emodin has been researched along with Insulin Sensitivity in 10 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of emodin on the treatment of non-alcoholic fatty liver in rats induced by high caloric laboratory chaw." | 7.73 | Effects of emodin on treating murine nonalcoholic fatty liver induced by high caloric laboratory chaw. ( Dong, H; Gao, ZQ; Lu, FE; Wang, KF; Xu, LJ; Zou, X, 2005) |
| "Emodin (EMO) is a major bioactive constituent of CMD that has apparent therapeutic efficacy against obesity and fatty liver." | 5.62 | Emodin palliates high-fat diet-induced nonalcoholic fatty liver disease in mice via activating the farnesoid X receptor pathway. ( Cai, J; Deng, Z; Guo, J; Huang, Q; Lan, S; Liu, H; Liu, M; Liu, Z; Pan, Z; Shen, C; Si, Y; Tu, H; Wu, H; Wu, S; Xian, S; Xin, X; Yu, Y; Zhang, J; Zheng, M; Zhong, C; Zhong, Y; Zhu, Z, 2021) |
| "Insulin resistance was induced by feeding a high fat diet to Sprague-Dawley rats." | 5.43 | Emodin ameliorates high-fat-diet induced insulin resistance in rats by reducing lipid accumulation in skeletal muscle. ( Cao, Y; Chang, S; Cui, J; Dong, J; Li, J; Long, R; Zhang, Y; Zheng, X; Zhou, Y; Zhu, S, 2016) |
| "Emodin ameliorated hyperglycemia and dyslipidemia in T2DM rats, and glucose metabolism in a concentration- and time-dependent manner." | 3.91 | Emodin improves glucose metabolism by targeting microRNA-20b in insulin-resistant skeletal muscle. ( Fu, Y; Hu, Y; Li, M; Li, X; Li, Z; Wang, R; Xiao, D; Xu, C; Xuan, L; Yang, B; Zhang, H; Zhang, Y, 2019) |
| " The ability of emodin to inhibit prednisone- or dexamethasone-induced insulin resistance was investigated in C57BL/6J mice and its effect on metabolic abnormalities was observed in DIO mice." | 3.76 | Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice. ( Chen, JH; Dou, W; Feng, Y; Huang, SL; Leng, Y; Shen, JH; Shen, Y; Zhang, S, 2010) |
| "To investigate the effects of emodin on the treatment of non-alcoholic fatty liver in rats induced by high caloric laboratory chaw." | 3.73 | Effects of emodin on treating murine nonalcoholic fatty liver induced by high caloric laboratory chaw. ( Dong, H; Gao, ZQ; Lu, FE; Wang, KF; Xu, LJ; Zou, X, 2005) |
| "Emodin (EMO) is a major bioactive constituent of CMD that has apparent therapeutic efficacy against obesity and fatty liver." | 1.62 | Emodin palliates high-fat diet-induced nonalcoholic fatty liver disease in mice via activating the farnesoid X receptor pathway. ( Cai, J; Deng, Z; Guo, J; Huang, Q; Lan, S; Liu, H; Liu, M; Liu, Z; Pan, Z; Shen, C; Si, Y; Tu, H; Wu, H; Wu, S; Xian, S; Xin, X; Yu, Y; Zhang, J; Zheng, M; Zhong, C; Zhong, Y; Zhu, Z, 2021) |
| "Emodin was admixed to high fat-food of obese mice at two doses (2 and 5g/kg; daily emodin uptake 103 and 229mg/kg)." | 1.46 | Emodin, a compound with putative antidiabetic potential, deteriorates glucose tolerance in rodents. ( Abu Eid, S; Adams, M; Fürnsinn, C; Hackl, MT; Kaplanian, M; Luger, A; Riedl, R; Scherer, T; Torres-Gómez, H, 2017) |
| "Currently, obesity has become a worldwide epidemic associated with Type 2 diabetes, dyslipidemia, cardiovascular disease and chronic metabolic diseases." | 1.43 | Emodin improves lipid and glucose metabolism in high fat diet-induced obese mice through regulating SREBP pathway. ( Ding, L; Li, J; Qi, M; Song, B; Tang, X; Wang, Z; Xiao, X; Yang, L; Yang, Q, 2016) |
| "Insulin resistance was induced by feeding a high fat diet to Sprague-Dawley rats." | 1.43 | Emodin ameliorates high-fat-diet induced insulin resistance in rats by reducing lipid accumulation in skeletal muscle. ( Cao, Y; Chang, S; Cui, J; Dong, J; Li, J; Long, R; Zhang, Y; Zheng, X; Zhou, Y; Zhu, S, 2016) |
| "Increased insulin sensitivity was also confirmed after daily injection of emodin for 8 days using an insulin tolerance test and insulin-stimulated PI3K phosphorylation in wild type and high fat diet-induced diabetic mouse models." | 1.39 | Emodin regulates glucose utilization by activating AMP-activated protein kinase. ( Berggren, PO; Choi, HS; Ghim, J; Hyun, H; Kim, JH; Kwon, Y; Lee, A; Moon, HY; Ryu, SH; Song, P; Suh, PG; Yoon, JH, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 7 (70.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nuankaew, W | 1 |
| Heemman, A | 1 |
| Wattanapiromsakul, C | 1 |
| Shim, JH | 1 |
| Kim, NW | 1 |
| Yasmin, T | 1 |
| Jeong, SY | 1 |
| Nam, YH | 1 |
| Hong, BN | 1 |
| Dej-Adisai, S | 1 |
| Kang, TH | 1 |
| Shen, C | 1 |
| Pan, Z | 1 |
| Wu, S | 1 |
| Zheng, M | 1 |
| Zhong, C | 1 |
| Xin, X | 1 |
| Lan, S | 1 |
| Zhu, Z | 1 |
| Liu, M | 1 |
| Wu, H | 1 |
| Huang, Q | 1 |
| Zhang, J | 1 |
| Liu, Z | 1 |
| Si, Y | 1 |
| Tu, H | 1 |
| Deng, Z | 1 |
| Yu, Y | 1 |
| Liu, H | 1 |
| Zhong, Y | 1 |
| Guo, J | 1 |
| Cai, J | 1 |
| Xian, S | 1 |
| Xiao, D | 1 |
| Hu, Y | 1 |
| Fu, Y | 1 |
| Wang, R | 1 |
| Zhang, H | 1 |
| Li, M | 1 |
| Li, Z | 1 |
| Zhang, Y | 3 |
| Xuan, L | 1 |
| Li, X | 1 |
| Xu, C | 1 |
| Yang, B | 1 |
| Li, J | 2 |
| Ding, L | 1 |
| Song, B | 1 |
| Xiao, X | 1 |
| Qi, M | 1 |
| Yang, Q | 2 |
| Tang, X | 1 |
| Wang, Z | 1 |
| Yang, L | 1 |
| Cao, Y | 1 |
| Chang, S | 1 |
| Dong, J | 1 |
| Zhu, S | 1 |
| Zheng, X | 1 |
| Long, R | 1 |
| Zhou, Y | 1 |
| Cui, J | 1 |
| Abu Eid, S | 1 |
| Adams, M | 1 |
| Scherer, T | 1 |
| Torres-Gómez, H | 1 |
| Hackl, MT | 1 |
| Kaplanian, M | 1 |
| Riedl, R | 1 |
| Luger, A | 1 |
| Fürnsinn, C | 1 |
| Xue, J | 1 |
| Ding, W | 1 |
| Liu, Y | 1 |
| Feng, Y | 1 |
| Huang, SL | 1 |
| Dou, W | 1 |
| Zhang, S | 1 |
| Chen, JH | 1 |
| Shen, Y | 1 |
| Shen, JH | 1 |
| Leng, Y | 1 |
| Song, P | 1 |
| Kim, JH | 1 |
| Ghim, J | 1 |
| Yoon, JH | 1 |
| Lee, A | 1 |
| Kwon, Y | 1 |
| Hyun, H | 1 |
| Moon, HY | 1 |
| Choi, HS | 1 |
| Berggren, PO | 1 |
| Suh, PG | 1 |
| Ryu, SH | 1 |
| Dong, H | 1 |
| Lu, FE | 1 |
| Gao, ZQ | 1 |
| Xu, LJ | 1 |
| Wang, KF | 1 |
| Zou, X | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Efficacy of Chinese Herbal Medicine in Patients With Obesity: a Retrospective Study[NCT04481464] | 500 participants (Anticipated) | Observational | 2020-11-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 other studies available for emodin and Insulin Sensitivity
| Article | Year |
|---|---|
Anti-insulin resistance effect of constituents from Senna siamea on zebrafish model, its molecular docking, and structure-activity relationships.
Topics: alpha-Glucosidases; Animals; Anthraquinones; Diabetes Mellitus; Dipeptidyl Peptidase 4; Emodin; Hypo | 2021 |
Emodin palliates high-fat diet-induced nonalcoholic fatty liver disease in mice via activating the farnesoid X receptor pathway.
Topics: Animals; Cassia; Diet, High-Fat; Dose-Response Relationship, Drug; Emodin; Glucose; Hepatocytes; Inf | 2021 |
Emodin improves glucose metabolism by targeting microRNA-20b in insulin-resistant skeletal muscle.
Topics: Animals; Diabetes Mellitus, Type 2; Down-Regulation; Emodin; Glucose; Glucose Transporter Type 4; Hy | 2019 |
Emodin improves lipid and glucose metabolism in high fat diet-induced obese mice through regulating SREBP pathway.
Topics: Adipose Tissue; Animals; Cell Line; Diet, High-Fat; Down-Regulation; Emodin; Glucose; Humans; Insuli | 2016 |
Emodin ameliorates high-fat-diet induced insulin resistance in rats by reducing lipid accumulation in skeletal muscle.
Topics: Animals; CD36 Antigens; Diet, High-Fat; Emodin; Fatty Acid Transport Proteins; Gene Expression Regul | 2016 |
Emodin, a compound with putative antidiabetic potential, deteriorates glucose tolerance in rodents.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Dose-Response Relationship, Drug; Eating; Emodi | 2017 |
Anti-diabetic effects of emodin involved in the activation of PPARgamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice.
Topics: Adipocytes; Animals; Blood Glucose; Cholesterol, HDL; Diabetes Mellitus, Experimental; Dietary Fats; | 2010 |
Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adrenal Cortex Hormones; Animals; Cell Line; Dexamethas | 2010 |
Emodin regulates glucose utilization by activating AMP-activated protein kinase.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Calcium; Cell Line; Diabetes Mellitus, Type 2 | 2013 |
Effects of emodin on treating murine nonalcoholic fatty liver induced by high caloric laboratory chaw.
Topics: Alanine Transaminase; Animal Feed; Animals; Aspartate Aminotransferases; Blood Glucose; Body Weight; | 2005 |