emodin has been researched along with Acute Lung Injury in 15 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Acute Lung Injury: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Numerous preclinical investigations have exhibited the beneficial impact of emodin (EMO) on the management of severe acute pancreatitis (SAP)-associated acute lung injury (ALI)." | 8.31 | Emodin Ameliorates Severe Acute Pancreatitis-Associated Acute Lung Injury in Rats by Modulating Exosome-Specific miRNA Expression Profiles. ( Cao, Y; Chen, H; Ge, P; Lan, B; Liu, J; Luo, Y; Sun, Z; Wen, H; Yang, Q; Yuan, H; Zhang, G; Zhang, L, 2023) |
| " Both emodin and dexamethasone (DEX) have been used for treating severe acute pancreatitis-associated acute lung injury (SAP-ALI)." | 8.02 | Effect of emodin on long non-coding RNA-mRNA networks in rats with severe acute pancreatitis-induced acute lung injury. ( Chen, H; Jiang, L; Li, L; Li, Z; Luo, Y; Ntim, M; Quan, W; Shang, D; Xu, C; Xu, Q; Zhang, G; Zhang, J, 2021) |
| "This study aimed to investigate the anti-pulmonary inflammation effect of emodin on Wistar rats with lipopolysaccharide (LPS)-induced acute lung injury (ALI) and RAW264." | 7.96 | Emodin alleviated pulmonary inflammation in rats with LPS-induced acute lung injury through inhibiting the mTOR/HIF-1α/VEGF signaling pathway. ( Li, X; Shan, C; Tan, B; Wu, Z; Yang, A; Yu, H, 2020) |
| "The present study aimed to evaluate the protective effects of emodin on severe acute pancreatitis (SAP)‑associated acute lung injury (ALI), and investigated the possible mechanism involved." | 7.85 | Emodin alleviates severe acute pancreatitis-associated acute lung injury by decreasing pre-B-cell colony-enhancing factor expression and promoting polymorphonuclear neutrophil apoptosis. ( Chen, H; Cui, H; Li, S; Sun, Z; Xu, C; Zhang, J, 2017) |
| "The present study investigates the ameliorating effects of emodin on acute lung injury (ALI) induced by severe acute pancreatitis (SAP)." | 7.83 | Emodin ameliorates acute lung injury induced by severe acute pancreatitis through the up-regulated expressions of AQP1 and AQP5 in lung. ( Fan, R; Gao, Z; Huang, B; Tong, C; Wang, Y; Xie, P; Xu, J, 2016) |
| "To investigate the effects of emodin on aquaporin 5 (AQP5) expression in rats with sepsis-induced acute lung injury." | 7.81 | Effect of emodin on Aquaporin 5 expression in rats with sepsis-induced acute lung injury. ( Cheng, J; Liu, J; Liu, S; Song, J; Sun, L; Sun, Y, 2015) |
| "Emodin was found to upregulate AQP and TJ expression in the CLP model." | 5.56 | Emodin attenuates acute lung injury in Cecal-ligation and puncture rats. ( Guo, R; Han, M; Li, Y; Liu, J; Sun, Y, 2020) |
| "Lung injury is a common complication of acute pancreatitis (AP), which leads to the development of acute respiratory distress syndrome and causes high mortality." | 5.56 | Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling. ( Dong, X; Fan, R; Gao, Z; Qu, W; Sui, J; Sun, D, 2020) |
| "Uncontrolled and self-amplified pulmonary inflammation lies at the center of the pathology of this disease." | 5.40 | Emodin ameliorates LPS-induced acute lung injury, involving the inactivation of NF-κB in mice. ( Shen, YC; Wan, QF; Wang, T; Wen, FQ; Xiao, M; Zhang, W; Zhu, T, 2014) |
| "Numerous preclinical investigations have exhibited the beneficial impact of emodin (EMO) on the management of severe acute pancreatitis (SAP)-associated acute lung injury (ALI)." | 4.31 | Emodin Ameliorates Severe Acute Pancreatitis-Associated Acute Lung Injury in Rats by Modulating Exosome-Specific miRNA Expression Profiles. ( Cao, Y; Chen, H; Ge, P; Lan, B; Liu, J; Luo, Y; Sun, Z; Wen, H; Yang, Q; Yuan, H; Zhang, G; Zhang, L, 2023) |
| " Both emodin and dexamethasone (DEX) have been used for treating severe acute pancreatitis-associated acute lung injury (SAP-ALI)." | 4.02 | Effect of emodin on long non-coding RNA-mRNA networks in rats with severe acute pancreatitis-induced acute lung injury. ( Chen, H; Jiang, L; Li, L; Li, Z; Luo, Y; Ntim, M; Quan, W; Shang, D; Xu, C; Xu, Q; Zhang, G; Zhang, J, 2021) |
| "This study aimed to investigate the anti-pulmonary inflammation effect of emodin on Wistar rats with lipopolysaccharide (LPS)-induced acute lung injury (ALI) and RAW264." | 3.96 | Emodin alleviated pulmonary inflammation in rats with LPS-induced acute lung injury through inhibiting the mTOR/HIF-1α/VEGF signaling pathway. ( Li, X; Shan, C; Tan, B; Wu, Z; Yang, A; Yu, H, 2020) |
| "The present study aimed to evaluate the protective effects of emodin on severe acute pancreatitis (SAP)‑associated acute lung injury (ALI), and investigated the possible mechanism involved." | 3.85 | Emodin alleviates severe acute pancreatitis-associated acute lung injury by decreasing pre-B-cell colony-enhancing factor expression and promoting polymorphonuclear neutrophil apoptosis. ( Chen, H; Cui, H; Li, S; Sun, Z; Xu, C; Zhang, J, 2017) |
| "The present study investigates the ameliorating effects of emodin on acute lung injury (ALI) induced by severe acute pancreatitis (SAP)." | 3.83 | Emodin ameliorates acute lung injury induced by severe acute pancreatitis through the up-regulated expressions of AQP1 and AQP5 in lung. ( Fan, R; Gao, Z; Huang, B; Tong, C; Wang, Y; Xie, P; Xu, J, 2016) |
| "To investigate the effects of emodin on aquaporin 5 (AQP5) expression in rats with sepsis-induced acute lung injury." | 3.81 | Effect of emodin on Aquaporin 5 expression in rats with sepsis-induced acute lung injury. ( Cheng, J; Liu, J; Liu, S; Song, J; Sun, L; Sun, Y, 2015) |
| "Silicosis is a fatal pulmonary disease caused by the inhalation of silica dust, and characterized by inflammation and fibrosis of the lung, with no effective treatment to date." | 1.62 | Emodin attenuates silica-induced lung injury by inhibition of inflammation, apoptosis and epithelial-mesenchymal transition. ( Jia, Q; Lavin, MF; Li, C; Nie, X; Pang, X; Peng, C; Shao, H; Shao, L; Xia, Q; Yan, H; Yeo, AJ; Yu, G, 2021) |
| "Emodin was found to upregulate AQP and TJ expression in the CLP model." | 1.56 | Emodin attenuates acute lung injury in Cecal-ligation and puncture rats. ( Guo, R; Han, M; Li, Y; Liu, J; Sun, Y, 2020) |
| "Lung injury is a common complication of acute pancreatitis (AP), which leads to the development of acute respiratory distress syndrome and causes high mortality." | 1.56 | Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling. ( Dong, X; Fan, R; Gao, Z; Qu, W; Sui, J; Sun, D, 2020) |
| "Uncontrolled and self-amplified pulmonary inflammation lies at the center of the pathology of this disease." | 1.40 | Emodin ameliorates LPS-induced acute lung injury, involving the inactivation of NF-κB in mice. ( Shen, YC; Wan, QF; Wang, T; Wen, FQ; Xiao, M; Zhang, W; Zhu, T, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 10 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Y | 1 |
| Shang, L | 1 |
| Zhou, J | 1 |
| Pan, G | 1 |
| Zhou, F | 1 |
| Yang, S | 1 |
| Liu, FJ | 1 |
| Gu, TJ | 1 |
| Wei, DY | 1 |
| Yang, Q | 1 |
| Luo, Y | 2 |
| Ge, P | 1 |
| Lan, B | 1 |
| Liu, J | 3 |
| Wen, H | 1 |
| Cao, Y | 1 |
| Sun, Z | 2 |
| Zhang, G | 2 |
| Yuan, H | 1 |
| Zhang, L | 2 |
| Chen, H | 3 |
| Li, X | 1 |
| Shan, C | 1 |
| Wu, Z | 1 |
| Yu, H | 1 |
| Yang, A | 1 |
| Tan, B | 1 |
| Lei, J | 1 |
| Shen, Y | 1 |
| Xv, G | 1 |
| Di, Z | 1 |
| Li, Y | 2 |
| Li, G | 2 |
| Guo, R | 1 |
| Han, M | 1 |
| Sun, Y | 2 |
| Gao, Z | 2 |
| Sui, J | 1 |
| Fan, R | 2 |
| Qu, W | 1 |
| Dong, X | 1 |
| Sun, D | 1 |
| Qian, J | 1 |
| Jin, X | 1 |
| Ma, C | 1 |
| Cai, W | 1 |
| Jiang, N | 1 |
| Zheng, J | 1 |
| Pang, X | 1 |
| Shao, L | 1 |
| Nie, X | 1 |
| Yan, H | 1 |
| Li, C | 1 |
| Yeo, AJ | 1 |
| Lavin, MF | 1 |
| Xia, Q | 1 |
| Shao, H | 1 |
| Yu, G | 1 |
| Jia, Q | 1 |
| Peng, C | 1 |
| Xu, C | 2 |
| Ntim, M | 1 |
| Quan, W | 1 |
| Li, Z | 1 |
| Xu, Q | 1 |
| Jiang, L | 1 |
| Zhang, J | 2 |
| Shang, D | 1 |
| Li, L | 1 |
| Cui, H | 1 |
| Li, S | 1 |
| Dong, Y | 1 |
| Jiang, Y | 1 |
| Dai, J | 1 |
| Tang, L | 1 |
| Liu, G | 1 |
| Xiao, M | 1 |
| Zhu, T | 1 |
| Zhang, W | 1 |
| Wang, T | 1 |
| Shen, YC | 1 |
| Wan, QF | 1 |
| Wen, FQ | 1 |
| Sun, L | 1 |
| Liu, S | 1 |
| Song, J | 1 |
| Cheng, J | 1 |
| Xu, J | 1 |
| Huang, B | 1 |
| Wang, Y | 1 |
| Tong, C | 1 |
| Xie, P | 1 |
15 other studies available for emodin and Acute Lung Injury
| Article | Year |
|---|---|
Emodin Attenuates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis Signaling Pathway In vitro and In vivo.
Topics: Acute Lung Injury; Animals; Emodin; Inflammasomes; Lipopolysaccharides; NLR Family, Pyrin Domain-Con | 2022 |
Emodin alleviates sepsis-mediated lung injury via inhibition and reduction of NF-kB and HMGB1 pathways mediated by SIRT1.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage; Cell Line; Emodin; HMGB1 Protein; Interleukin-1b | 2022 |
Emodin Ameliorates Severe Acute Pancreatitis-Associated Acute Lung Injury in Rats by Modulating Exosome-Specific miRNA Expression Profiles.
Topics: Acute Disease; Acute Lung Injury; Animals; Emodin; Exosomes; MicroRNAs; Pancreatitis; Rats | 2023 |
Emodin alleviated pulmonary inflammation in rats with LPS-induced acute lung injury through inhibiting the mTOR/HIF-1α/VEGF signaling pathway.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cytokines; Emodi | 2020 |
Aloin suppresses lipopolysaccharide-induced acute lung injury by inhibiting NLRP3/NF-κB via activation of SIRT1 in mice.
Topics: Acute Lung Injury; Aloe; Animals; Dose-Response Relationship, Drug; Emodin; Female; Lipopolysacchari | 2020 |
Emodin attenuates acute lung injury in Cecal-ligation and puncture rats.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Aquaporin 1; Aquaporin 5; Cecum; Cl | 2020 |
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Topics: Acute Disease; Acute Lung Injury; Administration, Oral; Animals; Cell Proliferation; Cells, Cultured | 2020 |
Emodin protects against intestinal and lung injury induced by acute intestinal injury by modulating SP-A and TLR4/NF-κB pathway.
Topics: Acetic Acid; Acute Lung Injury; Animals; Colon; Disease Models, Animal; Emodin; Humans; Intestinal M | 2020 |
Emodin attenuates silica-induced lung injury by inhibition of inflammation, apoptosis and epithelial-mesenchymal transition.
Topics: A549 Cells; Acute Lung Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Apoptosis Regulatory Pr | 2021 |
Effect of emodin on long non-coding RNA-mRNA networks in rats with severe acute pancreatitis-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Biomarkers; Biopsy; Computational Biology; Cytokines; Disease Models, An | 2021 |
Emodin alleviates severe acute pancreatitis-associated acute lung injury by decreasing pre-B-cell colony-enhancing factor expression and promoting polymorphonuclear neutrophil apoptosis.
Topics: Acute Disease; Acute Lung Injury; Amylases; Animals; Apoptosis; Cytokines; Dexamethasone; Emodin; Ge | 2017 |
Emodin reactivated autophagy and alleviated inflammatory lung injury in mice with lethal endotoxemia.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Autophagy; Disease Models, Animal; Emodin; End | 2019 |
Emodin ameliorates LPS-induced acute lung injury, involving the inactivation of NF-κB in mice.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Chemokine CCL2; E-Selectin; Emodin; Enzyme | 2014 |
Effect of emodin on Aquaporin 5 expression in rats with sepsis-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Aquaporin 5; Disease Models, Animal; Down-Regulation; Emodin; Humans; Lu | 2015 |
Emodin ameliorates acute lung injury induced by severe acute pancreatitis through the up-regulated expressions of AQP1 and AQP5 in lung.
Topics: Acute Lung Injury; Animals; Aquaporin 1; Aquaporin 5; Emodin; Gene Expression; Male; Pancreatitis; R | 2016 |