elatol and Schistosomiasis

Schistosomiasis has been controlled for more than 40 years with a single drug, praziquantel, and only one molluscicide, niclosamide, raising concern of the possibility of the emergence of resistant strains. However, the molecular targets for both agents are thus far unknown. Consequently, the search for lead compounds from natural sources has been encouraged due to their diverse structure and function. Our search for natural compounds with potential use in schistosomiasis control led to the identification of an algal species,

Topics: Animals; Anthelmintics; Larva; Laurencia; Molluscacides; Schistosoma mansoni; Schistosomiasis; Sesquiterpenes; Spiro Compounds