1
Leung, EL1
Kim, HJ1
Choi, JW1
Ree, J1
Lim, JS1
Lee, J1
Kim, JI1
Thapa, SB1
Sohng, JK1
Park, YI1
Fang, XQ1
Kim, YS1
Lee, YM1
Lee, M1
Lim, WJ1
Yim, WJ1
Han, MW1
Lim, JH1
Wang, L1
Han, X1
Li, H1
Lv, C1
Wang, M2
McDonald, SJ1
Bullard, BM1
VanderVeen, BN1
Cardaci, TD1
Chatzistamou, I1
Fan, D3
Murphy, EA1
Lin, H2
Hu, B1
He, X1
Mao, J1
Wang, Y3
Wang, J3
Zhang, T1
Zheng, J1
Peng, Y1
Zhang, F1
Teng, X1
Wang, SY1
Shi, YQ1
Fan, XF1
Liu, S1
Xing, Y1
Guo, YY1
Dong, M1
Ying, Y1
Qingwu, L1
Mingming, X1
Zhenju, S1
Chaoyang, T1
Zhengang, T1
Wan, L1
Zhang, L2
Fan, K1
Wang, X3
Li, L1
Guan, R1
Zhu, D1
Song, N1
Shen, L1
Haque, E2
Kamil, M2
Irfan, S2
Sheikh, S2
Hasan, A2
Nazir, A2
Mir, SS2
Iyer, VV1
Priya, PY1
Kangeyavelu, J1
Du, Y1
Lv, Z1
Sun, D1
Li, Y1
Sun, L1
Zhou, J1
Alam, S1
Ansari, KM1
Li, Z1
Lin, Y1
Zhang, S1
Zhou, L1
Yan, G1
Zhang, M1
Tong, Q1
Duan, Y1
Du, G1
Chen, S1
Zhang, Z1
Zhang, J2
Kapoor, S1
Li, WY1
Ng, YF1
Zhang, H2
Guo, ZD1
Guo, DJ1
Kwan, YW1
Leung, GP1
Lee, SM1
Yu, PH1
Chan, SW1
Chen, X2
Yang, Z1
Sun, R1
Mo, Z1
Jin, G1
Wei, F1
Hu, J2
Guan, W1
Zhong, N1
Jia, X1
Yu, F1
Iwanowycz, S1
Saaoud, F1
Wang, Q1
Sun, Y1
Zhou, Q1
Lu, Y1
Chen, Q1
Zhao, M1
Su, S1
Ma, J1
Lu, H1
Wang, S1
Chen, B1
Liu, Z2
Ke, X1
Liu, T1
Fu, J1
Zhang, D1
Jiang, C1
Yang, S1
Gao, M1
Huang, D1
Shao, H1
Feng, Y1
Sun, Z1
Ni, Y1
Yin, Z1
Guo, H1
Li, F1
Su, J1
Yan, Y1
Qu, J1
Xue, X1
Cai, H1
Tang, Q1
Wu, J1
Zheng, F1
Hann, SS1
Chen, Y1
Ko, JC2
Su, YJ3
Lin, ST3
Jhan, JY2
Ciou, SC2
Cheng, CM3
Lin, YW3
Chiu, YF2
Kuo, YH2
Tsai, MS2
Ok, S1
Kim, SM1
Kim, C1
Nam, D1
Shim, BS1
Kim, SH1
Ahn, KS2
Choi, SH1
Yeh, FT1
Wu, CH3
Lee, HZ6
Chang, SP2
Su, YT1
Chang, HL1
Shyue, SK1
Hsu, SL2
Li, JN2
Lu, FZ1
Xiao, JL2
Bao, Y1
Lin, CJ1
Yang, WH1
Leung, WC1
Lv, FZ1
Fu, ZY1
Han, JX1
Huang, HY1
Hung, MC1
Wang, HW1
Chen, TL1
Yang, PC1
Ueng, TH1
Liu, MC1

Other Studies

42 other studies available for emodin and Lung Neoplasms

ArticleYear
Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-IIa.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 95

    Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Down-Regulation; Emodin; Humans; Lung Neoplasms; Phosphol

2022
Aloe emodin 3-O-glucoside inhibits cell growth and migration and induces apoptosis of non-small-cell lung cancer cells via suppressing MEK/ERK and Akt signalling pathways.
    Life sciences, 2022, Jul-01, Volume: 300

    Topics: Animals; Anthraquinones; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Prolifera

2022
    Nutrients, 2022, Apr-05, Volume: 14, Issue:7

    Topics: Animals; Cachexia; Emodin; Fallopia japonica; Humans; Lung Neoplasms; Mammals; Mice; Nuclear Protein

2022
The ethyl acetate extract of Wenxia Changfu Formula inhibits the carcinogenesis of lung adenocarcinoma by regulating PI3K-AKT signaling pathway.
    Scientific reports, 2023, 03-22, Volume: 13, Issue:1

    Topics: Adenocarcinoma of Lung; Carcinogenesis; Emodin; Humans; Lung Neoplasms; Matrix Metalloproteinase 3;

2023
Emodin reduces surgical wounding-accelerated tumor growth and metastasis via macrophage suppression in a murine triple-negative breast cancer model.
    Physiological reports, 2023, Volume: 11, Issue:19

    Topics: Animals; Cell Line, Tumor; Emodin; Humans; Lung; Lung Neoplasms; Macrophages; Mice; Triple Negative

2023
Overcoming Taxol-resistance in A549 cells: A comprehensive strategy of targeting P-gp transporter, AKT/ERK pathways, and cytochrome P450 enzyme CYP1B1 by 4-hydroxyemodin.
    Biochemical pharmacology, 2020, Volume: 171

    Topics: A549 Cells; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transport

2020
The role of emodin on cisplatin resistance reversal of lung adenocarcinoma A549/DDP cell.
    Anti-cancer drugs, 2021, 10-01, Volume: 32, Issue:9

    Topics: A549 Cells; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transport

2021
Emodin: One Main Ingredient of Shufeng Jiedu Capsule Reverses Chemoresistance of Lung Cancer Cells Through Inhibition of EMT.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 42, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Emodin;

2017
Aloin promotes A549 cell apoptosis via the reactive oxygen species‑mitogen activated protein kinase signaling pathway and p53 phosphorylation.
    Molecular medicine reports, 2017, Volume: 16, Issue:5

    Topics: A549 Cells; Animals; Apoptosis; Cell Proliferation; Emodin; Gene Expression Regulation, Neoplastic;

2017
Emodin Inhibits ATP-Induced Proliferation and Migration by Suppressing P2Y Receptors in Human Lung Adenocarcinoma Cells.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 44, Issue:4

    Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Adenosine Triphosphate; bcl-2-Associated X Prote

2017
Blocking mutation independent p53 aggregation by emodin modulates autophagic cell death pathway in lung cancer.
    The international journal of biochemistry & cell biology, 2018, Volume: 96

    Topics: A549 Cells; Autophagy; Emodin; Humans; Lung Neoplasms; Protein Aggregates; Tumor Suppressor Protein

2018
Effects of increased accumulation of doxorubicin due to emodin on efflux transporter and LRP1 expression in lung adenocarcinoma and colorectal carcinoma cells.
    Molecular and cellular biochemistry, 2018, Volume: 449, Issue:1-2

    Topics: A549 Cells; Adenocarcinoma of Lung; Carrier Proteins; Colorectal Neoplasms; Doxorubicin; Emodin; Hum

2018
Physcion 8-O-β-Glucopyranoside Exerts Anti-Tumor Activity Against Non-Small Cell Lung Cancer by Targeting PPARγ.
    Anatomical record (Hoboken, N.J. : 2007), 2019, Volume: 302, Issue:5

    Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Ch

2019
Hydroxyl Group Difference between Anthraquinone Derivatives Regulate Different Cell Death Pathways via Nucleo-Cytoplasmic Shuttling of p53.
    Anti-cancer agents in medicinal chemistry, 2019, Volume: 19, Issue:2

    Topics: A549 Cells; Anthraquinones; Antineoplastic Agents; Cell Death; Cell Proliferation; Dose-Response Rel

2019
Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis.
    Journal of translational medicine, 2019, 03-18, Volume: 17, Issue:1

    Topics: Allografts; Animals; Blood Coagulation Disorders; Carcinogenesis; Carcinoma, Lewis Lung; Emodin; Ext

2019
Emodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo.
    Drug design, development and therapy, 2019, Volume: 13

    Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Non-Small-Cell Lung; C

2019
Emodin: inhibitory effects on growth in malignant tumors.
    Immunopharmacology and immunotoxicology, 2013, Volume: 35, Issue:2

    Topics: Cell Movement; Down-Regulation; Emodin; Humans; Lung Neoplasms; Male; Prostatic Neoplasms; Protein K

2013
Emodin elicits cytotoxicity in human lung adenocarcinoma A549 cells through inducing apoptosis.
    Inflammopharmacology, 2014, Volume: 22, Issue:2

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle Checkpo

2014
Preparation of lung-targeting, emodin-loaded polylactic acid microspheres and their properties.
    International journal of molecular sciences, 2014, Apr-11, Volume: 15, Issue:4

    Topics: Animals; Drug Carriers; Emodin; Gelatin; Injections, Intravenous; Lactic Acid; Lung Diseases; Lung N

2014
Emodin suppresses pulmonary metastasis of breast cancer accompanied with decreased macrophage recruitment and M2 polarization in the lungs.
    Breast cancer research and treatment, 2014, Volume: 148, Issue:2

    Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell Movement; Cell Prolifer

2014
Inhibitory effect of emodin on migration, invasion and metastasis of human breast cancer MDA-MB-231 cells in vitro and in vivo.
    Oncology reports, 2015, Volume: 33, Issue:1

    Topics: Animals; Antineoplastic Agents; Body Weight; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Dose

2015
The anthraquinone derivative Emodin inhibits angiogenesis and metastasis through downregulating Runx2 activity in breast cancer.
    International journal of oncology, 2015, Volume: 46, Issue:4

    Topics: Angiogenesis Inhibitors; Animals; Breast Neoplasms; Cell Proliferation; Core Binding Factor Alpha 1

2015
Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones.
    Journal of drug targeting, 2016, Volume: 24, Issue:6

    Topics: Animals; Anthracenes; Cell Line, Tumor; Disease Models, Animal; Drug Delivery Systems; Drug Design;

2016
Physcion 8-O-β-glucopyranoside suppresses the metastasis of breast cancer in vitro and in vivo by modulating DNMT1.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:1

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; DNA (Cytosine-5-)-Methyltransferase 1; D

2017
Emodin induces apoptosis of lung cancer cells through ER stress and the TRIB3/NF-κB pathway.
    Oncology reports, 2017, Volume: 37, Issue:3

    Topics: Animals; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Cell Pro

2017
Emodin Increases Expression of Insulin-Like Growth Factor Binding Protein 1 through Activation of MEK/ERK/AMPKα and Interaction of PPARγ and Sp1 in Lung Cancer.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 41, Issue:1

    Topics: A549 Cells; AMP-Activated Protein Kinases; Animals; Cell Cycle Checkpoints; Cell Line, Tumor; Cell M

2017
Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells.
    Biochemical pharmacology, 2010, Feb-15, Volume: 79, Issue:4

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Repair; DNA-Binding Proteins; Dose-Response Re

2010
Emodin enhances cisplatin-induced cytotoxicity via down-regulation of ERCC1 and inactivation of ERK1/2.
    Lung cancer (Amsterdam, Netherlands), 2010, Volume: 69, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Butadienes; Carcinoma, Non-Small-Cell Lun

2010
Role of Rad51 down-regulation and extracellular signal-regulated kinases 1 and 2 inactivation in emodin and mitomycin C-induced synergistic cytotoxicity in human non-small-cell lung cancer cells.
    Molecular pharmacology, 2010, Volume: 77, Issue:4

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Down-Regulation; Drug Synergism; Emodin; Humans; L

2010
Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4.
    Immunopharmacology and immunotoxicology, 2012, Volume: 34, Issue:5

    Topics: Cell Line, Tumor; Cell Movement; Chemokine CXCL12; Down-Regulation; Emodin; Humans; Lung Neoplasms;

2012
Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell.
    International journal of cancer, 2003, Aug-10, Volume: 106, Issue:1

    Topics: Alkaloids; Anthraquinones; Apoptosis; Benzophenanthridines; Blotting, Western; Carcinoma, Non-Small-

2003
Release of nucleophosmin from the nucleus: Involvement in aloe-emodin-induced human lung non small carcinoma cell apoptosis.
    International journal of cancer, 2005, Mar-01, Volume: 113, Issue:6

    Topics: Amino Acid Sequence; Anthraquinones; Apoptosis; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Ad

2005
Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway.
    Biochemical pharmacology, 2005, Jul-15, Volume: 70, Issue:2

    Topics: Adenocarcinoma; Animals; Apoptosis; Cell Line, Tumor; Emodin; Humans; Lung Neoplasms; Mitochondria;

2005
[Inhibitory effect of emodin on proliferation of human lung adenocarcinoma cells in vitro].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2005, Volume: 25, Issue:7

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation;

2005
Aloe-emodin induced DNA damage through generation of reactive oxygen species in human lung carcinoma cells.
    Cancer letters, 2006, Jul-28, Volume: 239, Issue:1

    Topics: Anthraquinones; Apoptosis; Comet Assay; DNA Damage; DNA Glycosylases; DNA Repair; DNA Repair Enzymes

2006
[Effects of emodin on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line Anip 973].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2006, Volume: 26, Issue:11

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase 3; Ce

2006
Effects of emodin on gene expression profile in small cell lung cancer NCI-H446 cells.
    Chinese medical journal, 2007, Oct-05, Volume: 120, Issue:19

    Topics: Apoptosis; Carcinoma, Small Cell; Cell Line, Tumor; Cell Survival; Emodin; Gene Expression Profiling

2007
Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin.
    Oncogene, 1996, Feb-01, Volume: 12, Issue:3

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Division; Cisplatin; Dose-Response Relat

1996
Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5.
    Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:9

    Topics: Adenocarcinoma; Anthracenes; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-45

2001
Effects and mechanisms of emodin on cell death in human lung squamous cell carcinoma.
    British journal of pharmacology, 2001, Volume: 134, Issue:1

    Topics: Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Ca

2001
Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell.
    British journal of pharmacology, 2001, Volume: 134, Issue:5

    Topics: Anthraquinones; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Survi

2001
Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma.
    European journal of pharmacology, 2001, Nov-23, Volume: 431, Issue:3

    Topics: Anthraquinones; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Caspases; Cytochrome c G

2001