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emodin and Glioma

emodin has been researched along with Glioma in 7 studies

Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
" Here, we examined the effects of emodin (1,3,8-trihydroxy-6-methylanthraquinone), an active component of the root and rhizome of Rheum palmatum that has several biological activities, including antitumor effects, on primary cultured glioma stem cells (GSCs)."7.81Emodin suppresses maintenance of stemness by augmenting proteosomal degradation of epidermal growth factor receptor/epidermal growth factor receptor variant III in glioma stem cells. ( Jung, J; Kim, J; Lee, JS; Lee, JY; Lim, I; Park, MJ, 2015)
"The effect of aloe emodin (AE), a herbal anthraquinone derivative, on the rat C6 glioma cell line was investigated."7.73Anti-glioma action of aloe emodin: the role of ERK inhibition. ( Harhaji, Lj; Maksimovic-Ivanic, D; Mijatovic, S; Miljkovic, Dj; Mostarica Stojkovic, M; Radovic, J; Stosic-Grujicic, S; Trajkovic, V; Vuckovic, O, 2005)
" Here, we examined the effects of emodin (1,3,8-trihydroxy-6-methylanthraquinone), an active component of the root and rhizome of Rheum palmatum that has several biological activities, including antitumor effects, on primary cultured glioma stem cells (GSCs)."3.81Emodin suppresses maintenance of stemness by augmenting proteosomal degradation of epidermal growth factor receptor/epidermal growth factor receptor variant III in glioma stem cells. ( Jung, J; Kim, J; Lee, JS; Lee, JY; Lim, I; Park, MJ, 2015)
"The effect of aloe emodin (AE), a herbal anthraquinone derivative, on the rat C6 glioma cell line was investigated."3.73Anti-glioma action of aloe emodin: the role of ERK inhibition. ( Harhaji, Lj; Maksimovic-Ivanic, D; Mijatovic, S; Miljkovic, Dj; Mostarica Stojkovic, M; Radovic, J; Stosic-Grujicic, S; Trajkovic, V; Vuckovic, O, 2005)
"The present study describes the ability of an anthraquinone derivative aloe emodin (AE) to reduce the cytotoxic activity of the platinum(II)-based anticancer agent cisplatin toward murine L929 fibrosarcoma and C6 glioma cell lines."3.73Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin. ( Kaludjerovic, GN; Maksimovic-Ivanic, D; Mijatovic, S; Miljkovic, D; Radovic, J; Sabo, TJ; Trajkovic, V, 2005)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's2 (28.57)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Zhou, J1
Li, G1
Han, G1
Feng, S1
Liu, Y1
Chen, J1
Liu, C1
Zhao, L1
Jin, F1
Kim, J1
Lee, JS1
Jung, J1
Lim, I1
Lee, JY1
Park, MJ2
Verebova, V1
Belej, D1
Joniova, J1
Jurasekova, Z1
Miskovsky, P1
Kozar, T1
Horvath, D1
Stanicova, J1
Huntosova, V1
Acevedo-Duncan, M1
Russell, C1
Patel, S1
Patel, R1
Mijatovic, S2
Maksimovic-Ivanic, D2
Radovic, J2
Miljkovic, Dj1
Harhaji, Lj1
Vuckovic, O1
Stosic-Grujicic, S1
Mostarica Stojkovic, M1
Trajkovic, V2
Miljkovic, D1
Kaludjerovic, GN1
Sabo, TJ1
Kim, MS1
Kim, SJ1
Lee, CH1
Yoo, H1
Shin, SH1
Song, ES1
Lee, SH1

Other Studies

7 other studies available for emodin and Glioma

ArticleYear
Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway.
    Investigational new drugs, 2020, Volume: 38, Issue:1

    Topics: Animals; Cell Cycle; Cell Proliferation; Emodin; Female; Glioma; Humans; Mice; Mice, Inbred BALB C;

2020
Emodin suppresses maintenance of stemness by augmenting proteosomal degradation of epidermal growth factor receptor/epidermal growth factor receptor variant III in glioma stem cells.
    Stem cells and development, 2015, Feb-01, Volume: 24, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Self Renewal; Emodin; ErbB Receptors; Gamma Rays;

2015
Deeper insights into the drug defense of glioma cells against hydrophobic molecules.
    International journal of pharmaceutics, 2016, Apr-30, Volume: 503, Issue:1-2

    Topics: Anthracenes; Anthraquinones; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tum

2016
Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells.
    International immunopharmacology, 2004, Dec-20, Volume: 4, Issue:14

    Topics: Anthraquinones; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Fractionation; Cell

2004
Anti-glioma action of aloe emodin: the role of ERK inhibition.
    Cellular and molecular life sciences : CMLS, 2005, Volume: 62, Issue:5

    Topics: Animals; Anthraquinones; Antineoplastic Agents, Phytogenic; Apoptosis; Autolysis; Cell Differentiati

2005
Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin.
    Cellular and molecular life sciences : CMLS, 2005, Volume: 62, Issue:11

    Topics: Animals; Anthraquinones; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Cisplati

2005
Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells.
    International journal of oncology, 2005, Volume: 27, Issue:3

    Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Emodi

2005