elastin and Parotid-Neoplasms

elastin has been researched along with Parotid-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for elastin and Parotid-Neoplasms

Article	Year
Synthesis of elastin by pleomorphic adenomas. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1996, Volume: 25, Issue:1 Previous morphologic and histochemical studies have documented extracellular elastin and elastic fibers within the matrix of pleomorphic adenomas of the salivary glands. By morphologic criteria, the elastin appeared to be synthesized by the tumor rather than being a consequence of stroma produced in response to the tumor cells. To examine this issue, nine pleomorphic adenomas were studied by immunohistochemistry and in situ hybridization with tropoelastin-specific antibodies and complementary DNAs. Corroborating the previous morphologic studies, immunohistochemistry demonstrated abundant extracellular elastin within the matrix of pleomorphic adenomas. Additionally, both immunohistochemistry and in situ hybridization demonstrated continued synthesis of tropoelastin by the neoplastic cells. Tropoelastin production was seen in neoplastic cells with all morphologies. Topics: Adenoma, Pleomorphic; Adult; Aged; Aged, 80 and over; Antibodies; DNA, Complementary; Elastin; Extracellular Matrix; Female; Humans; Immunohistochemistry; In Situ Hybridization; Keratins; Male; Middle Aged; Parotid Neoplasms; S100 Proteins; Tropoelastin	1996

Article

Year

Synthesis of elastin by pleomorphic adenomas.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1996, Volume: 25, Issue:1

Previous morphologic and histochemical studies have documented extracellular elastin and elastic fibers within the matrix of pleomorphic adenomas of the salivary glands. By morphologic criteria, the elastin appeared to be synthesized by the tumor rather than being a consequence of stroma produced in response to the tumor cells. To examine this issue, nine pleomorphic adenomas were studied by immunohistochemistry and in situ hybridization with tropoelastin-specific antibodies and complementary DNAs. Corroborating the previous morphologic studies, immunohistochemistry demonstrated abundant extracellular elastin within the matrix of pleomorphic adenomas. Additionally, both immunohistochemistry and in situ hybridization demonstrated continued synthesis of tropoelastin by the neoplastic cells. Tropoelastin production was seen in neoplastic cells with all morphologies.

Topics: Adenoma, Pleomorphic; Adult; Aged; Aged, 80 and over; Antibodies; DNA, Complementary; Elastin; Extracellular Matrix; Female; Humans; Immunohistochemistry; In Situ Hybridization; Keratins; Male; Middle Aged; Parotid Neoplasms; S100 Proteins; Tropoelastin

1996