elastin and Vitiligo

elastin has been researched along with Vitiligo* in 3 studies

Other Studies

3 other study(ies) available for elastin and Vitiligo

ArticleYear
Differential expression of extracellular matrix proteins in the lesional skin of vitiligo patients.
    Archives of dermatological research, 2023, Volume: 315, Issue:8

    Skin pigmentation is regulated by intricate interaction of the dermis and epidermis. The extracellular components present in the dermis play a very important role in the maintenance of skin homeostasis. Therefore, our objective was to check the expression of various ECM components secreted by the dermal fibroblasts in the lesional skin and non-lesional skin of vitiligo patients. For this study, skin punch biopsies (4 mm) were collected from lesional skin (n = 12), non-lesional skin (n = 6) of non-segmental vitiligo patient's (NSV) and healthy control skin (n = 10). Masson's trichrome staining was performed to check the collagen fibre. The expression of collagen type 1, IV, elastin, fibronectin, E-cadherin and integrin β1 was checked by real-time PCR and immunohistochemistry. In this study, we demonstrated an increased expression of collagen type 1 in the lesional skin of vitiligo patients. The expression of collagen type IV, fibronectin, elastin and adhesion components such as E-cadherin and integrin β1 was observed to be significantly decreased in the lesional skin of NSV patients as compared to healthy control, whereas insignificant difference was observed between non-lesional and control skin. Increased expression of collagen type 1 in the lesional skin of vitiligo patients might be inhibiting the migration of melanocytes, whereas the decreased expression of elastin, collagen type IV, fibronectin, E-cadherins and integrins in the lesional skin may inhibit adhesion, migration, growth and differentiation of cells.

    Topics: Cadherins; Collagen Type IV; Elastin; Extracellular Matrix; Extracellular Matrix Proteins; Fibronectins; Humans; Integrin beta1; Melanocytes; Skin; Vitiligo

2023
Reply to "Elastin fiber but not collagen fiber is decreased dramatically in the dermis of vitiligo patients": possible mechanisms of decreased elastin fibers.
    International journal of dermatology, 2021, Volume: 60, Issue:3

    Topics: Dermis; Elastic Tissue; Elastin; Humans; Skin; Vitiligo

2021
Elastin fiber but not collagen fiber is decreased dramatically in the dermis of vitiligo patients.
    International journal of dermatology, 2020, Volume: 59, Issue:10

    Topics: Dermis; Elastic Tissue; Elastin; Humans; Skin; Vitiligo

2020