emodin and Glioma
emodin has been researched along with Glioma in 7 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we examined the effects of emodin (1,3,8-trihydroxy-6-methylanthraquinone), an active component of the root and rhizome of Rheum palmatum that has several biological activities, including antitumor effects, on primary cultured glioma stem cells (GSCs)." | 7.81 | Emodin suppresses maintenance of stemness by augmenting proteosomal degradation of epidermal growth factor receptor/epidermal growth factor receptor variant III in glioma stem cells. ( Jung, J; Kim, J; Lee, JS; Lee, JY; Lim, I; Park, MJ, 2015) |
| "The effect of aloe emodin (AE), a herbal anthraquinone derivative, on the rat C6 glioma cell line was investigated." | 7.73 | Anti-glioma action of aloe emodin: the role of ERK inhibition. ( Harhaji, Lj; Maksimovic-Ivanic, D; Mijatovic, S; Miljkovic, Dj; Mostarica Stojkovic, M; Radovic, J; Stosic-Grujicic, S; Trajkovic, V; Vuckovic, O, 2005) |
| " Here, we examined the effects of emodin (1,3,8-trihydroxy-6-methylanthraquinone), an active component of the root and rhizome of Rheum palmatum that has several biological activities, including antitumor effects, on primary cultured glioma stem cells (GSCs)." | 3.81 | Emodin suppresses maintenance of stemness by augmenting proteosomal degradation of epidermal growth factor receptor/epidermal growth factor receptor variant III in glioma stem cells. ( Jung, J; Kim, J; Lee, JS; Lee, JY; Lim, I; Park, MJ, 2015) |
| "The effect of aloe emodin (AE), a herbal anthraquinone derivative, on the rat C6 glioma cell line was investigated." | 3.73 | Anti-glioma action of aloe emodin: the role of ERK inhibition. ( Harhaji, Lj; Maksimovic-Ivanic, D; Mijatovic, S; Miljkovic, Dj; Mostarica Stojkovic, M; Radovic, J; Stosic-Grujicic, S; Trajkovic, V; Vuckovic, O, 2005) |
| "The present study describes the ability of an anthraquinone derivative aloe emodin (AE) to reduce the cytotoxic activity of the platinum(II)-based anticancer agent cisplatin toward murine L929 fibrosarcoma and C6 glioma cell lines." | 3.73 | Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin. ( Kaludjerovic, GN; Maksimovic-Ivanic, D; Mijatovic, S; Miljkovic, D; Radovic, J; Sabo, TJ; Trajkovic, V, 2005) |
Research
Studies (7)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Zhou, J | 1 |
| Li, G | 1 |
| Han, G | 1 |
| Feng, S | 1 |
| Liu, Y | 1 |
| Chen, J | 1 |
| Liu, C | 1 |
| Zhao, L | 1 |
| Jin, F | 1 |
| Kim, J | 1 |
| Lee, JS | 1 |
| Jung, J | 1 |
| Lim, I | 1 |
| Lee, JY | 1 |
| Park, MJ | 2 |
| Verebova, V | 1 |
| Belej, D | 1 |
| Joniova, J | 1 |
| Jurasekova, Z | 1 |
| Miskovsky, P | 1 |
| Kozar, T | 1 |
| Horvath, D | 1 |
| Stanicova, J | 1 |
| Huntosova, V | 1 |
| Acevedo-Duncan, M | 1 |
| Russell, C | 1 |
| Patel, S | 1 |
| Patel, R | 1 |
| Mijatovic, S | 2 |
| Maksimovic-Ivanic, D | 2 |
| Radovic, J | 2 |
| Miljkovic, Dj | 1 |
| Harhaji, Lj | 1 |
| Vuckovic, O | 1 |
| Stosic-Grujicic, S | 1 |
| Mostarica Stojkovic, M | 1 |
| Trajkovic, V | 2 |
| Miljkovic, D | 1 |
| Kaludjerovic, GN | 1 |
| Sabo, TJ | 1 |
| Kim, MS | 1 |
| Kim, SJ | 1 |
| Lee, CH | 1 |
| Yoo, H | 1 |
| Shin, SH | 1 |
| Song, ES | 1 |
| Lee, SH | 1 |
Other Studies
7 other studies available for emodin and Glioma
| Article | Year |
|---|---|
Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway.
Topics: Animals; Cell Cycle; Cell Proliferation; Emodin; Female; Glioma; Humans; Mice; Mice, Inbred BALB C; | 2020 |
Emodin suppresses maintenance of stemness by augmenting proteosomal degradation of epidermal growth factor receptor/epidermal growth factor receptor variant III in glioma stem cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Self Renewal; Emodin; ErbB Receptors; Gamma Rays; | 2015 |
Deeper insights into the drug defense of glioma cells against hydrophobic molecules.
Topics: Anthracenes; Anthraquinones; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tum | 2016 |
Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells.
Topics: Anthraquinones; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Fractionation; Cell | 2004 |
Anti-glioma action of aloe emodin: the role of ERK inhibition.
Topics: Animals; Anthraquinones; Antineoplastic Agents, Phytogenic; Apoptosis; Autolysis; Cell Differentiati | 2005 |
Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Cisplati | 2005 |
Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Emodi | 2005 |