emodin has been researched along with Granulocytic Leukemia, Chronic in 7 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The clinical outcome of chronic myeloid leukemia (CML) patients has been changed dramatically due to the development of imatinib (IM)." | 1.42 | Inhibition of 32Dp210 cells harboring T315I mutation by a novel derivative of emodin correlates with down-regulation of BCR-ABL and its downstream signaling pathways. ( Chen, B; Chen, C; Chen, Y; Hu, J; Li, J; Liu, T; Qiu, B; Wang, W; Zheng, J; Zheng, Z, 2015) |
| "Emodin could cause the regression of tumor." | 1.36 | Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo. ( Bei-Zhong, L; Chong, W; Chun-Guang, W; Dan, Z; Dan-Ting, J; Jun-Qing, Y; Liang, Z; Yan, W, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, W | 1 |
| Liu, F | 1 |
| Yuan, L | 1 |
| Zhao, C | 1 |
| Chen, C | 2 |
| Wang, XY | 1 |
| Sun, GB | 1 |
| Wang, YJ | 1 |
| Yan, F | 2 |
| Min, H | 1 |
| Niu, M | 1 |
| Zhang, W | 1 |
| Yan, J | 1 |
| Li, J | 2 |
| Tan, X | 1 |
| Li, B | 1 |
| Su, M | 1 |
| Di, B | 1 |
| Chen, Y | 1 |
| Chen, B | 1 |
| Qiu, B | 1 |
| Zheng, Z | 1 |
| Zheng, J | 1 |
| Liu, T | 1 |
| Wang, W | 1 |
| Hu, J | 1 |
| Li, BJ | 1 |
| Liu, TB | 1 |
| Wang, WF | 1 |
| Lin, MH | 1 |
| Hu, JD | 1 |
| Wang, CG | 1 |
| Zhong, L | 1 |
| Liu, YL | 1 |
| Shi, XJ | 1 |
| Shi, LQ | 1 |
| Zeng, L | 1 |
| Liu, BZ | 1 |
| Chun-Guang, W | 1 |
| Jun-Qing, Y | 1 |
| Bei-Zhong, L | 1 |
| Dan-Ting, J | 1 |
| Chong, W | 1 |
| Liang, Z | 1 |
| Dan, Z | 1 |
| Yan, W | 1 |
7 other studies available for emodin and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Emodin and AZT synergistically inhibit the proliferation and induce the apoptosis of leukemia K562 cells through the EGR1 and the Wnt/β‑catenin pathway.
Topics: beta Catenin; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; | 2020 |
Emodin Inhibits Resistance to Imatinib by Downregulation of Bcr-Abl and STAT5 and Allosteric Inhibition in Chronic Myeloid Leukemia Cells.
Topics: Allosteric Regulation; Dose-Response Relationship, Drug; Down-Regulation; Drug Resistance, Multiple; | 2020 |
Emodin reverses leukemia multidrug resistance by competitive inhibition and downregulation of P-glycoprotein.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Binding Sites; Cac | 2017 |
Inhibition of 32Dp210 cells harboring T315I mutation by a novel derivative of emodin correlates with down-regulation of BCR-ABL and its downstream signaling pathways.
Topics: Apoptosis; Benzamides; Blotting, Western; Cell Proliferation; Colony-Forming Units Assay; Down-Regul | 2015 |
[Effect of A Novel Emodin Derivative on Chronic Myelogenous Leukemia K562 Cells and Imatinib-resistant K562/G01 Cells].
Topics: Apoptosis; Cell Proliferation; Down-Regulation; Drug Resistance, Neoplasm; Emodin; Fusion Proteins, | 2016 |
Emodin Exerts an Antiapoptotic Effect on Human Chronic Myelocytic Leukemia K562 Cell Lines by Targeting the PTEN/PI3K-AKT Signaling Pathway and Deleting BCR-ABL.
Topics: Antineoplastic Agents; Apoptosis; Biological Products; Cell Proliferation; Drug Resistance, Neoplasm | 2017 |
Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Division; Cell Survival; Emodin; Enzyme Ac | 2010 |