embelin has been researched along with Neoplasm Metastasis in 4 studies
embelin: from Embelia fruit (Myrsinaceae)
embelin : A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease.
Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Embelin-treated mice showed significant inhibition in tumor growth which was associated with reduced expression of markers of cell proliferation (Ki67, PCNA and Bcl-2) and cell cycle (cyclin D1, CDK2, and CDK6), and induction of apoptosis (activation of caspase-3 and cleavage of PARP, and increased expression of Bax)." | 1.40 | Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways. ( Huang, M; Jackman, CP; Marsh, JL; Shankar, S; Srivastava, RK; Tang, SN; Upadhyay, G, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sumalatha, KR | 1 |
| Abiramasundari, G | 1 |
| Chetan, GK | 1 |
| Divya, T | 1 |
| Sudhandiran, G | 1 |
| Sreepriya, M | 1 |
| Huang, M | 1 |
| Tang, SN | 1 |
| Upadhyay, G | 1 |
| Marsh, JL | 1 |
| Jackman, CP | 1 |
| Shankar, S | 1 |
| Srivastava, RK | 1 |
| Dhanjal, JK | 1 |
| Nigam, N | 2 |
| Sharma, S | 1 |
| Chaudhary, A | 1 |
| Kaul, SC | 2 |
| Grover, A | 2 |
| Wadhwa, R | 2 |
| Goyal, S | 1 |
| Katiyar, SP | 1 |
| Bhargava, P | 1 |
| Wang, PC | 1 |
| Sundar, D | 1 |
4 other studies available for embelin and Neoplasm Metastasis
| Article | Year |
|---|---|
XIAP inhibitor and antiestrogen embelin abrogates metastasis and augments apoptosis in estrogen receptor positive human breast adenocarcinoma cell line MCF-7.
Topics: Adenocarcinoma; Apoptosis; Benzoquinones; Cell Proliferation; Estrogen Receptor Modulators; Female; | 2014 |
Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways.
Topics: Animals; Benzoquinones; Cell Line, Tumor; Hedgehog Proteins; Heterografts; Humans; Mice; Mice, Inbre | 2014 |
Embelin inhibits TNF-α converting enzyme and cancer cell metastasis: molecular dynamics and experimental evidence.
Topics: ADAM Proteins; ADAM17 Protein; Benzoquinones; Catalytic Domain; Cell Line, Tumor; Cell Movement; Cel | 2014 |
Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells.
Topics: Apoptosis; Benzoquinones; Blotting, Western; Breast Neoplasms; Cell Proliferation; Female; Gene Expr | 2015 |