embelin has been researched along with Innate Inflammatory Response in 13 studies
embelin: from Embelia fruit (Myrsinaceae)
embelin : A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study was designed to investigate the effect of embelin in metabolic endotoxemia (ME) mediated inflammation and associated obesity in high fat diet (HFD)-fed C57BL/6 mice." | 8.02 | Embelin modulates metabolic endotoxemia and associated obesity in high fat diet fed C57BL/6 mice. ( Arya, P; Bansal, P; Bhandari, U; Sharma, K, 2021) |
| "To investigate the effect of Embelin, an inhibitor of X-Linked Inhibitor of Apoptosis Protein (XIAP), on inflammation and bone erosion in a collagen antibody induced arthritis (CAIA) in mice." | 7.81 | The X-Linked Inhibitor of Apoptosis Protein Inhibitor Embelin Suppresses Inflammation and Bone Erosion in Collagen Antibody Induced Arthritis Mice. ( Cantley, MD; Crotti, TN; Dharmapatni, AA; Haynes, DR; Marino, V; Perilli, E; Smith, MD, 2015) |
| " The present study was designed to investigate the effects of embelin on lipopolysachharide induced TNF-α production in mice and in human keratinocytes in vitro and also to study the effect of embelin on acute and chronic skin inflammation in mice." | 7.77 | Embelin reduces cutaneous TNF-α level and ameliorates skin edema in acute and chronic model of skin inflammation in mice. ( Ashfaque, M; Dhamotharan, R; Gunasekaran, J; Kalyan Kumar, G; Kulkarni, NM; Mahat, MY, 2011) |
| "Embelin treatment caused inhibitory effects on the IL-1β-stimulated production of COX-2, IL-6, IL-8, and TNF-α, which were abolished by LY294002 treatment." | 5.91 | Embelin protects against apoptosis and inflammation by regulating PI3K/Akt signaling in IL-1β-stimulated human nucleus pulposus cells. ( Bai, X; Ding, S; Guo, S; Jiang, M; Mu, W; Pei, B; Wang, J; Yang, S; Yao, M; Zhang, M; Zhu, X, 2023) |
| "Embelin treatment demonstrated a significant curtailment of oxidative stress as well as increased the activities of antioxidant enzymes, endogenously." | 5.51 | Embelin attenuates cisplatin-induced nephrotoxicity: Involving inhibition of oxidative stress and inflammation in addition with activation of Nrf-2/Ho-1 pathway. ( Gowthami, M; Honeyshmitha, D; Krishna, CG; Manasa, J; Meghana, K; Qin, X; Sita, GJA; Sowjanya, NL; SreeHarsha, N; Srikanth, G; Sushma, KR, 2019) |
| "Embelin has been reported to suppress cytokine expressions in inflammatory disorders." | 5.42 | Embelin Reduces Systemic Inflammation and Ameliorates Organ Injuries in Septic Rats Through Downregulating STAT3 and NF-κB Pathways. ( Cao, J; Huang, L; Zhou, XL, 2015) |
| "The present study was designed to investigate the effect of embelin in metabolic endotoxemia (ME) mediated inflammation and associated obesity in high fat diet (HFD)-fed C57BL/6 mice." | 4.02 | Embelin modulates metabolic endotoxemia and associated obesity in high fat diet fed C57BL/6 mice. ( Arya, P; Bansal, P; Bhandari, U; Sharma, K, 2021) |
| "To investigate the effect of Embelin, an inhibitor of X-Linked Inhibitor of Apoptosis Protein (XIAP), on inflammation and bone erosion in a collagen antibody induced arthritis (CAIA) in mice." | 3.81 | The X-Linked Inhibitor of Apoptosis Protein Inhibitor Embelin Suppresses Inflammation and Bone Erosion in Collagen Antibody Induced Arthritis Mice. ( Cantley, MD; Crotti, TN; Dharmapatni, AA; Haynes, DR; Marino, V; Perilli, E; Smith, MD, 2015) |
| " The present study was designed to investigate the effects of embelin on lipopolysachharide induced TNF-α production in mice and in human keratinocytes in vitro and also to study the effect of embelin on acute and chronic skin inflammation in mice." | 3.77 | Embelin reduces cutaneous TNF-α level and ameliorates skin edema in acute and chronic model of skin inflammation in mice. ( Ashfaque, M; Dhamotharan, R; Gunasekaran, J; Kalyan Kumar, G; Kulkarni, NM; Mahat, MY, 2011) |
| "Embelin treatment caused inhibitory effects on the IL-1β-stimulated production of COX-2, IL-6, IL-8, and TNF-α, which were abolished by LY294002 treatment." | 1.91 | Embelin protects against apoptosis and inflammation by regulating PI3K/Akt signaling in IL-1β-stimulated human nucleus pulposus cells. ( Bai, X; Ding, S; Guo, S; Jiang, M; Mu, W; Pei, B; Wang, J; Yang, S; Yao, M; Zhang, M; Zhu, X, 2023) |
| "Embelin treatment significantly decreased MDA and increased SOD, CAT, and GSH Px." | 1.56 | Embelin impact on paraquat-induced lung injury through suppressing oxidative stress, inflammatory cascade, and MAPK/NF-κB signaling pathway. ( SreeHarsha, N, 2020) |
| "Embelin is an active component isolated from Embelia ribes Burm." | 1.51 | Embelin can protect mice from thioacetamide-induced acute liver injury. ( Wang, D; Wang, H; Wang, Y; Yang, L; Zhang, H, 2019) |
| "Embelin treatment demonstrated a significant curtailment of oxidative stress as well as increased the activities of antioxidant enzymes, endogenously." | 1.51 | Embelin attenuates cisplatin-induced nephrotoxicity: Involving inhibition of oxidative stress and inflammation in addition with activation of Nrf-2/Ho-1 pathway. ( Gowthami, M; Honeyshmitha, D; Krishna, CG; Manasa, J; Meghana, K; Qin, X; Sita, GJA; Sowjanya, NL; SreeHarsha, N; Srikanth, G; Sushma, KR, 2019) |
| "Embelin has been reported to suppress cytokine expressions in inflammatory disorders." | 1.42 | Embelin Reduces Systemic Inflammation and Ameliorates Organ Injuries in Septic Rats Through Downregulating STAT3 and NF-κB Pathways. ( Cao, J; Huang, L; Zhou, XL, 2015) |
| "Pancreatic cancer is an aggressive malignancy and unresponsive to conventional chemotherapies." | 1.40 | Embelin inhibits pancreatic cancer progression by directly inducing cancer cell apoptosis and indirectly restricting IL-6 associated inflammatory and immune suppressive cells. ( Cheng, X; Da, Y; Dai, Y; Fu, S; Huang, B; Peng, M; Qiao, L; Wang, D; Wu, X; Xue, Z; Yang, Q; Yao, Z; Zhang, D; Zhang, L; Zhang, Q; Zhang, R, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (69.23) | 24.3611 |
| 2020's | 4 (30.77) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Khan, H | 1 |
| Rengasamy, KRR | 1 |
| Pervaiz, A | 1 |
| Nabavi, SM | 1 |
| Atanasov, AG | 1 |
| Kamal, MA | 1 |
| Bai, X | 1 |
| Wang, J | 1 |
| Ding, S | 1 |
| Yang, S | 1 |
| Pei, B | 1 |
| Yao, M | 1 |
| Zhu, X | 1 |
| Jiang, M | 1 |
| Zhang, M | 1 |
| Mu, W | 1 |
| Guo, S | 1 |
| Wang, H | 1 |
| Zhang, H | 1 |
| Wang, Y | 1 |
| Yang, L | 1 |
| Wang, D | 2 |
| SreeHarsha, N | 2 |
| Khare, T | 1 |
| Palakurthi, SS | 1 |
| Shah, BM | 1 |
| Palakurthi, S | 1 |
| Khare, S | 1 |
| Bansal, P | 1 |
| Bhandari, U | 1 |
| Sharma, K | 1 |
| Arya, P | 1 |
| Wang, B | 1 |
| Chen, X | 1 |
| Zhou, T | 1 |
| Wang, X | 1 |
| Qin, X | 1 |
| Meghana, K | 1 |
| Sowjanya, NL | 1 |
| Sushma, KR | 1 |
| Krishna, CG | 1 |
| Manasa, J | 1 |
| Sita, GJA | 1 |
| Gowthami, M | 1 |
| Honeyshmitha, D | 1 |
| Srikanth, G | 1 |
| Peng, M | 1 |
| Huang, B | 1 |
| Zhang, Q | 1 |
| Fu, S | 1 |
| Cheng, X | 1 |
| Wu, X | 1 |
| Xue, Z | 1 |
| Zhang, L | 1 |
| Zhang, D | 1 |
| Da, Y | 1 |
| Dai, Y | 1 |
| Yang, Q | 1 |
| Yao, Z | 1 |
| Qiao, L | 1 |
| Zhang, R | 1 |
| Zhou, XL | 1 |
| Huang, L | 1 |
| Cao, J | 1 |
| Dharmapatni, AA | 1 |
| Cantley, MD | 1 |
| Marino, V | 1 |
| Perilli, E | 1 |
| Crotti, TN | 1 |
| Smith, MD | 1 |
| Haynes, DR | 1 |
| Kalyan Kumar, G | 1 |
| Dhamotharan, R | 1 |
| Kulkarni, NM | 1 |
| Mahat, MY | 1 |
| Gunasekaran, J | 1 |
| Ashfaque, M | 1 |
2 reviews available for embelin and Innate Inflammatory Response
| Article | Year |
|---|---|
Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation.
Topics: Animals; Anti-Inflammatory Agents; Biological Products; Drug Discovery; Enzyme Inhibitors; Humans; I | 2018 |
Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease.
Topics: Animals; Benzoquinones; Biological Products; Biomimetics; Caffeic Acids; Curcumin; Cytokines; Exosom | 2020 |
11 other studies available for embelin and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Embelin protects against apoptosis and inflammation by regulating PI3K/Akt signaling in IL-1β-stimulated human nucleus pulposus cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Benzoquinones; Caspase 3; Cells, Cultured; Cyclooxygenase 2; | 2023 |
Embelin can protect mice from thioacetamide-induced acute liver injury.
Topics: Acute Disease; Animals; Apoptosis; Benzoquinones; Female; Inflammation; Liver; Macrophages; Mice, In | 2019 |
Embelin impact on paraquat-induced lung injury through suppressing oxidative stress, inflammatory cascade, and MAPK/NF-κB signaling pathway.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Benzoquinones; Cytokines; Inflam | 2020 |
Embelin modulates metabolic endotoxemia and associated obesity in high fat diet fed C57BL/6 mice.
Topics: Adipose Tissue; Animals; Benzoquinones; Body Weight; Diet, High-Fat; Endotoxemia; Inflammation; Lipo | 2021 |
Antidepressant-like effects of embelin and its possible mechanisms of action in chronic unpredictable stress-induced mice.
Topics: Animals; Antidepressive Agents; Benzoquinones; Brain; Brain-Derived Neurotrophic Factor; Chronic Dis | 2018 |
Embelin attenuates cisplatin-induced nephrotoxicity: Involving inhibition of oxidative stress and inflammation in addition with activation of Nrf-2/Ho-1 pathway.
Topics: Animals; Antioxidants; Benzoquinones; Cisplatin; Heme Oxygenase-1; Inflammation; Kidney; Male; NF-E2 | 2019 |
Embelin inhibits pancreatic cancer progression by directly inducing cancer cell apoptosis and indirectly restricting IL-6 associated inflammatory and immune suppressive cells.
Topics: Animals; Apoptosis; Benzoquinones; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Mode | 2014 |
Embelin Reduces Systemic Inflammation and Ameliorates Organ Injuries in Septic Rats Through Downregulating STAT3 and NF-κB Pathways.
Topics: Animals; Benzoquinones; Dose-Response Relationship, Drug; Down-Regulation; Inflammation; Male; Multi | 2015 |
The X-Linked Inhibitor of Apoptosis Protein Inhibitor Embelin Suppresses Inflammation and Bone Erosion in Collagen Antibody Induced Arthritis Mice.
Topics: Acid Phosphatase; Animals; Arthritis, Experimental; Benzoquinones; Bone Resorption; Inflammation; Is | 2015 |
Embelin reduces cutaneous TNF-α level and ameliorates skin edema in acute and chronic model of skin inflammation in mice.
Topics: Acute Disease; Adult; Animals; Benzoquinones; Chronic Disease; Cytokines; Disease Models, Animal; Ea | 2011 |