emedastine has been researched along with Muscle Contraction in 6 studies
emedastine: structure given in first source
emedastine : 1-Methyl-1,4-diazepane in which the hydrogen attached to the nitrogen at position 4 is substituted by a 1-(2-ethoxyethyl)-1H-benzimidazol-2-yl group. A relatively selective histamine H1 antagonist, it is used as the difumatate salt for allergic rhinitis, urticaria, and pruritic skin disorders, and in eyedrops for the symptomatic relief of allergic conjuntivitis.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Emedastine was determined by the receptor assay after the separation from its metabolites by the use of high-performance liquid chromatography (HPLC)." | 1.28 | [Selective and sensitive determination of an antiallergic agent, emedastine difumarate (KG-2413), in human plasma by the radioreceptor assay combined with a high-performance liquid chromatography]. ( Awata, N; Hamada, T; Kawashima, T, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iemura, R | 3 |
| Kawashima, T | 3 |
| Fukuda, T | 3 |
| Ito, K | 2 |
| Tsukamoto, G | 2 |
| Morimoto, Y | 2 |
| Takizawa, T | 1 |
| Matsumoto, J | 1 |
| Tohma, T | 1 |
| Kanke, T | 1 |
| Wada, Y | 1 |
| Nagao, M | 1 |
| Inagaki, N | 1 |
| Nagai, H | 1 |
| Zhang, MQ | 1 |
| Timmerman, H | 1 |
| Hori, M | 1 |
| Ohtaka, H | 1 |
| Hamada, T | 1 |
| Awata, N | 1 |
| Saito, T | 1 |
| Tajima, S | 1 |
| Sukamoto, T | 1 |
| Yamashita, A | 1 |
| Kanazawa, T | 1 |
| Shimohara, K | 1 |
| Nishimura, N | 1 |
| Yokota, K | 1 |
6 other studies available for emedastine and Muscle Contraction
| Article | Year |
|---|---|
Synthesis of 2-(4-substituted-1-piperazinyl)benzimidazoles as H1-antihistaminic agents.
Topics: Animals; Benzimidazoles; Guinea Pigs; Histamine; Histamine H1 Antagonists; In Vitro Techniques; Indi | 1986 |
Effect of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)-benzimida zole difumarate (KB-2413), a new antiallergic, on chemical mediators.
Topics: Acetylcholine; Airway Resistance; Animals; Benzimidazoles; Bradykinin; Capillary Permeability; Guine | 1984 |
VUF-K-8788, a periphery-selective histamine H1 antagonist with anti-pruritic activities.
Topics: Animals; Anti-Allergic Agents; Behavior, Animal; Benzimidazoles; Capillary Permeability; Guinea Pigs | 2001 |
Syntheses of the metabolites of 1-(2-ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-1H benzimidazole difumarate (KG-2413) and related compounds.
Topics: Animals; Benzimidazoles; Chemical Phenomena; Chemistry; Guinea Pigs; Histamine H1 Antagonists; In Vi | 1989 |
[Selective and sensitive determination of an antiallergic agent, emedastine difumarate (KG-2413), in human plasma by the radioreceptor assay combined with a high-performance liquid chromatography].
Topics: Adult; Animals; Benzimidazoles; Chromatography, High Pressure Liquid; Guinea Pigs; Histamine H1 Anta | 1989 |
General pharmacology of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate. 2nd communication: Effects on the circulation and the other systems.
Topics: Animals; Benzimidazoles; Bile; Blood Pressure; Cats; Electrocardiography; Female; Gastrointestinal T | 1988 |