Page last updated: 2024-10-26

embelin and Breast Neoplasms

embelin has been researched along with Breast Neoplasms in 9 studies

embelin: from Embelia fruit (Myrsinaceae)
embelin : A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease.

Breast Neoplasms: Tumors or cancer of the human BREAST.

Research Excerpts

ExcerptRelevanceReference
"Using Western blot and immunofluorescence, we found that breast cancer cell lines treated with low-dose embelin (2."8.31Anti-tumor Effects of IL-1β Induced TRAIL-Expressing hUCMSCs on Embelin Treated Breast Cancer Cell Lines. ( Chiu, YH; Hung, E; Liang, YH; Teng, JW; Tyan, YS; Wang, HS; Wu, JM, 2023)
"Breast cancer is the leading cause of cancer-related death for women."5.62Embelin downregulated cFLIP in breast cancer cell lines facilitate anti-tumor effect of IL-1β-stimulated human umbilical cord mesenchymal stem cells. ( Hung, E; Liang, YH; Teng, JW; Wang, HS; Wu, JM, 2021)
"Embelin (EB) is a benzoquinone derivative isolated from Embelia ribes Burm plant."5.43Embelin Inhibits Invasion and Migration of MDA-MB-231 Breast Cancer Cells by Suppression of CXC Chemokine Receptor 4, Matrix Metalloproteinases-9/2, and Epithelial-Mesenchymal Transition. ( Ahn, KS; Baek, SH; Kim, SH; Ko, JH; Lee, H; Lee, J; Lee, SG; Nam, D; Shim, BS; Um, JY; Yang, WM, 2016)
"Using Western blot and immunofluorescence, we found that breast cancer cell lines treated with low-dose embelin (2."4.31Anti-tumor Effects of IL-1β Induced TRAIL-Expressing hUCMSCs on Embelin Treated Breast Cancer Cell Lines. ( Chiu, YH; Hung, E; Liang, YH; Teng, JW; Tyan, YS; Wang, HS; Wu, JM, 2023)
"Breast cancer is the leading cause of cancer-related death for women."1.62Embelin downregulated cFLIP in breast cancer cell lines facilitate anti-tumor effect of IL-1β-stimulated human umbilical cord mesenchymal stem cells. ( Hung, E; Liang, YH; Teng, JW; Wang, HS; Wu, JM, 2021)
"Embelin (EB) is a benzoquinone derivative isolated from Embelia ribes Burm plant."1.43Embelin Inhibits Invasion and Migration of MDA-MB-231 Breast Cancer Cells by Suppression of CXC Chemokine Receptor 4, Matrix Metalloproteinases-9/2, and Epithelial-Mesenchymal Transition. ( Ahn, KS; Baek, SH; Kim, SH; Ko, JH; Lee, H; Lee, J; Lee, SG; Nam, D; Shim, BS; Um, JY; Yang, WM, 2016)
"Embelin is a natural product and exhibits antitumor activity through blocking the activity of X-linked inhibitor of apoptosis protein (XIAP)."1.39PEG-derivatized embelin as a nanomicellar carrier for delivery of paclitaxel to breast and prostate cancers. ( Gao, X; Huang, Y; Li, J; Li, S; Lu, J; Marquez, RT; Meng, X; Venkataramanan, R; Wang, Z; Zhao, W, 2013)
"Inflammatory breast cancer (IBC) is a highly aggressive subtype of breast cancer that is often characterized by ErbB2 overexpression."1.36X-linked inhibitor of apoptosis protein inhibits apoptosis in inflammatory breast cancer cells with acquired resistance to an ErbB1/2 tyrosine kinase inhibitor. ( Aird, KM; Devi, GR; Ghanayem, RB; Lyerly, HK; Peplinski, S, 2010)
"Common tumors, such as breast, multiple myeloma, and prostate tumors, frequently metastasize to the bone."1.36Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathway. ( Aggarwal, BB; Kannappan, R; Phromnoi, K; Prasad, S; Reuter, S; Yadav, VR, 2010)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (11.11)29.6817
2010's6 (66.67)24.3611
2020's2 (22.22)2.80

Authors

AuthorsStudies
Chen, J1
Nikolovska-Coleska, Z1
Wang, G1
Qiu, S1
Wang, S1
Teng, JW2
Hung, E2
Wu, JM2
Liang, YH2
Chiu, YH1
Tyan, YS1
Wang, HS2
Lu, J2
Zhao, W2
Huang, Y2
Liu, H1
Marquez, R1
Gibbs, RB1
Li, J2
Venkataramanan, R2
Xu, L1
Li, S3
Nigam, N1
Grover, A1
Goyal, S1
Katiyar, SP1
Bhargava, P1
Wang, PC1
Sundar, D1
Kaul, SC1
Wadhwa, R1
Lee, H1
Ko, JH1
Baek, SH1
Nam, D1
Lee, SG1
Lee, J1
Yang, WM1
Um, JY1
Kim, SH1
Shim, BS1
Ahn, KS1
Aird, KM1
Ghanayem, RB1
Peplinski, S1
Lyerly, HK1
Devi, GR1
Reuter, S1
Prasad, S1
Phromnoi, K1
Kannappan, R1
Yadav, VR1
Aggarwal, BB1
Marquez, RT1
Meng, X1
Gao, X1
Wang, Z1

Other Studies

9 other studies available for embelin and Breast Neoplasms

ArticleYear
Design, synthesis, and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis protein.
    Bioorganic & medicinal chemistry letters, 2006, Nov-15, Volume: 16, Issue:22

    Topics: Antineoplastic Agents; Apoptosis; Benzoquinones; Binding, Competitive; Breast Neoplasms; Cell Line,

2006
Anti-tumor Effects of IL-1β Induced TRAIL-Expressing hUCMSCs on Embelin Treated Breast Cancer Cell Lines.
    Asian Pacific journal of cancer prevention : APJCP, 2023, Apr-01, Volume: 24, Issue:4

    Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Interleukin-1beta; Ligands; MCF-7 Cel

2023
Embelin downregulated cFLIP in breast cancer cell lines facilitate anti-tumor effect of IL-1β-stimulated human umbilical cord mesenchymal stem cells.
    Scientific reports, 2021, 07-19, Volume: 11, Issue:1

    Topics: Apoptosis; Benzoquinones; Breast Neoplasms; CASP8 and FADD-Like Apoptosis Regulating Protein; Cells,

2021
Targeted delivery of Doxorubicin by folic acid-decorated dual functional nanocarrier.
    Molecular pharmaceutics, 2014, Nov-03, Volume: 11, Issue:11

    Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzo

2014
Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells.
    PloS one, 2015, Volume: 10, Issue:9

    Topics: Apoptosis; Benzoquinones; Blotting, Western; Breast Neoplasms; Cell Proliferation; Female; Gene Expr

2015
Embelin Inhibits Invasion and Migration of MDA-MB-231 Breast Cancer Cells by Suppression of CXC Chemokine Receptor 4, Matrix Metalloproteinases-9/2, and Epithelial-Mesenchymal Transition.
    Phytotherapy research : PTR, 2016, Volume: 30, Issue:6

    Topics: Benzoquinones; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition;

2016
X-linked inhibitor of apoptosis protein inhibits apoptosis in inflammatory breast cancer cells with acquired resistance to an ErbB1/2 tyrosine kinase inhibitor.
    Molecular cancer therapeutics, 2010, Volume: 9, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Benzoquinones; Breast Neoplasms; Carcinoma; Cells, Cultured; Down-

2010
Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathway.
    Molecular cancer research : MCR, 2010, Volume: 8, Issue:10

    Topics: Animals; Benzoquinones; Bone Density Conservation Agents; Bone Neoplasms; Breast Neoplasms; Cell Lin

2010
PEG-derivatized embelin as a nanomicellar carrier for delivery of paclitaxel to breast and prostate cancers.
    Biomaterials, 2013, Volume: 34, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzoquinones; Breast Neoplasms; Cell Line,

2013