elastin and Urticaria

Topics: Adult; Allergens; Animals; Dermatitis, Allergic Contact; Elastin; Female; Fishes; Humans; Immunoglobulin E; Skin Cream; Urticaria

Topics: Adult; Biopsy; Chronic Disease; Cutis Laxa; Elastin; Extracellular Matrix Proteins; Humans; Male; Mutation; Skin; Urticaria; Young Adult

Cutis laxa (CL) is a rare disorder in which the skin hangs in loose fields, so that affected individuals appear to be prematurely aged. The changes are more evident when effect the face with a prematurely-aged appearance. The acute form follows an inflammatory skin lesions. Its aetiology is not well known. We report a case of a head acute CL of a 17 years patient, secondary to a generalized skin eruption. The prematurely-aged appearance concern especially forehead, ear lobes and nasolabial folds. A two stages surgical treatment has associated: a forehead lifting associated to a Coleman lipofilling and an ear lobe reduction, a secondary Coleman lipofilling of the nasolabial folds. The skin biopsy confirm the diagnosis. The correction is stable and satisfactory after one year. The confrontation of our findings to those previously described confirm complexity of diagnosis and histological observations of this rare disorder.

Topics: Adolescent; Cutis Laxa; Elastin; Humans; Male; Plastic Surgery Procedures; Skin; Urticaria

A 31-year-old man had cutis laxa after an urticarial eruption. He had no systemic manifestations. In urticarial lesions, elastolysis occurred only within the inflammatory infiltrate of neutrophils around the vessels and between the collagen bundles. In lax skin, elastolysis occurred throughout the entire dermis. Electron microscopic study showed a markedly decreased number of elastic fibers, with elastolysis most predominant near the inflammatory cells. These findings suggest that the neutrophil plays a significant role in the destruction of elastic fibers and subsequent development of cutis laxa.

Topics: Adult; Biopsy; Chronic Disease; Cutis Laxa; Elastic Tissue; Elastin; Epidermis; Fibroblasts; Humans; Male; Microscopy, Electron; Neck; Skin; Thorax; Urticaria