emedastine has been researched along with Anaphylactic Reaction in 4 studies
emedastine: structure given in first source
emedastine : 1-Methyl-1,4-diazepane in which the hydrogen attached to the nitrogen at position 4 is substituted by a 1-(2-ethoxyethyl)-1H-benzimidazol-2-yl group. A relatively selective histamine H1 antagonist, it is used as the difumatate salt for allergic rhinitis, urticaria, and pruritic skin disorders, and in eyedrops for the symptomatic relief of allergic conjuntivitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effects of KB-2413 on experimental asthma and respiration were examined in comparison with ketotifen and chlorpheniramine in guinea pigs." | 3.67 | Antiasthmatic effect of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidaz ole difumarate (KB-2413), a new antiallergic. ( Fukuda, T; Ito, K; Saito, T, 1984) |
| " Comparisons of relative potency 30 min post dosing between emedastine and other anti-histamines demonstrated that emedastine is equipotent to ketotifen, and 7, 7, 10, 10, 100, 357, 3333, and 5813 times more potent than brompheniramine, chlorpheniramine, clemastine, pyrilamine, levocabastine, pheniramine, diphenhydramine, and antazoline, respectively." | 1.29 | Preclinical efficacy of emedastine, a potent, selective histamine H1 antagonist for topical ocular use. ( Parnell, DW; Spellman, JM; Stephens, DJ; Yanni, JM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukuda, T | 2 |
| Saito, T | 3 |
| Ito, K | 3 |
| Tajima, S | 1 |
| Shimohara, K | 1 |
| Hagihara, A | 1 |
| Igarashi, N | 1 |
| Matsuda, N | 1 |
| Yamashita, A | 1 |
| Mio, M | 1 |
| Tasaka, K | 1 |
| Yanni, JM | 1 |
| Stephens, DJ | 1 |
| Parnell, DW | 1 |
| Spellman, JM | 1 |
4 other studies available for emedastine and Anaphylactic Reaction
| Article | Year |
|---|---|
Antiasthmatic effect of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidaz ole difumarate (KB-2413), a new antiallergic.
Topics: Airway Resistance; Anaphylaxis; Animals; Asthma; Benzimidazoles; Chlorpheniramine; Guinea Pigs; Hist | 1984 |
Antiallergic effect of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidaz ole difumarate (KB-2413).
Topics: Anaphylaxis; Animals; Benzimidazoles; Capillary Permeability; Guinea Pigs; Histamine; Histamine H1 A | 1984 |
Inhibitory effects of emedastine difumarate on histamine release.
Topics: Anaphylaxis; Animals; Benzimidazoles; Calcium; Female; Guinea Pigs; Histamine H1 Antagonists; Histam | 1993 |
Preclinical efficacy of emedastine, a potent, selective histamine H1 antagonist for topical ocular use.
Topics: Administration, Topical; Anaphylaxis; Animals; Benzimidazoles; Capillary Permeability; Conjunctiva; | 1994 |