emodin has been researched along with Disease Models, Animal in 103 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Emodin has a protective effect on asthma." | 8.12 | Emodin inhibits NF-κB signaling pathway to protect obese asthmatic rats from pathological damage via Visfatin. ( Cai, W; He, X; Hu, J; Miao, J, 2022) |
| " Both emodin and dexamethasone (DEX) have been used for treating severe acute pancreatitis-associated acute lung injury (SAP-ALI)." | 8.02 | Effect of emodin on long non-coding RNA-mRNA networks in rats with severe acute pancreatitis-induced acute lung injury. ( Chen, H; Jiang, L; Li, L; Li, Z; Luo, Y; Ntim, M; Quan, W; Shang, D; Xu, C; Xu, Q; Zhang, G; Zhang, J, 2021) |
| " Moreover, a unilateral ureteral obstruction-induced mouse model of renal fibrosis was established for investigating the antifibrotic effect of emodin in combination with HGF in vivo." | 7.96 | Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ-Smad Signaling Pathway. ( Chen, M; Deng, L; Hu, Y; Li, J; Liu, Y; Yang, F; Zhong, W, 2020) |
| "BACKGROUND This study investigated the effects and underlying mechanisms of emodin on cough variant asthma (CVA) in mice." | 7.91 | Emodin Alleviates the Airway Inflammation of Cough Variant Asthma in Mice by Regulating the Notch Pathway. ( Hua, S; Liu, F; Wang, M, 2019) |
| " The aim of the current study was to investigate the protective effect of emodin on experimental autoimmune thyroiditis (EAT) in mice, which is considered an excellent model for CLT." | 7.88 | Effect of emodin on T cell subsets in NOD mice with NaI‑induced experimental autoimmune thyroiditis. ( Jin, F; Li, N; Sun, H; Wu, K; Yan, J; Ye, Z, 2018) |
| "Emodin, a traditional Chinese medicine, has a therapeutic effect on severe acute pancreatitis (SAP), whereas the underlying mechanism is still unclear." | 7.85 | Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition. ( Gu, ML; Ji, F; Ning, JW; Usman, A; Xu, J; Yu, MS; Zhang, Y, 2017) |
| " In this study, we tested the ability of emodin, a Chinese herb-derived compound, to inhibit breast cancer growth in mice and examined the underlying mechanisms." | 7.83 | Emodin Inhibits Breast Cancer Growth by Blocking the Tumor-Promoting Feedforward Loop between Cancer Cells and Macrophages. ( Fan, D; Hodge, J; Iwanowycz, S; Wang, J; Wang, Y; Yu, F, 2016) |
| "Pulmonary silicosis is characterized by lung fibrosis, which leads to impairment of pulmonary function; the specific mechanism remains to be fully elucidated Emodin shows antifibrotic effects in several organs with fibrosis, however, it has not been investigated in pulmonary silicosis." | 7.83 | Emodin suppresses silica-induced lung fibrosis by promoting Sirt1 signaling via direct contact. ( Chen, M; Dang, X; Liu, Y; Pang, Y; Ren, H; Shang, D; Wang, J; Yang, T, 2016) |
| "To investigate the effects of emodin on aquaporin 5 (AQP5) expression in rats with sepsis-induced acute lung injury." | 7.81 | Effect of emodin on Aquaporin 5 expression in rats with sepsis-induced acute lung injury. ( Cheng, J; Liu, J; Liu, S; Song, J; Sun, L; Sun, Y, 2015) |
| "Emodin can significantly reduce serum levels of TB, DB, ALT, and TBA in rats with ANIT-induced cholestatic hepatitis, probably by promoting FXR expression." | 7.80 | [Effect of emodin on expression of farnesoid X receptor in rats with acute cholestatic hepatitis]. ( Ding, Y; Li, HR; Xiong, XL; Xu, F, 2014) |
| "Emodin is the main active constituent of rhubarb and is often used in Chinese herbal medicine for the treatment of systemic inflammatory response syndrome (SIRS)." | 7.80 | In vitro effects of emodin on peritoneal macrophages that express membrane-bound CD14 protein in a rat model of severe acute pancreatitis/systemic inflammatory response syndrome. ( Chen, G; Ni, Q; Shang, D; Sun, K, 2014) |
| " A study was conducted to evaluate the therapeutic potential of phytogenically derived aloin mediated nanosilver particles (AAgNPs), prepared by reduction of silver nitrate with aloin, in Staphylococcus aureus induced murine mastitis." | 7.79 | Evaluation of therapeutic potential of nanosilver particles synthesised using aloin in experimental murine mastitis model. ( Alpha Raj, M; Chaitanya Kumar, TV; Muralidhar, Y; Prasad, PE; Prasad, TN, 2013) |
| " The present study evaluated the anti-inflammatory effects of aloe components (aloin, aloesin and aloe-gel) known to be biologically active in the rat model of colitis." | 7.77 | Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model. ( Kwon, HJ; Park, MY; Sung, MK, 2011) |
| "To investigate the therapeutic effects of emodin on acute cholestatic hepatitis and mechanism thereof." | 7.75 | [Therapeutic effects of emodin on acute cholestatic hepatitis and mechanism thereof: experiment with rats]. ( Ding, Y; Dong, HF; Dong, JH; Huang, ZH; Mei, H; Zhao, L, 2009) |
| "To study the effect of emodin on pancreatic fibrosis and potential mechanism thereof." | 7.73 | [Effect of emodin on pancreatic fibrosis: experiment with rats]. ( Cai, JT; Du, Q; Gao, ZQ; Qian, KD; Wang, CH; Xie, CG; Ye, B, 2006) |
| "Emodin has been reported to alleviate I/R injury in the heart, brain, and small intestine in rats and mice through its anti-inflammatory effects." | 5.72 | Emodin prevents renal ischemia-reperfusion injury via suppression of CAMKII/DRP1-mediated mitochondrial fission. ( Bae, ON; Cai, J; Huyan, T; Li, X; Liu, Q; Shi, Y; Su, J; Tie, L; Wang, D; Wang, H; Wang, Q; Wang, Y; Wu, P; Zhang, F, 2022) |
| "Atherosclerosis is an inflammatory disease of high lethality associated with endothelial dysfunction." | 5.72 | Aloe-emodin derivative produces anti-atherosclerosis effect by reinforcing AMBRA1-mediated endothelial autophagy. ( Chen, H; Chen, Y; Cui, H; Li, X; Lin, Y; Liu, X; Meng, Z; Shi, Y; Tang, X; Wang, Z; Xu, H; Yang, B; Zhang, Y; Zhao, H; Zhao, L; Zhu, M, 2022) |
| "Emodin was administered at 10, 30, or 100 mg/kg, while simvastatin was administered at 10 mg/kg." | 5.62 | Low Dose of Emodin Inhibits Hypercholesterolemia in a Rat Model of High Cholesterol. ( Guo, XJ; Liu, SY; Lv, CF; Wang, J; Wu, JH; Xu, Y; Zhang, H; Zhang, J, 2021) |
| "Emodin was administered orally (30 mg/kg body weight) every other day starting in the third week for 9 weeks." | 5.56 | Effects of emodin on inflammatory bowel disease-related osteoporosis. ( Luo, JS; Yang, Y; Zhao, X, 2020) |
| "Nonalcoholic fatty liver disease (NAFLD) has become a predictor of death in many diseases." | 5.56 | Radix Polygoni Multiflori and Its Main Component Emodin Attenuate Non-Alcoholic Fatty Liver Disease in Zebrafish by Regulation of AMPK Signaling Pathway. ( Dai, X; Gong, L; Hu, N; Li, Y; Tang, Y; Wang, C; Yu, L; Zheng, L, 2020) |
| "Emodin has been considered to play a protective role for acute lung edema in cecal ligation and puncture (CLP)-induced sepsis model." | 5.56 | Emodin attenuates acute lung injury in Cecal-ligation and puncture rats. ( Guo, R; Han, M; Li, Y; Liu, J; Sun, Y, 2020) |
| " (2) Methods: The three pharmacodynamic indicators are neurological function score, brain water content, and cerebral infarction area; UPLC-MS/MS was used in pharmacokinetic studies to detect plasma concentrations at different time points, and DAS software was used to calculate pharmacokinetic parameters in a noncompartmental model." | 5.51 | Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia. ( Feng, SX; Li, JS; Li, RR; Liu, XF; Qu, LB; Shu, SN; Wang, PY; Zhang, N, 2019) |
| "Emodin is a natural anthraquinone derivative that occurs in many widely used Chinese medicinal herbs." | 5.51 | Emodin ameliorates rheumatoid arthritis by promoting neutrophil apoptosis and inhibiting neutrophil extracellular trap formation. ( Huang, G; Li, X; Lu, Q; Luo, G; Wang, H; Wang, T; Xu, A; Yuan, K; Zhang, S; Zhao, L; Zhu, M; Zhu, Q, 2019) |
| "Emodin is a major ingredient of rhubarb and has been proven to protect against lung disruptions." | 5.48 | Emodin Attenuates Bleomycin-Induced Pulmonary Fibrosis via Anti-Inflammatory and Anti-Oxidative Activities in Rats. ( Liu, XL; Tian, SL; Xu, QB; Yang, Y, 2018) |
| "Inflammation is a defense and protective response to multiple harmful stimuli." | 5.43 | Emodin suppresses LPS-induced inflammation in RAW264.7 cells through a PPARγ-dependent pathway. ( Feng, SJ; Yu, HP; Zhang, W; Zhu, T, 2016) |
| " Dose-response studies showed that emodin at 100 µM was not cytotoxic to naive cells, and that the same dose caused proliferation to be significantly reduced in ConA-stimulated cells." | 5.43 | Emodin inhibits splenocyte proliferation and inflammation by modulating cytokine responses in a mouse model system. ( Sharma, R; Tiku, AB, 2016) |
| "Severe acute pancreatitis (SAP) accounts for up to 20% of acute pancreatitis (AP) cases." | 5.42 | Emodin has a protective effect in cases of severe acute pancreatitis via inhibition of nuclear factor‑κB activation resulting in antioxidation. ( Qian, AH; Qiao, MM; Yang, SL; Yao, WY; Yuan, YZ; Zhai, ZK; Zhang, YP; Zhou, YF, 2015) |
| "3." | 5.35 | Inhibitory effect of emodin on bleomycin-induced pulmonary fibrosis in mice. ( Chen, XH; Guan, WD; Hu, JM; Jin, GY; Mo, ZY; Sun, RS; Yang, ZF; Zhong, NS, 2009) |
| "Emodin plays an anti-inflammatory role in several inflammatory diseases." | 5.34 | Emodin-mediated protection from acute myocardial infarction via inhibition of inflammation and apoptosis in local ischemic myocardium. ( Chen, G; Cheng, Z; Fu, J; Huang, H; Lin, G; Liu, DX; Liu, M; Liu, Q; Tu, X; Wan, J; Wu, Y; Xia, H; Zhang, H, 2007) |
| "Ulcerative colitis was induced by 3% sodium dextran sulfate (DSS) on mice, and the mice were respectively treated with mesalazine, rosiglitazone, emodin, and emodin combined with GW9662 (PPARγ inhibitor) simultaneously." | 4.12 | Emodin targeting the colonic metabolism via PPARγ alleviates UC by inhibiting facultative anaerobe. ( Chen, Y; Guo, S; He, J; Huang, B; Huang, S; Li, Y; Luo, S; Luo, X; Su, Y; Wang, X; Yang, G; Zhou, L, 2022) |
| "Emodin has a protective effect on asthma." | 4.12 | Emodin inhibits NF-κB signaling pathway to protect obese asthmatic rats from pathological damage via Visfatin. ( Cai, W; He, X; Hu, J; Miao, J, 2022) |
| " By stimulating macrophages with imiquimod (IMQ) to model the inflammation in psoriasis, it was found that the anthraquinones significantly reduced IL-6, IL-23, and TNF." | 4.12 | A systematic comparison of the effect of topically applied anthraquinone aglycones to relieve psoriasiform lesion: The evaluation of percutaneous absorption and anti-inflammatory potency. ( Alalaiwe, A; Chuang, SY; Fang, JY; Huang, TH; Lin, CF; Nguyen, TMH; Wang, PW, 2022) |
| " Both emodin and dexamethasone (DEX) have been used for treating severe acute pancreatitis-associated acute lung injury (SAP-ALI)." | 4.02 | Effect of emodin on long non-coding RNA-mRNA networks in rats with severe acute pancreatitis-induced acute lung injury. ( Chen, H; Jiang, L; Li, L; Li, Z; Luo, Y; Ntim, M; Quan, W; Shang, D; Xu, C; Xu, Q; Zhang, G; Zhang, J, 2021) |
| " Moreover, a unilateral ureteral obstruction-induced mouse model of renal fibrosis was established for investigating the antifibrotic effect of emodin in combination with HGF in vivo." | 3.96 | Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ-Smad Signaling Pathway. ( Chen, M; Deng, L; Hu, Y; Li, J; Liu, Y; Yang, F; Zhong, W, 2020) |
| "BACKGROUND This study investigated the effects and underlying mechanisms of emodin on cough variant asthma (CVA) in mice." | 3.91 | Emodin Alleviates the Airway Inflammation of Cough Variant Asthma in Mice by Regulating the Notch Pathway. ( Hua, S; Liu, F; Wang, M, 2019) |
| " The aim of the current study was to investigate the protective effect of emodin on experimental autoimmune thyroiditis (EAT) in mice, which is considered an excellent model for CLT." | 3.88 | Effect of emodin on T cell subsets in NOD mice with NaI‑induced experimental autoimmune thyroiditis. ( Jin, F; Li, N; Sun, H; Wu, K; Yan, J; Ye, Z, 2018) |
| "To investigate the effects of combined use of emodin and baicalein (CEB) at the cellular and organism levels in severe acute pancreatitis (SAP) and explore the underlying mechanism." | 3.88 | Emodin and baicalein inhibit sodium taurocholate-induced vacuole formation in pancreatic acinar cells. ( Bie, BB; Chen, HY; Guo, Y; Huang, N; Li, J; Li, ZF; Shi, MJ; Yang, J; Zhang, J; Zhou, R, 2018) |
| "Emodin, a traditional Chinese medicine, has a therapeutic effect on severe acute pancreatitis (SAP), whereas the underlying mechanism is still unclear." | 3.85 | Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition. ( Gu, ML; Ji, F; Ning, JW; Usman, A; Xu, J; Yu, MS; Zhang, Y, 2017) |
| " In this study, we tested the ability of emodin, a Chinese herb-derived compound, to inhibit breast cancer growth in mice and examined the underlying mechanisms." | 3.83 | Emodin Inhibits Breast Cancer Growth by Blocking the Tumor-Promoting Feedforward Loop between Cancer Cells and Macrophages. ( Fan, D; Hodge, J; Iwanowycz, S; Wang, J; Wang, Y; Yu, F, 2016) |
| "Pulmonary silicosis is characterized by lung fibrosis, which leads to impairment of pulmonary function; the specific mechanism remains to be fully elucidated Emodin shows antifibrotic effects in several organs with fibrosis, however, it has not been investigated in pulmonary silicosis." | 3.83 | Emodin suppresses silica-induced lung fibrosis by promoting Sirt1 signaling via direct contact. ( Chen, M; Dang, X; Liu, Y; Pang, Y; Ren, H; Shang, D; Wang, J; Yang, T, 2016) |
| "These results suggest that emodin may afford a significant neuroprotective effect against glutamate-induced apoptosis through activation of the PI3K/Akt signaling pathway, and subsequently enhance behavioral function in cerebral ischemia." | 3.83 | Emodin from Polygonum multiflorum ameliorates oxidative toxicity in HT22 cells and deficits in photothrombotic ischemia. ( Ahn, SM; Choi, BT; Choi, YW; Kim, CM; Kim, HN; Kim, YR; Shin, HK, 2016) |
| "To investigate the effects of emodin on aquaporin 5 (AQP5) expression in rats with sepsis-induced acute lung injury." | 3.81 | Effect of emodin on Aquaporin 5 expression in rats with sepsis-induced acute lung injury. ( Cheng, J; Liu, J; Liu, S; Song, J; Sun, L; Sun, Y, 2015) |
| "Emodin can significantly reduce serum levels of TB, DB, ALT, and TBA in rats with ANIT-induced cholestatic hepatitis, probably by promoting FXR expression." | 3.80 | [Effect of emodin on expression of farnesoid X receptor in rats with acute cholestatic hepatitis]. ( Ding, Y; Li, HR; Xiong, XL; Xu, F, 2014) |
| "Emodin is the main active constituent of rhubarb and is often used in Chinese herbal medicine for the treatment of systemic inflammatory response syndrome (SIRS)." | 3.80 | In vitro effects of emodin on peritoneal macrophages that express membrane-bound CD14 protein in a rat model of severe acute pancreatitis/systemic inflammatory response syndrome. ( Chen, G; Ni, Q; Shang, D; Sun, K, 2014) |
| " A study was conducted to evaluate the therapeutic potential of phytogenically derived aloin mediated nanosilver particles (AAgNPs), prepared by reduction of silver nitrate with aloin, in Staphylococcus aureus induced murine mastitis." | 3.79 | Evaluation of therapeutic potential of nanosilver particles synthesised using aloin in experimental murine mastitis model. ( Alpha Raj, M; Chaitanya Kumar, TV; Muralidhar, Y; Prasad, PE; Prasad, TN, 2013) |
| " The present study evaluated the anti-inflammatory effects of aloe components (aloin, aloesin and aloe-gel) known to be biologically active in the rat model of colitis." | 3.77 | Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model. ( Kwon, HJ; Park, MY; Sung, MK, 2011) |
| "Rat models of experimental hepatic fibrosis were established by injection with CCl(4); the treated rats received emodin via oral administration at a dosage of 20 mg/kg twice a week at the same time." | 3.75 | Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation. ( Dong, MX; Geng, YT; Jia, Y; Li, CC; Li, XY; Liu, JC; Niu, YC; Zhang, YB; Zhou, L, 2009) |
| "To investigate the therapeutic effects of emodin on acute cholestatic hepatitis and mechanism thereof." | 3.75 | [Therapeutic effects of emodin on acute cholestatic hepatitis and mechanism thereof: experiment with rats]. ( Ding, Y; Dong, HF; Dong, JH; Huang, ZH; Mei, H; Zhao, L, 2009) |
| "To study the effect of emodin on pancreatic fibrosis and potential mechanism thereof." | 3.73 | [Effect of emodin on pancreatic fibrosis: experiment with rats]. ( Cai, JT; Du, Q; Gao, ZQ; Qian, KD; Wang, CH; Xie, CG; Ye, B, 2006) |
| " Emodin and rhein showed greater inhibition than the other compounds; dosage at 50 μM reduced intracellular triglyceride (TG) by about 30% in the differentiated adipocytes." | 1.72 | Rhubarb hydroxyanthraquinones act as antiobesity agents to inhibit adipogenesis and enhance lipolysis. ( Aljuffali, IA; Chen, WJ; Fang, JY; Hsu, CY; Huang, TH, 2022) |
| "Colitis was evaluated by disease active index (DAI), colon length, inflammation response, and intestinal barrier function." | 1.72 | Aloin A prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing the Notch signaling pathway. ( Fang, YX; Jiang, H; Liu, YQ; Shi, GF; Wang, Q; Yin, ZQ; Zhang, DJ; Zhang, J; Zheng, X, 2022) |
| "Emodin has been reported to alleviate I/R injury in the heart, brain, and small intestine in rats and mice through its anti-inflammatory effects." | 1.72 | Emodin prevents renal ischemia-reperfusion injury via suppression of CAMKII/DRP1-mediated mitochondrial fission. ( Bae, ON; Cai, J; Huyan, T; Li, X; Liu, Q; Shi, Y; Su, J; Tie, L; Wang, D; Wang, H; Wang, Q; Wang, Y; Wu, P; Zhang, F, 2022) |
| "Atherosclerosis is an inflammatory disease of high lethality associated with endothelial dysfunction." | 1.72 | Aloe-emodin derivative produces anti-atherosclerosis effect by reinforcing AMBRA1-mediated endothelial autophagy. ( Chen, H; Chen, Y; Cui, H; Li, X; Lin, Y; Liu, X; Meng, Z; Shi, Y; Tang, X; Wang, Z; Xu, H; Yang, B; Zhang, Y; Zhao, H; Zhao, L; Zhu, M, 2022) |
| "Emodin was administered at 10, 30, or 100 mg/kg, while simvastatin was administered at 10 mg/kg." | 1.62 | Low Dose of Emodin Inhibits Hypercholesterolemia in a Rat Model of High Cholesterol. ( Guo, XJ; Liu, SY; Lv, CF; Wang, J; Wu, JH; Xu, Y; Zhang, H; Zhang, J, 2021) |
| "Silicosis is a fatal pulmonary disease caused by the inhalation of silica dust, and characterized by inflammation and fibrosis of the lung, with no effective treatment to date." | 1.62 | Emodin attenuates silica-induced lung injury by inhibition of inflammation, apoptosis and epithelial-mesenchymal transition. ( Jia, Q; Lavin, MF; Li, C; Nie, X; Pang, X; Peng, C; Shao, H; Shao, L; Xia, Q; Yan, H; Yeo, AJ; Yu, G, 2021) |
| "Nonalcoholic fatty liver disease (NAFLD) has become a predictor of death in many diseases." | 1.56 | Radix Polygoni Multiflori and Its Main Component Emodin Attenuate Non-Alcoholic Fatty Liver Disease in Zebrafish by Regulation of AMPK Signaling Pathway. ( Dai, X; Gong, L; Hu, N; Li, Y; Tang, Y; Wang, C; Yu, L; Zheng, L, 2020) |
| "Emodin is an anthraquinone that has been implicated in cardiac protection." | 1.56 | Emodin and emodin-rich rhubarb inhibits histone deacetylase (HDAC) activity and cardiac myocyte hypertrophy. ( Angermann, JE; Bender, A; Burnett, L; Evans, LW; Ferguson, BS; Godoy, L; Shen, Y; Staten, D; Zhou, T, 2020) |
| "Emodin was administered orally (30 mg/kg body weight) every other day starting in the third week for 9 weeks." | 1.56 | Effects of emodin on inflammatory bowel disease-related osteoporosis. ( Luo, JS; Yang, Y; Zhao, X, 2020) |
| "Emodin has been considered to play a protective role for acute lung edema in cecal ligation and puncture (CLP)-induced sepsis model." | 1.56 | Emodin attenuates acute lung injury in Cecal-ligation and puncture rats. ( Guo, R; Han, M; Li, Y; Liu, J; Sun, Y, 2020) |
| "Emodin was used as a potential therapeutic for ICH." | 1.56 | Functions of lactate in the brain of rat with intracerebral hemorrhage evaluated with MRI/MRS and in vitro approaches. ( Cai, E; Lin, L; Liu, Y; Nie, B; Tian, Q; Wang, J; Xu, F; Yang, S; Zeng, P, 2020) |
| "Emodin is a natural anthraquinone derivative that occurs in many widely used Chinese medicinal herbs." | 1.51 | Emodin ameliorates rheumatoid arthritis by promoting neutrophil apoptosis and inhibiting neutrophil extracellular trap formation. ( Huang, G; Li, X; Lu, Q; Luo, G; Wang, H; Wang, T; Xu, A; Yuan, K; Zhang, S; Zhao, L; Zhu, M; Zhu, Q, 2019) |
| " (2) Methods: The three pharmacodynamic indicators are neurological function score, brain water content, and cerebral infarction area; UPLC-MS/MS was used in pharmacokinetic studies to detect plasma concentrations at different time points, and DAS software was used to calculate pharmacokinetic parameters in a noncompartmental model." | 1.51 | Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia. ( Feng, SX; Li, JS; Li, RR; Liu, XF; Qu, LB; Shu, SN; Wang, PY; Zhang, N, 2019) |
| " It is well-known that some compounds could influence other compounds' pharmacokinetic parameters significantly." | 1.51 | Pharmacokinetic studies unveiled the drug-drug interaction between trans-2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucopyranoside and emodin that may contribute to the idiosyncratic hepatotoxicity of Polygoni Multiflori Radix. ( Gao, X; Han, L; Hu, L; Wang, C; Wang, L; Xing, Y; Yang, W; Zhang, Y, 2019) |
| "Liver fibrosis is a chronic disease that exhibits a complicated pathophysiology." | 1.48 | Emodin alleviates CCl4‑induced liver fibrosis by suppressing epithelial‑mesenchymal transition and transforming growth factor‑β1 in rats. ( Liu, F; Ma, Z; Qian, J; Wu, G; Zhang, J, 2018) |
| "Emodin is a major ingredient of rhubarb and has been proven to protect against lung disruptions." | 1.48 | Emodin Attenuates Bleomycin-Induced Pulmonary Fibrosis via Anti-Inflammatory and Anti-Oxidative Activities in Rats. ( Liu, XL; Tian, SL; Xu, QB; Yang, Y, 2018) |
| "Emodin has a direct inhibitory effect on the growth and metastasis of a variety of malignant tumor cells." | 1.48 | Emodin inhibits pancreatic cancer EMT and invasion by up‑regulating microRNA‑1271. ( Li, N; Wang, C; You, S; Zhang, P, 2018) |
| " Their biodistribution and pharmacokinetic properties were determined in rat models of induced necrosis." | 1.43 | Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones. ( Feng, Y; Gao, M; Huang, D; Jiang, C; Ni, Y; Shao, H; Sun, Z; Wang, X; Yang, S; Yin, Z; Zhang, D; Zhang, J, 2016) |
| "Inflammation is a defense and protective response to multiple harmful stimuli." | 1.43 | Emodin suppresses LPS-induced inflammation in RAW264.7 cells through a PPARγ-dependent pathway. ( Feng, SJ; Yu, HP; Zhang, W; Zhu, T, 2016) |
| " Dose-response studies showed that emodin at 100 µM was not cytotoxic to naive cells, and that the same dose caused proliferation to be significantly reduced in ConA-stimulated cells." | 1.43 | Emodin inhibits splenocyte proliferation and inflammation by modulating cytokine responses in a mouse model system. ( Sharma, R; Tiku, AB, 2016) |
| "Emodin treatment abated the DEP-induced increase in airway resistance, and prevented the influx of neutrophils in bronchoalveolar lavage fluid." | 1.42 | Emodin mitigates diesel exhaust particles-induced increase in airway resistance, inflammation and oxidative stress in mice. ( Al-Salam, S; Ali, BH; Beegam, S; Nemmar, A; Yuvaraju, P, 2015) |
| "Emodin was administrated with intraperitoneal bolus injection of emodin (20 or 40 mg/kg) daily 1 h before CS exposure." | 1.42 | Emodin Attenuates Cigarette Smoke Induced Lung Injury in a Mouse Model via Suppression of Reactive Oxygen Species Production. ( Liang, SH; Liu, KF; Shi, XQ; Xue, WH; Zhao, J; Zhou, L, 2015) |
| "Emodin is a traditional Chinese medicine, which has been demonstrated to inhibit the growth of pancreatic cancer cells." | 1.42 | Emodin inhibits angiogenesis in pancreatic cancer by regulating the transforming growth factor-β/drosophila mothers against decapentaplegic pathway and angiogenesis-associated microRNAs. ( Chen, H; Chen, L; Chen, MY; Guo, JQ; Hu, P; Ji, X; Lin, SZ; Lu, D; Tong, HF; Wang, ZH; Xu, HT; Xu, JB, 2015) |
| "Severe acute pancreatitis (SAP) accounts for up to 20% of acute pancreatitis (AP) cases." | 1.42 | Emodin has a protective effect in cases of severe acute pancreatitis via inhibition of nuclear factor‑κB activation resulting in antioxidation. ( Qian, AH; Qiao, MM; Yang, SL; Yao, WY; Yuan, YZ; Zhai, ZK; Zhang, YP; Zhou, YF, 2015) |
| "Treatment with emodin led to significant decreases in the levels of IL-4, IL-5, IL-13 and eotaxin in BALF and total IgE level in serum." | 1.42 | Protective effect of emodin against airway inflammation in the ovalbumin-induced mouse model. ( Gao, YS; Jia, X; Li, YH; Liu, M; Wang, T; Wu, RH; Zhang, SJ; Zhong, XG, 2015) |
| "Treatment with emodin normalized the change of plasma corticosterone level, which demonstrated that emodin could partially restore CUMS-induced HPA axis impairments." | 1.40 | Emodin opposes chronic unpredictable mild stress induced depressive-like behavior in mice by upregulating the levels of hippocampal glucocorticoid receptor and brain-derived neurotrophic factor. ( Fu, Q; Li, M; Li, S; Li, Y; Ma, S; Xue, J, 2014) |
| "We concluded that acute pancreatitis may significantly affect the pharmacokinetics of Liu-He-Dan while external applied on belly, which indicated the dosage modification in AP." | 1.39 | Effect of acute pancreatitis on the pharmacokinetics of Chinese herbal ointment Liu-He-Dan in anaesthetized rats. ( Chen, GY; Chen, WW; Tang, WF; Wan, MH; Xiang, J; Yu, Q; Zhao, XL, 2013) |
| "3." | 1.35 | Inhibitory effect of emodin on bleomycin-induced pulmonary fibrosis in mice. ( Chen, XH; Guan, WD; Hu, JM; Jin, GY; Mo, ZY; Sun, RS; Yang, ZF; Zhong, NS, 2009) |
| "Emodin plays an anti-inflammatory role in several inflammatory diseases." | 1.34 | Emodin-mediated protection from acute myocardial infarction via inhibition of inflammation and apoptosis in local ischemic myocardium. ( Chen, G; Cheng, Z; Fu, J; Huang, H; Lin, G; Liu, DX; Liu, M; Liu, Q; Tu, X; Wan, J; Wu, Y; Xia, H; Zhang, H, 2007) |
| "Emodin has an effect on hepatic fibrosis in rats." | 1.31 | [Effects of emodin on hepatic fibrosis in rats]. ( Huang, X; Li, D; Lu, H; Wang, Z; Wei, H; Xu, Q; Zhan, Y, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (1.94) | 18.2507 |
| 2000's | 11 (10.68) | 29.6817 |
| 2010's | 55 (53.40) | 24.3611 |
| 2020's | 35 (33.98) | 2.80 |
| Authors | Studies |
|---|---|
| Fuchi, N | 1 |
| Iura, Y | 1 |
| Kaneko, H | 1 |
| Nitta, A | 1 |
| Suyama, K | 1 |
| Ueda, H | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Efficacy of Ru-Yi-Jin-Huang-Saan on Colles' Fracture ---a Randomized, Double-blind, Placebo-controlled Trial[NCT05638360] | Phase 2 | 100 participants (Anticipated) | Interventional | 2023-05-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
103 other studies available for emodin and Disease Models, Animal
| Article | Year |
|---|---|
Discovery and structure-activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2.
Topics: Animals; Binding Sites; Casein Kinase II; Computer Simulation; Disease Models, Animal; Drug Evaluati | 2012 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Emodin Alleviates Intestinal Barrier Dysfunction by Inhibiting Apoptosis and Regulating the Immune Response in Severe Acute Pancreatitis.
Topics: Animals; Apoptosis; Disease Models, Animal; Emodin; Intestinal Mucosa; Mice; Pancreatitis | 2021 |
The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats.
Topics: Aflatoxin B1; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2 | 2021 |
Emodin prevents renal ischemia-reperfusion injury via suppression of CAMKII/DRP1-mediated mitochondrial fission.
Topics: Acute Kidney Injury; Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Li | 2022 |
Aloe-emodin derivative produces anti-atherosclerosis effect by reinforcing AMBRA1-mediated endothelial autophagy.
Topics: Adaptor Proteins, Signal Transducing; Aloe; Animals; Aorta; Atherosclerosis; Autophagy; Collagen; Di | 2022 |
Rhubarb hydroxyanthraquinones act as antiobesity agents to inhibit adipogenesis and enhance lipolysis.
Topics: 3T3 Cells; Adipocytes; Adipogenesis; Animals; Anthraquinones; Anti-Obesity Agents; Cell Survival; Cy | 2022 |
A systematic comparison of the effect of topically applied anthraquinone aglycones to relieve psoriasiform lesion: The evaluation of percutaneous absorption and anti-inflammatory potency.
Topics: Administration, Topical; Animals; Anthraquinones; Anti-Inflammatory Agents; Cytokines; Disease Model | 2022 |
Emodin inhibits NF-κB signaling pathway to protect obese asthmatic rats from pathological damage via Visfatin.
Topics: Animals; Asthma; Cytokines; Disease Models, Animal; Emodin; Male; NF-kappa B; Nicotinamide Phosphori | 2022 |
Emodin targeting the colonic metabolism via PPARγ alleviates UC by inhibiting facultative anaerobe.
Topics: Animals; Caco-2 Cells; Chromatography, Liquid; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; | 2022 |
[Mechanism of combined treatment of rhein and emodin in Rhubarb for ulcerative colitis].
Topics: Animals; Anthraquinones; Colitis, Ulcerative; Colon; Disease Models, Animal; Emodin; Interleukin-6; | 2022 |
Aloin A prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing the Notch signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; | 2022 |
Discovery of anti-allergic components in Guomingkang Formula using sensitive HEMT biochips coupled with in vitro and in vivo validation.
Topics: Animals; Anti-Allergic Agents; Disease Models, Animal; Emodin; Mice; Molecular Docking Simulation; R | 2023 |
Aloe-Emodin Ameliorates Cecal Ligation and Puncture-Induced Sepsis.
Topics: Aloe; Animals; Anti-Inflammatory Agents; Cecum; Disease Models, Animal; Emodin; Ligation; Mice; Punc | 2023 |
Effects of emodin on inflammatory bowel disease-related osteoporosis.
Topics: Animals; Biomarkers; Bone and Bones; Bone Density; Cell Differentiation; Colon; Disease Models, Anim | 2020 |
Emodin and emodin-rich rhubarb inhibits histone deacetylase (HDAC) activity and cardiac myocyte hypertrophy.
Topics: Acetylation; Angiotensin II; Animals; Animals, Newborn; Cardiomegaly; Cardiotonic Agents; Disease Mo | 2020 |
[Effect of emodin on TLR4 signaling pathway in acute liver injury in animal model].
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Emodin; Liver; Mice; Signal | 2020 |
Aloin Protects Against Blood-Brain Barrier Damage After Traumatic Brain Injury in Mice.
Topics: Animals; Blood-Brain Barrier; Brain Injuries, Traumatic; Disease Models, Animal; Emodin; Endothelial | 2020 |
Radix Polygoni Multiflori and Its Main Component Emodin Attenuate Non-Alcoholic Fatty Liver Disease in Zebrafish by Regulation of AMPK Signaling Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Dr | 2020 |
Functions of lactate in the brain of rat with intracerebral hemorrhage evaluated with MRI/MRS and in vitro approaches.
Topics: Animals; Cerebral Hemorrhage; Disease Models, Animal; Emodin; Lactic Acid; Magnetic Resonance Spectr | 2020 |
Emodin attenuates acute lung injury in Cecal-ligation and puncture rats.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Aquaporin 1; Aquaporin 5; Cecum; Cl | 2020 |
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.
Topics: Angiogenesis Inhibitors; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Disease Models, | 2020 |
Prolongation of metallothionein induction combats Aß and α-synuclein toxicity in aged transgenic Caenorhabditis elegans.
Topics: Aging; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modi | 2020 |
Enhanced therapeutic efficacy of a novel colon-specific nanosystem loading emodin on DSS-induced experimental colitis.
Topics: Administration, Oral; Animals; Caco-2 Cells; Colitis, Ulcerative; Cyclooxygenase 2; Dextran Sulfate; | 2020 |
Emodin ameliorates ovalbumin-induced airway remodeling in mice by suppressing airway smooth muscle cells proliferation.
Topics: Actins; Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Proliferation; Cells, | 2020 |
Emodin ameliorates renal injury in BXSB mice by modulating TNF-α/ICAM-1.
Topics: Administration, Oral; Animals; Cell Line; Cell Transdifferentiation; Disease Models, Animal; Emodin; | 2020 |
Emodin protects against intestinal and lung injury induced by acute intestinal injury by modulating SP-A and TLR4/NF-κB pathway.
Topics: Acetic Acid; Acute Lung Injury; Animals; Colon; Disease Models, Animal; Emodin; Humans; Intestinal M | 2020 |
Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ-Smad Signaling Pathway.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Emodin; Fibrosis | 2020 |
Inhibition of PI3K/Akt/NF-κB signaling by Aloin for ameliorating the progression of osteoarthritis: In vitro and in vivo studies.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Chondrocytes; Disease Models, Animal; Emodin; Ex | 2020 |
Emodin ameliorates tubulointerstitial fibrosis in obstructed kidneys by inhibiting EZH2.
Topics: Animals; Connective Tissue Growth Factor; Disease Models, Animal; Drugs, Chinese Herbal; Emodin; Enh | 2021 |
Emodin attenuates silica-induced lung injury by inhibition of inflammation, apoptosis and epithelial-mesenchymal transition.
Topics: A549 Cells; Acute Lung Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Apoptosis Regulatory Pr | 2021 |
Optimal combination of anti-inflammatory components from Chinese medicinal formula Liang-Ge-San.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drugs, Chinese Herbal; Emo | 2021 |
Effect of emodin on long non-coding RNA-mRNA networks in rats with severe acute pancreatitis-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Biomarkers; Biopsy; Computational Biology; Cytokines; Disease Models, An | 2021 |
Kanglexin delays heart aging by promoting mitophagy.
Topics: Aging; Animals; Anthraquinones; Benzofurans; Disease Models, Animal; Emodin; Female; Galactose; Hear | 2022 |
Low Dose of Emodin Inhibits Hypercholesterolemia in a Rat Model of High Cholesterol.
Topics: Animals; Antioxidants; Aorta; Atherosclerosis; Cholesterol, HDL; Cholesterol, LDL; Disease Models, A | 2021 |
Synergistic effect of combined treatment with baicalin and emodin on DSS-induced colitis in mouse.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Emodin; Flavo | 2021 |
Dose-dependent role of novel agents emodin and BTB14431 in colonic cancer treatment in rats.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Blood Cell Count; Colonic Neoplasms; Dise | 2017 |
Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition.
Topics: Acute Disease; Animals; Caspase 1; Caspase Inhibitors; Disease Models, Animal; Emodin; Inflammation | 2017 |
Effect of Emodin on Preventing Postoperative Intra-Abdominal Adhesion Formation.
Topics: Abdomen; Animals; Disease Models, Animal; Emodin; Postoperative Complications; Rats; Rats, Sprague-D | 2017 |
Emodin Inhibition of Influenza A Virus Replication and Influenza Viral Pneumonia via the Nrf2, TLR4, p38/JNK and NF-kappaB Pathways.
Topics: Animals; Disease Models, Animal; Emodin; Humans; Influenza A virus; Influenza, Human; Mice; Myeloid | 2017 |
Emodin Attenuates Bleomycin-Induced Pulmonary Fibrosis via Anti-Inflammatory and Anti-Oxidative Activities in Rats.
Topics: A549 Cells; Animals; Anti-Inflammatory Agents; Antioxidants; Bleomycin; Cell Culture Techniques; Cyt | 2018 |
Emodin and baicalein inhibit sodium taurocholate-induced vacuole formation in pancreatic acinar cells.
Topics: Acinar Cells; Acute Disease; Animals; Calcium; Calcium Signaling; Cell Survival; Cells, Cultured; Di | 2018 |
Aloin Suppresses Lipopolysaccharide-Induced Inflammatory Response and Apoptosis by Inhibiting the Activation of NF-κB.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cell Survival; Cyclooxygenase 2; Cytokines; Disease Mo | 2018 |
Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo.
Topics: ADAMTS4 Protein; ADAMTS5 Protein; Animals; Anterior Cruciate Ligament; Cartilage, Articular; Cells, | 2018 |
Emodin inhibits pancreatic cancer EMT and invasion by up‑regulating microRNA‑1271.
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Emodin; Ep | 2018 |
Emodin alleviates CCl4‑induced liver fibrosis by suppressing epithelial‑mesenchymal transition and transforming growth factor‑β1 in rats.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Collagen; Disease Models, Animal; Emodin; Epithelial-Mese | 2018 |
Effect of emodin on T cell subsets in NOD mice with NaI‑induced experimental autoimmune thyroiditis.
Topics: Animals; Biopsy; Disease Models, Animal; Emodin; Hashimoto Disease; Immunohistochemistry; Immunophen | 2018 |
Aloin Inhibits Müller Cells Swelling in a Rat Model of Thioacetamide-Induced Hepatic Retinopathy.
Topics: Ammonia; Animals; Aquaporin 4; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Emodi | 2018 |
Pharmacokinetic studies unveiled the drug-drug interaction between trans-2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucopyranoside and emodin that may contribute to the idiosyncratic hepatotoxicity of Polygoni Multiflori Radix.
Topics: Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure | 2019 |
Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway.
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Emodin; Humans; Male; NLR Family, Pyrin Doma | 2019 |
Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia.
Topics: Aloe; Animals; Anthraquinones; Brain Ischemia; Disease Models, Animal; Drug Therapy, Combination; Em | 2019 |
Emodin ameliorates rheumatoid arthritis by promoting neutrophil apoptosis and inhibiting neutrophil extracellular trap formation.
Topics: Animals; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantigens; Autophagy; Cytokin | 2019 |
Emodin reactivated autophagy and alleviated inflammatory lung injury in mice with lethal endotoxemia.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Autophagy; Disease Models, Animal; Emodin; End | 2019 |
Emodin attenuates Alzheimer's disease by activating the protein kinase C signaling pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Cell Survival; Cognition; Disea | 2019 |
Emodin Alleviates the Airway Inflammation of Cough Variant Asthma in Mice by Regulating the Notch Pathway.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cough; Cytokines; Disease Models, Animal; Emodin; Eos | 2019 |
The role of protein kinase CK2 in cyclosporine-induced nephropathy in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Casein Kinase II; Caspase 3; Casp | 2013 |
Emodin-6-O-β-D-glucoside down-regulates endothelial protein C receptor shedding.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Cells | 2013 |
Evaluation of therapeutic potential of nanosilver particles synthesised using aloin in experimental murine mastitis model.
Topics: Animals; Antioxidants; Body Weight; Disease Models, Animal; Drug Design; Emodin; Female; Mastitis; M | 2013 |
Emodin-6-O-β-D--glucoside inhibits high-glucose-induced vascular inflammation.
Topics: Animals; Anti-Inflammatory Agents; Capillary Permeability; Cell Adhesion; Cell Adhesion Molecules; C | 2014 |
In vitro effects of emodin on peritoneal macrophages that express membrane-bound CD14 protein in a rat model of severe acute pancreatitis/systemic inflammatory response syndrome.
Topics: Acute Disease; Animals; Dexamethasone; Disease Models, Animal; Emodin; Lipopolysaccharide Receptors; | 2014 |
Aloin protects against chronic alcoholic liver injury via attenuating lipid accumulation, oxidative stress and inflammation in mice.
Topics: Animals; Antioxidants; Biomarkers; Cytokines; Disease Models, Animal; Emodin; Hepatitis, Alcoholic; | 2014 |
Anti-inflammatory and antioxidant effects of Aloe saponaria Haw in a model of UVB-induced paw sunburn in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Chromatography, High Pressure Liquid; D | 2014 |
[Effect of emodin on expression of farnesoid X receptor in rats with acute cholestatic hepatitis].
Topics: Acute Disease; Alanine Transaminase; Animals; Cholestasis, Intrahepatic; Disease Models, Animal; Emo | 2014 |
Emodin opposes chronic unpredictable mild stress induced depressive-like behavior in mice by upregulating the levels of hippocampal glucocorticoid receptor and brain-derived neurotrophic factor.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; | 2014 |
Emodin inhibits inducible nitric oxide synthase in a rat model of craniocerebral explosive injury.
Topics: Animals; Brain Injuries; Disease Models, Animal; Emodin; Explosions; Male; Nitric Oxide; Nitric Oxid | 2014 |
Emodin ameliorates ethanol-induced fatty liver injury in mice.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Collagen Type I; Cytochrome P-45 | 2014 |
Emodin has a protective effect in cases of severe acute pancreatitis via inhibition of nuclear factor‑κB activation resulting in antioxidation.
Topics: Acute Disease; Amylases; Animals; Antioxidants; Disease Models, Animal; Drugs, Chinese Herbal; Emodi | 2015 |
Protective effect of emodin against airway inflammation in the ovalbumin-induced mouse model.
Topics: Animals; Bronchoalveolar Lavage Fluid; Chemokines; Disease Models, Animal; Emodin; Female; Gene Expr | 2015 |
Emodin inhibits splenocyte proliferation and inflammation by modulating cytokine responses in a mouse model system.
Topics: Animals; Anti-Inflammatory Agents; Cathartics; Cell Proliferation; Cells, Cultured; Cytokines; Disea | 2016 |
Blockade of emodin on amyloid-β 25-35-induced neurotoxicity in AβPP/PS1 mice and PC12 cells through activation of the class III phosphatidylinositol 3-kinase/Beclin-1/B-cell lymphoma 2 pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autophagy; Cell Survival; Class III Phosphatidyli | 2015 |
The direct anti-MRSA effect of emodin via damaging cell membrane.
Topics: Animals; Anti-Bacterial Agents; Cell Membrane; Cell Survival; Disease Models, Animal; Drug Resistanc | 2015 |
Emodin mitigates diesel exhaust particles-induced increase in airway resistance, inflammation and oxidative stress in mice.
Topics: Airway Resistance; Animals; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Emo | 2015 |
Emodin plays an interventional role in epileptic rats via multidrug resistance gene 1 (MDR1).
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Behavior, Animal; Brain; Br | 2015 |
Emodin Attenuates Cigarette Smoke Induced Lung Injury in a Mouse Model via Suppression of Reactive Oxygen Species Production.
Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Emodin; Female; Lung Injury; Mice; Mi | 2015 |
Emodin inhibits angiogenesis in pancreatic cancer by regulating the transforming growth factor-β/drosophila mothers against decapentaplegic pathway and angiogenesis-associated microRNAs.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Biomarkers; Cell Line, Tumor; Disease Model | 2015 |
Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones.
Topics: Animals; Anthracenes; Cell Line, Tumor; Disease Models, Animal; Drug Delivery Systems; Drug Design; | 2016 |
[Influence of Emodin Gel on the Fibroblasts of Hypertrophic Scars in Rabbit Ear Model].
Topics: Animals; Cicatrix, Hypertrophic; Cytoplasm; Disease Models, Animal; Emodin; Fibroblasts; Gels; Hardn | 2015 |
Effect of emodin on Aquaporin 5 expression in rats with sepsis-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Aquaporin 5; Disease Models, Animal; Down-Regulation; Emodin; Humans; Lu | 2015 |
Emodin suppresses LPS-induced inflammation in RAW264.7 cells through a PPARγ-dependent pathway.
Topics: Aconitum; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Emodin; Humans; Inflammation; L | 2016 |
Emodin from Polygonum multiflorum ameliorates oxidative toxicity in HT22 cells and deficits in photothrombotic ischemia.
Topics: Animals; Antioxidants; Apoptosis Regulatory Proteins; Behavior, Animal; Brain Ischemia; Brain-Derive | 2016 |
Emodin Inhibits Breast Cancer Growth by Blocking the Tumor-Promoting Feedforward Loop between Cancer Cells and Macrophages.
Topics: Animals; Biomarkers; Breast Neoplasms; Cell Communication; Cell Line, Tumor; Cell Survival; Disease | 2016 |
Emodin suppresses silica-induced lung fibrosis by promoting Sirt1 signaling via direct contact.
Topics: Actins; Animals; Bronchoalveolar Lavage Fluid; Collagen Type I; Disease Models, Animal; Emodin; Enzy | 2016 |
Inhibitory effect of emodin on bleomycin-induced pulmonary fibrosis in mice.
Topics: Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Cell Proliferation; Collagen; Cytokines; Disease M | 2009 |
Equivocal colonic carcinogenicity of Aloe arborescens Miller var. natalensis berger at high-dose level in a Wistar Hannover rat 2-y study.
Topics: Aloe; Animals; Colonic Neoplasms; Diarrhea; Disease Models, Animal; Emodin; Female; Glucosides; Male | 2009 |
[Therapeutic effects of emodin on acute cholestatic hepatitis and mechanism thereof: experiment with rats].
Topics: Alanine Transaminase; Animals; Bilirubin; Chemokine CXCL1; Chemokine CXCL2; Cholestasis; Disease Mod | 2009 |
Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, An | 2009 |
In vitro & in vivo assessment of a herbal formula used topically for bone fracture treatment.
Topics: Administration, Cutaneous; Alkaline Phosphatase; Animals; Bony Callus; Cell Line; Cell Proliferation | 2010 |
Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model.
Topics: Aloe; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromones; Colitis; Colon; Diet; Dietary Sup | 2011 |
A comparative study on the tissue distributions of rhubarb anthraquinones in normal and CCl4-injured rats orally administered rhubarb extract.
Topics: Administration, Oral; Animals; Anthraquinones; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2011 |
Hepatoprotection of emodin and Polygonum multiflorum against CCl(4)-induced liver injury.
Topics: Animals; Disease Models, Animal; Emodin; Inflammation; Lipid Peroxidation; Liver Diseases; Liver Fun | 2012 |
Characteristics of emodin on modulating the contractility of jejunal smooth muscle.
Topics: Animals; Atropine; Constipation; Diarrhea; Diphenhydramine; Disease Models, Animal; Dose-Response Re | 2012 |
Effect of acute pancreatitis on the pharmacokinetics of Chinese herbal ointment Liu-He-Dan in anaesthetized rats.
Topics: Administration, Cutaneous; Amylases; Animals; Anthraquinones; Arginine; Disease Models, Animal; Drug | 2013 |
Emodin-6-O-β-D-glucoside inhibits HMGB1-induced inflammatory responses in vitro and in vivo.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cecum; Cell Adhesion; Cell Movement; Cytoskeleton; | 2013 |
[Effect of emodin on pancreatic fibrosis: experiment with rats].
Topics: Animals; Blotting, Western; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Emod | 2006 |
Emodin-mediated protection from acute myocardial infarction via inhibition of inflammation and apoptosis in local ischemic myocardium.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Blotting, Western; Disease Models, Anim | 2007 |
Emodin suppression of ocular surface inflammatory reaction.
Topics: Animals; Blotting, Western; Cell Movement; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Cocu | 2007 |
The anthraquinone derivative Emodin ameliorates neurobehavioral deficits of a rodent model for schizophrenia.
Topics: Animals; Anthraquinones; Antipsychotic Agents; Behavior, Animal; Blotting, Western; Cathartics; Dise | 2008 |
Up-regulation of Toll-like receptor 4 was suppressed by emodin and baicalin in the setting of acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Therapy, Co | 2009 |
Anti-inflammatory effects of emodin from ventilago leiocarpa.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Drugs, Chinese Her | 1996 |
Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cell Division; Disease Models, An | 1999 |
Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride.
Topics: Albumins; Animals; Anthraquinones; Antineoplastic Agents; Aspartate Aminotransferases; Blotting, Nor | 2000 |
[Effects of emodin on hepatic fibrosis in rats].
Topics: Actins; Animals; Disease Models, Animal; Emodin; Enzyme Inhibitors; Hyaluronic Acid; Laminin; Liver | 2001 |