emodin has been researched along with Lung Neoplasms in 42 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study suggests a novel function of emodin, whereby it selectively suppresses N2 neutrophils to prevent hypercoagulation and lung carcinogenesis." | 7.91 | Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis. ( Du, G; Duan, Y; Li, Z; Lin, H; Lin, Y; Tong, Q; Wang, M; Wang, Y; Yan, G; Zhang, M; Zhang, S; Zhou, L, 2019) |
| "This study investigated the mechanism of the cytotoxic effect of emodin, an active anthraquinone, on human lung adenocarcinoma A549 cells." | 7.80 | Emodin elicits cytotoxicity in human lung adenocarcinoma A549 cells through inducing apoptosis. ( Chan, SW; Guo, DJ; Guo, ZD; Kwan, YW; Lee, SM; Leung, GP; Li, WY; Ng, YF; Yu, PH; Zhang, H, 2014) |
| "To investigate the anti-tumor mechanisms of emodin on human lung adenocarcinoma cell line Anip973 (LACC)." | 7.73 | [Inhibitory effect of emodin on proliferation of human lung adenocarcinoma cells in vitro]. ( Bao, Y; Li, JN; Lu, FZ; Xiao, JL, 2005) |
| "To study the suppressive role of emodin on the growth and its effect on the proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line Anip 973." | 7.73 | [Effects of emodin on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line Anip 973]. ( Li, JN; Lv, FZ; Xiao, JL, 2006) |
| "Lung adenocarcinoma is the most common type of lung cancer." | 5.91 | The ethyl acetate extract of Wenxia Changfu Formula inhibits the carcinogenesis of lung adenocarcinoma by regulating PI3K-AKT signaling pathway. ( Han, X; Li, H; Lv, C; Wang, L; Wang, M, 2023) |
| "Emodin is an anthraquinone derivative originally isolated from Chinese rhubarb, possesses anticancer properties." | 5.46 | Emodin Inhibits ATP-Induced Proliferation and Migration by Suppressing P2Y Receptors in Human Lung Adenocarcinoma Cells. ( Guan, R; Li, L; Shen, L; Song, N; Wang, X; Zhu, D, 2017) |
| "In the present study, we used breast cancer MDA-MB-231 cells and a mouse xenograft model to demonstrate the effect of emodin on the migration, invasion and metastasis of human breast cancer MDA-MB-231 cells and the related mechanisms." | 5.42 | Inhibitory effect of emodin on migration, invasion and metastasis of human breast cancer MDA-MB-231 cells in vitro and in vivo. ( Chen, Q; Lu, Y; Su, S; Sun, Y; Wang, X; Zhang, H; Zhao, M; Zhou, Q, 2015) |
| "Emodin (EMD) is an anthraquinone derivative extracted from the root and rhizome of Rheum palmatum L." | 5.42 | The anthraquinone derivative Emodin inhibits angiogenesis and metastasis through downregulating Runx2 activity in breast cancer. ( Chen, B; Fu, J; Ke, X; Liu, T; Liu, Z; Lu, H; Ma, J; Wang, S, 2015) |
| "Emodin has been found to exert anti-tumor effects through promoting cell cycle arrest and apoptosis, and inhibiting angiogenesis, but its effects on tumor-associated macrophages during cancer metastasis have not been investigated." | 5.40 | Emodin suppresses pulmonary metastasis of breast cancer accompanied with decreased macrophage recruitment and M2 polarization in the lungs. ( Fan, D; Hu, J; Iwanowycz, S; Jia, X; Saaoud, F; Wang, J; Wang, Q; Wang, Y; Yu, F, 2014) |
| "The emodin treatment induced P450s 1A1 and 1B1 mRNA in human lung carcinoma NCI-H322 and breast cancer MCF-7 cells." | 5.31 | Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5. ( Chen, TL; Ueng, TH; Wang, HW; Yang, PC, 2001) |
| "This study suggests a novel function of emodin, whereby it selectively suppresses N2 neutrophils to prevent hypercoagulation and lung carcinogenesis." | 3.91 | Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis. ( Du, G; Duan, Y; Li, Z; Lin, H; Lin, Y; Tong, Q; Wang, M; Wang, Y; Yan, G; Zhang, M; Zhang, S; Zhou, L, 2019) |
| "This study investigated the mechanism of the cytotoxic effect of emodin, an active anthraquinone, on human lung adenocarcinoma A549 cells." | 3.80 | Emodin elicits cytotoxicity in human lung adenocarcinoma A549 cells through inducing apoptosis. ( Chan, SW; Guo, DJ; Guo, ZD; Kwan, YW; Lee, SM; Leung, GP; Li, WY; Ng, YF; Yu, PH; Zhang, H, 2014) |
| "To investigate the anti-tumor mechanisms of emodin on human lung adenocarcinoma cell line Anip973 (LACC)." | 3.73 | [Inhibitory effect of emodin on proliferation of human lung adenocarcinoma cells in vitro]. ( Bao, Y; Li, JN; Lu, FZ; Xiao, JL, 2005) |
| "To study the suppressive role of emodin on the growth and its effect on the proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line Anip 973." | 3.73 | [Effects of emodin on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line Anip 973]. ( Li, JN; Lv, FZ; Xiao, JL, 2006) |
| "Lung adenocarcinoma is the most common type of lung cancer." | 1.91 | The ethyl acetate extract of Wenxia Changfu Formula inhibits the carcinogenesis of lung adenocarcinoma by regulating PI3K-AKT signaling pathway. ( Han, X; Li, H; Lv, C; Wang, L; Wang, M, 2023) |
| "Emodin is a Chinese herb-derived compound extracted from the roots of Rheum officinale that exhibits numerous pharmacological characteristics." | 1.72 | Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-IIa. ( Fan, XX; Guan, XX; Leung, EL; Li, JX; Li, RZ; Liang, TL; Liu, L; Meng, WY; Pan, HD; Wang, XR; Wu, QB; Xu, C; Yao, XJ; Zhang, FY, 2022) |
| "Lung cancer is one of the most common causes of cancer related mortality." | 1.51 | Physcion 8-O-β-Glucopyranoside Exerts Anti-Tumor Activity Against Non-Small Cell Lung Cancer by Targeting PPARγ. ( Du, Y; Li, Y; Lv, Z; Sun, D; Sun, L; Zhou, J, 2019) |
| "Emodin is an anthraquinone derivative originally isolated from Chinese rhubarb, possesses anticancer properties." | 1.46 | Emodin Inhibits ATP-Induced Proliferation and Migration by Suppressing P2Y Receptors in Human Lung Adenocarcinoma Cells. ( Guan, R; Li, L; Shen, L; Song, N; Wang, X; Zhu, D, 2017) |
| "Given the aggressive properties of breast cancer, the current study suggests that PG can serve as a safe therapeutic agent for suppressing breast cancer metastasis, although additional data is necessitated." | 1.46 | Physcion 8-O-β-glucopyranoside suppresses the metastasis of breast cancer in vitro and in vivo by modulating DNMT1. ( Chen, X; Fan, D; Guo, H; Li, F, 2017) |
| "Emodin is a phytochemical with potent anticancer activities against various human malignant cancer types, including lung cancer; however, the molecular mechanisms underlying the effects of emodin remain unclear." | 1.46 | Emodin induces apoptosis of lung cancer cells through ER stress and the TRIB3/NF-κB pathway. ( Cai, H; Liu, Z; Qu, J; Su, J; Xue, X; Yan, Y, 2017) |
| "Emodin has anti-neoplastic activities on multiple tumors." | 1.46 | Emodin Increases Expression of Insulin-Like Growth Factor Binding Protein 1 through Activation of MEK/ERK/AMPKα and Interaction of PPARγ and Sp1 in Lung Cancer. ( Chen, Y; Hann, SS; Tang, Q; Wu, J; Zheng, F, 2017) |
| " Their biodistribution and pharmacokinetic properties were determined in rat models of induced necrosis." | 1.43 | Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones. ( Feng, Y; Gao, M; Huang, D; Jiang, C; Ni, Y; Shao, H; Sun, Z; Wang, X; Yang, S; Yin, Z; Zhang, D; Zhang, J, 2016) |
| "In the present study, we used breast cancer MDA-MB-231 cells and a mouse xenograft model to demonstrate the effect of emodin on the migration, invasion and metastasis of human breast cancer MDA-MB-231 cells and the related mechanisms." | 1.42 | Inhibitory effect of emodin on migration, invasion and metastasis of human breast cancer MDA-MB-231 cells in vitro and in vivo. ( Chen, Q; Lu, Y; Su, S; Sun, Y; Wang, X; Zhang, H; Zhao, M; Zhou, Q, 2015) |
| "Emodin (EMD) is an anthraquinone derivative extracted from the root and rhizome of Rheum palmatum L." | 1.42 | The anthraquinone derivative Emodin inhibits angiogenesis and metastasis through downregulating Runx2 activity in breast cancer. ( Chen, B; Fu, J; Ke, X; Liu, T; Liu, Z; Lu, H; Ma, J; Wang, S, 2015) |
| "Emodin has been found to exert anti-tumor effects through promoting cell cycle arrest and apoptosis, and inhibiting angiogenesis, but its effects on tumor-associated macrophages during cancer metastasis have not been investigated." | 1.40 | Emodin suppresses pulmonary metastasis of breast cancer accompanied with decreased macrophage recruitment and M2 polarization in the lungs. ( Fan, D; Hu, J; Iwanowycz, S; Jia, X; Saaoud, F; Wang, J; Wang, Q; Wang, Y; Yu, F, 2014) |
| "In emodin- and MMC-cotreated cells, ERK1/2 phosphorylation was enhanced by constitutively active MKK1/2 (MKK1/2-CA), thus increasing Rad51 protein levels and protein stability." | 1.36 | Role of Rad51 down-regulation and extracellular signal-regulated kinases 1 and 2 inactivation in emodin and mitomycin C-induced synergistic cytotoxicity in human non-small-cell lung cancer cells. ( Cheng, CM; Chiu, YF; Kuo, YH; Lin, ST; Lin, YW; Su, YJ; Tsai, MS, 2010) |
| "Emodin has been shown to exhibit an anti-cancer effect." | 1.34 | Effects of emodin on gene expression profile in small cell lung cancer NCI-H446 cells. ( Fu, ZY; Han, JX; Huang, HY, 2007) |
| "The emodin treatment induced P450s 1A1 and 1B1 mRNA in human lung carcinoma NCI-H322 and breast cancer MCF-7 cells." | 1.31 | Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5. ( Chen, TL; Ueng, TH; Wang, HW; Yang, PC, 2001) |
| "Aloe-emodin-treated CH27 cells had an increased relative abundance of cytochrome c in the cytosolic fraction." | 1.31 | Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma. ( Hsu, SL; Lee, HZ; Liu, MC; Wu, CH, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.38) | 18.2507 |
| 2000's | 11 (26.19) | 29.6817 |
| 2010's | 23 (54.76) | 24.3611 |
| 2020's | 7 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, FY | 1 |
| Li, RZ | 1 |
| Xu, C | 1 |
| Fan, XX | 1 |
| Li, JX | 1 |
| Meng, WY | 1 |
| Wang, XR | 1 |
| Liang, TL | 1 |
| Guan, XX | 1 |
| Pan, HD | 1 |
| Liu, L | 1 |
| Yao, XJ | 1 |
| Wu, QB | 1 |
| Leung, EL | 1 |
| Kim, HJ | 1 |
| Choi, JW | 1 |
| Ree, J | 1 |
| Lim, JS | 1 |
| Lee, J | 1 |
| Kim, JI | 1 |
| Thapa, SB | 1 |
| Sohng, JK | 1 |
| Park, YI | 1 |
| Fang, XQ | 1 |
| Kim, YS | 1 |
| Lee, YM | 1 |
| Lee, M | 1 |
| Lim, WJ | 1 |
| Yim, WJ | 1 |
| Han, MW | 1 |
| Lim, JH | 1 |
| Wang, L | 1 |
| Han, X | 1 |
| Li, H | 1 |
| Lv, C | 1 |
| Wang, M | 2 |
| McDonald, SJ | 1 |
| Bullard, BM | 1 |
| VanderVeen, BN | 1 |
| Cardaci, TD | 1 |
| Chatzistamou, I | 1 |
| Fan, D | 3 |
| Murphy, EA | 1 |
| Lin, H | 2 |
| Hu, B | 1 |
| He, X | 1 |
| Mao, J | 1 |
| Wang, Y | 3 |
| Wang, J | 3 |
| Zhang, T | 1 |
| Zheng, J | 1 |
| Peng, Y | 1 |
| Zhang, F | 1 |
| Teng, X | 1 |
| Wang, SY | 1 |
| Shi, YQ | 1 |
| Fan, XF | 1 |
| Liu, S | 1 |
| Xing, Y | 1 |
| Guo, YY | 1 |
| Dong, M | 1 |
| Ying, Y | 1 |
| Qingwu, L | 1 |
| Mingming, X | 1 |
| Zhenju, S | 1 |
| Chaoyang, T | 1 |
| Zhengang, T | 1 |
| Wan, L | 1 |
| Zhang, L | 2 |
| Fan, K | 1 |
| Wang, X | 3 |
| Li, L | 1 |
| Guan, R | 1 |
| Zhu, D | 1 |
| Song, N | 1 |
| Shen, L | 1 |
| Haque, E | 2 |
| Kamil, M | 2 |
| Irfan, S | 2 |
| Sheikh, S | 2 |
| Hasan, A | 2 |
| Nazir, A | 2 |
| Mir, SS | 2 |
| Iyer, VV | 1 |
| Priya, PY | 1 |
| Kangeyavelu, J | 1 |
| Du, Y | 1 |
| Lv, Z | 1 |
| Sun, D | 1 |
| Li, Y | 1 |
| Sun, L | 1 |
| Zhou, J | 1 |
| Alam, S | 1 |
| Ansari, KM | 1 |
| Li, Z | 1 |
| Lin, Y | 1 |
| Zhang, S | 1 |
| Zhou, L | 1 |
| Yan, G | 1 |
| Zhang, M | 1 |
| Tong, Q | 1 |
| Duan, Y | 1 |
| Du, G | 1 |
| Chen, S | 1 |
| Zhang, Z | 1 |
| Zhang, J | 2 |
| Kapoor, S | 1 |
| Li, WY | 1 |
| Ng, YF | 1 |
| Zhang, H | 2 |
| Guo, ZD | 1 |
| Guo, DJ | 1 |
| Kwan, YW | 1 |
| Leung, GP | 1 |
| Lee, SM | 1 |
| Yu, PH | 1 |
| Chan, SW | 1 |
| Chen, X | 2 |
| Yang, Z | 1 |
| Sun, R | 1 |
| Mo, Z | 1 |
| Jin, G | 1 |
| Wei, F | 1 |
| Hu, J | 2 |
| Guan, W | 1 |
| Zhong, N | 1 |
| Jia, X | 1 |
| Yu, F | 1 |
| Iwanowycz, S | 1 |
| Saaoud, F | 1 |
| Wang, Q | 1 |
| Sun, Y | 1 |
| Zhou, Q | 1 |
| Lu, Y | 1 |
| Chen, Q | 1 |
| Zhao, M | 1 |
| Su, S | 1 |
| Ma, J | 1 |
| Lu, H | 1 |
| Wang, S | 1 |
| Chen, B | 1 |
| Liu, Z | 2 |
| Ke, X | 1 |
| Liu, T | 1 |
| Fu, J | 1 |
| Zhang, D | 1 |
| Jiang, C | 1 |
| Yang, S | 1 |
| Gao, M | 1 |
| Huang, D | 1 |
| Shao, H | 1 |
| Feng, Y | 1 |
| Sun, Z | 1 |
| Ni, Y | 1 |
| Yin, Z | 1 |
| Guo, H | 1 |
| Li, F | 1 |
| Su, J | 1 |
| Yan, Y | 1 |
| Qu, J | 1 |
| Xue, X | 1 |
| Cai, H | 1 |
| Tang, Q | 1 |
| Wu, J | 1 |
| Zheng, F | 1 |
| Hann, SS | 1 |
| Chen, Y | 1 |
| Ko, JC | 2 |
| Su, YJ | 3 |
| Lin, ST | 3 |
| Jhan, JY | 2 |
| Ciou, SC | 2 |
| Cheng, CM | 3 |
| Lin, YW | 3 |
| Chiu, YF | 2 |
| Kuo, YH | 2 |
| Tsai, MS | 2 |
| Ok, S | 1 |
| Kim, SM | 1 |
| Kim, C | 1 |
| Nam, D | 1 |
| Shim, BS | 1 |
| Kim, SH | 1 |
| Ahn, KS | 2 |
| Choi, SH | 1 |
| Yeh, FT | 1 |
| Wu, CH | 3 |
| Lee, HZ | 6 |
| Chang, SP | 2 |
| Su, YT | 1 |
| Chang, HL | 1 |
| Shyue, SK | 1 |
| Hsu, SL | 2 |
| Li, JN | 2 |
| Lu, FZ | 1 |
| Xiao, JL | 2 |
| Bao, Y | 1 |
| Lin, CJ | 1 |
| Yang, WH | 1 |
| Leung, WC | 1 |
| Lv, FZ | 1 |
| Fu, ZY | 1 |
| Han, JX | 1 |
| Huang, HY | 1 |
| Hung, MC | 1 |
| Wang, HW | 1 |
| Chen, TL | 1 |
| Yang, PC | 1 |
| Ueng, TH | 1 |
| Liu, MC | 1 |
42 other studies available for emodin and Lung Neoplasms
| Article | Year |
|---|---|
Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-IIa.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Down-Regulation; Emodin; Humans; Lung Neoplasms; Phosphol | 2022 |
Aloe emodin 3-O-glucoside inhibits cell growth and migration and induces apoptosis of non-small-cell lung cancer cells via suppressing MEK/ERK and Akt signalling pathways.
Topics: Animals; Anthraquinones; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Prolifera | 2022 |
Topics: Animals; Cachexia; Emodin; Fallopia japonica; Humans; Lung Neoplasms; Mammals; Mice; Nuclear Protein | 2022 |
The ethyl acetate extract of Wenxia Changfu Formula inhibits the carcinogenesis of lung adenocarcinoma by regulating PI3K-AKT signaling pathway.
Topics: Adenocarcinoma of Lung; Carcinogenesis; Emodin; Humans; Lung Neoplasms; Matrix Metalloproteinase 3; | 2023 |
Emodin reduces surgical wounding-accelerated tumor growth and metastasis via macrophage suppression in a murine triple-negative breast cancer model.
Topics: Animals; Cell Line, Tumor; Emodin; Humans; Lung; Lung Neoplasms; Macrophages; Mice; Triple Negative | 2023 |
Overcoming Taxol-resistance in A549 cells: A comprehensive strategy of targeting P-gp transporter, AKT/ERK pathways, and cytochrome P450 enzyme CYP1B1 by 4-hydroxyemodin.
Topics: A549 Cells; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transport | 2020 |
The role of emodin on cisplatin resistance reversal of lung adenocarcinoma A549/DDP cell.
Topics: A549 Cells; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transport | 2021 |
Emodin: One Main Ingredient of Shufeng Jiedu Capsule Reverses Chemoresistance of Lung Cancer Cells Through Inhibition of EMT.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Emodin; | 2017 |
Aloin promotes A549 cell apoptosis via the reactive oxygen species‑mitogen activated protein kinase signaling pathway and p53 phosphorylation.
Topics: A549 Cells; Animals; Apoptosis; Cell Proliferation; Emodin; Gene Expression Regulation, Neoplastic; | 2017 |
Emodin Inhibits ATP-Induced Proliferation and Migration by Suppressing P2Y Receptors in Human Lung Adenocarcinoma Cells.
Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Adenosine Triphosphate; bcl-2-Associated X Prote | 2017 |
Blocking mutation independent p53 aggregation by emodin modulates autophagic cell death pathway in lung cancer.
Topics: A549 Cells; Autophagy; Emodin; Humans; Lung Neoplasms; Protein Aggregates; Tumor Suppressor Protein | 2018 |
Effects of increased accumulation of doxorubicin due to emodin on efflux transporter and LRP1 expression in lung adenocarcinoma and colorectal carcinoma cells.
Topics: A549 Cells; Adenocarcinoma of Lung; Carrier Proteins; Colorectal Neoplasms; Doxorubicin; Emodin; Hum | 2018 |
Physcion 8-O-β-Glucopyranoside Exerts Anti-Tumor Activity Against Non-Small Cell Lung Cancer by Targeting PPARγ.
Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Ch | 2019 |
Hydroxyl Group Difference between Anthraquinone Derivatives Regulate Different Cell Death Pathways via Nucleo-Cytoplasmic Shuttling of p53.
Topics: A549 Cells; Anthraquinones; Antineoplastic Agents; Cell Death; Cell Proliferation; Dose-Response Rel | 2019 |
Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis.
Topics: Allografts; Animals; Blood Coagulation Disorders; Carcinogenesis; Carcinoma, Lewis Lung; Emodin; Ext | 2019 |
Emodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo.
Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Non-Small-Cell Lung; C | 2019 |
Emodin: inhibitory effects on growth in malignant tumors.
Topics: Cell Movement; Down-Regulation; Emodin; Humans; Lung Neoplasms; Male; Prostatic Neoplasms; Protein K | 2013 |
Emodin elicits cytotoxicity in human lung adenocarcinoma A549 cells through inducing apoptosis.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle Checkpo | 2014 |
Preparation of lung-targeting, emodin-loaded polylactic acid microspheres and their properties.
Topics: Animals; Drug Carriers; Emodin; Gelatin; Injections, Intravenous; Lactic Acid; Lung Diseases; Lung N | 2014 |
Emodin suppresses pulmonary metastasis of breast cancer accompanied with decreased macrophage recruitment and M2 polarization in the lungs.
Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell Movement; Cell Prolifer | 2014 |
Inhibitory effect of emodin on migration, invasion and metastasis of human breast cancer MDA-MB-231 cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Body Weight; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Dose | 2015 |
The anthraquinone derivative Emodin inhibits angiogenesis and metastasis through downregulating Runx2 activity in breast cancer.
Topics: Angiogenesis Inhibitors; Animals; Breast Neoplasms; Cell Proliferation; Core Binding Factor Alpha 1 | 2015 |
Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones.
Topics: Animals; Anthracenes; Cell Line, Tumor; Disease Models, Animal; Drug Delivery Systems; Drug Design; | 2016 |
Physcion 8-O-β-glucopyranoside suppresses the metastasis of breast cancer in vitro and in vivo by modulating DNMT1.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; DNA (Cytosine-5-)-Methyltransferase 1; D | 2017 |
Emodin induces apoptosis of lung cancer cells through ER stress and the TRIB3/NF-κB pathway.
Topics: Animals; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Cell Pro | 2017 |
Emodin Increases Expression of Insulin-Like Growth Factor Binding Protein 1 through Activation of MEK/ERK/AMPKα and Interaction of PPARγ and Sp1 in Lung Cancer.
Topics: A549 Cells; AMP-Activated Protein Kinases; Animals; Cell Cycle Checkpoints; Cell Line, Tumor; Cell M | 2017 |
Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Repair; DNA-Binding Proteins; Dose-Response Re | 2010 |
Emodin enhances cisplatin-induced cytotoxicity via down-regulation of ERCC1 and inactivation of ERK1/2.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Butadienes; Carcinoma, Non-Small-Cell Lun | 2010 |
Role of Rad51 down-regulation and extracellular signal-regulated kinases 1 and 2 inactivation in emodin and mitomycin C-induced synergistic cytotoxicity in human non-small-cell lung cancer cells.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Down-Regulation; Drug Synergism; Emodin; Humans; L | 2010 |
Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4.
Topics: Cell Line, Tumor; Cell Movement; Chemokine CXCL12; Down-Regulation; Emodin; Humans; Lung Neoplasms; | 2012 |
Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell.
Topics: Alkaloids; Anthraquinones; Apoptosis; Benzophenanthridines; Blotting, Western; Carcinoma, Non-Small- | 2003 |
Release of nucleophosmin from the nucleus: Involvement in aloe-emodin-induced human lung non small carcinoma cell apoptosis.
Topics: Amino Acid Sequence; Anthraquinones; Apoptosis; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Ad | 2005 |
Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway.
Topics: Adenocarcinoma; Animals; Apoptosis; Cell Line, Tumor; Emodin; Humans; Lung Neoplasms; Mitochondria; | 2005 |
[Inhibitory effect of emodin on proliferation of human lung adenocarcinoma cells in vitro].
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; | 2005 |
Aloe-emodin induced DNA damage through generation of reactive oxygen species in human lung carcinoma cells.
Topics: Anthraquinones; Apoptosis; Comet Assay; DNA Damage; DNA Glycosylases; DNA Repair; DNA Repair Enzymes | 2006 |
[Effects of emodin on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line Anip 973].
Topics: Adenocarcinoma; Aged; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase 3; Ce | 2006 |
Effects of emodin on gene expression profile in small cell lung cancer NCI-H446 cells.
Topics: Apoptosis; Carcinoma, Small Cell; Cell Line, Tumor; Cell Survival; Emodin; Gene Expression Profiling | 2007 |
Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Division; Cisplatin; Dose-Response Relat | 1996 |
Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5.
Topics: Adenocarcinoma; Anthracenes; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-45 | 2001 |
Effects and mechanisms of emodin on cell death in human lung squamous cell carcinoma.
Topics: Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Ca | 2001 |
Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell.
Topics: Anthraquinones; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Survi | 2001 |
Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma.
Topics: Anthraquinones; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Caspases; Cytochrome c G | 2001 |