emodin has been researched along with Cardiomegaly in 4 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Emodin significantly attenuated cardiac hypertrophy in the female mice." | 8.31 | Emodin Inhibited Pathological Cardiac Hypertrophy in Response to Angiotensin-Induced Hypertension and Altered the Gut Microbiome. ( Athukorala, M; Evans, L; Ferguson, BS; Frese, S; Hubert, N; Martinez-Guryn, K; Moore, J; Price, T; Shen, Y, 2023) |
| "Emodin significantly attenuated cardiac hypertrophy in the female mice." | 4.31 | Emodin Inhibited Pathological Cardiac Hypertrophy in Response to Angiotensin-Induced Hypertension and Altered the Gut Microbiome. ( Athukorala, M; Evans, L; Ferguson, BS; Frese, S; Hubert, N; Martinez-Guryn, K; Moore, J; Price, T; Shen, Y, 2023) |
| "Pathological cardiac hypertrophy is a characteristic feature in many cardiovascular diseases (CVDs)." | 1.72 | Aloin alleviates pathological cardiac hypertrophy via modulation of the oxidative and fibrotic response. ( Kulhari, U; Kumar, A; Kundu, S; Mugale, MN; Murty, US; Ram, C; Sahu, BD; Syed, AM, 2022) |
| "Emodin is an anthraquinone that has been implicated in cardiac protection." | 1.56 | Emodin and emodin-rich rhubarb inhibits histone deacetylase (HDAC) activity and cardiac myocyte hypertrophy. ( Angermann, JE; Bender, A; Burnett, L; Evans, LW; Ferguson, BS; Godoy, L; Shen, Y; Staten, D; Zhou, T, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 4 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Syed, AM | 1 |
| Kundu, S | 1 |
| Ram, C | 1 |
| Kulhari, U | 1 |
| Kumar, A | 1 |
| Mugale, MN | 1 |
| Murty, US | 1 |
| Sahu, BD | 1 |
| Evans, L | 1 |
| Price, T | 1 |
| Hubert, N | 1 |
| Moore, J | 1 |
| Shen, Y | 2 |
| Athukorala, M | 1 |
| Frese, S | 1 |
| Martinez-Guryn, K | 1 |
| Ferguson, BS | 2 |
| Evans, LW | 1 |
| Bender, A | 1 |
| Burnett, L | 1 |
| Godoy, L | 1 |
| Staten, D | 1 |
| Zhou, T | 1 |
| Angermann, JE | 1 |
| Gao, J | 1 |
| Zhang, K | 1 |
| Wang, Y | 1 |
| Guo, R | 1 |
| Liu, H | 1 |
| Jia, C | 1 |
| Sun, X | 1 |
| Wu, C | 1 |
| Wang, W | 1 |
| Du, J | 1 |
| Chen, J | 1 |
4 other studies available for emodin and Cardiomegaly
| Article | Year |
|---|---|
Aloin alleviates pathological cardiac hypertrophy via modulation of the oxidative and fibrotic response.
Topics: Adrenergic beta-Agonists; Animals; Antioxidants; Cardiomegaly; Cathartics; Emodin; Fibrosis; Isoprot | 2022 |
Emodin Inhibited Pathological Cardiac Hypertrophy in Response to Angiotensin-Induced Hypertension and Altered the Gut Microbiome.
Topics: Angiotensins; Animals; Cardiomegaly; Emodin; Female; Gastrointestinal Microbiome; Hypertension; Mice | 2023 |
Emodin and emodin-rich rhubarb inhibits histone deacetylase (HDAC) activity and cardiac myocyte hypertrophy.
Topics: Acetylation; Angiotensin II; Animals; Animals, Newborn; Cardiomegaly; Cardiotonic Agents; Disease Mo | 2020 |
A machine learning-driven study indicates emodin improves cardiac hypertrophy by modulation of mitochondrial SIRT3 signaling.
Topics: Animals; Cardiomegaly; Cell Line; Emodin; Machine Learning; Male; Mice, Inbred C57BL; Mice, Knockout | 2020 |