elastin has been researched along with Starvation* in 3 studies
3 other study(ies) available for elastin and Starvation
Article | Year |
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Effects of starvation on lung mechanics and biochemistry in young and old rats.
Two groups of rats (young and old) were food-deprived for 3 wk and were compared with age-matched fed groups. Final body weight and dry and wet weights of lungs were significantly reduced in both young and old starved rats. As determined by saline volume-pressure (VP) curves, lungs of young starved rats accepted significantly less volume at all pressure levels compared with lungs of young fed rats. When expressed as a percent of maximum lung volume, the VP curve in young starved rats was significantly shifted upward at low lung volumes. In the old rats, the VP curves were similar in fed and starved rats. Total lung content of protein, DNA, crude connective tissue, hydroxyproline, and elastin were significantly reduced in young starved compared with young fed rats, whereas in old starved rats only protein and DNA contents were lower than those in old fed animals. It appears that in rapidly growing young rats starvation leads to growth retardation, loss of connective tissue components, and possibly reduction in tissue elastic forces at low lung volumes, whereas starvation has no significant effects on lung mechanics and connective tissue in old rats. Topics: Age Factors; Animals; Body Weight; Connective Tissue; DNA; Elasticity; Elastin; Hydroxyproline; Lung; Lung Volume Measurements; Male; Organ Size; Proteins; Rats; Specific Pathogen-Free Organisms; Starvation; Time Factors | 1985 |
Changes in connective tissue composition of the lung in starvation and refeeding.
Adult male rats were starved by allowing them one fifth of their measured daily food consumption until they lost 40% of their initial body weights. Some of these rats were then refed until their initial body weights were reached. We measured the total content of the following in the lung tissue of fed, starved, and refed animals: (1) elastin, (2) hydroxyproline, and (3) protein. Body weight and lung dry and wet weights were significantly reduced in starved and similar in refed rats compared with fed animals. Total contents of crude connective tissue, hydroxyproline, elastin, and protein were significantly lower in starved than in fed rat lungs. After refeeding, hydroxyproline content returned completely to levels found in fed rats, but other components only partially returned to normal values. These results provide a biochemical counterpart for our previous observations on the effects of starvation and refeeding on lung mechanics and morphologic aspects. It appears that the emphysema like changes in the lungs of starved rats are at least partly related to the loss of connective tissue elements. Topics: Animals; Body Weight; Connective Tissue; Elastin; Hydroxyproline; Lung; Male; Organ Size; Proteins; Rats; Starvation | 1983 |
Changes in lung lysyl oxidase activity in streptozotocin-diabetes and in starvation.
The effects of streptozotocin-induced diabetes and of starvation on the lysyl oxidase activity of rat lung were investigated. Enzyme activity was elevated 2--3 fold in the lungs of streptozotocin-diabetic rats. In contrast, starvation of rats produced a rapid loss of lung lysyl oxidase activity, with levels approximating 25% of control values after 48--72 h of starvation. Enzyme activity was essentially fully restored to control values upon refeeding the 48-h starved animals for 3 h. These studies demonstrate the responsiveness of lysyl oxidase to these physiological states and suggest a component, enzymatic basis of change in lung function known to occur in the diabetic state. Topics: Amino Acid Oxidoreductases; Animals; Collagen; Diabetes Mellitus, Experimental; Elastin; Lung; Male; Protein-Lysine 6-Oxidase; Rats; Starvation | 1979 |