emodin has been researched along with Carcinoma, Non-Small Cell Lung in 13 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Emodin is a Chinese herb-derived compound extracted from the roots of Rheum officinale that exhibits numerous pharmacological characteristics." | 1.72 | Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-IIa. ( Fan, XX; Guan, XX; Leung, EL; Li, JX; Li, RZ; Liang, TL; Liu, L; Meng, WY; Pan, HD; Wang, XR; Wu, QB; Xu, C; Yao, XJ; Zhang, FY, 2022) |
| "Lung cancer is one of the most common causes of cancer related mortality." | 1.51 | Physcion 8-O-β-Glucopyranoside Exerts Anti-Tumor Activity Against Non-Small Cell Lung Cancer by Targeting PPARγ. ( Du, Y; Li, Y; Lv, Z; Sun, D; Sun, L; Zhou, J, 2019) |
| "Emodin is a phytochemical with potent anticancer activities against various human malignant cancer types, including lung cancer; however, the molecular mechanisms underlying the effects of emodin remain unclear." | 1.46 | Emodin induces apoptosis of lung cancer cells through ER stress and the TRIB3/NF-κB pathway. ( Cai, H; Liu, Z; Qu, J; Su, J; Xue, X; Yan, Y, 2017) |
| "In emodin- and MMC-cotreated cells, ERK1/2 phosphorylation was enhanced by constitutively active MKK1/2 (MKK1/2-CA), thus increasing Rad51 protein levels and protein stability." | 1.36 | Role of Rad51 down-regulation and extracellular signal-regulated kinases 1 and 2 inactivation in emodin and mitomycin C-induced synergistic cytotoxicity in human non-small-cell lung cancer cells. ( Cheng, CM; Chiu, YF; Kuo, YH; Lin, ST; Lin, YW; Su, YJ; Tsai, MS, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 3 (23.08) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, FY | 1 |
| Li, RZ | 1 |
| Xu, C | 1 |
| Fan, XX | 1 |
| Li, JX | 1 |
| Meng, WY | 1 |
| Wang, XR | 1 |
| Liang, TL | 1 |
| Guan, XX | 1 |
| Pan, HD | 1 |
| Liu, L | 1 |
| Yao, XJ | 1 |
| Wu, QB | 1 |
| Leung, EL | 1 |
| Kim, HJ | 1 |
| Choi, JW | 1 |
| Ree, J | 1 |
| Lim, JS | 1 |
| Lee, J | 1 |
| Kim, JI | 1 |
| Thapa, SB | 1 |
| Sohng, JK | 1 |
| Park, YI | 1 |
| Lin, H | 1 |
| Hu, B | 1 |
| He, X | 1 |
| Mao, J | 1 |
| Wang, Y | 1 |
| Wang, J | 1 |
| Zhang, T | 1 |
| Zheng, J | 1 |
| Peng, Y | 1 |
| Zhang, F | 1 |
| Du, Y | 1 |
| Lv, Z | 1 |
| Sun, D | 1 |
| Li, Y | 1 |
| Sun, L | 1 |
| Zhou, J | 1 |
| Chen, S | 1 |
| Zhang, Z | 1 |
| Zhang, J | 1 |
| Su, J | 1 |
| Yan, Y | 1 |
| Qu, J | 1 |
| Xue, X | 1 |
| Liu, Z | 1 |
| Cai, H | 1 |
| Ko, JC | 2 |
| Su, YJ | 3 |
| Lin, ST | 3 |
| Jhan, JY | 2 |
| Ciou, SC | 2 |
| Cheng, CM | 3 |
| Lin, YW | 3 |
| Chiu, YF | 2 |
| Kuo, YH | 2 |
| Tsai, MS | 2 |
| He, L | 1 |
| Bi, JJ | 1 |
| Guo, Q | 1 |
| Yu, Y | 1 |
| Ye, XF | 1 |
| Yeh, FT | 1 |
| Wu, CH | 2 |
| Lee, HZ | 2 |
| Chang, SP | 1 |
| Zhang, L | 1 |
| Hung, MC | 1 |
13 other studies available for emodin and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-IIa.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Down-Regulation; Emodin; Humans; Lung Neoplasms; Phosphol | 2022 |
Aloe emodin 3-O-glucoside inhibits cell growth and migration and induces apoptosis of non-small-cell lung cancer cells via suppressing MEK/ERK and Akt signalling pathways.
Topics: Animals; Anthraquinones; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Prolifera | 2022 |
Overcoming Taxol-resistance in A549 cells: A comprehensive strategy of targeting P-gp transporter, AKT/ERK pathways, and cytochrome P450 enzyme CYP1B1 by 4-hydroxyemodin.
Topics: A549 Cells; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transport | 2020 |
Physcion 8-O-β-Glucopyranoside Exerts Anti-Tumor Activity Against Non-Small Cell Lung Cancer by Targeting PPARγ.
Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Ch | 2019 |
Emodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo.
Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Non-Small-Cell Lung; C | 2019 |
Emodin induces apoptosis of lung cancer cells through ER stress and the TRIB3/NF-κB pathway.
Topics: Animals; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Cell Pro | 2017 |
Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Repair; DNA-Binding Proteins; Dose-Response Re | 2010 |
Emodin enhances cisplatin-induced cytotoxicity via down-regulation of ERCC1 and inactivation of ERK1/2.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Butadienes; Carcinoma, Non-Small-Cell Lun | 2010 |
Role of Rad51 down-regulation and extracellular signal-regulated kinases 1 and 2 inactivation in emodin and mitomycin C-induced synergistic cytotoxicity in human non-small-cell lung cancer cells.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Down-Regulation; Drug Synergism; Emodin; Humans; L | 2010 |
Effects of emodin extracted from Chinese herbs on proliferation of non-small cell lung cancer and underlying mechanisms.
Topics: Analysis of Variance; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; DNA-Bind | 2012 |
Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell.
Topics: Alkaloids; Anthraquinones; Apoptosis; Benzophenanthridines; Blotting, Western; Carcinoma, Non-Small- | 2003 |
Release of nucleophosmin from the nucleus: Involvement in aloe-emodin-induced human lung non small carcinoma cell apoptosis.
Topics: Amino Acid Sequence; Anthraquinones; Apoptosis; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Ad | 2005 |
Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Division; Cisplatin; Dose-Response Relat | 1996 |