Page last updated: 2024-10-26
emodin and Cirrhosis
emodin has been researched along with Cirrhosis in 21 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " In search of a potential treatment, we investigated the effect of emodin on IC/BPS inflammation and fibrosis, and explore the potential mechanism." | 8.31 | Emodin inhibits bladder inflammation and fibrosis in mice with interstitial cystitis by regulating JMJD3. ( Huang, M; Lai, J; Liu, X; Luo, S; Su, H; Tang, H; Xin, K; Zhu, Y, 2023) |
| "In order to enhance renal fibrosis therapy of emodin, an innovative combination therapy based on deoxycholic acid-chitosan coated liposomes (DCS-Lips) and in situ colonic gel (IGE) was developed." | 8.12 | Deoxycholic acid-chitosan coated liposomes combined with in situ colonic gel enhances renal fibrosis therapy of emodin. ( Fan, X; Hou, Y; Piao, JG; Sun, J; Wei, Y; Xu, Z; Yao, W; Zhang, K; Zhang, Q; Zhu, L, 2022) |
| "We aim to explore the effects of emodin and its mechanisms on renal fibrosis (RF)." | 8.02 | Emodin-induced autophagic cell death hinders epithelial-mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis. ( Gu, R; He, C; Li, D; Liu, W; Lou, Y; Zhang, Q, 2021) |
| " Moreover, a unilateral ureteral obstruction-induced mouse model of renal fibrosis was established for investigating the antifibrotic effect of emodin in combination with HGF in vivo." | 7.96 | Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ-Smad Signaling Pathway. ( Chen, M; Deng, L; Hu, Y; Li, J; Liu, Y; Yang, F; Zhong, W, 2020) |
| "Our results showed that the histopathological abnormalities, the decrease in rat body weight and the abnormal renal function caused by renal fibrosis were improved by emodin." | 7.88 | Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2. ( Chen, K; Deng, G; Jiang, K; Jiang, P; Li, H; Ma, L; Xiong, X; Zhang, S, 2018) |
| "Pulmonary silicosis is characterized by lung fibrosis, which leads to impairment of pulmonary function; the specific mechanism remains to be fully elucidated Emodin shows antifibrotic effects in several organs with fibrosis, however, it has not been investigated in pulmonary silicosis." | 7.83 | Emodin suppresses silica-induced lung fibrosis by promoting Sirt1 signaling via direct contact. ( Chen, M; Dang, X; Liu, Y; Pang, Y; Ren, H; Shang, D; Wang, J; Yang, T, 2016) |
| "To establish the rats model of chronic fibrosing pancreatitis and to prove the anti-fibrotic effect of emodin in chronic pancreatitis with fibrosis." | 7.74 | Effect of emodin on pancreatic fibrosis in rats. ( Cai, JT; Du, Q; Gao, ZQ; Qian, KD; Wang, CH; Xie, CG; Ye, B, 2007) |
| "The aim of this article was to investigate the mechanisms of emodin in antagonizing against organ fibrosis, and to illustrate that emodin can be an effective Chinese herbal preparation for treatment of organ fibrosis." | 7.73 | [Emodin and organ fibrosis]. ( Gao, ZQ; Wang, CH, 2005) |
| "To study the effect of emodin on pancreatic fibrosis and potential mechanism thereof." | 7.73 | [Effect of emodin on pancreatic fibrosis: experiment with rats]. ( Cai, JT; Du, Q; Gao, ZQ; Qian, KD; Wang, CH; Xie, CG; Ye, B, 2006) |
| " The oral bioavailability of EMO and Tan IIA was significantly improved when they were loaded into the hierarchically structured microcapsules, ultimately contributing to superior therapeutic outcomes in rats with unilateral ureteral obstruction." | 5.72 | Hierarchically structured microcapsules for oral delivery of emodin and tanshinone IIA to treat renal fibrosis. ( Fan, X; Hou, Y; Li, F; Piao, J; Sun, J; Wei, Y; Xu, Z; Yao, W; Zheng, H, 2022) |
| " In vitro, AE could protect neonatal mouse cardiomyocytes (NMCM) from angiotensin II (Ang II)-induced cardiomyocyte hypertrophy and apoptosis, and significantly inhibited (p < 0." | 4.31 | Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7. ( Du, Z; Hao, Y; Li, W; Liang, Z; Liu, Y; Tao, Y; Wang, J; Yan, X; Yang, Y; Yu, J; Yuan, Y; Zhao, X, 2023) |
| " In search of a potential treatment, we investigated the effect of emodin on IC/BPS inflammation and fibrosis, and explore the potential mechanism." | 4.31 | Emodin inhibits bladder inflammation and fibrosis in mice with interstitial cystitis by regulating JMJD3. ( Huang, M; Lai, J; Liu, X; Luo, S; Su, H; Tang, H; Xin, K; Zhu, Y, 2023) |
| "In order to enhance renal fibrosis therapy of emodin, an innovative combination therapy based on deoxycholic acid-chitosan coated liposomes (DCS-Lips) and in situ colonic gel (IGE) was developed." | 4.12 | Deoxycholic acid-chitosan coated liposomes combined with in situ colonic gel enhances renal fibrosis therapy of emodin. ( Fan, X; Hou, Y; Piao, JG; Sun, J; Wei, Y; Xu, Z; Yao, W; Zhang, K; Zhang, Q; Zhu, L, 2022) |
| "We aim to explore the effects of emodin and its mechanisms on renal fibrosis (RF)." | 4.02 | Emodin-induced autophagic cell death hinders epithelial-mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis. ( Gu, R; He, C; Li, D; Liu, W; Lou, Y; Zhang, Q, 2021) |
| " Moreover, a unilateral ureteral obstruction-induced mouse model of renal fibrosis was established for investigating the antifibrotic effect of emodin in combination with HGF in vivo." | 3.96 | Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ-Smad Signaling Pathway. ( Chen, M; Deng, L; Hu, Y; Li, J; Liu, Y; Yang, F; Zhong, W, 2020) |
| "Our results showed that the histopathological abnormalities, the decrease in rat body weight and the abnormal renal function caused by renal fibrosis were improved by emodin." | 3.88 | Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2. ( Chen, K; Deng, G; Jiang, K; Jiang, P; Li, H; Ma, L; Xiong, X; Zhang, S, 2018) |
| "Pulmonary silicosis is characterized by lung fibrosis, which leads to impairment of pulmonary function; the specific mechanism remains to be fully elucidated Emodin shows antifibrotic effects in several organs with fibrosis, however, it has not been investigated in pulmonary silicosis." | 3.83 | Emodin suppresses silica-induced lung fibrosis by promoting Sirt1 signaling via direct contact. ( Chen, M; Dang, X; Liu, Y; Pang, Y; Ren, H; Shang, D; Wang, J; Yang, T, 2016) |
| "Rat models of experimental hepatic fibrosis were established by injection with CCl(4); the treated rats received emodin via oral administration at a dosage of 20 mg/kg twice a week at the same time." | 3.75 | Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation. ( Dong, MX; Geng, YT; Jia, Y; Li, CC; Li, XY; Liu, JC; Niu, YC; Zhang, YB; Zhou, L, 2009) |
| "To establish the rats model of chronic fibrosing pancreatitis and to prove the anti-fibrotic effect of emodin in chronic pancreatitis with fibrosis." | 3.74 | Effect of emodin on pancreatic fibrosis in rats. ( Cai, JT; Du, Q; Gao, ZQ; Qian, KD; Wang, CH; Xie, CG; Ye, B, 2007) |
| "The aim of this article was to investigate the mechanisms of emodin in antagonizing against organ fibrosis, and to illustrate that emodin can be an effective Chinese herbal preparation for treatment of organ fibrosis." | 3.73 | [Emodin and organ fibrosis]. ( Gao, ZQ; Wang, CH, 2005) |
| "To study the effect of emodin on pancreatic fibrosis and potential mechanism thereof." | 3.73 | [Effect of emodin on pancreatic fibrosis: experiment with rats]. ( Cai, JT; Du, Q; Gao, ZQ; Qian, KD; Wang, CH; Xie, CG; Ye, B, 2006) |
| "The study aimed to explore the pharmacokinetic and pharmacodynamic alterations of the active components of Shenkang injection (i." | 1.91 | Pharmacokinetic-pharmacodynamic modeling of the active components of Shenkang injection in rats with chronic renal failure and its protective effect on damaged renal cells. ( Fu, Z; Jia, Q; Sun, Z; Wang, X; Xia, J; Xue, L; Zhang, L; Zhou, L, 2023) |
| "Pathological cardiac hypertrophy is a characteristic feature in many cardiovascular diseases (CVDs)." | 1.72 | Aloin alleviates pathological cardiac hypertrophy via modulation of the oxidative and fibrotic response. ( Kulhari, U; Kumar, A; Kundu, S; Mugale, MN; Murty, US; Ram, C; Sahu, BD; Syed, AM, 2022) |
| " The oral bioavailability of EMO and Tan IIA was significantly improved when they were loaded into the hierarchically structured microcapsules, ultimately contributing to superior therapeutic outcomes in rats with unilateral ureteral obstruction." | 1.72 | Hierarchically structured microcapsules for oral delivery of emodin and tanshinone IIA to treat renal fibrosis. ( Fan, X; Hou, Y; Li, F; Piao, J; Sun, J; Wei, Y; Xu, Z; Yao, W; Zheng, H, 2022) |
Research
Studies (21)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 4 (19.05) | 24.3611 |
| 2020's | 12 (57.14) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Syed, AM | 1 |
| Kundu, S | 1 |
| Ram, C | 1 |
| Kulhari, U | 1 |
| Kumar, A | 1 |
| Mugale, MN | 1 |
| Murty, US | 1 |
| Sahu, BD | 1 |
| Sun, J | 2 |
| Xu, Z | 2 |
| Hou, Y | 2 |
| Yao, W | 2 |
| Fan, X | 2 |
| Zheng, H | 1 |
| Piao, J | 1 |
| Li, F | 1 |
| Wei, Y | 2 |
| Brenes, R | 1 |
| Nguyen, LMN | 1 |
| Miller, DL | 1 |
| Rohde, ML | 1 |
| Zhu, L | 1 |
| Zhang, Q | 2 |
| Zhang, K | 1 |
| Piao, JG | 1 |
| Yu, J | 1 |
| Zhao, X | 1 |
| Yan, X | 1 |
| Li, W | 1 |
| Liu, Y | 3 |
| Wang, J | 4 |
| Yang, Y | 1 |
| Hao, Y | 1 |
| Liang, Z | 1 |
| Tao, Y | 1 |
| Yuan, Y | 1 |
| Du, Z | 1 |
| Chen, L | 1 |
| Liang, B | 1 |
| Xia, S | 1 |
| Wang, F | 1 |
| Li, Z | 1 |
| Shao, J | 1 |
| Zhang, Z | 1 |
| Chen, A | 1 |
| Zheng, S | 1 |
| Zhang, F | 1 |
| Zhou, L | 2 |
| Wang, X | 1 |
| Xia, J | 1 |
| Zhang, L | 1 |
| Xue, L | 1 |
| Jia, Q | 1 |
| Fu, Z | 1 |
| Sun, Z | 1 |
| Lai, J | 1 |
| Liu, X | 1 |
| Su, H | 1 |
| Zhu, Y | 1 |
| Xin, K | 1 |
| Huang, M | 1 |
| Luo, S | 1 |
| Tang, H | 1 |
| Xiong, G | 1 |
| Chen, H | 1 |
| Wan, Q | 1 |
| Dai, J | 1 |
| Sun, Y | 1 |
| Li, X | 2 |
| Yang, F | 2 |
| Deng, L | 1 |
| Li, J | 1 |
| Chen, M | 2 |
| Hu, Y | 1 |
| Zhong, W | 1 |
| Xu, L | 1 |
| Gao, J | 1 |
| Huang, D | 2 |
| Lin, P | 1 |
| Yao, D | 1 |
| Zhang, Y | 1 |
| Yang, X | 1 |
| Wu, M | 1 |
| Ye, C | 1 |
| Carver, W | 1 |
| Fix, E | 1 |
| Fix, C | 1 |
| Fan, D | 1 |
| Chakrabarti, M | 1 |
| Azhar, M | 1 |
| Liu, W | 2 |
| Gu, R | 1 |
| Lou, Y | 1 |
| He, C | 1 |
| Li, D | 1 |
| Ma, L | 1 |
| Li, H | 1 |
| Zhang, S | 1 |
| Xiong, X | 1 |
| Chen, K | 1 |
| Jiang, P | 1 |
| Jiang, K | 1 |
| Deng, G | 1 |
| Chen, Q | 1 |
| Pang, L | 1 |
| Huang, S | 1 |
| Lei, W | 1 |
| Yang, T | 1 |
| Pang, Y | 1 |
| Dang, X | 1 |
| Ren, H | 1 |
| Shang, D | 1 |
| Wang, Q | 1 |
| Liu, P | 1 |
| Deng, Y | 1 |
| Lan, T | 1 |
| Zhang, X | 1 |
| Qiu, B | 1 |
| Ning, H | 1 |
| Huang, H | 1 |
| Dong, MX | 1 |
| Jia, Y | 1 |
| Zhang, YB | 1 |
| Li, CC | 1 |
| Geng, YT | 1 |
| Li, XY | 1 |
| Liu, JC | 1 |
| Niu, YC | 1 |
| Gao, ZQ | 3 |
| Wang, CH | 3 |
| Ye, B | 2 |
| Xie, CG | 2 |
| Qian, KD | 2 |
| Cai, JT | 2 |
| Du, Q | 2 |
Other Studies
21 other studies available for emodin and Cirrhosis
| Article | Year |
|---|---|
Aloin alleviates pathological cardiac hypertrophy via modulation of the oxidative and fibrotic response.
Topics: Adrenergic beta-Agonists; Animals; Antioxidants; Cardiomegaly; Cathartics; Emodin; Fibrosis; Isoprot | 2022 |
Hierarchically structured microcapsules for oral delivery of emodin and tanshinone IIA to treat renal fibrosis.
Topics: Abietanes; Animals; Capsules; Emodin; Fibrosis; Rats | 2022 |
HEPATOCELLULAR TOXICITY OF THE METABOLITE EMODIN PRODUCED BY THE COMMON BUCKTHORN (RHAMNUS CATHARTICA) IN GREEN FROG (LITHOBATES CLAMITANS) TADPOLES.
Topics: Animals; Carcinoma, Hepatocellular; Emodin; Fibrosis; Larva; Liver Neoplasms; Rana clamitans; Rhamnu | 2022 |
Deoxycholic acid-chitosan coated liposomes combined with in situ colonic gel enhances renal fibrosis therapy of emodin.
Topics: Animals; Caco-2 Cells; Chitosan; Deoxycholic Acid; DNA, Ribosomal; Dysbiosis; Emodin; Female; Fibros | 2022 |
Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7.
Topics: Aloe; Angiotensin II; Animals; Cardiomyopathies; Emodin; Fibrosis; Hypertrophy; Mice; Myocardial Inf | 2023 |
Emodin promotes hepatic stellate cell senescence and alleviates liver fibrosis via a nuclear receptor (Nur77)-mediated epigenetic regulation of glutaminase 1.
Topics: Animals; Cell Proliferation; Emodin; Epigenesis, Genetic; Extracellular Signal-Regulated MAP Kinases | 2023 |
Pharmacokinetic-pharmacodynamic modeling of the active components of Shenkang injection in rats with chronic renal failure and its protective effect on damaged renal cells.
Topics: Animals; Drugs, Chinese Herbal; Emodin; Fibrosis; Kidney; Kidney Failure, Chronic; Rats; Rats, Sprag | 2023 |
Emodin inhibits bladder inflammation and fibrosis in mice with interstitial cystitis by regulating JMJD3.
Topics: Animals; Cystitis; Cystitis, Interstitial; Emodin; Fibrosis; Humans; Inflammation; Mice | 2023 |
Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats.
Topics: Animals; Apoptosis; Drug Evaluation, Preclinical; Emodin; Endoplasmic Reticulum Chaperone BiP; Endop | 2019 |
Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ-Smad Signaling Pathway.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Emodin; Fibrosis | 2020 |
Emodin ameliorates tubulointerstitial fibrosis in obstructed kidneys by inhibiting EZH2.
Topics: Animals; Connective Tissue Growth Factor; Disease Models, Animal; Drugs, Chinese Herbal; Emodin; Enh | 2021 |
Effects of emodin, a plant-derived anthraquinone, on TGF-β1-induced cardiac fibroblast activation and function.
Topics: Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen; Emodin; Fibroblasts; Fibrosis | 2021 |
Emodin-induced autophagic cell death hinders epithelial-mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis.
Topics: Animals; Autophagic Cell Death; Bone Morphogenetic Protein 7; Cells, Cultured; Emodin; Epithelial-Me | 2021 |
Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2.
Topics: Animals; Body Weight; Emodin; Fibrosis; Gene Expression Regulation; Kidney; Kidney Diseases; Kidney | 2018 |
Effects of emodin and irbesartan on ventricular fibrosis in Goldblatt hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Blotting, West | 2014 |
Emodin suppresses silica-induced lung fibrosis by promoting Sirt1 signaling via direct contact.
Topics: Actins; Animals; Bronchoalveolar Lavage Fluid; Collagen Type I; Disease Models, Animal; Emodin; Enzy | 2016 |
Emodin suppresses cell proliferation and fibronectin expression via p38MAPK pathway in rat mesangial cells cultured under high glucose.
Topics: Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Connective Tissue Growth Factor; Cyclic AM | 2009 |
Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, An | 2009 |
[Emodin and organ fibrosis].
Topics: Animals; Emodin; Fibrosis; Glomerulosclerosis, Focal Segmental; Humans; Kidney; Liver Cirrhosis; Phy | 2005 |
[Effect of emodin on pancreatic fibrosis: experiment with rats].
Topics: Animals; Blotting, Western; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Emod | 2006 |
Effect of emodin on pancreatic fibrosis in rats.
Topics: Animals; Collagen; Drugs, Chinese Herbal; Emodin; Enzyme Inhibitors; Fibrosis; Hyaluronic Acid; Immu | 2007 |