emodin has been researched along with Acute Liver Injury, Drug-Induced in 38 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cotreatment with emodin and STF-083010 led to the downregulation of BiP and upregulation of CHOP, the Bax/Bcl-2 ratio, and cleaved caspase-3 compared with single treatment with emodin." | 1.91 | Emodin, an Emerging Mycotoxin, Induces Endoplasmic Reticulum Stress-Related Hepatotoxicity through IRE1α-XBP1 Axis in HepG2 Cells. ( Cho, GH; Chun, HS; Park, SB; Park, YE, 2023) |
| " multiflorum vary, and the toxic components are even more controversial." | 1.72 | Polygonum multiflorum Thunb. Induces hepatotoxicity in SD rats and hepatocyte spheroids by Disrupting the metabolism of bilirubin and bile acid. ( Ma, S; Wang, Q; Wen, H; Zhang, Y, 2022) |
| " Recent results showed that emodin is the potential toxic components of PMT, but the molecular mechanisms of emodin on liver toxicity remain to be elucidated." | 1.72 | Emodin-induced hepatotoxicity is enhanced by 3-methylcholanthrene through activating aryl hydrocarbon receptor and inducing CYP1A1 in vitro and in vivo. ( Gao, Y; Ruan, P; Wang, M; Wang, Y; Xiao, C; Zhang, G; Zhang, Z, 2022) |
| "Emodin pretreatment significantly reduced the levels of ALT, AST, and ALP; increased the levels of ALB; alleviated hepatocellular damage and apoptosis; attenuated the exhaustion of GSH and SOD and the accumulation of MDA; and increased the expression of antioxidative enzymes, including nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), and NAD(P)H quinone dehydrogenase 1 (NQO1)." | 1.72 | Emodin Attenuates Acetaminophen-Induced Hepatotoxicity via the cGAS-STING Pathway. ( Chen, G; Cheng, Z; Han, L; Liu, Q; Shen, P, 2022) |
| " The results suggested that the emodin-type monoterpene and rhein might be the potential hepatotoxic components, while the metabolites of emodin-8-O-β-D-glucoside and emodin methyl ether showed more toxic risks." | 1.56 | [Study on potential hepatotoxicity of main monomers of Polygonum multiflorum based on liver micro-tissue]. ( Guo, HX; Ma, SC; Wang, Q; Wen, HR; Zhang, LS; Zhang, QH, 2020) |
| " It is well-known that some compounds could influence other compounds' pharmacokinetic parameters significantly." | 1.51 | Pharmacokinetic studies unveiled the drug-drug interaction between trans-2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucopyranoside and emodin that may contribute to the idiosyncratic hepatotoxicity of Polygoni Multiflori Radix. ( Gao, X; Han, L; Hu, L; Wang, C; Wang, L; Xing, Y; Yang, W; Zhang, Y, 2019) |
| "Emodin is an active ingredient in many herbal medicines and has a broad spectrum of pharmacological activities." | 1.51 | Paradoxical Effects of Emodin on ANIT-Induced Intrahepatic Cholestasis and Herb-Induced Hepatotoxicity in Mice. ( Bi, Y; Fan, G; Gao, X; Han, L; Li, C; Wang, X; Zhang, Y, 2019) |
| " Pathological state is an important factor affecting the efficacy of drugs, the pharmacokinetic behavior of drugs could be significantly changed when people or animal were under different pathological state." | 1.51 | Nine components pharmacokinetic study of rat plasma after oral administration raw and prepared Semen Cassiae in normal and acute liver injury rats. ( Cai, B; Jin, J; Peng, S; Qin, K; Sun, K; Xie, L; Yang, B; Zhen, Y, 2019) |
| "Radix Wikstroemia indica (RWI), named "Liao Ge Wang" in Chinese, is a kind of toxic Chinese herbal medicine (CHM) commonly used in Miao nationality of South China." | 1.48 | Exploring the Q-marker of "sweat soaking method" processed radix Wikstroemia indica: Based on the "effect-toxicity-chemicals" study. ( Chen, YL; Feng, G; Hai, Y; He, X; Li, LL; Li, W; Liu, CX; Wu, ZG; Wu, ZJ; Zhang, SC; Zheng, CQ, 2018) |
| " However, liver adverse reactions caused by RPM or RPMP were frequently reported all around the world recent years." | 1.37 | Hepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori Praeparata. ( Li, N; Mao, XJ; Wang, J; Wang, MJ; Xie, J; Yu, J; Zhao, RH; Zhaori, GT, 2011) |
| "Emodin treatment can reduce the levels of TB, DB and ALT in ANIT induced-cholestatic hepatitis." | 1.35 | [Effect and mechanism of emodin on cholestatic hepatitis]. ( DING, Y; GAO, Y; HUANG, ZH; KANG, SX; MEI, H; PENG, HM; ZHAO, L, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.63) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (7.89) | 29.6817 |
| 2010's | 17 (44.74) | 24.3611 |
| 2020's | 17 (44.74) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, T | 2 |
| He, X | 2 |
| Sun, L | 1 |
| Wang, D | 1 |
| Zhang, S | 1 |
| Mao, J | 1 |
| Zhang, F | 1 |
| Hua, H | 1 |
| Sheng, J | 1 |
| Cui, Y | 1 |
| Zhang, W | 1 |
| Hu, B | 1 |
| Cheng, Y | 1 |
| Guo, Y | 1 |
| Qian, H | 1 |
| Wang, Q | 5 |
| Wen, H | 1 |
| Ma, S | 1 |
| Zhang, Y | 5 |
| Li, D | 1 |
| Song, Q | 1 |
| Ji, X | 1 |
| Lyu, Y | 1 |
| Lai, YS | 1 |
| Zuo, Z | 1 |
| Chen, C | 2 |
| Qian, J | 1 |
| Zhao, X | 1 |
| Han, X | 1 |
| Tang, X | 1 |
| Gao, J | 1 |
| Liu, Y | 7 |
| Jiang, J | 1 |
| Wen, B | 1 |
| Wang, M | 1 |
| Zhang, Z | 1 |
| Ruan, P | 1 |
| Zhang, G | 1 |
| Xiao, C | 1 |
| Wang, Y | 3 |
| Gao, Y | 3 |
| Ni, B | 1 |
| Gao, X | 3 |
| Cai, M | 1 |
| Fu, J | 1 |
| Yin, X | 1 |
| Ni, J | 1 |
| Dong, X | 1 |
| Wang, X | 4 |
| Dong, L | 2 |
| Zhao, G | 2 |
| Li, W | 3 |
| Peng, Y | 2 |
| Zheng, J | 2 |
| Liu, L | 1 |
| Feng, M | 1 |
| Wu, H | 1 |
| Dai, Y | 1 |
| Jia, Z | 1 |
| Fang, C | 1 |
| Liu, M | 3 |
| Yan, X | 1 |
| Zhu, M | 1 |
| Huang, B | 1 |
| Qu, B | 1 |
| Xiao, H | 2 |
| Ju, C | 1 |
| Ding, Z | 1 |
| Park, SB | 1 |
| Cho, GH | 1 |
| Park, YE | 1 |
| Chun, HS | 1 |
| Zhang, L | 1 |
| Liu, X | 2 |
| Tu, C | 1 |
| Li, C | 2 |
| Song, D | 1 |
| Zhu, J | 1 |
| Zhou, Y | 1 |
| Li, R | 1 |
| Xiao, X | 1 |
| Wang, J | 3 |
| Wang, BX | 1 |
| Liu, P | 1 |
| Ding, Y | 2 |
| Mei, H | 2 |
| Zhang, QH | 1 |
| Wen, HR | 2 |
| Guo, HX | 1 |
| Zhang, LS | 1 |
| Ma, SC | 4 |
| Li, HY | 1 |
| Yang, JB | 2 |
| Li, WF | 1 |
| Qiu, CX | 1 |
| Hu, G | 1 |
| Wang, ST | 1 |
| Song, YF | 1 |
| Gao, HY | 1 |
| Cheng, XL | 1 |
| Wei, F | 1 |
| Jin, HT | 1 |
| Gu, J | 1 |
| Wu, Y | 1 |
| Yang, A | 1 |
| Chen, T | 1 |
| Zhou, T | 1 |
| Liu, Z | 1 |
| Shen, P | 1 |
| Han, L | 3 |
| Chen, G | 1 |
| Cheng, Z | 1 |
| Liu, Q | 1 |
| Yu, Q | 2 |
| Jiang, LL | 2 |
| Luo, N | 1 |
| Fan, YX | 2 |
| Ma, J | 2 |
| Li, P | 2 |
| Li, HJ | 3 |
| Meng, YK | 1 |
| Li, CY | 1 |
| Li, RY | 1 |
| He, LZ | 1 |
| Cui, HR | 1 |
| Yin, P | 1 |
| Zhang, CE | 1 |
| Li, PY | 1 |
| Sang, XX | 1 |
| Niu, M | 1 |
| Zhang, YM | 1 |
| Guo, YM | 1 |
| Sun, R | 1 |
| Wang, JB | 2 |
| Bai, ZF | 1 |
| Xiao, XH | 2 |
| Dai, Z | 1 |
| Zhang, YJ | 1 |
| Feng, G | 1 |
| Chen, YL | 1 |
| Li, LL | 1 |
| Wu, ZG | 1 |
| Wu, ZJ | 1 |
| Hai, Y | 1 |
| Zhang, SC | 1 |
| Zheng, CQ | 1 |
| Liu, CX | 1 |
| Jiang, Y | 1 |
| Zhao, DS | 1 |
| Wu, L | 1 |
| Chen, Y | 1 |
| Liu, H | 1 |
| Zhan, Z | 1 |
| Liang, Z | 1 |
| Cai, Z | 1 |
| Ye, L | 1 |
| Zhao, J | 1 |
| Liu, S | 1 |
| Tang, L | 1 |
| Jung, E | 1 |
| Kim, J | 1 |
| Xing, Y | 1 |
| Wang, L | 1 |
| Wang, C | 1 |
| Hu, L | 1 |
| Yang, W | 1 |
| Bi, Y | 1 |
| Fan, G | 1 |
| Yang, B | 1 |
| Xie, L | 1 |
| Peng, S | 1 |
| Sun, K | 1 |
| Jin, J | 1 |
| Zhen, Y | 1 |
| Qin, K | 1 |
| Cai, B | 1 |
| Xie, R | 1 |
| Li, S | 1 |
| Wang, YD | 1 |
| Zheng, L | 1 |
| He, YS | 1 |
| Cheng, M | 1 |
| ZHAO, L | 1 |
| PENG, HM | 1 |
| HUANG, ZH | 1 |
| KANG, SX | 1 |
| Wang, G | 1 |
| Wang, GK | 1 |
| Liu, JS | 1 |
| Yu, B | 1 |
| Wang, F | 1 |
| Liu, JK | 1 |
| Yu, J | 1 |
| Xie, J | 1 |
| Mao, XJ | 1 |
| Wang, MJ | 1 |
| Li, N | 1 |
| Zhaori, GT | 1 |
| Zhao, RH | 1 |
| Fang, F | 1 |
| Zhao, YL | 1 |
| Jin, C | 1 |
| Kong, WJ | 1 |
| Zhao, HP | 1 |
| Wang, HJ | 1 |
| Chiu, PY | 1 |
| Mak, DH | 1 |
| Poon, MK | 1 |
| Ko, KM | 1 |
| Ueno, Y | 1 |
| Arosio, B | 1 |
| Gagliano, N | 1 |
| Fusaro, LM | 1 |
| Parmeggiani, L | 1 |
| Tagliabue, J | 1 |
| Galetti, P | 1 |
| De Castri, D | 1 |
| Moscheni, C | 1 |
| Annoni, G | 1 |
1 review available for emodin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
[Mycotoxins as a tool for the analysis of biological function].
Topics: Aflatoxins; Animals; Chemical and Drug Induced Liver Injury; Cytochalasins; Cytochrome P-450 Enzyme | 1983 |
37 other studies available for emodin and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Insight into the practical models for prediciting the essential role of the cytochrome P450-mediated biotransformation in emodin-associated hepatotoxicity.
Topics: Animals; Animals, Outbred Strains; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme S | 2021 |
The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats.
Topics: Aflatoxin B1; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2 | 2021 |
Polygonum multiflorum Thunb. Induces hepatotoxicity in SD rats and hepatocyte spheroids by Disrupting the metabolism of bilirubin and bile acid.
Topics: Animals; Bile Acids and Salts; Bilirubin; Chemical and Drug Induced Liver Injury; Drug-Related Side | 2022 |
2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside enhances the hepatotoxicity of emodin in vitro and in vivo.
Topics: Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 2022 |
Metabolic profiling of emodin drug-induced liver injury and silybin treatment in rats using ultra-performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry: A metabolomic and mechanistic approach.
Topics: Animals; Aspartate Aminotransferases; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile | 2022 |
Emodin-induced hepatotoxicity is enhanced by 3-methylcholanthrene through activating aryl hydrocarbon receptor and inducing CYP1A1 in vitro and in vivo.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A1; Emodin; Methylcholanthrene | 2022 |
Isoliquiritigenin attenuates emodin-induced hepatotoxicity in vivo and in vitro through Nrf2 pathway.
Topics: Chalcones; Chemical and Drug Induced Liver Injury; Emodin; Glutathione; Humans; Kelch-Like ECH-Assoc | 2022 |
2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside, a mechanism-based inactivator of CYP2C19 and CYP3A4, potentiates hepatic protein adduction and hepatotoxicity induced by emodin in vivo.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; E | 2022 |
Discovery of Hepatotoxic Equivalent Markers and Mechanism of
Topics: Chemical and Drug Induced Liver Injury; Emodin; Fallopia multiflora; Glucosides; Molecular Docking S | 2022 |
Reduction of emodin-8-O-ß-D-glucoside content participates in processing-based detoxification of polygoni multiflori radix.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Emodin; Glucosides; Mice; Pl | 2023 |
Emodin, an Emerging Mycotoxin, Induces Endoplasmic Reticulum Stress-Related Hepatotoxicity through IRE1α-XBP1 Axis in HepG2 Cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Caspase 3; Chemical and Drug Induced Liver Injury; Emodin; En | 2023 |
Components synergy between stilbenes and emodin derivatives contributes to hepatotoxicity induced by
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Interactions; Drugs, Chinese Herbal; Emodin; F | 2020 |
[Effect of emodin on TLR4 signaling pathway in acute liver injury in animal model].
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Emodin; Liver; Mice; Signal | 2020 |
[Study on potential hepatotoxicity of main monomers of Polygonum multiflorum based on liver micro-tissue].
Topics: Animals; Chemical and Drug Induced Liver Injury; Emodin; Fallopia multiflora; Glucosides; Plant Extr | 2020 |
In vivo hepatotoxicity screening of different extracts, components, and constituents of Polygoni Multiflori Thunb. in zebrafish (Danio rerio) larvae.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Emodin; Fallopia mult | 2020 |
Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced | 2021 |
Emodin Attenuates Acetaminophen-Induced Hepatotoxicity via the cGAS-STING Pathway.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2022 |
Enhanced absorption and inhibited metabolism of emodin by 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside: Possible mechanisms for Polygoni Multiflori Radix-induced liver injury.
Topics: Caco-2 Cells; Chemical and Drug Induced Liver Injury; Emodin; Fallopia multiflora; Glucosides; Glucu | 2017 |
Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ.
Topics: Animals; Chemical and Drug Induced Liver Injury; Emodin; Fallopia multiflora; Glucosides; Lipopolysa | 2017 |
[Hepatotoxicity of emodin based on UGT1A1 enzyme-mediated bilirubin in liver microsomes].
Topics: Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Emodin; Glucuronides; Glucuronosyltransf | 2016 |
Exploring the Q-marker of "sweat soaking method" processed radix Wikstroemia indica: Based on the "effect-toxicity-chemicals" study.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers, Pharmacological; Chemical | 2018 |
CYP3A Activation and Glutathione Depletion Aggravate Emodin-Induced Liver Injury.
Topics: Animals; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Inj | 2018 |
Emodin-induced hepatotoxicity was exacerbated by probenecid through inhibiting UGTs and MRP2.
Topics: Animals; ATP-Binding Cassette Transporters; Cathartics; Cell Survival; Chemical and Drug Induced Liv | 2018 |
Aloin Inhibits Müller Cells Swelling in a Rat Model of Thioacetamide-Induced Hepatic Retinopathy.
Topics: Ammonia; Animals; Aquaporin 4; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Emodi | 2018 |
Pharmacokinetic studies unveiled the drug-drug interaction between trans-2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucopyranoside and emodin that may contribute to the idiosyncratic hepatotoxicity of Polygoni Multiflori Radix.
Topics: Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure | 2019 |
Paradoxical Effects of Emodin on ANIT-Induced Intrahepatic Cholestasis and Herb-Induced Hepatotoxicity in Mice.
Topics: 1-Naphthylisothiocyanate; Alanine Transaminase; AMP-Activated Protein Kinases; Animals; ATP Binding | 2019 |
Nine components pharmacokinetic study of rat plasma after oral administration raw and prepared Semen Cassiae in normal and acute liver injury rats.
Topics: Administration, Oral; Animals; Anthraquinones; Cassia; Chemical and Drug Induced Liver Injury; Drugs | 2019 |
Emodin weakens liver inflammatory injury triggered by lipopolysaccharide through elevating microRNA-145 in vitro and in vivo.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Emodin; Female; Inflammation; Lipopolysa | 2019 |
[Study on hepatotoxicity of physcion based on liver metabolism in vitro].
Topics: Animals; Chemical and Drug Induced Liver Injury; Emodin; Glucuronosyltransferase; Kinetics; Microsom | 2019 |
Hepatotoxic assessment of Polygoni Multiflori Radix extract and toxicokinetic study of stilbene glucoside and anthraquinones in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Emodin; Glucosides; Liver; Male; Plant Extracts; Pl | 2015 |
[Application of ultra high performance liquid chromatography-mass spectrometry to metabolomics study of drug-induced hepatotoxicity].
Topics: Acetaminophen; Aristolochic Acids; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced | 2015 |
[Effect and mechanism of emodin on cholestatic hepatitis].
Topics: 1-Naphthylisothiocyanate; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; | 2009 |
[Studies on the chemical constituents of Kalimeris indica].
Topics: Anthraquinones; Anti-Inflammatory Agents; Asteraceae; Benzaldehydes; Carbon Tetrachloride; Cell Surv | 2010 |
Hepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori Praeparata.
Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Cell Line; Cell Proliferati | 2011 |
A comparative study on the tissue distributions of rhubarb anthraquinones in normal and CCl4-injured rats orally administered rhubarb extract.
Topics: Administration, Oral; Animals; Anthraquinones; Carbon Tetrachloride; Chemical and Drug Induced Liver | 2011 |
In vivo antioxidant action of a lignan-enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodin.
Topics: Alanine Transaminase; alpha-Tocopherol; Animals; Antioxidants; Carbon Tetrachloride; Chemical and Dr | 2002 |
Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride.
Topics: Albumins; Animals; Anthraquinones; Antineoplastic Agents; Aspartate Aminotransferases; Blotting, Nor | 2000 |