ellagitannin and Hypertension

Hypertension is defined as the persistence of elevated blood pressure in the circulation system. The renin-angiotensin-aldosterone system is a major modulator of blood pressure. Among the risk factors of cardiovascular disease, hypertension is the most preventable and treatable, with drugs such as ACE inhibitors. Many ACE inhibitors are known to have undesirable side effects and hence, natural alternatives are being sought. Dietary polyphenols, particularly ellagitannins, are derived from plant products and are known to exhibit a variety of bioactivities. Geraniin, an ellagitannin has been shown to have antihypertensive activity in animal experiments. It is speculated that the metabolites of geraniin are responsible for its ACE inhibitory activity. We have performed

Topics: Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Carboxypeptidases; Computer Simulation; Coumarins; Ellagic Acid; Glucosides; Humans; Hydrolyzable Tannins; Hypertension; Molecular Docking Simulation; Peptidyl-Dipeptidase A; Polyphenols; Rabbits

This study aimed to evaluate the protective role of ground raspberry seeds (RBS) as a source of polyphenols and essential fatty acids on blood plasma enzymatic antioxidant status, lipid profile, and endothelium-intact vasodilation during physiological and pathological conditions. Young normotensive Wistar-Kyoto rats (WKYs) and spontaneously hypertensive rats (SHRs) at ten weeks of age were fed with either a control diet or were supplemented with added 7% RBS for six weeks (

Topics: Acetylcholine; Animals; Aspartate Aminotransferases; Atherosclerosis; Cardiovascular Diseases; Catalase; Cyclooxygenase 2; Dietary Fiber; Dietary Supplements; Disease Models, Animal; Epoprostenol; Flavonoids; Hydrolyzable Tannins; Hypertension; Liver; Male; Nitric Oxide Synthase Type II; Rats, Inbred SHR; Rats, Inbred WKY; Rubus; Vasodilation