Page last updated: 2024-10-26

embelin and Leukemia

embelin has been researched along with Leukemia in 3 studies

embelin: from Embelia fruit (Myrsinaceae)
embelin : A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"The present study was designed to explore the effects of low-toxicity Embelin on TRAIL-induced apoptosis and its possible mechanism in human leukemia cells."7.81The XIAP inhibitor Embelin enhances TRAIL-induced apoptosis in human leukemia cells by DR4 and DR5 upregulation. ( Hu, R; Jiang, H; Li, J; Liu, Z; Xu, W; Yang, Y; Zhu, K, 2015)
"The present study was undertaken to determine the molecular mechanisms by which embelin induces apoptosis in human leukemia cells."7.77Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells. ( Hu, R; Li, Y; Liu, Z; Wang, H; Yang, W; Yao, K; Zhang, R; Zhu, K, 2011)
"The present study was designed to explore the effects of low-toxicity Embelin on TRAIL-induced apoptosis and its possible mechanism in human leukemia cells."3.81The XIAP inhibitor Embelin enhances TRAIL-induced apoptosis in human leukemia cells by DR4 and DR5 upregulation. ( Hu, R; Jiang, H; Li, J; Liu, Z; Xu, W; Yang, Y; Zhu, K, 2015)
"The present study was undertaken to determine the molecular mechanisms by which embelin induces apoptosis in human leukemia cells."3.77Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells. ( Hu, R; Li, Y; Liu, Z; Wang, H; Yang, W; Yao, K; Zhang, R; Zhu, K, 2011)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Prabhu, KS1
Siveen, KS1
Kuttikrishnan, S1
Iskandarani, A1
Tsakou, M1
Achkar, IW1
Therachiyil, L1
Krishnankutty, R1
Parray, A1
Kulinski, M1
Merhi, M1
Dermime, S1
Mohammad, RM1
Uddin, S1
Hu, R2
Yang, Y1
Liu, Z2
Jiang, H1
Zhu, K2
Li, J1
Xu, W1
Li, Y1
Yao, K1
Zhang, R1
Wang, H1
Yang, W1

Other Studies

3 other studies available for embelin and Leukemia

ArticleYear
Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells.
    PloS one, 2017, Volume: 12, Issue:7

    Topics: Benzoquinones; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Drug Synergism; Gene

2017
The XIAP inhibitor Embelin enhances TRAIL-induced apoptosis in human leukemia cells by DR4 and DR5 upregulation.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:2

    Topics: Apoptosis; Benzoquinones; Caspases; Cell Proliferation; Gene Expression Regulation, Leukemic; HL-60

2015
Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells.
    Medical oncology (Northwood, London, England), 2011, Volume: 28, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Benzoquinones; Blotting, Western; Caspases; Cell Line, Tumor; Cell

2011