elastin has been researched along with Ulcer* in 2 studies
2 other study(ies) available for elastin and Ulcer
| Article | Year |
|---|---|
Topics: Animals; Elastic Tissue; Elastin; Fibrillin-2; Fibroblasts; Gene Silencing; Humans; Hypoxia; Mice; Protein-Lysine 6-Oxidase; Ulcer | 2022 |
Self-healing, antibacterial and anti-inflammatory chitosan-PEG hydrogels for ulcerated skin wound healing and drug delivery.
Great efforts have been performed on the production of advanced biomaterials with the combination of self-healing and wound healing properties in implant/tissue engineering biomedical area. Inspired by this idea, chitosan (CHI) based hydrogels can be used to treat a less investigated class of harmful chronic wounds: ulcers or pressure ulcers. Thus, CHI was crosslinked with previously synthesized polyethylene glycol diacid (PEG-diacid) to obtain different CHI-PEG hydrogel formulations with high H-bonding tendency resulting in self-repair ability. Here presented results show biocompatible, antibacterial, anti-inflammatory, and self-healing CHI-PEG hydrogels with a promising future in the treatment of ulcerated wounds by a significant improvement in metabolic activity (94.51 ± 4.38 %), collagen and elastin quantities (2.12 ± 0.63 μg collagen and 4.97 ± 0.61 μg elastin per mg dermal tissue) and histological analysis. Furthermore, cefuroxime (CFX), tetracycline (TCN) and amoxicillin (AMX) antibiotics, and acetylsalicylic acid (ASA) anti-inflammatory agent were sustainedly released for enhancing antibacterial and anti-inflammatory activities of hydrogels. Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Biocompatible Materials; Chitosan; Collagen; Elastin; Humans; Hydrogels; Ulcer; Wound Healing | 2022 |