emedastine has been researched along with Hypersensitivity in 7 studies
emedastine: structure given in first source
emedastine : 1-Methyl-1,4-diazepane in which the hydrogen attached to the nitrogen at position 4 is substituted by a 1-(2-ethoxyethyl)-1H-benzimidazol-2-yl group. A relatively selective histamine H1 antagonist, it is used as the difumatate salt for allergic rhinitis, urticaria, and pruritic skin disorders, and in eyedrops for the symptomatic relief of allergic conjuntivitis.
Hypersensitivity: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results of this study suggest that emedastine and ketotifen are not significantly different with respect to anti-itching efficacy in the CAC model of acute allergic conjunctivitis." | 5.10 | Randomized, double-masked, placebo-controlled comparison of the efficacy of emedastine difumarate 0.05% ophthalmic solution and ketotifen fumarate 0.025% ophthalmic solution in the human conjunctival allergen challenge model. ( Bensch, G; D'Arienzo, PA; Leonardi, A, 2002) |
| "Although additional evidence is required, emerging evidence suggests that emedastine difumarate may be of value in the prevention of excess tissue remodeling in allergic skin inflammation." | 4.85 | Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases. ( Katayama, I; Murota, H, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Murota, H | 1 |
| Katayama, I | 1 |
| Fukuda, T | 2 |
| Saito, T | 2 |
| Tajima, S | 2 |
| Shimohara, K | 1 |
| Ito, K | 3 |
| Sharif, NA | 1 |
| Xu, SX | 1 |
| Magnino, PE | 1 |
| Pang, IH | 1 |
| Okubo, K | 1 |
| Pawankar, R | 1 |
| Gotoh, M | 1 |
| Yagi, T | 1 |
| D'Arienzo, PA | 1 |
| Leonardi, A | 1 |
| Bensch, G | 1 |
| Nishimura, N | 2 |
| Tomioka, H | 1 |
| Yoshida, S | 1 |
1 review available for emedastine and Hypersensitivity
| Article | Year |
|---|---|
Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases.
Topics: Animals; Anti-Allergic Agents; Benzimidazoles; Clinical Trials as Topic; Humans; Hypersensitivity; I | 2009 |
1 trial available for emedastine and Hypersensitivity
| Article | Year |
|---|---|
Randomized, double-masked, placebo-controlled comparison of the efficacy of emedastine difumarate 0.05% ophthalmic solution and ketotifen fumarate 0.025% ophthalmic solution in the human conjunctival allergen challenge model.
Topics: Allergens; Anti-Allergic Agents; Benzimidazoles; Conjunctivitis; Double-Blind Method; Eye Color; Fem | 2002 |
5 other studies available for emedastine and Hypersensitivity
| Article | Year |
|---|---|
Antiallergic effect of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidaz ole difumarate (KB-2413).
Topics: Anaphylaxis; Animals; Benzimidazoles; Capillary Permeability; Guinea Pigs; Histamine; Histamine H1 A | 1984 |
Human conjunctival epithelial cells express histamine-1 receptors coupled to phosphoinositide turnover and intracellular calcium mobilization: role in ocular allergic and inflammatory diseases.
Topics: Benzimidazoles; Calcium; Cells, Cultured; Chromatography, Ion Exchange; Conjunctiva; Cytokines; Epit | 1996 |
Adhesive explant culture of allergic nasal mucosa: effect of emedastine difumarate, an anti-allergic drug.
Topics: Anti-Allergic Agents; Basophils; Benzimidazoles; Blood Proteins; Cell Count; Cell Movement; Culture | 1999 |
Inhibition of chemical mediator release from human leukocytes and lung in vitro by a novel antiallergic agent, KB-2413.
Topics: Benzimidazoles; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity; Immunoglobuli | 1987 |
[Anti-allergic effects of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole fumarate (KB-2413)].
Topics: Animals; Benzimidazoles; Guinea Pigs; Histamine H1 Antagonists; Hypersensitivity; Hypersensitivity, | 1987 |