emodin has been researched along with Cancer of Pancreas in 22 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Emodin could inhibit the proliferation ability of pancreatic cancer cells and increased miR‑1271 expression level." | 1.48 | Emodin inhibits pancreatic cancer EMT and invasion by up‑regulating microRNA‑1271. ( Li, N; Wang, C; You, S; Zhang, P, 2018) |
| "When emodin was combined with 5-Aza-CdR, the demethylation was more significant." | 1.43 | Emodin enhances the demethylation by 5-Aza-CdR of pancreatic cancer cell tumor-suppressor genes P16, RASSF1A and ppENK. ( Bu, HQ; Chen, L; Chen, ZQ; Chu, YQ; Fei, Y; Lin, SZ; Liu, DL; Pan, FP; Pan, J; Tang, J; Xu, LP; Yu, QJ; Zhang, H; Zhou, HK, 2016) |
| "Emodin is a traditional Chinese medicine, which has been demonstrated to inhibit the growth of pancreatic cancer cells." | 1.42 | Emodin inhibits angiogenesis in pancreatic cancer by regulating the transforming growth factor-β/drosophila mothers against decapentaplegic pathway and angiogenesis-associated microRNAs. ( Chen, H; Chen, L; Chen, MY; Guo, JQ; Hu, P; Ji, X; Lin, SZ; Lu, D; Tong, HF; Wang, ZH; Xu, HT; Xu, JB, 2015) |
| "Gemcitabine resistance is a common problem of pancreatic cancer chemotherapy, and how to reverse it plays an important role in the treatment of pancreatic cancer." | 1.38 | Emodin reverses gemcitabine resistance in pancreatic cancer cells via the mitochondrial apoptosis pathway in vitro. ( Bu, H; Chen, H; Guo, HC; Li, H; Lin, SZ; Liu, DL; Liu, HB; Ni, ZL; Tong, HF; Wang, ZH, 2012) |
| "Emodin has therapeutic potential against cancers." | 1.38 | Emodin potentiates the antitumor effects of gemcitabine in PANC-1 pancreatic cancer xenograft model in vivo via inhibition of inhibitors of apoptosis. ( Bu, HQ; Chen, H; Guo, HC; Li, HH; Li, W; Lin, SZ; Liu, DL; Luo, J; Tong, HF; Wang, ZH; Wei, WT; Wu, HY; Zuo, MM, 2012) |
| "After human pancreatic cancer cell line SW1990 was treated with emodin (40 micromol/L), gemcitabine (20 micromol/L), and emodin combined gemcitabine, the cell proliferation was detected by cell counting kit-8 (CCK-8) assay." | 1.38 | [Emodin combined gemcitabine inhibited the growth of pancreatic cancer in vitro and in vivo and its mechanisms study]. ( Liu, A; Luo, J; Zhang, JH, 2012) |
| "Emodin has been showed to induce apoptosis of pancreatic cancer cells and inhibit tumor growth in our previous studies." | 1.38 | Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis. ( Chen, H; Chen, KJ; Guo, HC; Lin, SZ; Liu, DL; Liu, HB; Ni, ZL; Tong, HF; Wang, ZH; Wei, WT, 2012) |
| "In vitro, human pancreatic cancer cell line Panc-1 was exposed to varying concentrations of emodin (0, 10, 20, 40 or 80 µmol/l)." | 1.38 | Emodin induces Panc-1 cell apoptosis via declining the mitochondrial membrane potential. ( Chen, H; Chen, KJ; Guo, HC; Lai, FJ; Li, HH; Lin, SZ; Liu, JX; Luo, J; Wang, ZH; Zhang, JH, 2012) |
| "After gemcitabine-resistant pancreatic cancer cell line (SW1990/GZ) was established by escalating doses of gemcitabine serially in pancreatic cancer cell line (SW1990)." | 1.37 | [Role of nuclear factor-kappaB on emodin-induced sensitization of pancreatic cancer to gemcitabine]. ( Hu, YS; Ke, PY; Lin, SZ; Liu, A; Tang, LL; Wang, ZH, 2011) |
| "Emodin is an active component of Chinese medicinal herbs and can inhibit the activation of Akt and NF-κB." | 1.37 | Antitumor and apoptosis-promoting properties of emodin, an anthraquinone derivative from Rheum officinale Baill, against pancreatic cancer in mice via inhibition of Akt activation. ( Chen, H; Fan, L; Guo, HC; Lin, SZ; Liu, A; Liu, DL; Liu, HB; Ni, ZL; Qiu, MX; Tong, HF; Wang, ZH; Wei, WT, 2011) |
| "To investigate the anti-metastasis effect of emodin on the pancreatic cancer in vitro and in vivo." | 1.37 | [Experimental study on anti-metastasis effect of emodin on human pancreatic cancer]. ( Huang, L; Lin, S; Liu, A; Sha, L; Shen, Y; Tang, X, 2011) |
| "Pancreatic cancer is one human malignancy which has chemoresistant behavior to gemcitabine treatment." | 1.35 | Potentiation of the effect of gemcitabine by emodin in pancreatic cancer is associated with survivin inhibition. ( Chen, Y; Guo, Q; Kang, M; Wu, Y; Xie, Q; Zhang, B, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 17 (77.27) | 24.3611 |
| 2020's | 4 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, X | 2 |
| Periyasamy, L | 1 |
| Murugantham, B | 1 |
| Sundaraj, R | 1 |
| Krishnamoorthi, S | 1 |
| Muthusami, S | 1 |
| Shi, X | 1 |
| Huang, B | 1 |
| Zhu, J | 1 |
| Yamaguchi, T | 1 |
| Hu, A | 1 |
| Tabuchi, M | 1 |
| Watanabe, D | 1 |
| Yoshikawa, S | 1 |
| Mizushima, S | 1 |
| Mizushima, A | 1 |
| Xia, S | 1 |
| Li, Q | 1 |
| Zhang, D | 1 |
| Sui, X | 1 |
| Song, T | 1 |
| Hu, L | 1 |
| Xu, X | 1 |
| Wang, F | 1 |
| Li, N | 1 |
| Wang, C | 1 |
| Zhang, P | 1 |
| You, S | 1 |
| Zhang, H | 2 |
| Chen, L | 3 |
| Bu, HQ | 3 |
| Yu, QJ | 2 |
| Jiang, DD | 1 |
| Pan, FP | 2 |
| Wang, Y | 1 |
| Liu, DL | 6 |
| Lin, SZ | 10 |
| Wu, L | 1 |
| Zhang, F | 1 |
| Zheng, SZ | 1 |
| Lu, Y | 1 |
| Cai, BC | 1 |
| Xu, JB | 1 |
| Ji, X | 1 |
| Chen, H | 9 |
| Xu, HT | 1 |
| Hu, P | 1 |
| Guo, JQ | 1 |
| Chen, MY | 1 |
| Lu, D | 1 |
| Wang, ZH | 8 |
| Tong, HF | 7 |
| Zhou, HK | 1 |
| Chen, ZQ | 1 |
| Xu, LP | 1 |
| Tang, J | 1 |
| Chu, YQ | 1 |
| Pan, J | 1 |
| Fei, Y | 1 |
| Guo, Q | 1 |
| Chen, Y | 1 |
| Zhang, B | 1 |
| Kang, M | 1 |
| Xie, Q | 1 |
| Wu, Y | 1 |
| Wei, W | 2 |
| Guo, Y | 1 |
| Liu, A | 7 |
| Tong, H | 1 |
| Wang, Z | 1 |
| Tan, W | 2 |
| Liu, J | 1 |
| Lin, S | 3 |
| Ye, S | 1 |
| Liao, W | 1 |
| Gong, J | 1 |
| Jiang, Z | 1 |
| Wang, L | 1 |
| Hu, YS | 1 |
| Tang, LL | 1 |
| Ke, PY | 1 |
| Zeng, Y | 1 |
| Guo, HC | 6 |
| Liu, JX | 2 |
| Wei, WT | 4 |
| Ni, ZL | 4 |
| Liu, HB | 4 |
| Fan, L | 1 |
| Qiu, MX | 1 |
| Bu, H | 1 |
| Li, H | 1 |
| Sha, L | 1 |
| Shen, Y | 1 |
| Huang, L | 1 |
| Tang, X | 1 |
| Luo, J | 3 |
| Wu, HY | 1 |
| Li, HH | 2 |
| Zuo, MM | 1 |
| Li, W | 1 |
| Zhang, JH | 2 |
| Chen, KJ | 2 |
| Lai, FJ | 1 |
22 other studies available for emodin and Cancer of Pancreas
| Article | Year |
|---|---|
Comments on "Emodin-Conjugated PEGylation of Fe
Topics: Cell Line, Tumor; Contrast Media; Emodin; Humans; Magnetic Resonance Imaging; Nanoparticles; Pancrea | 2022 |
Comments on "Emodin-Conjugated PEGylation of Fe
Topics: Cell Line, Tumor; Contrast Media; Emodin; Humans; Magnetic Resonance Imaging; Nanoparticles; Pancrea | 2022 |
Comments on "Emodin-Conjugated PEGylation of Fe
Topics: Cell Line, Tumor; Contrast Media; Emodin; Humans; Magnetic Resonance Imaging; Nanoparticles; Pancrea | 2022 |
Comments on "Emodin-Conjugated PEGylation of Fe
Topics: Cell Line, Tumor; Contrast Media; Emodin; Humans; Magnetic Resonance Imaging; Nanoparticles; Pancrea | 2022 |
Screening of MMP-2 Inhibiting Phytoconstituents for the Development of Newer Pancreatic Cancer Treatment Modalities.
Topics: Cell Line, Tumor; Early Detection of Cancer; Emodin; Humans; Matrix Metalloproteinase 2; Molecular D | 2023 |
Screening of MMP-2 Inhibiting Phytoconstituents for the Development of Newer Pancreatic Cancer Treatment Modalities.
Topics: Cell Line, Tumor; Early Detection of Cancer; Emodin; Humans; Matrix Metalloproteinase 2; Molecular D | 2023 |
Screening of MMP-2 Inhibiting Phytoconstituents for the Development of Newer Pancreatic Cancer Treatment Modalities.
Topics: Cell Line, Tumor; Early Detection of Cancer; Emodin; Humans; Matrix Metalloproteinase 2; Molecular D | 2023 |
Screening of MMP-2 Inhibiting Phytoconstituents for the Development of Newer Pancreatic Cancer Treatment Modalities.
Topics: Cell Line, Tumor; Early Detection of Cancer; Emodin; Humans; Matrix Metalloproteinase 2; Molecular D | 2023 |
A network pharmacology-based investigation of emodin against pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Emodin; Gene Expression Regulation, Neoplastic; Humans; Molecular Docking Simulation | 2023 |
A network pharmacology-based investigation of emodin against pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Emodin; Gene Expression Regulation, Neoplastic; Humans; Molecular Docking Simulation | 2023 |
A network pharmacology-based investigation of emodin against pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Emodin; Gene Expression Regulation, Neoplastic; Humans; Molecular Docking Simulation | 2023 |
A network pharmacology-based investigation of emodin against pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Emodin; Gene Expression Regulation, Neoplastic; Humans; Molecular Docking Simulation | 2023 |
The Warburg effect drives cachectic states in patients with pancreatobiliary adenocarcinoma.
Topics: Adenocarcinoma; Animals; Cachexia; Emodin; Mice; Mice, Nude; Pancreatic Neoplasms | 2023 |
Emodin inhibits pancreatic cancer EMT and invasion by up‑regulating microRNA‑1271.
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Emodin; Ep | 2018 |
Effects of emodin on the demethylation of tumor-suppressor genes in pancreatic cancer PANC-1 cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p16; DNA Methylat | 2015 |
[Effect of emodin in attenuating endoplasmic reticulum stress of pancreatic acinar AR42J cells].
Topics: Animals; Calcium; Cell Line, Tumor; Emodin; Endoplasmic Reticulum Stress; Pancreatic Neoplasms; Rats | 2015 |
Emodin inhibits angiogenesis in pancreatic cancer by regulating the transforming growth factor-β/drosophila mothers against decapentaplegic pathway and angiogenesis-associated microRNAs.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Biomarkers; Cell Line, Tumor; Disease Model | 2015 |
Emodin enhances the demethylation by 5-Aza-CdR of pancreatic cancer cell tumor-suppressor genes P16, RASSF1A and ppENK.
Topics: Azacitidine; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p16; Decitabine | 2016 |
Potentiation of the effect of gemcitabine by emodin in pancreatic cancer is associated with survivin inhibition.
Topics: Animals; Antimetabolites, Antineoplastic; Caspase 3; Cell Division; Cell Line; Cell Line, Tumor; Cel | 2009 |
Enhanced effect of gemcitabine by emodin against pancreatic cancer in vivo via cytochrome C-regulated apoptosis.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Lin | 2011 |
Antiproliferative and antimetastatic effects of emodin on human pancreatic cancer.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Emodi | 2011 |
[Role of nuclear factor-kappaB on emodin-induced sensitization of pancreatic cancer to gemcitabine].
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Deoxycyti | 2011 |
[Effect of emodin combined gemcitabine on the growth and apoptosis of pancreatic cancer cell line BxPC-3 in vitro].
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Emodin; Gemcitabine; Humans; Pancrea | 2011 |
Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Prolifera | 2011 |
Antitumor and apoptosis-promoting properties of emodin, an anthraquinone derivative from Rheum officinale Baill, against pancreatic cancer in mice via inhibition of Akt activation.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Body Weight; | 2011 |
Emodin reverses gemcitabine resistance in pancreatic cancer cells via the mitochondrial apoptosis pathway in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Growth Processes; Cell Line, Tumor; | 2012 |
[Experimental study on anti-metastasis effect of emodin on human pancreatic cancer].
Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Emodin; Female; Humans; Matrix Metalloproteinase | 2011 |
Emodin potentiates the antitumor effects of gemcitabine in PANC-1 pancreatic cancer xenograft model in vivo via inhibition of inhibitors of apoptosis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; C | 2012 |
[Emodin combined gemcitabine inhibited the growth of pancreatic cancer in vitro and in vivo and its mechanisms study].
Topics: Animals; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Emodin; Fe | 2012 |
Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Emodin; Enzyme | 2012 |
Emodin induces Panc-1 cell apoptosis via declining the mitochondrial membrane potential.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drugs, Chinese Herbal; Eating; Emodin; Hum | 2012 |