embelin has been researched along with Brain Neoplasms in 2 studies
embelin: from Embelia fruit (Myrsinaceae)
embelin : A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Embelin has been reported to exhibit therapeutic activity in cancer." | 5.35 | The XIAP inhibitor Embelin enhances TRAIL-mediated apoptosis in malignant glioma cells by down-regulation of the short isoform of FLIP. ( Gaiser, T; Siegelin, MD; Siegelin, Y, 2009) |
| " Taking into account that lipoxygenase (LOX) metabolites, from arachidonic acid and linoleic acid, have been implicated in tumor progression, here, we determined whether RF-Id was able to hinder glioblastoma (GBM) cancer cell growth and the related mechanisms." | 3.83 | The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells. ( Caraglia, M; Cossu, AM; De Rosa, M; Filosa, R; Ingrosso, D; Schiraldi, C; Scuotto, M; Zappavigna, S, 2016) |
| "Embelin has been reported to exhibit therapeutic activity in cancer." | 1.35 | The XIAP inhibitor Embelin enhances TRAIL-mediated apoptosis in malignant glioma cells by down-regulation of the short isoform of FLIP. ( Gaiser, T; Siegelin, MD; Siegelin, Y, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zappavigna, S | 1 |
| Scuotto, M | 1 |
| Cossu, AM | 1 |
| Ingrosso, D | 1 |
| De Rosa, M | 1 |
| Schiraldi, C | 1 |
| Filosa, R | 1 |
| Caraglia, M | 1 |
| Siegelin, MD | 1 |
| Gaiser, T | 1 |
| Siegelin, Y | 1 |
2 other studies available for embelin and Brain Neoplasms
| Article | Year |
|---|---|
The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Autophagy; Benzoquinones; Brain Neoplasms; Cell Line, | 2016 |
The XIAP inhibitor Embelin enhances TRAIL-mediated apoptosis in malignant glioma cells by down-regulation of the short isoform of FLIP.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulato | 2009 |