emodin has been researched along with Cancer of Prostate in 15 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study explores the link between the antiproliferative activity of emodin through the generation of reactive oxygen species (ROS) in various cancer cell lines and the expression of the androgen receptor (AR) in the prostate cancer cell lines LNCaP (androgen-sensitive) and PC-3 (androgen-refractory), as well as the pro-metastatic low-density lipoprotein receptor-related protein 1 (LRP1) in the above prostate cancer cells and the nonprostate cell lines A549 (lung), HCT-15 (colon) and MG-63 (bone) under normoxic and hypoxia-like conditions." | 7.80 | Exploration of effects of emodin in selected cancer cell lines: enhanced growth inhibition by ascorbic acid and regulation of LRP1 and AR under hypoxia-like conditions. ( Iyer, VV; Masaldan, S, 2014) |
| "This study explores the link between the antiproliferative activity of emodin through the generation of reactive oxygen species (ROS) in various cancer cell lines and the expression of the androgen receptor (AR) in the prostate cancer cell lines LNCaP (androgen-sensitive) and PC-3 (androgen-refractory), as well as the pro-metastatic low-density lipoprotein receptor-related protein 1 (LRP1) in the above prostate cancer cells and the nonprostate cell lines A549 (lung), HCT-15 (colon) and MG-63 (bone) under normoxic and hypoxia-like conditions." | 3.80 | Exploration of effects of emodin in selected cancer cell lines: enhanced growth inhibition by ascorbic acid and regulation of LRP1 and AR under hypoxia-like conditions. ( Iyer, VV; Masaldan, S, 2014) |
| "Currently, prostate cancer is one of the major malignant tumors in males." | 1.91 | Emodin-Induced Necroptosis in Prostate Cancer Cells via the Mitochondrial Fission HSP90/MLKL/PGAM Pathway. ( Xie, Y; Yang, P; Yeasmin Khusbu, F; Zhou, X, 2023) |
| "Emodin treatment resulted in repressing androgen-dependent transactivation of AR by inhibiting AR nuclear translocation." | 1.33 | Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth. ( Cha, TL; Chen, CT; Hung, MC; Qiu, L; Wen, Y, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 4 (26.67) | 2.80 |
| Authors | Studies |
|---|---|
| Schroeder, RL | 1 |
| Goyal, N | 1 |
| Bratton, M | 1 |
| Townley, I | 1 |
| Pham, NA | 1 |
| Tram, P | 1 |
| Stone, T | 1 |
| Geathers, J | 1 |
| Nguyen, K | 1 |
| Sridhar, J | 1 |
| Berlin, IG | 1 |
| Jennings, CC | 1 |
| Shin, S | 1 |
| Kenealey, J | 1 |
| Zhou, X | 1 |
| Yeasmin Khusbu, F | 1 |
| Xie, Y | 1 |
| Yang, P | 1 |
| Zhao, J | 1 |
| Sun, Y | 2 |
| Ren, L | 1 |
| Huang, S | 1 |
| Zhang, J | 1 |
| Gillis, JL | 1 |
| Hinneh, JA | 1 |
| Ryan, NK | 1 |
| Irani, S | 1 |
| Moldovan, M | 1 |
| Quek, LE | 1 |
| Shrestha, RK | 1 |
| Hanson, AR | 1 |
| Xie, J | 1 |
| Hoy, AJ | 1 |
| Holst, J | 1 |
| Centenera, MM | 1 |
| Mills, IG | 1 |
| Lynn, DJ | 1 |
| Selth, LA | 1 |
| Butler, LM | 1 |
| Kapoor, S | 1 |
| Deng, G | 1 |
| Ju, X | 1 |
| Meng, Q | 1 |
| Yu, ZJ | 1 |
| Ma, LB | 1 |
| Sandholt, IS | 1 |
| Olsen, BB | 1 |
| Guerra, B | 1 |
| Issinger, OG | 1 |
| Ok, S | 1 |
| Kim, SM | 1 |
| Kim, C | 1 |
| Nam, D | 1 |
| Shim, BS | 1 |
| Kim, SH | 1 |
| Ahn, KS | 2 |
| Choi, SH | 1 |
| Masaldan, S | 1 |
| Iyer, VV | 1 |
| Cha, TL | 1 |
| Qiu, L | 1 |
| Chen, CT | 1 |
| Wen, Y | 1 |
| Hung, MC | 1 |
| Götz, C | 1 |
| Bachmann, C | 1 |
| Montenarh, M | 1 |
| Huang, XZ | 1 |
| Wang, J | 1 |
| Huang, C | 1 |
| Chen, YY | 1 |
| Shi, GY | 1 |
| Hu, QS | 1 |
| Yi, J | 1 |
| Yu, CX | 1 |
| Zhang, XQ | 1 |
| Kang, LD | 1 |
| Zhang, PJ | 1 |
| Chen, WW | 1 |
| Liu, WW | 1 |
| Liu, QW | 1 |
| Zhang, JY | 1 |
15 other studies available for emodin and Cancer of Prostate
| Article | Year |
|---|---|
Identification of quinones as novel PIM1 kinase inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug | 2016 |
Utilizing mixture design response surface methodology to determine effective combinations of plant derived compounds as prostate cancer treatments.
Topics: Androgens; Berberine; Cell Line, Tumor; Docetaxel; Emodin; Humans; Male; Phytochemicals; Prostatic N | 2023 |
Emodin-Induced Necroptosis in Prostate Cancer Cells via the Mitochondrial Fission HSP90/MLKL/PGAM Pathway.
Topics: Apoptosis; Cell Line; Emodin; Humans; Male; Mitochondrial Dynamics; Necroptosis; Prostatic Neoplasms | 2023 |
Antagonism of androgen receptor signaling by aloe-emodin.
Topics: Aloe; Androgen Receptor Antagonists; Anthraquinones; Apoptosis; Cell Line, Tumor; Emodin; Humans; Ma | 2023 |
A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Cell Line; Emodin; Feedback; Gene Expression | 2021 |
Emodin: inhibitory effects on growth in malignant tumors.
Topics: Cell Movement; Down-Regulation; Emodin; Humans; Lung Neoplasms; Male; Prostatic Neoplasms; Protein K | 2013 |
Emodin inhibits the proliferation of PC3 prostate cancer cells in vitro via the Notch signaling pathway.
Topics: Antineoplastic Agents; Apoptosis; Calcium-Binding Proteins; Cell Cycle; Cell Line, Tumor; Cell Proli | 2015 |
Resorufin: a lead for a new protein kinase CK2 inhibitor.
Topics: Apoptosis; Casein Kinase II; Cell Line, Tumor; Colorectal Neoplasms; Emodin; Humans; Inhibitory Conc | 2009 |
Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4.
Topics: Cell Line, Tumor; Cell Movement; Chemokine CXCL12; Down-Regulation; Emodin; Humans; Lung Neoplasms; | 2012 |
Exploration of effects of emodin in selected cancer cell lines: enhanced growth inhibition by ascorbic acid and regulation of LRP1 and AR under hypoxia-like conditions.
Topics: Ascorbic Acid; Cell Line, Tumor; Down-Regulation; Emodin; Gene Expression Regulation, Neoplastic; Hu | 2014 |
Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth.
Topics: Androgen Receptor Antagonists; Animals; Cell Growth Processes; Cell Line, Tumor; Cell Nucleus; Chlor | 2005 |
Inhibition of protein kinase CK2 leads to a modulation of androgen receptor dependent transcription in prostate cancer cells.
Topics: Adenocarcinoma; Benzimidazoles; Blotting, Western; Casein Kinase II; Cell Line, Tumor; Dose-Response | 2007 |
Chemosensitization by emodin, a plant-derived anti-cancer agent: mechanism of action.
Topics: Antineoplastic Agents; Drug Resistance, Multiple; Emodin; Humans; Male; Plant Extracts; Prostatic Ne | 2008 |
Emodin enhances cytotoxicity of chemotherapeutic drugs in prostate cancer cells: the mechanisms involve ROS-mediated suppression of multidrug resistance and hypoxia inducible factor-1.
Topics: Antineoplastic Agents; Cell Survival; Drug Resistance, Multiple; Emodin; Humans; Hypoxia-Inducible F | 2008 |
Emodin induces apoptosis in human prostate cancer cell LNCaP.
Topics: Adenocarcinoma; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Line, Tumor; Cell | 2008 |