embelin has been researched along with Leukemia in 3 studies
embelin: from Embelia fruit (Myrsinaceae)
embelin : A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study was designed to explore the effects of low-toxicity Embelin on TRAIL-induced apoptosis and its possible mechanism in human leukemia cells." | 7.81 | The XIAP inhibitor Embelin enhances TRAIL-induced apoptosis in human leukemia cells by DR4 and DR5 upregulation. ( Hu, R; Jiang, H; Li, J; Liu, Z; Xu, W; Yang, Y; Zhu, K, 2015) |
| "The present study was undertaken to determine the molecular mechanisms by which embelin induces apoptosis in human leukemia cells." | 7.77 | Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells. ( Hu, R; Li, Y; Liu, Z; Wang, H; Yang, W; Yao, K; Zhang, R; Zhu, K, 2011) |
| "The present study was designed to explore the effects of low-toxicity Embelin on TRAIL-induced apoptosis and its possible mechanism in human leukemia cells." | 3.81 | The XIAP inhibitor Embelin enhances TRAIL-induced apoptosis in human leukemia cells by DR4 and DR5 upregulation. ( Hu, R; Jiang, H; Li, J; Liu, Z; Xu, W; Yang, Y; Zhu, K, 2015) |
| "The present study was undertaken to determine the molecular mechanisms by which embelin induces apoptosis in human leukemia cells." | 3.77 | Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells. ( Hu, R; Li, Y; Liu, Z; Wang, H; Yang, W; Yao, K; Zhang, R; Zhu, K, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prabhu, KS | 1 |
| Siveen, KS | 1 |
| Kuttikrishnan, S | 1 |
| Iskandarani, A | 1 |
| Tsakou, M | 1 |
| Achkar, IW | 1 |
| Therachiyil, L | 1 |
| Krishnankutty, R | 1 |
| Parray, A | 1 |
| Kulinski, M | 1 |
| Merhi, M | 1 |
| Dermime, S | 1 |
| Mohammad, RM | 1 |
| Uddin, S | 1 |
| Hu, R | 2 |
| Yang, Y | 1 |
| Liu, Z | 2 |
| Jiang, H | 1 |
| Zhu, K | 2 |
| Li, J | 1 |
| Xu, W | 1 |
| Li, Y | 1 |
| Yao, K | 1 |
| Zhang, R | 1 |
| Wang, H | 1 |
| Yang, W | 1 |
3 other studies available for embelin and Leukemia
| Article | Year |
|---|---|
Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells.
Topics: Benzoquinones; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Drug Synergism; Gene | 2017 |
The XIAP inhibitor Embelin enhances TRAIL-induced apoptosis in human leukemia cells by DR4 and DR5 upregulation.
Topics: Apoptosis; Benzoquinones; Caspases; Cell Proliferation; Gene Expression Regulation, Leukemic; HL-60 | 2015 |
Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; Benzoquinones; Blotting, Western; Caspases; Cell Line, Tumor; Cell | 2011 |