emodin has been researched along with Cancer of Liver in 44 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Reduced therapeutic efficacy of sorafenib, a first-generation multikinase inhibitor, is often observed during the treatment of advanced hepatocellular carcinoma (HCC)." | 7.88 | Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism. ( Kan, SY; Kang, H; Kim, BM; Kim, GH; Kim, JH; Kim, YS; Lee, YM; Lim, JH; Oh, TI; Shin, DH; Yim, WJ, 2018) |
| "However, the role of emodin in hepatocellular carcinoma (HCC) remain unknown." | 5.72 | Emodin inhibits invasion and migration of hepatocellular carcinoma cells via regulating autophagy-mediated degradation of snail and β-catenin. ( Gu, W; Peng, G; Qin, B; Shangwen, J; Tang, Y; Wang, Q; Wang, S; Wu, Y; Xu, J; Ye, ZJ; Zeng, Z, 2022) |
| "Emodin is a promising anti-cancer reagent." | 5.56 | Emodin succinyl ester inhibits malignant proliferation and migration of hepatocellular carcinoma by suppressing the interaction of AR and EZH2. ( Bai, Y; Feng, H; Feng, J; Jia, W; Jiang, Y; Khan, H; Song, H; Yang, B; Yu, Z; Zaib, T, 2020) |
| "Emodin treatment also resulted in generation of reactive oxygen species (ROS), which abrogated mitochondrial membrane potential (MMP)." | 5.48 | Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase‑dependent pathway. ( Dong, X; Fu, J; Leng, X; Liang, X; Ni, B; Ni, J; Yin, X; You, L, 2018) |
| "Emodin is an active ingredient derived from root and rhizome of Rheum palmatum L and many studies have reported that it exhibits anticancer effects in a number of human tumors." | 5.43 | Emodin induces hepatocellular carcinoma cell apoptosis through MAPK and PI3K/AKT signaling pathways in vitro and in vivo. ( Cao, Q; Chen, Y; Lin, W; Ling, C; Wang, C; Yin, H; Zhong, M, 2016) |
| "Reduced therapeutic efficacy of sorafenib, a first-generation multikinase inhibitor, is often observed during the treatment of advanced hepatocellular carcinoma (HCC)." | 3.88 | Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism. ( Kan, SY; Kang, H; Kim, BM; Kim, GH; Kim, JH; Kim, YS; Lee, YM; Lim, JH; Oh, TI; Shin, DH; Yim, WJ, 2018) |
| "To investigate the molecular mechanisms underlying the reversal effect of emodin on platinum resistance in hepatocellular carcinoma." | 3.79 | Emodin regulating excision repair cross-complementation group 1 through fibroblast growth factor receptor 2 signaling. ( Chen, G; Hu, SM; Ke, SD; Qiu, H; Yu, SY; Zou, SQ, 2013) |
| "Emodin can inhibit the growth of liver tumor cells in vitro and in vivo, inducing cell apoptosis is one of its mechanisms." | 2.44 | [Experimental advance of applying emodin for prevention and treatment of liver diseases]. ( Lin, SZ; Xu, XC, 2008) |
| "Emodin can enhance the sensitivity of HepG2 HCC cells to cisplatin by inhibiting epithelial-mesenchymal transition, and thus, play a role in preventing recurrence and metastasis in HCC." | 1.91 | Effect of emodin combined with cisplatin on the invasion and migration of HepG2 hepatoma cells. ( Chen, X; Deng, H; Lai, Q; Leng, Y; Wang, H; Xiong, Z; Yang, M, 2023) |
| "However, the role of emodin in hepatocellular carcinoma (HCC) remain unknown." | 1.72 | Emodin inhibits invasion and migration of hepatocellular carcinoma cells via regulating autophagy-mediated degradation of snail and β-catenin. ( Gu, W; Peng, G; Qin, B; Shangwen, J; Tang, Y; Wang, Q; Wang, S; Wu, Y; Xu, J; Ye, ZJ; Zeng, Z, 2022) |
| "Emodin has been reported to fulfill an important function in suppressing the vicious outcome of liver cancer." | 1.72 | Emodin regulates the autophagy via the miR-371a-5p/PTEN axis to inhibit hepatic malignancy. ( Huang, Y; Li, C; Liu, Y; Lu, P; Wu, W; Zhu, Z, 2022) |
| "Hepatoma is one of the most common malignant tumors." | 1.72 | Investigating the Role of Dahuang in Hepatoma Treatment Using Network Pharmacology, Molecular Docking, and Survival Analysis. ( Dai, X; Gao, R; Ning, H; Wang, M; Xu, H; Yu, B; Zhu, Y, 2022) |
| "Emodin is a promising anti-cancer reagent." | 1.56 | Emodin succinyl ester inhibits malignant proliferation and migration of hepatocellular carcinoma by suppressing the interaction of AR and EZH2. ( Bai, Y; Feng, H; Feng, J; Jia, W; Jiang, Y; Khan, H; Song, H; Yang, B; Yu, Z; Zaib, T, 2020) |
| "Hepatocellular carcinoma is rapidly becoming one of the leading causes of cancer-related deaths, largely due to the increasing incidence of non-alcoholic fatty liver disease." | 1.56 | The effects of fructose and metabolic inhibition on hepatocellular carcinoma. ( Alanazy, M; Dewdney, B; George, J; Gillman, R; Hebbard, L; Qiao, L; Roberts, A; Walker, S; Wankell, M, 2020) |
| "Primary liver cancer (PLC) is one of the most common malignant tumours and has the third highest mortality rate worldwide." | 1.48 | N-acetylaminogalactosyl-decorated biodegradable PLGA-TPGS copolymer nanoparticles containing emodin for the active targeting therapy of liver cancer. ( Dong, H; Gao, M; Li, Q; Pang, Y; Tian, Y; Wang, J; Wu, G; Xu, H; Zhang, B; Zhang, C; Zhang, H, 2018) |
| "Emodin could inhibit the proliferation ability of pancreatic cancer cells and increased miR‑1271 expression level." | 1.48 | Emodin inhibits pancreatic cancer EMT and invasion by up‑regulating microRNA‑1271. ( Li, N; Wang, C; You, S; Zhang, P, 2018) |
| "Emodin treatment also resulted in generation of reactive oxygen species (ROS), which abrogated mitochondrial membrane potential (MMP)." | 1.48 | Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase‑dependent pathway. ( Dong, X; Fu, J; Leng, X; Liang, X; Ni, B; Ni, J; Yin, X; You, L, 2018) |
| "Emodin (EMO) has multi-targets and multi-way antitumor effect, which was limited by the instability and poor solubility of EMO." | 1.43 | A Promising Emodin-Loaded Poly (Lactic-Co-Glycolic Acid)-d-α-Tocopheryl Polyethylene Glycol 1000 Succinate Nanoparticles for Liver Cancer Therapy. ( Deng, S; Gao, M; Guan, X; Liu, H; Lv, L; Tian, Y; Xu, H; Zhang, C, 2016) |
| "Emodin is an active ingredient derived from root and rhizome of Rheum palmatum L and many studies have reported that it exhibits anticancer effects in a number of human tumors." | 1.43 | Emodin induces hepatocellular carcinoma cell apoptosis through MAPK and PI3K/AKT signaling pathways in vitro and in vivo. ( Cao, Q; Chen, Y; Lin, W; Ling, C; Wang, C; Yin, H; Zhong, M, 2016) |
| "Human hepatocellular carcinoma (HCC) cell line HepG2 was examined." | 1.43 | Physcion 8-O-β-glucopyranoside induces apoptosis, suppresses invasion and inhibits epithelial to mesenchymal transition of hepatocellular carcinoma HepG2 cells. ( Guo, P; Qin, F; Wang, Q; Wang, Y; Xing, Y; Yan, Y; Zhang, J; Zhuang, J, 2016) |
| "Heparin sodium (HS)-loaded polylactic-co-glycolic acid-D-α-tocopheryl polyethylene glycol 1000 succinate (PLGA-TPGS) nanoparticles (HPTNs) were prepared as a sustained and targeting delivery carrier and combined with emodin (EMO)-loaded PLGA-TPGS nanoparticles (EPTNs), which were investigated previously to form a combination therapy system for the treatment of liver cancer." | 1.43 | Emodin-Loaded PLGA-TPGS Nanoparticles Combined with Heparin Sodium-Loaded PLGA-TPGS Nanoparticles to Enhance Chemotherapeutic Efficacy Against Liver Cancer. ( Deng, S; Gao, D; Gao, M; Gao, X; Liu, H; Lv, L; Ma, C; Tian, Y; Wang, C; Xu, H; Zhang, C, 2016) |
| "Emodin can inhibit human hepatoma cell line SMMC-7721." | 1.42 | Inhibitory effect of emodin on human hepatoma cell line SMMC-7721 and its mechanism. ( Chen, Y; Zhang, T; Zhang, X; Zhang, Y, 2015) |
| "Emodin is a multifunctional Chinese traditional medicine with poor water solubility." | 1.38 | Formulation, antileukemia mechanism, pharmacokinetics, and biodistribution of a novel liposomal emodin. ( Lu, Y; Shan, W; Wang, T; Xiong, S; Yin, X, 2012) |
| "Hepatocellular carcinoma has high-incidence rates and is associated with poor prognosis and high mortality rates." | 1.36 | Emodin inhibits the growth of hepatoma cells: finding the common anti-cancer pathway using Huh7, Hep3B, and HepG2 cells. ( Hsu, CM; Hsu, YA; Huang, SH; Shieh, FK; Tsai, FJ; Tsai, Y; Wan, L, 2010) |
| "Emodin could inhibit the growth of HepG2 cells significantly with IC(50) of 36+/-2." | 1.32 | [Apoptosis of human hepatoma HepG2 cells induced by emodin in vitro]. ( Gao, XG; Li, KZ; Lian, T; Liu, JB; Zhao, AZ, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (18.18) | 29.6817 |
| 2010's | 24 (54.55) | 24.3611 |
| 2020's | 12 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Brenes, R | 1 |
| Nguyen, LMN | 1 |
| Miller, DL | 1 |
| Rohde, ML | 1 |
| Zhao, H | 1 |
| Wang, Y | 2 |
| He, C | 1 |
| Yang, J | 1 |
| Shi, Y | 1 |
| Zhu, X | 1 |
| Wu, L | 1 |
| Yang, FR | 1 |
| Xing, ML | 1 |
| Lu, SF | 1 |
| Chen, HL | 1 |
| Yang, QW | 1 |
| Zhang, YT | 1 |
| Lu, Y | 2 |
| Huang, Y | 2 |
| Yin, J | 1 |
| Zhao, X | 1 |
| Chen, X | 2 |
| Shen, G | 1 |
| Qin, B | 1 |
| Zeng, Z | 1 |
| Xu, J | 1 |
| Shangwen, J | 1 |
| Ye, ZJ | 2 |
| Wang, S | 1 |
| Wu, Y | 1 |
| Peng, G | 1 |
| Wang, Q | 3 |
| Gu, W | 1 |
| Tang, Y | 2 |
| Wu, W | 1 |
| Lu, P | 2 |
| Zhu, Z | 1 |
| Li, C | 2 |
| Liu, Y | 1 |
| Yu, B | 1 |
| Wang, M | 1 |
| Xu, H | 4 |
| Gao, R | 1 |
| Zhu, Y | 1 |
| Ning, H | 1 |
| Dai, X | 1 |
| Chaudhary, A | 1 |
| Bhardwaj, SK | 1 |
| Khan, A | 1 |
| Srivastava, A | 1 |
| Sinha, KK | 1 |
| Ali, M | 1 |
| Haque, R | 1 |
| Yang, M | 1 |
| Xiong, Z | 1 |
| Deng, H | 1 |
| Lai, Q | 1 |
| Wang, H | 1 |
| Leng, Y | 1 |
| Sun, R | 1 |
| Zhai, R | 1 |
| Ma, C | 2 |
| Miao, W | 1 |
| Khan, H | 1 |
| Jia, W | 1 |
| Yu, Z | 1 |
| Zaib, T | 1 |
| Feng, J | 1 |
| Jiang, Y | 2 |
| Song, H | 1 |
| Bai, Y | 1 |
| Yang, B | 1 |
| Feng, H | 1 |
| Dewdney, B | 1 |
| Alanazy, M | 1 |
| Gillman, R | 1 |
| Walker, S | 1 |
| Wankell, M | 1 |
| Qiao, L | 1 |
| George, J | 1 |
| Roberts, A | 1 |
| Hebbard, L | 1 |
| Guo, R | 1 |
| Lv, R | 1 |
| Liu, T | 1 |
| Wei, H | 1 |
| Ming, H | 1 |
| Tian, X | 1 |
| Pan, XP | 1 |
| Wang, C | 5 |
| Li, Y | 2 |
| Huang, LH | 1 |
| Dong, H | 1 |
| Wu, G | 1 |
| Zhang, C | 3 |
| Wang, J | 1 |
| Gao, M | 3 |
| Pang, Y | 1 |
| Zhang, H | 1 |
| Zhang, B | 1 |
| Tian, Y | 3 |
| Li, Q | 1 |
| Li, N | 1 |
| Zhang, P | 1 |
| You, S | 1 |
| Dong, X | 1 |
| Ni, B | 1 |
| Fu, J | 1 |
| Yin, X | 2 |
| You, L | 1 |
| Leng, X | 1 |
| Liang, X | 1 |
| Ni, J | 1 |
| Kim, YS | 1 |
| Lee, YM | 1 |
| Oh, TI | 1 |
| Shin, DH | 1 |
| Kim, GH | 1 |
| Kan, SY | 1 |
| Kang, H | 1 |
| Kim, JH | 1 |
| Kim, BM | 1 |
| Yim, WJ | 1 |
| Lim, JH | 1 |
| Pan, X | 1 |
| Zhu, L | 1 |
| Zhang, T | 2 |
| Zhou, RS | 1 |
| Wang, XW | 1 |
| Sun, QF | 1 |
| Liu, JW | 1 |
| Zhou, DH | 1 |
| Gao, S | 1 |
| Yang, WS | 1 |
| Jin, GZ | 1 |
| Sun, S | 1 |
| Manu, KA | 2 |
| Shanmugam, MK | 3 |
| Ong, TH | 2 |
| Subramaniam, A | 3 |
| Siveen, KS | 2 |
| Perumal, E | 3 |
| Samy, RP | 1 |
| Bist, P | 1 |
| Lim, LH | 1 |
| Kumar, AP | 3 |
| Hui, KM | 3 |
| Sethi, G | 3 |
| Chen, G | 1 |
| Qiu, H | 1 |
| Ke, SD | 1 |
| Hu, SM | 1 |
| Yu, SY | 1 |
| Zou, SQ | 1 |
| Loo, SY | 1 |
| Rajendran, P | 1 |
| Li, F | 2 |
| Park, JI | 1 |
| Ahn, KS | 2 |
| Chen, L | 1 |
| Vali, S | 1 |
| Abbasi, T | 1 |
| Kapoor, S | 1 |
| Zhang, X | 1 |
| Chen, Y | 2 |
| Zhang, Y | 1 |
| Liu, H | 2 |
| Guan, X | 1 |
| Lv, L | 2 |
| Deng, S | 2 |
| He, Y | 1 |
| Huang, J | 1 |
| Wang, P | 1 |
| Shen, X | 1 |
| Li, S | 1 |
| Yang, L | 1 |
| Liu, W | 1 |
| Suksamrarn, A | 1 |
| Zhang, G | 1 |
| Wang, F | 1 |
| Cui, Y | 1 |
| Song, G | 1 |
| Liu, Q | 1 |
| Zhu, D | 1 |
| Liu, X | 1 |
| Lin, W | 1 |
| Zhong, M | 1 |
| Yin, H | 1 |
| Cao, Q | 1 |
| Ling, C | 1 |
| Xing, Y | 1 |
| Yan, Y | 1 |
| Guo, P | 1 |
| Zhuang, J | 1 |
| Qin, F | 1 |
| Zhang, J | 1 |
| Gao, X | 1 |
| Gao, D | 1 |
| Hsu, CM | 1 |
| Hsu, YA | 1 |
| Tsai, Y | 1 |
| Shieh, FK | 1 |
| Huang, SH | 1 |
| Wan, L | 1 |
| Tsai, FJ | 1 |
| Alisi, A | 1 |
| Ghidinelli, M | 1 |
| Zerbini, A | 1 |
| Missale, G | 1 |
| Balsano, C | 1 |
| Jeon, W | 1 |
| Jeon, YK | 1 |
| Nam, MJ | 1 |
| Wang, T | 1 |
| Shan, W | 1 |
| Xiong, S | 1 |
| Nagashima, H | 1 |
| Nakamura, K | 1 |
| Goto, T | 1 |
| Liu, JB | 1 |
| Gao, XG | 1 |
| Lian, T | 1 |
| Zhao, AZ | 1 |
| Li, KZ | 1 |
| Shieh, DE | 1 |
| Chen, YY | 1 |
| Yen, MH | 1 |
| Chiang, LC | 1 |
| Lin, CC | 1 |
| Wang, XD | 1 |
| Gu, LQ | 1 |
| Wu, JY | 1 |
| Lu, GD | 1 |
| Shen, HM | 1 |
| Chung, MC | 1 |
| Ong, CN | 1 |
| Kim, HR | 1 |
| Kim, K | 1 |
| Lee, KH | 1 |
| Kim, SJ | 1 |
| Kim, J | 1 |
| Xu, XC | 1 |
| Lin, SZ | 1 |
1 review available for emodin and Cancer of Liver
| Article | Year |
|---|---|
[Experimental advance of applying emodin for prevention and treatment of liver diseases].
Topics: Animals; Apoptosis; Cell Line, Tumor; Emodin; Humans; Liver Cirrhosis; Liver Neoplasms; Protective A | 2008 |
43 other studies available for emodin and Cancer of Liver
| Article | Year |
|---|---|
HEPATOCELLULAR TOXICITY OF THE METABOLITE EMODIN PRODUCED BY THE COMMON BUCKTHORN (RHAMNUS CATHARTICA) IN GREEN FROG (LITHOBATES CLAMITANS) TADPOLES.
Topics: Animals; Carcinoma, Hepatocellular; Emodin; Fibrosis; Larva; Liver Neoplasms; Rana clamitans; Rhamnu | 2022 |
Automatic Segmentation of Magnetic Resonance Images of Severe Patients with Advanced Liver Cancer and the Molecular Mechanism of Emodin-Induced Apoptosis of HepG2 Cells under the Deep Learning.
Topics: Apoptosis; Deep Learning; Emodin; Hep G2 Cells; Humans; Image Processing, Computer-Assisted; Liver N | 2022 |
Multi-material basis and multi-mechanisms of the Dahuang Zhechong pill for regulating Treg/Th1 balance in hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Drugs, Chinese Herbal; Emodin; Glutamine; Liver Neoplasms; Mice; | 2022 |
Emodin suppresses hepatocellular carcinoma growth by regulating macrophage polarization via microRNA-26a/transforming growth factor beta 1/protein kinase B.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Emodin; Humans; Liver Neoplasms; Macrophages; MicroRNAs | 2022 |
Emodin inhibits invasion and migration of hepatocellular carcinoma cells via regulating autophagy-mediated degradation of snail and β-catenin.
Topics: Autophagy; beta Catenin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferat | 2022 |
Emodin regulates the autophagy via the miR-371a-5p/PTEN axis to inhibit hepatic malignancy.
Topics: Autophagy; Cell Proliferation; Emodin; Humans; Liver Neoplasms; MicroRNAs; PTEN Phosphohydrolase | 2022 |
Investigating the Role of Dahuang in Hepatoma Treatment Using Network Pharmacology, Molecular Docking, and Survival Analysis.
Topics: Carcinoma, Hepatocellular; Drugs, Chinese Herbal; Emodin; Humans; Liver Neoplasms; Medicine, Chinese | 2022 |
Combinatorial Effect of Arsenic and Herbal Compounds in Telomerase-Mediated Apoptosis Induction in Liver Cancer.
Topics: Antineoplastic Agents; Apoptosis; Arsenic; Arsenic Trioxide; Arsenicals; Carcinoma, Hepatocellular; | 2023 |
Effect of emodin combined with cisplatin on the invasion and migration of HepG2 hepatoma cells.
Topics: Cadherins; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cisplatin | 2023 |
Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Dru | 2020 |
Emodin succinyl ester inhibits malignant proliferation and migration of hepatocellular carcinoma by suppressing the interaction of AR and EZH2.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Moveme | 2020 |
The effects of fructose and metabolic inhibition on hepatocellular carcinoma.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Databases, Fact | 2020 |
RETRACTED: Physcion 8-O-β-glucopyranoside suppresses tumor growth of Hepatocellular carcinoma by downregulating PIM1.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relationship, Drug; Down-Regulat | 2017 |
Physcion induces apoptosis through triggering endoplasmic reticulum stress in hepatocellular carcinoma.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hep | 2018 |
N-acetylaminogalactosyl-decorated biodegradable PLGA-TPGS copolymer nanoparticles containing emodin for the active targeting therapy of liver cancer.
Topics: Apoptosis; Biological Transport; Drug Carriers; Emodin; Galactose; Hep G2 Cells; Humans; Liver Neopl | 2018 |
Emodin inhibits pancreatic cancer EMT and invasion by up‑regulating microRNA‑1271.
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Emodin; Ep | 2018 |
Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase‑dependent pathway.
Topics: Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Cycle Checkpoints; Cell Proliferation; Emodin; | 2018 |
Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cholesterol | 2018 |
RETRACTED: Protective autophagy induced by physcion suppresses hepatocellular carcinoma cell metastasis by inactivating the JAK2/STAT3 Axis.
Topics: Animals; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Emodin; H | 2018 |
Anticancer Effects of Emodin on HepG2 Cell: Evidence from Bioinformatic Analysis.
Topics: Biomarkers, Tumor; Carcinoma, Hepatocellular; Computational Biology; Emodin; Gene Expression Profili | 2019 |
β-Dihydroartemisinin-Emodin Promotes Apoptosis by Activating Extrinsic and Intrinsic Pathways in Human Liver Cancer Cells.
Topics: Apoptosis; Artemisinins; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Shape | 2019 |
Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Dru | 2013 |
Emodin regulating excision repair cross-complementation group 1 through fibroblast growth factor receptor 2 signaling.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; DNA Damage; DNA-Binding Protei | 2013 |
An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Hepatocellular; Cell Lin | 2013 |
Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Dose-Respo | 2013 |
Inhibitory effect of emodin on human hepatoma cell line SMMC-7721 and its mechanism.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relatio | 2015 |
A Promising Emodin-Loaded Poly (Lactic-Co-Glycolic Acid)-d-α-Tocopheryl Polyethylene Glycol 1000 Succinate Nanoparticles for Liver Cancer Therapy.
Topics: alpha-Tocopherol; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Delayed-Action Prepar | 2016 |
Emodin potentiates the antiproliferative effect of interferon α/β by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome.
Topics: Animals; Antiviral Agents; Apoptosis; Blotting, Western; Cell Proliferation; Emodin; Female; Fluores | 2016 |
Involvement of PI3K/Akt, ERK and p38 signaling pathways in emodin-mediated extrinsic and intrinsic human hepatoblastoma cell apoptosis.
Topics: Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Emodin; Extracellular Signal-Regulated MAP Kinas | 2016 |
Emodin induces hepatocellular carcinoma cell apoptosis through MAPK and PI3K/AKT signaling pathways in vitro and in vivo.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Emodin; Humans; | 2016 |
Physcion 8-O-β-glucopyranoside induces apoptosis, suppresses invasion and inhibits epithelial to mesenchymal transition of hepatocellular carcinoma HepG2 cells.
Topics: Adenylate Kinase; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Cycle Checkpoints; Cell Movem | 2016 |
Emodin-Loaded PLGA-TPGS Nanoparticles Combined with Heparin Sodium-Loaded PLGA-TPGS Nanoparticles to Enhance Chemotherapeutic Efficacy Against Liver Cancer.
Topics: Animals; Antimicrobial Cationic Peptides; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell S | 2016 |
Emodin inhibits the growth of hepatoma cells: finding the common anti-cancer pathway using Huh7, Hep3B, and HepG2 cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Cycle Proteins; Cell L | 2010 |
Hepatitis C virus and alcohol: same mitotic targets but different signaling pathways.
Topics: Aurora Kinase A; Aurora Kinases; Biopsy; Carcinoma, Hepatocellular; Central Nervous System Depressan | 2011 |
Apoptosis by aloe-emodin is mediated through down-regulation of calpain-2 and ubiquitin-protein ligase E3A in human hepatoma Huh-7 cells.
Topics: Aloe; Antineoplastic Agents, Phytogenic; Apoptosis; Calpain; Carcinoma, Hepatocellular; Cell Line, T | 2012 |
Formulation, antileukemia mechanism, pharmacokinetics, and biodistribution of a novel liposomal emodin.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell | 2012 |
Rubratoxin B induced the secretion of hepatic injury-related colony stimulating factors in human hepatoma cells.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Emodin; Enzyme Inhibitors; Granulocyte-Macrophage Colon | 2003 |
[Apoptosis of human hepatoma HepG2 cells induced by emodin in vitro].
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Division; Emodin; Enzyme Inhibitors; Flow Cytometry; Huma | 2003 |
Emodin-induced apoptosis through p53-dependent pathway in human hepatoma cells.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cell Cycle; Cell D | 2004 |
Aloe vera (Aloe barbadensis, Aloe capensis).
Topics: Aloe; Apoptosis; Emodin; Humans; Liver Neoplasms | 2007 |
Apoptosis-inducing activity of new pyrazole emodin derivatives in human hepatocellular carcinoma HepG2 cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; | 2007 |
Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells.
Topics: Aloe; Apoptosis; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Emodin; Glutathione; Gluta | 2007 |
Inhibition of casein kinase 2 enhances the death ligand- and natural kiler cell-induced hepatocellular carcinoma cell death.
Topics: Apoptosis; Carcinoma, Hepatocellular; Casein Kinase II; Cytoplasmic Granules; Cytotoxicity, Immunolo | 2008 |