Page last updated: 2024-10-26

emodin and Cirrhosis

emodin has been researched along with Cirrhosis in 21 studies

Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.

Research Excerpts

ExcerptRelevanceReference
" In search of a potential treatment, we investigated the effect of emodin on IC/BPS inflammation and fibrosis, and explore the potential mechanism."8.31Emodin inhibits bladder inflammation and fibrosis in mice with interstitial cystitis by regulating JMJD3. ( Huang, M; Lai, J; Liu, X; Luo, S; Su, H; Tang, H; Xin, K; Zhu, Y, 2023)
"In order to enhance renal fibrosis therapy of emodin, an innovative combination therapy based on deoxycholic acid-chitosan coated liposomes (DCS-Lips) and in situ colonic gel (IGE) was developed."8.12Deoxycholic acid-chitosan coated liposomes combined with in situ colonic gel enhances renal fibrosis therapy of emodin. ( Fan, X; Hou, Y; Piao, JG; Sun, J; Wei, Y; Xu, Z; Yao, W; Zhang, K; Zhang, Q; Zhu, L, 2022)
"We aim to explore the effects of emodin and its mechanisms on renal fibrosis (RF)."8.02Emodin-induced autophagic cell death hinders epithelial-mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis. ( Gu, R; He, C; Li, D; Liu, W; Lou, Y; Zhang, Q, 2021)
" Moreover, a unilateral ureteral obstruction-induced mouse model of renal fibrosis was established for investigating the antifibrotic effect of emodin in combination with HGF in vivo."7.96Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ-Smad Signaling Pathway. ( Chen, M; Deng, L; Hu, Y; Li, J; Liu, Y; Yang, F; Zhong, W, 2020)
"Our results showed that the histopathological abnormalities, the decrease in rat body weight and the abnormal renal function caused by renal fibrosis were improved by emodin."7.88Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2. ( Chen, K; Deng, G; Jiang, K; Jiang, P; Li, H; Ma, L; Xiong, X; Zhang, S, 2018)
"Pulmonary silicosis is characterized by lung fibrosis, which leads to impairment of pulmonary function; the specific mechanism remains to be fully elucidated Emodin shows antifibrotic effects in several organs with fibrosis, however, it has not been investigated in pulmonary silicosis."7.83Emodin suppresses silica-induced lung fibrosis by promoting Sirt1 signaling via direct contact. ( Chen, M; Dang, X; Liu, Y; Pang, Y; Ren, H; Shang, D; Wang, J; Yang, T, 2016)
"To establish the rats model of chronic fibrosing pancreatitis and to prove the anti-fibrotic effect of emodin in chronic pancreatitis with fibrosis."7.74Effect of emodin on pancreatic fibrosis in rats. ( Cai, JT; Du, Q; Gao, ZQ; Qian, KD; Wang, CH; Xie, CG; Ye, B, 2007)
"The aim of this article was to investigate the mechanisms of emodin in antagonizing against organ fibrosis, and to illustrate that emodin can be an effective Chinese herbal preparation for treatment of organ fibrosis."7.73[Emodin and organ fibrosis]. ( Gao, ZQ; Wang, CH, 2005)
"To study the effect of emodin on pancreatic fibrosis and potential mechanism thereof."7.73[Effect of emodin on pancreatic fibrosis: experiment with rats]. ( Cai, JT; Du, Q; Gao, ZQ; Qian, KD; Wang, CH; Xie, CG; Ye, B, 2006)
" The oral bioavailability of EMO and Tan IIA was significantly improved when they were loaded into the hierarchically structured microcapsules, ultimately contributing to superior therapeutic outcomes in rats with unilateral ureteral obstruction."5.72Hierarchically structured microcapsules for oral delivery of emodin and tanshinone IIA to treat renal fibrosis. ( Fan, X; Hou, Y; Li, F; Piao, J; Sun, J; Wei, Y; Xu, Z; Yao, W; Zheng, H, 2022)
" In vitro, AE could protect neonatal mouse cardiomyocytes (NMCM) from angiotensin II (Ang II)-induced cardiomyocyte hypertrophy and apoptosis, and significantly inhibited (p < 0."4.31Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7. ( Du, Z; Hao, Y; Li, W; Liang, Z; Liu, Y; Tao, Y; Wang, J; Yan, X; Yang, Y; Yu, J; Yuan, Y; Zhao, X, 2023)
" In search of a potential treatment, we investigated the effect of emodin on IC/BPS inflammation and fibrosis, and explore the potential mechanism."4.31Emodin inhibits bladder inflammation and fibrosis in mice with interstitial cystitis by regulating JMJD3. ( Huang, M; Lai, J; Liu, X; Luo, S; Su, H; Tang, H; Xin, K; Zhu, Y, 2023)
"In order to enhance renal fibrosis therapy of emodin, an innovative combination therapy based on deoxycholic acid-chitosan coated liposomes (DCS-Lips) and in situ colonic gel (IGE) was developed."4.12Deoxycholic acid-chitosan coated liposomes combined with in situ colonic gel enhances renal fibrosis therapy of emodin. ( Fan, X; Hou, Y; Piao, JG; Sun, J; Wei, Y; Xu, Z; Yao, W; Zhang, K; Zhang, Q; Zhu, L, 2022)
"We aim to explore the effects of emodin and its mechanisms on renal fibrosis (RF)."4.02Emodin-induced autophagic cell death hinders epithelial-mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis. ( Gu, R; He, C; Li, D; Liu, W; Lou, Y; Zhang, Q, 2021)
" Moreover, a unilateral ureteral obstruction-induced mouse model of renal fibrosis was established for investigating the antifibrotic effect of emodin in combination with HGF in vivo."3.96Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ-Smad Signaling Pathway. ( Chen, M; Deng, L; Hu, Y; Li, J; Liu, Y; Yang, F; Zhong, W, 2020)
"Our results showed that the histopathological abnormalities, the decrease in rat body weight and the abnormal renal function caused by renal fibrosis were improved by emodin."3.88Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2. ( Chen, K; Deng, G; Jiang, K; Jiang, P; Li, H; Ma, L; Xiong, X; Zhang, S, 2018)
"Pulmonary silicosis is characterized by lung fibrosis, which leads to impairment of pulmonary function; the specific mechanism remains to be fully elucidated Emodin shows antifibrotic effects in several organs with fibrosis, however, it has not been investigated in pulmonary silicosis."3.83Emodin suppresses silica-induced lung fibrosis by promoting Sirt1 signaling via direct contact. ( Chen, M; Dang, X; Liu, Y; Pang, Y; Ren, H; Shang, D; Wang, J; Yang, T, 2016)
"Rat models of experimental hepatic fibrosis were established by injection with CCl(4); the treated rats received emodin via oral administration at a dosage of 20 mg/kg twice a week at the same time."3.75Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation. ( Dong, MX; Geng, YT; Jia, Y; Li, CC; Li, XY; Liu, JC; Niu, YC; Zhang, YB; Zhou, L, 2009)
"To establish the rats model of chronic fibrosing pancreatitis and to prove the anti-fibrotic effect of emodin in chronic pancreatitis with fibrosis."3.74Effect of emodin on pancreatic fibrosis in rats. ( Cai, JT; Du, Q; Gao, ZQ; Qian, KD; Wang, CH; Xie, CG; Ye, B, 2007)
"The aim of this article was to investigate the mechanisms of emodin in antagonizing against organ fibrosis, and to illustrate that emodin can be an effective Chinese herbal preparation for treatment of organ fibrosis."3.73[Emodin and organ fibrosis]. ( Gao, ZQ; Wang, CH, 2005)
"To study the effect of emodin on pancreatic fibrosis and potential mechanism thereof."3.73[Effect of emodin on pancreatic fibrosis: experiment with rats]. ( Cai, JT; Du, Q; Gao, ZQ; Qian, KD; Wang, CH; Xie, CG; Ye, B, 2006)
"The study aimed to explore the pharmacokinetic and pharmacodynamic alterations of the active components of Shenkang injection (i."1.91Pharmacokinetic-pharmacodynamic modeling of the active components of Shenkang injection in rats with chronic renal failure and its protective effect on damaged renal cells. ( Fu, Z; Jia, Q; Sun, Z; Wang, X; Xia, J; Xue, L; Zhang, L; Zhou, L, 2023)
"Pathological cardiac hypertrophy is a characteristic feature in many cardiovascular diseases (CVDs)."1.72Aloin alleviates pathological cardiac hypertrophy via modulation of the oxidative and fibrotic response. ( Kulhari, U; Kumar, A; Kundu, S; Mugale, MN; Murty, US; Ram, C; Sahu, BD; Syed, AM, 2022)
" The oral bioavailability of EMO and Tan IIA was significantly improved when they were loaded into the hierarchically structured microcapsules, ultimately contributing to superior therapeutic outcomes in rats with unilateral ureteral obstruction."1.72Hierarchically structured microcapsules for oral delivery of emodin and tanshinone IIA to treat renal fibrosis. ( Fan, X; Hou, Y; Li, F; Piao, J; Sun, J; Wei, Y; Xu, Z; Yao, W; Zheng, H, 2022)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (23.81)29.6817
2010's4 (19.05)24.3611
2020's12 (57.14)2.80

Authors

AuthorsStudies
Syed, AM1
Kundu, S1
Ram, C1
Kulhari, U1
Kumar, A1
Mugale, MN1
Murty, US1
Sahu, BD1
Sun, J2
Xu, Z2
Hou, Y2
Yao, W2
Fan, X2
Zheng, H1
Piao, J1
Li, F1
Wei, Y2
Brenes, R1
Nguyen, LMN1
Miller, DL1
Rohde, ML1
Zhu, L1
Zhang, Q2
Zhang, K1
Piao, JG1
Yu, J1
Zhao, X1
Yan, X1
Li, W1
Liu, Y3
Wang, J4
Yang, Y1
Hao, Y1
Liang, Z1
Tao, Y1
Yuan, Y1
Du, Z1
Chen, L1
Liang, B1
Xia, S1
Wang, F1
Li, Z1
Shao, J1
Zhang, Z1
Chen, A1
Zheng, S1
Zhang, F1
Zhou, L2
Wang, X1
Xia, J1
Zhang, L1
Xue, L1
Jia, Q1
Fu, Z1
Sun, Z1
Lai, J1
Liu, X1
Su, H1
Zhu, Y1
Xin, K1
Huang, M1
Luo, S1
Tang, H1
Xiong, G1
Chen, H1
Wan, Q1
Dai, J1
Sun, Y1
Li, X2
Yang, F2
Deng, L1
Li, J1
Chen, M2
Hu, Y1
Zhong, W1
Xu, L1
Gao, J1
Huang, D2
Lin, P1
Yao, D1
Zhang, Y1
Yang, X1
Wu, M1
Ye, C1
Carver, W1
Fix, E1
Fix, C1
Fan, D1
Chakrabarti, M1
Azhar, M1
Liu, W2
Gu, R1
Lou, Y1
He, C1
Li, D1
Ma, L1
Li, H1
Zhang, S1
Xiong, X1
Chen, K1
Jiang, P1
Jiang, K1
Deng, G1
Chen, Q1
Pang, L1
Huang, S1
Lei, W1
Yang, T1
Pang, Y1
Dang, X1
Ren, H1
Shang, D1
Wang, Q1
Liu, P1
Deng, Y1
Lan, T1
Zhang, X1
Qiu, B1
Ning, H1
Huang, H1
Dong, MX1
Jia, Y1
Zhang, YB1
Li, CC1
Geng, YT1
Li, XY1
Liu, JC1
Niu, YC1
Gao, ZQ3
Wang, CH3
Ye, B2
Xie, CG2
Qian, KD2
Cai, JT2
Du, Q2

Other Studies

21 other studies available for emodin and Cirrhosis

ArticleYear
Aloin alleviates pathological cardiac hypertrophy via modulation of the oxidative and fibrotic response.
    Life sciences, 2022, Jan-01, Volume: 288

    Topics: Adrenergic beta-Agonists; Animals; Antioxidants; Cardiomegaly; Cathartics; Emodin; Fibrosis; Isoprot

2022
Hierarchically structured microcapsules for oral delivery of emodin and tanshinone IIA to treat renal fibrosis.
    International journal of pharmaceutics, 2022, Mar-25, Volume: 616

    Topics: Abietanes; Animals; Capsules; Emodin; Fibrosis; Rats

2022
HEPATOCELLULAR TOXICITY OF THE METABOLITE EMODIN PRODUCED BY THE COMMON BUCKTHORN (RHAMNUS CATHARTICA) IN GREEN FROG (LITHOBATES CLAMITANS) TADPOLES.
    Journal of wildlife diseases, 2022, 04-01, Volume: 58, Issue:2

    Topics: Animals; Carcinoma, Hepatocellular; Emodin; Fibrosis; Larva; Liver Neoplasms; Rana clamitans; Rhamnu

2022
Deoxycholic acid-chitosan coated liposomes combined with in situ colonic gel enhances renal fibrosis therapy of emodin.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 101

    Topics: Animals; Caco-2 Cells; Chitosan; Deoxycholic Acid; DNA, Ribosomal; Dysbiosis; Emodin; Female; Fibros

2022
Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 114

    Topics: Aloe; Angiotensin II; Animals; Cardiomyopathies; Emodin; Fibrosis; Hypertrophy; Mice; Myocardial Inf

2023
Emodin promotes hepatic stellate cell senescence and alleviates liver fibrosis via a nuclear receptor (Nur77)-mediated epigenetic regulation of glutaminase 1.
    British journal of pharmacology, 2023, Volume: 180, Issue:19

    Topics: Animals; Cell Proliferation; Emodin; Epigenesis, Genetic; Extracellular Signal-Regulated MAP Kinases

2023
Pharmacokinetic-pharmacodynamic modeling of the active components of Shenkang injection in rats with chronic renal failure and its protective effect on damaged renal cells.
    Biopharmaceutics & drug disposition, 2023, Volume: 44, Issue:6

    Topics: Animals; Drugs, Chinese Herbal; Emodin; Fibrosis; Kidney; Kidney Failure, Chronic; Rats; Rats, Sprag

2023
Emodin inhibits bladder inflammation and fibrosis in mice with interstitial cystitis by regulating JMJD3.
    Acta cirurgica brasileira, 2023, Volume: 38

    Topics: Animals; Cystitis; Cystitis, Interstitial; Emodin; Fibrosis; Humans; Inflammation; Mice

2023
Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats.
    Journal of orthopaedic surgery and research, 2019, Oct-10, Volume: 14, Issue:1

    Topics: Animals; Apoptosis; Drug Evaluation, Preclinical; Emodin; Endoplasmic Reticulum Chaperone BiP; Endop

2019
Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ-Smad Signaling Pathway.
    Drug design, development and therapy, 2020, Volume: 14

    Topics: Animals; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Emodin; Fibrosis

2020
Emodin ameliorates tubulointerstitial fibrosis in obstructed kidneys by inhibiting EZH2.
    Biochemical and biophysical research communications, 2021, 01-01, Volume: 534

    Topics: Animals; Connective Tissue Growth Factor; Disease Models, Animal; Drugs, Chinese Herbal; Emodin; Enh

2021
Effects of emodin, a plant-derived anthraquinone, on TGF-β1-induced cardiac fibroblast activation and function.
    Journal of cellular physiology, 2021, Volume: 236, Issue:11

    Topics: Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen; Emodin; Fibroblasts; Fibrosis

2021
Emodin-induced autophagic cell death hinders epithelial-mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis.
    Journal of pharmacological sciences, 2021, Volume: 146, Issue:4

    Topics: Animals; Autophagic Cell Death; Bone Morphogenetic Protein 7; Cells, Cultured; Emodin; Epithelial-Me

2021
Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2.
    International urology and nephrology, 2018, Volume: 50, Issue:2

    Topics: Animals; Body Weight; Emodin; Fibrosis; Gene Expression Regulation; Kidney; Kidney Diseases; Kidney

2018
Effects of emodin and irbesartan on ventricular fibrosis in Goldblatt hypertensive rats.
    Die Pharmazie, 2014, Volume: 69, Issue:5

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Blotting, West

2014
Emodin suppresses silica-induced lung fibrosis by promoting Sirt1 signaling via direct contact.
    Molecular medicine reports, 2016, Volume: 14, Issue:5

    Topics: Actins; Animals; Bronchoalveolar Lavage Fluid; Collagen Type I; Disease Models, Animal; Emodin; Enzy

2016
Emodin suppresses cell proliferation and fibronectin expression via p38MAPK pathway in rat mesangial cells cultured under high glucose.
    Molecular and cellular endocrinology, 2009, Aug-13, Volume: 307, Issue:1-2

    Topics: Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Connective Tissue Growth Factor; Cyclic AM

2009
Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation.
    World journal of gastroenterology, 2009, Oct-14, Volume: 15, Issue:38

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, An

2009
[Emodin and organ fibrosis].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2005, Volume: 25, Issue:11

    Topics: Animals; Emodin; Fibrosis; Glomerulosclerosis, Focal Segmental; Humans; Kidney; Liver Cirrhosis; Phy

2005
[Effect of emodin on pancreatic fibrosis: experiment with rats].
    Zhonghua yi xue za zhi, 2006, Sep-26, Volume: 86, Issue:36

    Topics: Animals; Blotting, Western; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Emod

2006
Effect of emodin on pancreatic fibrosis in rats.
    World journal of gastroenterology, 2007, Jan-21, Volume: 13, Issue:3

    Topics: Animals; Collagen; Drugs, Chinese Herbal; Emodin; Enzyme Inhibitors; Fibrosis; Hyaluronic Acid; Immu

2007