embelin has been researched along with Disease Models, Animal in 16 studies
embelin: from Embelia fruit (Myrsinaceae)
embelin : A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the present study was to investigate the effect of embelin on abdominal aortic aneurysm (AAA)." | 7.88 | Embelin inhibits abdominal aortic aneurysm through decreasing IL‑6‑induced STAT3 and NF‑κB inactivation. ( Li, H; Liu, Q; Wang, Q, 2018) |
| "Recent studies suggest that Embelin, a natural plant extract might have the potential to prevent body weight gain in rats." | 7.85 | Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity. ( Gao, Y; Li, J; Li, X; Wang, B; Wang, S; Xu, X; Yang, Y; Zhang, L; Zheng, F; Zhou, J, 2017) |
| " The present study was designed to investigate the effects of embelin on lipopolysachharide induced TNF-α production in mice and in human keratinocytes in vitro and also to study the effect of embelin on acute and chronic skin inflammation in mice." | 7.77 | Embelin reduces cutaneous TNF-α level and ameliorates skin edema in acute and chronic model of skin inflammation in mice. ( Ashfaque, M; Dhamotharan, R; Gunasekaran, J; Kalyan Kumar, G; Kulkarni, NM; Mahat, MY, 2011) |
| "Embelin is a small molecule inhibitor of X-linked inhibitor of apoptosis protein (XIAP), with antioxidant, anti-inflammatory, and antitumor activities." | 5.40 | Embelin reduces colitis-associated tumorigenesis through limiting IL-6/STAT3 signaling. ( Dai, Y; George, J; Hebbard, L; Jiao, H; Qiao, L; Teng, G; Wang, W; Wang, Y; Zhang, R, 2014) |
| "The aim of the present study was to investigate the effect of embelin on abdominal aortic aneurysm (AAA)." | 3.88 | Embelin inhibits abdominal aortic aneurysm through decreasing IL‑6‑induced STAT3 and NF‑κB inactivation. ( Li, H; Liu, Q; Wang, Q, 2018) |
| "Recent studies suggest that Embelin, a natural plant extract might have the potential to prevent body weight gain in rats." | 3.85 | Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity. ( Gao, Y; Li, J; Li, X; Wang, B; Wang, S; Xu, X; Yang, Y; Zhang, L; Zheng, F; Zhou, J, 2017) |
| " The present study was designed to investigate the effects of embelin on lipopolysachharide induced TNF-α production in mice and in human keratinocytes in vitro and also to study the effect of embelin on acute and chronic skin inflammation in mice." | 3.77 | Embelin reduces cutaneous TNF-α level and ameliorates skin edema in acute and chronic model of skin inflammation in mice. ( Ashfaque, M; Dhamotharan, R; Gunasekaran, J; Kalyan Kumar, G; Kulkarni, NM; Mahat, MY, 2011) |
| "Acute myocardial infarction is a serious acute cardiac disorder and heart disease is still a major public health problem in adults." | 1.43 | Molecular and biochemical evidence on the protective effects of embelin and carnosic acid in isoproterenol-induced acute myocardial injury in rats. ( Akcilar, R; Altuntas, I; Bayat, Z; Isiklar, OO; Kocak, C; Kocak, FE; Kocak, H; Simsek, H; Taser, F, 2016) |
| "Treatment with embelin LNs decreased MPO, LDH and LPO levels, increased reduced GSH levels which indicated better treatment of ulcerative colitis was achieved." | 1.42 | Embelin lipid nanospheres for enhanced treatment of ulcerative colitis - Preparation, characterization and in vivo evaluation. ( Badamaranahalli, SS; Bhagawati, ST; Durg, S; Kopparam, M, 2015) |
| "Embelin is a small molecule inhibitor of X-linked inhibitor of apoptosis protein (XIAP), with antioxidant, anti-inflammatory, and antitumor activities." | 1.40 | Embelin reduces colitis-associated tumorigenesis through limiting IL-6/STAT3 signaling. ( Dai, Y; George, J; Hebbard, L; Jiao, H; Qiao, L; Teng, G; Wang, W; Wang, Y; Zhang, R, 2014) |
| "Pancreatic cancer is an aggressive malignancy and unresponsive to conventional chemotherapies." | 1.40 | Embelin inhibits pancreatic cancer progression by directly inducing cancer cell apoptosis and indirectly restricting IL-6 associated inflammatory and immune suppressive cells. ( Cheng, X; Da, Y; Dai, Y; Fu, S; Huang, B; Peng, M; Qiao, L; Wang, D; Wu, X; Xue, Z; Yang, Q; Yao, Z; Zhang, D; Zhang, L; Zhang, Q; Zhang, R, 2014) |
| "Embelin is a benzoquinone phytochemical isolated from the Japanese herb Ardisiae Japonicae and has been shown to induce apoptosis in cancer cells." | 1.39 | Ellagic acid and embelin affect key cellular components of pancreatic adenocarcinoma, cancer, and stellate cells. ( Edderkaoui, M; Eibl, G; Go, VL; Hui, H; Li, G; Lu, QY; Lu, X; Lugea, A; Moro, A; Pandol, SJ, 2013) |
| "Embelin was also active by the oral route (25 and 50 mg/kg) in the incision and dead space wound models." | 1.39 | Embelin accelerates cutaneous wound healing in diabetic rats. ( Deshmukh, PT; Gupta, VB, 2013) |
| "Embelin treatment significantly decreased clinical activity score, gross lesion score, percent affected area and wet colon weight when compared to acetic acid induced controls." | 1.37 | Protective effect of embelin against acetic acid induced ulcerative colitis in rats. ( Badami, S; Biradar, MI; Mahendran, S; Raj, P; Srivastava, K; Thippeswamy, BS; Veerapur, VP, 2011) |
| "Pretreatment of embelin (25 and 50 mg/kg, p." | 1.37 | Protective effect of embelin from Embelia ribes Burm. against transient global ischemia-induced brain damage in rats. ( Badami, S; Mahendran, S; Nagakannan, P; Shivasharan, BD; Thippeswamy, BS; Veerapur, VP, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 15 (93.75) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Wang, B | 2 |
| Chen, X | 1 |
| Zhou, T | 1 |
| Wang, X | 1 |
| Liu, Q | 1 |
| Wang, Q | 1 |
| Li, H | 1 |
| Edderkaoui, M | 1 |
| Lugea, A | 1 |
| Hui, H | 1 |
| Eibl, G | 1 |
| Lu, QY | 1 |
| Moro, A | 1 |
| Lu, X | 1 |
| Li, G | 1 |
| Go, VL | 1 |
| Pandol, SJ | 1 |
| Coutelle, O | 1 |
| Hornig-Do, HT | 1 |
| Witt, A | 1 |
| Andree, M | 1 |
| Schiffmann, LM | 1 |
| Piekarek, M | 1 |
| Brinkmann, K | 1 |
| Seeger, JM | 1 |
| Liwschitz, M | 1 |
| Miwa, S | 1 |
| Hallek, M | 1 |
| Krönke, M | 1 |
| Trifunovic, A | 1 |
| Eming, SA | 1 |
| Wiesner, RJ | 1 |
| Hacker, UT | 1 |
| Kashkar, H | 1 |
| Dai, Y | 2 |
| Jiao, H | 1 |
| Teng, G | 1 |
| Wang, W | 1 |
| Zhang, R | 2 |
| Wang, Y | 1 |
| Hebbard, L | 1 |
| George, J | 1 |
| Qiao, L | 2 |
| Peng, M | 1 |
| Huang, B | 1 |
| Zhang, Q | 1 |
| Fu, S | 1 |
| Wang, D | 1 |
| Cheng, X | 1 |
| Wu, X | 1 |
| Xue, Z | 1 |
| Zhang, L | 2 |
| Zhang, D | 1 |
| Da, Y | 1 |
| Yang, Q | 1 |
| Yao, Z | 1 |
| Badamaranahalli, SS | 1 |
| Kopparam, M | 1 |
| Bhagawati, ST | 1 |
| Durg, S | 1 |
| Dhadde, SB | 1 |
| Nagakannan, P | 2 |
| Roopesh, M | 1 |
| Anand Kumar, SR | 1 |
| Thippeswamy, BS | 3 |
| Veerapur, VP | 3 |
| Badami, S | 3 |
| Kocak, C | 1 |
| Kocak, FE | 1 |
| Akcilar, R | 1 |
| Isiklar, OO | 1 |
| Kocak, H | 1 |
| Bayat, Z | 1 |
| Simsek, H | 1 |
| Taser, F | 1 |
| Altuntas, I | 1 |
| Dadwal, A | 1 |
| Hallan, SS | 1 |
| Sharma, S | 1 |
| Mishra, N | 1 |
| Gao, Y | 1 |
| Li, J | 1 |
| Xu, X | 1 |
| Wang, S | 1 |
| Yang, Y | 1 |
| Zhou, J | 1 |
| Zheng, F | 1 |
| Li, X | 1 |
| Mahendran, S | 2 |
| Biradar, MI | 1 |
| Raj, P | 1 |
| Srivastava, K | 1 |
| Kalyan Kumar, G | 1 |
| Dhamotharan, R | 1 |
| Kulkarni, NM | 1 |
| Mahat, MY | 1 |
| Gunasekaran, J | 1 |
| Ashfaque, M | 1 |
| Shivasharan, BD | 1 |
| Deshmukh, PT | 1 |
| Gupta, VB | 1 |
16 other studies available for embelin and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Antidepressant-like effects of embelin and its possible mechanisms of action in chronic unpredictable stress-induced mice.
Topics: Animals; Antidepressive Agents; Benzoquinones; Brain; Brain-Derived Neurotrophic Factor; Chronic Dis | 2018 |
Embelin inhibits abdominal aortic aneurysm through decreasing IL‑6‑induced STAT3 and NF‑κB inactivation.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Benzoquinones; Disease Models, Animal; Gene Exp | 2018 |
Ellagic acid and embelin affect key cellular components of pancreatic adenocarcinoma, cancer, and stellate cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Benzoquinones; Cell Line, Tumor; Cell Prolife | 2013 |
Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing.
Topics: Animals; Antineoplastic Agents; Benzoquinones; Cell Respiration; Disease Models, Animal; Endothelial | 2014 |
Embelin reduces colitis-associated tumorigenesis through limiting IL-6/STAT3 signaling.
Topics: Animals; Benzoquinones; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Cell Proliferation; Cell Trans | 2014 |
Embelin inhibits pancreatic cancer progression by directly inducing cancer cell apoptosis and indirectly restricting IL-6 associated inflammatory and immune suppressive cells.
Topics: Animals; Apoptosis; Benzoquinones; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Mode | 2014 |
Embelin lipid nanospheres for enhanced treatment of ulcerative colitis - Preparation, characterization and in vivo evaluation.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Benzoquinones; Chemistry, Pharmaceutical; Coconut Oi | 2015 |
Effect of embelin against 3-nitropropionic acid-induced Huntington's disease in rats.
Topics: Animals; Behavior, Animal; Benzoquinones; Body Weight; Brain; Catalase; Disease Models, Animal; Dose | 2016 |
Molecular and biochemical evidence on the protective effects of embelin and carnosic acid in isoproterenol-induced acute myocardial injury in rats.
Topics: Abietanes; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Benzoquinones; Cardiotonic Ag | 2016 |
Development of enteric-coated microspheres of embelin for their beneficial pharmacological potential in ulcerative colitis.
Topics: Acetic Acid; Animals; Benzoquinones; Coated Materials, Biocompatible; Colitis, Ulcerative; Disease M | 2017 |
Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Anti-Obesity Agents; Benzoquinones; Blotting, Weste | 2017 |
Protective effect of embelin against acetic acid induced ulcerative colitis in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Antioxidants; Benzoquinones; Colitis, Ulcerative; Di | 2011 |
Embelin reduces cutaneous TNF-α level and ameliorates skin edema in acute and chronic model of skin inflammation in mice.
Topics: Acute Disease; Adult; Animals; Benzoquinones; Chronic Disease; Cytokines; Disease Models, Animal; Ea | 2011 |
Protective effect of embelin from Embelia ribes Burm. against transient global ischemia-induced brain damage in rats.
Topics: Analysis of Variance; Animals; Benzoquinones; Brain Infarction; Disease Models, Animal; Dose-Respons | 2011 |
Embelin accelerates cutaneous wound healing in diabetic rats.
Topics: Administration, Cutaneous; Animals; Benzoquinones; Diabetes Mellitus, Experimental; Disease Models, | 2013 |