emodin and Leukemia
emodin has been researched along with Leukemia in 5 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was aimed to investigate the effects of emodin combined with 3'-azido-3'-deoxythymidine (AZT) on proliferation and apoptosis of leukemia cell line KG-1a cells and its mechanism." | 7.81 | [Effects of the Combination of Emodin and 3'-Azido-3'-Deoxythymidine on Proliferation and Apoptosis in leukemia KG-1a cells Transfected with Egr-1 siRNA]. ( Chen, C; Chu, HY; Liu, Y; Yuan, LY, 2015) |
| "To investigate the effect of Emodin combined with 3'-azido-3'-deoxythymidine (AZT) on the proliferation and apoptosis of concentrated leukemia stem cells (CLSC)-human acute myeloid leukemia KG-la cells and expression of BCL-2, NF-κB and TGF-β." | 7.81 | [Effect of Emodin Combined with AZT on the Proliferation and the Expression of BCL-2, NF-κB, TGF-β in the Leukemia Stem Cells-KG-1a cells]. ( Chen, C; Jia, MF; Li, M; Li, ZJ; Liu, CX; Ma, T; Wang, LN; Xi, YM; Zhang, H; Zhao, L, 2015) |
| "The aim of this study was to explore the inhibitory effect of newly synthesised emodin derivatives on the proliferation of leukemia cell lines and to select the most effective one from these emodin derivatives for further research." | 7.79 | [Synthesis of emodin derivatives and their inhibiting effects on proliferation of leukemia cell lines]. ( Hu, JD; Li, J; Liu, TB; Wang, WF; Zheng, JT; Zheng, ZH, 2013) |
| "This study was aimed to investigate the effects of emodin combined with 3'-azido-3'-deoxythymidine (AZT) on proliferation and apoptosis of leukemia cell line KG-1a cells and its mechanism." | 3.81 | [Effects of the Combination of Emodin and 3'-Azido-3'-Deoxythymidine on Proliferation and Apoptosis in leukemia KG-1a cells Transfected with Egr-1 siRNA]. ( Chen, C; Chu, HY; Liu, Y; Yuan, LY, 2015) |
| "To investigate the effect of Emodin combined with 3'-azido-3'-deoxythymidine (AZT) on the proliferation and apoptosis of concentrated leukemia stem cells (CLSC)-human acute myeloid leukemia KG-la cells and expression of BCL-2, NF-κB and TGF-β." | 3.81 | [Effect of Emodin Combined with AZT on the Proliferation and the Expression of BCL-2, NF-κB, TGF-β in the Leukemia Stem Cells-KG-1a cells]. ( Chen, C; Jia, MF; Li, M; Li, ZJ; Liu, CX; Ma, T; Wang, LN; Xi, YM; Zhang, H; Zhao, L, 2015) |
| "The aim of this study was to explore the inhibitory effect of newly synthesised emodin derivatives on the proliferation of leukemia cell lines and to select the most effective one from these emodin derivatives for further research." | 3.79 | [Synthesis of emodin derivatives and their inhibiting effects on proliferation of leukemia cell lines]. ( Hu, JD; Li, J; Liu, TB; Wang, WF; Zheng, JT; Zheng, ZH, 2013) |
Research
Studies (5)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Mai, LP | 1 |
| Guéritte, F | 1 |
| Dumontet, V | 1 |
| Tri, MV | 1 |
| Hill, B | 1 |
| Thoison, O | 1 |
| Guénard, D | 1 |
| Sévenet, T | 1 |
| Zheng, JT | 1 |
| Wang, WF | 1 |
| Li, J | 1 |
| Zheng, ZH | 1 |
| Liu, TB | 1 |
| Hu, JD | 1 |
| Yuan, LY | 1 |
| Chen, C | 2 |
| Chu, HY | 1 |
| Liu, Y | 1 |
| Wang, LN | 1 |
| Li, ZJ | 1 |
| Xi, YM | 1 |
| Ma, T | 1 |
| Zhao, L | 1 |
| Jia, MF | 1 |
| Li, M | 1 |
| Zhang, H | 1 |
| Liu, CX | 1 |
| Elf, S | 1 |
| Lin, R | 1 |
| Xia, S | 1 |
| Pan, Y | 1 |
| Shan, C | 1 |
| Wu, S | 1 |
| Lonial, S | 1 |
| Gaddh, M | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Boggon, TJ | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
Other Studies
5 other studies available for emodin and Leukemia
| Article | Year |
|---|---|
Cytotoxicity of Rhamnosylanthraquinones and Rhamnosylanthrones from Rhamnus nepalensis.
Topics: Animals; Anthraquinones; Antineoplastic Agents, Phytogenic; Chromatography, High Pressure Liquid; Ch | 2001 |
[Synthesis of emodin derivatives and their inhibiting effects on proliferation of leukemia cell lines].
Topics: Cell Proliferation; Emodin; Humans; K562 Cells; Leukemia | 2013 |
[Effects of the Combination of Emodin and 3'-Azido-3'-Deoxythymidine on Proliferation and Apoptosis in leukemia KG-1a cells Transfected with Egr-1 siRNA].
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Early Growth Response Protein 1; Emodin; Flow Cytom | 2015 |
[Effect of Emodin Combined with AZT on the Proliferation and the Expression of BCL-2, NF-κB, TGF-β in the Leukemia Stem Cells-KG-1a cells].
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Emodin; Humans; Leukemia; Neoplast | 2015 |
Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin.
Topics: Animals; Antimalarials; Antineoplastic Combined Chemotherapy Protocols; Artemisinins; Cell Line, Tum | 2017 |