emodin has been researched along with Cell Transformation, Neoplastic in 6 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The amplification and overexpression of the HER-2/neu proto-oncogene, which encodes the tyrosine kinase receptor p185neu, have been observed frequently in tumors from human breast cancer patients and are correlated with poor prognosis." | 7.69 | Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin. ( Bacus, SS; Chang, CJ; Hung, MC; Zhang, L, 1995) |
| "The amplification and overexpression of the HER-2/neu proto-oncogene, which encodes the tyrosine kinase receptor p185neu, have been observed frequently in tumors from human breast cancer patients and are correlated with poor prognosis." | 3.69 | Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin. ( Bacus, SS; Chang, CJ; Hung, MC; Zhang, L, 1995) |
| "Treatment with emodin resulted in a decrease in intracellular protein-tyrosine phosphorylation." | 1.29 | Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor. ( Chan, TC; Chang, CJ; Geahlen, RL; Koonchanok, NM, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, R | 1 |
| Zhang, J | 1 |
| Hu, Y | 1 |
| Wang, S | 1 |
| Chen, M | 1 |
| Wang, Y | 1 |
| Wei, W | 1 |
| Guo, Y | 1 |
| Chen, H | 1 |
| Liu, D | 1 |
| Guo, H | 1 |
| Lin, S | 1 |
| Acevedo-Duncan, M | 1 |
| Russell, C | 1 |
| Patel, S | 1 |
| Patel, R | 1 |
| Zhang, L | 2 |
| Chang, CJ | 2 |
| Bacus, SS | 1 |
| Hung, MC | 2 |
| Chan, TC | 1 |
| Koonchanok, NM | 1 |
| Geahlen, RL | 1 |
| Lau, YK | 1 |
| Xi, L | 1 |
| Hong, RL | 1 |
| Kim, DS | 1 |
| Chen, CF | 1 |
| Hortobagyi, GN | 1 |
| Chang, C | 1 |
1 review available for emodin and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Potential antineoplastic effects of Aloe-emodin: a comprehensive review.
Topics: Aloe; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Transformation, | 2014 |
5 other studies available for emodin and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
[Emodin enhances antitumor effect of gemcitabine in model of SW1990 cell xenograft on athymic mouse].
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Transf | 2010 |
Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells.
Topics: Anthraquinones; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Cycle; Cell Fractionation; Cell | 2004 |
Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin.
Topics: Breast Neoplasms; Cell Differentiation; Cell Division; Cell Line, Transformed; Cell Transformation, | 1995 |
Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor.
Topics: Bronchi; Cell Cycle; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Dose- | 1993 |
Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties.
Topics: 3T3 Cells; Animals; Breast Neoplasms; Cell Division; Cell Transformation, Neoplastic; Emodin; Enzyme | 1998 |