embelin has been researched along with Pancreatic Neoplasms in 6 studies
embelin: from Embelia fruit (Myrsinaceae)
embelin : A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Embelin inhibited pancreatic cancer growth in Kras(G12D) mice by modulating tumor immune microenvironment where CTL, NKT, γδT, NK, and IFNγ (Th1 type) cells were up-regulated, and Th17, PMN-MDSC, IL-6 and IL-8 (Th2 type) immune cells were inhibited." | 1.40 | Embelin suppresses pancreatic cancer growth by modulating tumor immune microenvironment. ( Jackman, CP; Marsh, JL; Shankar, S; Srivastava, RK; Tang, SN, 2014) |
| "Embelin-treated mice showed significant inhibition in tumor growth which was associated with reduced expression of markers of cell proliferation (Ki67, PCNA and Bcl-2) and cell cycle (cyclin D1, CDK2, and CDK6), and induction of apoptosis (activation of caspase-3 and cleavage of PARP, and increased expression of Bax)." | 1.40 | Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways. ( Huang, M; Jackman, CP; Marsh, JL; Shankar, S; Srivastava, RK; Tang, SN; Upadhyay, G, 2014) |
| "Pancreatic cancer is an aggressive malignancy and unresponsive to conventional chemotherapies." | 1.40 | Embelin inhibits pancreatic cancer progression by directly inducing cancer cell apoptosis and indirectly restricting IL-6 associated inflammatory and immune suppressive cells. ( Cheng, X; Da, Y; Dai, Y; Fu, S; Huang, B; Peng, M; Qiao, L; Wang, D; Wu, X; Xue, Z; Yang, Q; Yao, Z; Zhang, D; Zhang, L; Zhang, Q; Zhang, R, 2014) |
| "Embelin is a benzoquinone phytochemical isolated from the Japanese herb Ardisiae Japonicae and has been shown to induce apoptosis in cancer cells." | 1.39 | Ellagic acid and embelin affect key cellular components of pancreatic adenocarcinoma, cancer, and stellate cells. ( Edderkaoui, M; Eibl, G; Go, VL; Hui, H; Li, G; Lu, QY; Lu, X; Lugea, A; Moro, A; Pandol, SJ, 2013) |
| "We previously reported that a number of pancreatic cancer cell lines show resistance to TRAIL-induced apoptosis via overexpression of XIAP and FLIP." | 1.34 | Effect of the XIAP inhibitor Embelin on TRAIL-induced apoptosis of pancreatic cancer cells. ( Doi, R; Ito, D; Kami, K; Kawaguchi, Y; Kida, A; Mori, T; Nagai, K; Toyoda, E; Uemoto, S, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Nakajima, K | 1 |
| Ino, Y | 1 |
| Yamazaki-Itoh, R | 1 |
| Naito, C | 1 |
| Shimasaki, M | 1 |
| Takahashi, M | 1 |
| Esaki, M | 1 |
| Nara, S | 1 |
| Kishi, Y | 1 |
| Shimada, K | 1 |
| Hiraoka, N | 1 |
| Edderkaoui, M | 1 |
| Lugea, A | 1 |
| Hui, H | 1 |
| Eibl, G | 1 |
| Lu, QY | 1 |
| Moro, A | 1 |
| Lu, X | 1 |
| Li, G | 1 |
| Go, VL | 1 |
| Pandol, SJ | 1 |
| Marsh, JL | 2 |
| Jackman, CP | 2 |
| Tang, SN | 2 |
| Shankar, S | 2 |
| Srivastava, RK | 2 |
| Huang, M | 1 |
| Upadhyay, G | 1 |
| Peng, M | 1 |
| Huang, B | 1 |
| Zhang, Q | 1 |
| Fu, S | 1 |
| Wang, D | 1 |
| Cheng, X | 1 |
| Wu, X | 1 |
| Xue, Z | 1 |
| Zhang, L | 1 |
| Zhang, D | 1 |
| Da, Y | 1 |
| Dai, Y | 1 |
| Yang, Q | 1 |
| Yao, Z | 1 |
| Qiao, L | 1 |
| Zhang, R | 1 |
| Mori, T | 1 |
| Doi, R | 1 |
| Kida, A | 1 |
| Nagai, K | 1 |
| Kami, K | 1 |
| Ito, D | 1 |
| Toyoda, E | 1 |
| Kawaguchi, Y | 1 |
| Uemoto, S | 1 |
6 other studies available for embelin and Pancreatic Neoplasms
| Article | Year |
|---|---|
IAP inhibitor, Embelin increases VCAM-1 levels on the endothelium, producing lymphocytic infiltration and antitumor immunity.
Topics: Benzoquinones; Endothelial Cells; Endothelium; Humans; Pancreatic Neoplasms; Vascular Cell Adhesion | 2020 |
Ellagic acid and embelin affect key cellular components of pancreatic adenocarcinoma, cancer, and stellate cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Benzoquinones; Cell Line, Tumor; Cell Prolife | 2013 |
Ellagic acid and embelin affect key cellular components of pancreatic adenocarcinoma, cancer, and stellate cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Benzoquinones; Cell Line, Tumor; Cell Prolife | 2013 |
Ellagic acid and embelin affect key cellular components of pancreatic adenocarcinoma, cancer, and stellate cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Benzoquinones; Cell Line, Tumor; Cell Prolife | 2013 |
Ellagic acid and embelin affect key cellular components of pancreatic adenocarcinoma, cancer, and stellate cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Benzoquinones; Cell Line, Tumor; Cell Prolife | 2013 |
Embelin suppresses pancreatic cancer growth by modulating tumor immune microenvironment.
Topics: Animals; Benzoquinones; Blotting, Western; Cell Division; Cell Line, Tumor; Flow Cytometry; Heterogr | 2014 |
Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways.
Topics: Animals; Benzoquinones; Cell Line, Tumor; Hedgehog Proteins; Heterografts; Humans; Mice; Mice, Inbre | 2014 |
Embelin inhibits pancreatic cancer progression by directly inducing cancer cell apoptosis and indirectly restricting IL-6 associated inflammatory and immune suppressive cells.
Topics: Animals; Apoptosis; Benzoquinones; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Mode | 2014 |
Effect of the XIAP inhibitor Embelin on TRAIL-induced apoptosis of pancreatic cancer cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Benzoquinones; CASP8 and FADD-Like Apoptosis Regulating Pr | 2007 |