emodin has been researched along with Alzheimer Disease in 6 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Emodin is a naturally‑occurring medicinal herbal ingredient that possesses numerous pharmacological properties, including anti‑inflammatory and antioxidant effects." | 1.62 | Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice. ( Bi, H; Fei, X; Jiang, H; Li, Z; Meng, Q; Song, J; Zhang, Y, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 3 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bulic, B | 1 |
| Pickhardt, M | 1 |
| Mandelkow, E | 1 |
| Pretsch, D | 1 |
| Rollinger, JM | 1 |
| Schmid, A | 1 |
| Genov, M | 1 |
| Wöhrer, T | 1 |
| Krenn, L | 1 |
| Moloney, M | 1 |
| Kasture, A | 1 |
| Hummel, T | 1 |
| Pretsch, A | 1 |
| Wang, L | 1 |
| Liu, S | 1 |
| Xu, J | 1 |
| Watanabe, N | 1 |
| Mayo, KH | 1 |
| Li, J | 1 |
| Li, X | 1 |
| Li, Z | 1 |
| Bi, H | 1 |
| Jiang, H | 1 |
| Song, J | 1 |
| Meng, Q | 1 |
| Zhang, Y | 1 |
| Fei, X | 1 |
| Du, C | 1 |
| Shi, L | 1 |
| Wang, M | 2 |
| Mao, P | 1 |
| Wang, J | 1 |
| Wei, Y | 1 |
| Hou, J | 1 |
| Sun, YP | 1 |
| Liu, JP | 1 |
1 review available for emodin and Alzheimer Disease
| Article | Year |
|---|---|
Progress and developments in tau aggregation inhibitors for Alzheimer disease.
Topics: Alzheimer Disease; Animals; Clinical Trials as Topic; Humans; Hydrogen Bonding; Models, Molecular; P | 2013 |
5 other studies available for emodin and Alzheimer Disease
| Article | Year |
|---|---|
Prolongation of metallothionein induction combats Aß and α-synuclein toxicity in aged transgenic Caenorhabditis elegans.
Topics: Aging; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modi | 2020 |
Emodin inhibits aggregation of amyloid-β peptide 1-42 and improves cognitive deficits in Alzheimer's disease transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognitive Dysfunction; Emodin; Female; Male; Mice | 2021 |
Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Apoptosis; Cell Line, Tumor; Emodin; Hum | 2021 |
Emodin attenuates Alzheimer's disease by activating the protein kinase C signaling pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Cell Survival; Cognition; Disea | 2019 |
Blockade of emodin on amyloid-β 25-35-induced neurotoxicity in AβPP/PS1 mice and PC12 cells through activation of the class III phosphatidylinositol 3-kinase/Beclin-1/B-cell lymphoma 2 pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autophagy; Cell Survival; Class III Phosphatidyli | 2015 |