elastin and Diabetic-Foot

Topics: Animals; Collagen; Diabetic Foot; Elastin; Female; Humans; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred NOD; Nanoparticles; Peptides; Protease Inhibitors; Wound Healing

Topics: Accidents, Traffic; Adult; Aged, 80 and over; Burns; Cellulitis; Chondroitin Sulfates; Collagen; Debridement; Diabetic Foot; Elastin; Female; Foot Injuries; Humans; Leg Injuries; Male; Middle Aged; Necrosis; Skin, Artificial

The aim of our case report was to analyse the results obtained with the Matriderm system and autologous skin grafting for the surgical treatment of diabetic ulcers. We recruited one patient with diabetic ulcers admitted at the Department of Plastic and Reconstructive Surgery, University of Rome 'Tor Vergata'. The patient underwent Matriderm system and autologous skin grafting for diabetic ulcer treatment. After just a single treatment, we obtained reduction in ulcer after 15 days from the surgical treatment. We achieved a reduction in pain and exudate secretion of the ulcer. We noticed an almost complete restoration of the missing volume and good quality of skin. Matriderm system and autologous skin grafting is a simple, safe and feasible technique. This method, when compared with other methods of treatment, is simple, cheap, less time consuming and does not require sophisticated laboratory facilities.

Topics: Aged; Anti-Bacterial Agents; Bacterial Infections; Collagen; Combined Modality Therapy; Diabetic Foot; Elastin; Exudates and Transudates; Humans; Male; Pain; Skin Care; Skin Transplantation; Transplantation, Autologous; Treatment Outcome; Wound Healing; Wound Infection