Page last updated: 2024-10-26

emedastine and Pruritus

emedastine has been researched along with Pruritus in 7 studies

emedastine: structure given in first source
emedastine : 1-Methyl-1,4-diazepane in which the hydrogen attached to the nitrogen at position 4 is substituted by a 1-(2-ethoxyethyl)-1H-benzimidazol-2-yl group. A relatively selective histamine H1 antagonist, it is used as the difumatate salt for allergic rhinitis, urticaria, and pruritic skin disorders, and in eyedrops for the symptomatic relief of allergic conjuntivitis.

Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.

Research Excerpts

ExcerptRelevanceReference
"We aimed to compare the clinical efficacy and ocular surface variables of olopatadine, ketotifen fumarate, epinastine, emedastine and fluorometholone acetate ophthalmic solutions in preventing the signs and symptoms of seasonal allergic conjunctivitis (SAC)."9.14Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial. ( Akman, A; Akova, YA; Borazan, M; Erbek, SS; Karalezli, A; Kiyici, H, 2009)
" The aims of the present study were to establish whether there is a rapid effect of eyedrops containing the selective H1 receptor blocker emedastine on acute seasonal allergic conjunctivitis and, if so, the time required for this effect to develop."9.10[Effects of emedastine eyedrops on acute seasonal allergic conjunctivitis in children]. ( Endre, L, 2003)
"In a prospective, multicenter, randomized, double-masked, parallel group study, 222 patients with allergic conjunctivitis were randomized (221 received treatment) to either emedastine or levocabastine, instilled twice daily for 6 weeks."9.09Clinical evaluation of twice-daily emedastine 0.05% eye drops (Emadine eye drops) versus levocabastine 0.05% eye drops in patients with allergic conjunctivitis. ( Abrantes, P; Apel, AJ; Brancato, R; Carmichael, TR; Cerqueti, PM; Ciprandi, G; Coroneo, MT; Coster, DJ; Easty, DL; Estivin-Ebrardt, C; Harrisberg, CJ; Kent-Smith, BT; Knorr, M; Leonardi, A; Martinez, M; Modorati, G; Nemeth-Wasmer, G; Partouche, P; Secchi, A; Verin, P, 2001)
"During the first experiment 20 children (suffering from acute seasonal allergic conjunctivitis) had received Emadine eye drop (containing emedastine difumarate, an H1 antihistamine agent)."7.74[The prompt effect of emedastine eye drop and the safety of its permanent use in children suffering from acute seasonal allergic conjunctivitis]. ( Endre, L, 2007)
"We aimed to compare the clinical efficacy and ocular surface variables of olopatadine, ketotifen fumarate, epinastine, emedastine and fluorometholone acetate ophthalmic solutions in preventing the signs and symptoms of seasonal allergic conjunctivitis (SAC)."5.14Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial. ( Akman, A; Akova, YA; Borazan, M; Erbek, SS; Karalezli, A; Kiyici, H, 2009)
" The aims of the present study were to establish whether there is a rapid effect of eyedrops containing the selective H1 receptor blocker emedastine on acute seasonal allergic conjunctivitis and, if so, the time required for this effect to develop."5.10[Effects of emedastine eyedrops on acute seasonal allergic conjunctivitis in children]. ( Endre, L, 2003)
"The results of this study suggest that emedastine and ketotifen are not significantly different with respect to anti-itching efficacy in the CAC model of acute allergic conjunctivitis."5.10Randomized, double-masked, placebo-controlled comparison of the efficacy of emedastine difumarate 0.05% ophthalmic solution and ketotifen fumarate 0.025% ophthalmic solution in the human conjunctival allergen challenge model. ( Bensch, G; D'Arienzo, PA; Leonardi, A, 2002)
"In a prospective, multicenter, randomized, double-masked, parallel group study, 222 patients with allergic conjunctivitis were randomized (221 received treatment) to either emedastine or levocabastine, instilled twice daily for 6 weeks."5.09Clinical evaluation of twice-daily emedastine 0.05% eye drops (Emadine eye drops) versus levocabastine 0.05% eye drops in patients with allergic conjunctivitis. ( Abrantes, P; Apel, AJ; Brancato, R; Carmichael, TR; Cerqueti, PM; Ciprandi, G; Coroneo, MT; Coster, DJ; Easty, DL; Estivin-Ebrardt, C; Harrisberg, CJ; Kent-Smith, BT; Knorr, M; Leonardi, A; Martinez, M; Modorati, G; Nemeth-Wasmer, G; Partouche, P; Secchi, A; Verin, P, 2001)
"During the first experiment 20 children (suffering from acute seasonal allergic conjunctivitis) had received Emadine eye drop (containing emedastine difumarate, an H1 antihistamine agent)."3.74[The prompt effect of emedastine eye drop and the safety of its permanent use in children suffering from acute seasonal allergic conjunctivitis]. ( Endre, L, 2007)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Borazan, M1
Karalezli, A1
Akova, YA1
Akman, A1
Kiyici, H1
Erbek, SS1
Endre, L2
Andoh, T1
Kuraishi, Y1
Verin, P1
Easty, DL1
Secchi, A1
Ciprandi, G1
Partouche, P1
Nemeth-Wasmer, G1
Brancato, R1
Harrisberg, CJ1
Estivin-Ebrardt, C1
Coster, DJ1
Apel, AJ1
Coroneo, MT1
Knorr, M1
Carmichael, TR1
Kent-Smith, BT1
Abrantes, P1
Leonardi, A2
Cerqueti, PM1
Modorati, G1
Martinez, M1
Takizawa, T1
Matsumoto, J1
Tohma, T1
Kanke, T1
Wada, Y1
Nagao, M1
Inagaki, N1
Nagai, H1
Zhang, MQ1
Timmerman, H1
D'Arienzo, PA1
Bensch, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Controlled Trial Comparing Olopatadine 0.1% Ophthalmic Solution With Hylo-Dual Ophthalmic Preparation in Children With Seasonal Allergic Conjunctivitis[NCT03186755]Phase 442 participants (Anticipated)Interventional2017-06-11Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

4 trials available for emedastine and Pruritus

ArticleYear
Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial.
    Acta ophthalmologica, 2009, Volume: 87, Issue:5

    Topics: Adolescent; Adult; Anti-Allergic Agents; Benzimidazoles; Child; Conjunctival Diseases; Conjunctiviti

2009
[Effects of emedastine eyedrops on acute seasonal allergic conjunctivitis in children].
    Orvosi hetilap, 2003, Apr-06, Volume: 144, Issue:14

    Topics: Acute Disease; Adolescent; Adult; Ambrosia; Anti-Allergic Agents; Benzimidazoles; Child; Child, Pres

2003
Clinical evaluation of twice-daily emedastine 0.05% eye drops (Emadine eye drops) versus levocabastine 0.05% eye drops in patients with allergic conjunctivitis.
    American journal of ophthalmology, 2001, Volume: 131, Issue:6

    Topics: Adolescent; Adult; Aged; Benzimidazoles; Child; Child, Preschool; Conjunctivitis, Allergic; Double-B

2001
Randomized, double-masked, placebo-controlled comparison of the efficacy of emedastine difumarate 0.05% ophthalmic solution and ketotifen fumarate 0.025% ophthalmic solution in the human conjunctival allergen challenge model.
    Clinical therapeutics, 2002, Volume: 24, Issue:3

    Topics: Allergens; Anti-Allergic Agents; Benzimidazoles; Conjunctivitis; Double-Blind Method; Eye Color; Fem

2002

Other Studies

3 other studies available for emedastine and Pruritus

ArticleYear
[The prompt effect of emedastine eye drop and the safety of its permanent use in children suffering from acute seasonal allergic conjunctivitis].
    Orvosi hetilap, 2007, Feb-11, Volume: 148, Issue:6

    Topics: Acute Disease; Adolescent; Adult; Anti-Allergic Agents; Benzimidazoles; Child; Conjunctivitis, Aller

2007
Involvement of blockade of leukotriene B(4) action in anti-pruritic effects of emedastine in mice.
    European journal of pharmacology, 2000, Oct-06, Volume: 406, Issue:1

    Topics: Animals; Anti-Allergic Agents; Benzimidazoles; Dose-Response Relationship, Drug; Histamine; Injectio

2000
VUF-K-8788, a periphery-selective histamine H1 antagonist with anti-pruritic activities.
    Japanese journal of pharmacology, 2001, Volume: 86, Issue:1

    Topics: Animals; Anti-Allergic Agents; Behavior, Animal; Benzimidazoles; Capillary Permeability; Guinea Pigs

2001