Page last updated: 2024-10-26

emodin and Colonic Neoplasms

emodin has been researched along with Colonic Neoplasms in 15 studies

Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.

Colonic Neoplasms: Tumors or cancer of the COLON.

Research Excerpts

ExcerptRelevanceReference
"BACKGROUND Recently, colorectal cancer has become a more common type of tumor in the world."5.48Aloe-Emodin Induces Endoplasmic Reticulum Stress-Dependent Apoptosis in Colorectal Cancer Cells. ( Cheng, C; Dong, W, 2018)
"Emodin is a typical anthraquinone derivative from various plants that exhibits a wide spectrum of biological activities, such as anticancer, antibacterial, hepatoprotective and anti-inflammatory activities."2.82The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers. ( Chen, WW; Li, MY; Peng, W; Qian, D; Sun, X; Tang, DD; Wang, LY; Wu, CJ; Zhang, LL; Zhang, Q, 2022)
" Optimal dosing of iv emodin and especially BTB 14431 for maximal efficacy remains unclear and should be a subject of further research."1.56Anti-tumorigenic Effects of Emodin and Its' Homologue BTB14431 on Vascularized Colonic Cancer in a Rat Model. ( Braumann, C; Dubiel, W; Freiburger, M; Höhn, P; Koplin, G; Luu, AM, 2020)
"Emodin is an anthraquinone-active substance that has the ability to affect tumor progression."1.51Emodin Inhibits Colon Cancer Cell Invasion and Migration by Suppressing Epithelial-Mesenchymal Transition via the Wnt/β-Catenin Pathway. ( Cui, CF; Gu, J; Jiang, XH; Wang, L; Yang, L, 2019)
"BACKGROUND Recently, colorectal cancer has become a more common type of tumor in the world."1.48Aloe-Emodin Induces Endoplasmic Reticulum Stress-Dependent Apoptosis in Colorectal Cancer Cells. ( Cheng, C; Dong, W, 2018)
"Treatment with emodin reduced VEGFR phosphorylation, as evidenced by Western blot analysis."1.35The effect of emodin on VEGF receptors in human colon cancer cells. ( Lu, Y; Qian, J; Zhang, J, 2008)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (6.67)18.2507
2000's3 (20.00)29.6817
2010's9 (60.00)24.3611
2020's2 (13.33)2.80

Authors

AuthorsStudies
Han, YM1
Lee, SK1
Jeong, DG1
Ryu, SE1
Han, DC1
Kim, DK1
Kwon, BM2
Sabbah, DA1
Simms, NA1
Brattain, MG1
Vennerstrom, JL1
Zhong, H1
Zhang, Q1
Chen, WW1
Sun, X1
Qian, D1
Tang, DD1
Zhang, LL1
Li, MY1
Wang, LY1
Wu, CJ1
Peng, W1
Höhn, P2
Braumann, C2
Freiburger, M1
Koplin, G2
Dubiel, W2
Luu, AM1
Geier, C1
Pohlenz, J1
Rogalla, S1
Wang, Y2
Luo, Q1
He, X1
Wei, H1
Wang, T1
Shao, J1
Jiang, X1
Gu, J1
Cui, CF1
Yang, L1
Wang, L1
Jiang, XH1
Cheng, C1
Dong, W1
Xie, MJ1
Ma, YH1
Miao, L1
Wang, HZ1
Xing, YY1
Xi, T1
Lu, YY1
Lee, KH1
Lee, MS1
Cha, EY1
Sul, JY1
Lee, JS1
Kim, JS1
Park, JB1
Kim, JY1
Yokohira, M1
Matsuda, Y1
Suzuki, S1
Hosokawa, K1
Yamakawa, K1
Hashimoto, N1
Saoo, K1
Nabae, K1
Doi, Y1
Kuno, T1
Imaida, K1
Ma, YS1
Weng, SW1
Lin, MW1
Lu, CC1
Chiang, JH1
Yang, JS1
Lai, KC1
Lin, JP1
Tang, NY1
Lin, JG1
Chung, JG1
Choi, SG1
Kim, J1
Sung, ND1
Son, KH1
Cheon, HG1
Kim, KR1
Lu, Y1
Zhang, J1
Qian, J1
Mereto, E1
Ghia, M1
Brambilla, G1

Reviews

1 review available for emodin and Colonic Neoplasms

ArticleYear
The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers.
    International journal of biological sciences, 2022, Volume: 18, Issue:8

    Topics: Anthraquinones; Antineoplastic Agents; Apoptosis; Colonic Neoplasms; Emodin; Humans

2022

Other Studies

14 other studies available for emodin and Colonic Neoplasms

ArticleYear
Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity.
    Bioorganic & medicinal chemistry letters, 2012, Jan-01, Volume: 22, Issue:1

    Topics: Anthraquinones; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Collagen; Colonic Neoplasms;

2012
Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases.
    Bioorganic & medicinal chemistry letters, 2012, Jan-15, Volume: 22, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, D

2012
Anti-tumorigenic Effects of Emodin and Its' Homologue BTB14431 on Vascularized Colonic Cancer in a Rat Model.
    Asian Pacific journal of cancer prevention : APJCP, 2020, Jan-01, Volume: 21, Issue:1

    Topics: Animals; Apoptosis; Cell Proliferation; Colonic Neoplasms; Emodin; Female; Humans; Mice; Mice, Inbre

2020
Dose-dependent role of novel agents emodin and BTB14431 in colonic cancer treatment in rats.
    Acta chirurgica Belgica, 2017, Volume: 117, Issue:6

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Blood Cell Count; Colonic Neoplasms; Dise

2017
Emodin Induces Apoptosis of Colon Cancer Cells via Induction of Autophagy in a ROS-Dependent Manner.
    Oncology research, 2018, Jul-05, Volume: 26, Issue:6

    Topics: Apoptosis; Autophagy; Colonic Neoplasms; Emodin; Humans; Protein Kinase Inhibitors; Reactive Oxygen

2018
Emodin Inhibits Colon Cancer Cell Invasion and Migration by Suppressing Epithelial-Mesenchymal Transition via the Wnt/β-Catenin Pathway.
    Oncology research, 2019, 02-05, Volume: 27, Issue:2

    Topics: Animals; beta Catenin; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Emodin; Epithelial-Mesenc

2019
Aloe-Emodin Induces Endoplasmic Reticulum Stress-Dependent Apoptosis in Colorectal Cancer Cells.
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Sep-10, Volume: 24

    Topics: Aloe; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Colorectal

2018
Emodin-provoked oxidative stress induces apoptosis in human colon cancer HCT116 cells through a p53-mitochondrial apoptotic pathway.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:13

    Topics: Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Colonic Neoplasms; Emodin; HCT116 Cells; Hu

2014
Inhibitory effect of emodin on fatty acid synthase, colon cancer proliferation and apoptosis.
    Molecular medicine reports, 2017, Volume: 15, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Proliferation; Cell Survival; Colon; Colonic Neop

2017
Equivocal colonic carcinogenicity of Aloe arborescens Miller var. natalensis berger at high-dose level in a Wistar Hannover rat 2-y study.
    Journal of food science, 2009, Volume: 74, Issue:2

    Topics: Aloe; Animals; Colonic Neoplasms; Diarrhea; Disease Models, Animal; Emodin; Female; Glucosides; Male

2009
Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: roles of apoptotic cell death and LS1034 tumor xenografts model.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:5

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Base Sequence; Calcium; Caspase 3; Caspas

2012
Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb.
    Natural product research, 2007, May-20, Volume: 21, Issue:6

    Topics: cdc25 Phosphatases; Cell Cycle Proteins; Cell Line, Tumor; Colonic Neoplasms; Emodin; Enzyme Inhibit

2007
The effect of emodin on VEGF receptors in human colon cancer cells.
    Cancer biotherapy & radiopharmaceuticals, 2008, Volume: 23, Issue:2

    Topics: Apoptosis; Blotting, Western; Colonic Neoplasms; Emodin; HCT116 Cells; Humans; Phosphorylation; Rece

2008
Evaluation of the potential carcinogenic activity of Senna and Cascara glycosides for the rat colon.
    Cancer letters, 1996, Mar-19, Volume: 101, Issue:1

    Topics: Animals; Anthraquinones; Carcinogenicity Tests; Cathartics; Colon; Colonic Neoplasms; Emodin; Male;

1996