emerimicins and Pancreatic-Neoplasms

Leucinostatin Y, a new peptaibiotic, was isolated from the culture broth of the entomoparasitic fungus Purpureocillium lilacinum 40-H-28. The planar structure was elucidated by detailed analysis of its NMR and MS/MS data. The absolute configurations of the amino acids were partially determined by an advanced Marfey's method. The biological activities of leucinostatin Y were assessed using human pancreatic cancer cells, revealing the importance of the C-terminus of leucinostatins for preferential cytotoxicity to cancer cells under glucose-deprived conditions and inhibition of mitochondrial function.

Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; Magnetic Resonance Spectroscopy; Paecilomyces; Pancreatic Neoplasms; Peptaibols