embelin has been researched along with Angiogenesis, Pathologic in 3 studies
embelin: from Embelia fruit (Myrsinaceae)
embelin : A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Embelin-treated mice showed significant inhibition in tumor growth which was associated with reduced expression of markers of cell proliferation (Ki67, PCNA and Bcl-2) and cell cycle (cyclin D1, CDK2, and CDK6), and induction of apoptosis (activation of caspase-3 and cleavage of PARP, and increased expression of Bax)." | 1.40 | Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways. ( Huang, M; Jackman, CP; Marsh, JL; Shankar, S; Srivastava, RK; Tang, SN; Upadhyay, G, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coutelle, O | 1 |
| Hornig-Do, HT | 1 |
| Witt, A | 1 |
| Andree, M | 1 |
| Schiffmann, LM | 1 |
| Piekarek, M | 1 |
| Brinkmann, K | 1 |
| Seeger, JM | 1 |
| Liwschitz, M | 1 |
| Miwa, S | 1 |
| Hallek, M | 1 |
| Krönke, M | 1 |
| Trifunovic, A | 1 |
| Eming, SA | 1 |
| Wiesner, RJ | 1 |
| Hacker, UT | 1 |
| Kashkar, H | 1 |
| Huang, M | 1 |
| Tang, SN | 1 |
| Upadhyay, G | 1 |
| Marsh, JL | 1 |
| Jackman, CP | 1 |
| Shankar, S | 1 |
| Srivastava, RK | 1 |
| Heo, JY | 1 |
| Kim, HJ | 1 |
| Kim, SM | 1 |
| Park, KR | 1 |
| Park, SY | 1 |
| Kim, SW | 1 |
| Nam, D | 1 |
| Jang, HJ | 1 |
| Lee, SG | 1 |
| Ahn, KS | 2 |
| Kim, SH | 1 |
| Shim, BS | 1 |
| Choi, SH | 1 |
3 other studies available for embelin and Angiogenesis, Pathologic
| Article | Year |
|---|---|
Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing.
Topics: Animals; Antineoplastic Agents; Benzoquinones; Cell Respiration; Disease Models, Animal; Endothelial | 2014 |
Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways.
Topics: Animals; Benzoquinones; Cell Line, Tumor; Hedgehog Proteins; Heterografts; Humans; Mice; Mice, Inbre | 2014 |
Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN.
Topics: Apoptosis; Benzoquinones; Caspase 3; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; DNA, Neopl | 2011 |