elastin and Neuromuscular-Diseases

Stress urinary incontinence (SUI) is more prevalent among women who deliver vaginally than women who have had a cesarean section, suggesting that tissue repair after vaginal delivery is insufficient. A single dose of mesenchymal stem cells (MSCs) has been shown to partially restore urethral function in a model of SUI. The aim of the present study was to determine if increasing the number of doses of MSCs improves urethral and pudendal nerve function and anatomy. We hypothesized that increasing the number of MSC doses would accelerate recovery from SUI compared with vehicle treatment. Rats underwent pudendal nerve crush and vaginal distension or a sham injury and were treated intravenously with vehicle or one, two, or three doses of 2 × 10

Topics: Animals; Bone Marrow Transplantation; Connective Tissue; Elastin; Female; Mesenchymal Stem Cell Transplantation; Nerve Crush; Neuromuscular Diseases; Postpartum Period; Pudendal Nerve; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Urethra; Urinary Incontinence, Stress; Vagina