ellagitannin and Trichostrongyloidiasis

Worldwide, parasitic gastrointestinal nematodes continue to threaten animal health, welfare, and production in outdoor breeding systems of small ruminants. For more than 50 years, the control of these parasitic worms has relied on the use of commercial synthetic anthelmintics. However, anthelmintic resistance in worm populations is nowadays widespread and requires novel solutions. The use of tannin-rich plants has been suggested as an alternative to synthetic anthelmintics to control gastrointestinal nematodes. The majority of previous studies have focused on the activity of proanthocyanidins (syn condensed tannins), and less is known about ellagitannins. In this study, the effects of 30 structurally unique ellagitannins on the exsheathment of third-stage infective larvae were examined on

Topics: Animals; Anthelmintics; Drug Resistance; Haemonchus; Hydrolyzable Tannins; Larva; Molecular Structure; Molecular Weight; Plant Extracts; Polyphenols; Structure-Activity Relationship; Trichostrongyloidiasis; Trichostrongylus