Page last updated: 2024-10-26

eicosapentaenoic acid ethyl ester and Inflammation

eicosapentaenoic acid ethyl ester has been researched along with Inflammation in 14 studies

Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

Research Excerpts

ExcerptRelevanceReference
"Specialized pro-resolving mediator(s) (SPMs) are produced from the endogenous ω-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and accelerate resolution of acute inflammation."5.27Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation. ( Jensen, GL; Kris-Etherton, PM; Maddipati, KR; Norris, PC; Richter, CK; Riley, I; Serhan, CN; Skulas-Ray, AC, 2018)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.14)29.6817
2010's8 (57.14)24.3611
2020's5 (35.71)2.80

Authors

AuthorsStudies
Bäck, M1
Trivedi, K1
Le, V1
Nelson, JR1
Simopoulos, AP1
Serhan, CN3
Bazinet, RP1
Mehta, S1
Ruth Dugas, L1
Choo-Kang, C1
Bovet, P1
Forrester, T1
Bedu-Addo, K1
Lambert, EV1
Plange-Rhule, J1
Riesen, W1
Korte, W1
Luke, A1
Chang, WC1
So, J1
Lamon-Fava, S1
Mocking, RJT1
Assies, J1
Ruhé, HG1
Schene, AH1
Carion, TW1
Greenwood, M1
Ebrahim, AS1
Jerome, A1
Suvas, S1
Gronert, K1
Berger, EA1
Peng, J2
Zhou, Y1
Hong, Z1
Wu, Y1
Cai, A1
Xia, M1
Deng, Z1
Yang, Y1
Song, T1
Xiong, J1
Wei, H1
Norris, PC1
Skulas-Ray, AC1
Riley, I1
Richter, CK1
Kris-Etherton, PM1
Jensen, GL1
Maddipati, KR1
Yakubu, A1
Azlan, A1
Loh, SP1
Md Noor, S1
Cawood, AL1
Ding, R1
Napper, FL1
Young, RH1
Williams, JA1
Ward, MJ1
Gudmundsen, O1
Vige, R1
Payne, SP1
Ye, S1
Shearman, CP1
Gallagher, PJ1
Grimble, RF1
Calder, PC1
Zampelas, A1
Luchtman, DW1
Meng, Q1
Song, C1
Poulsen, RC1
Gotlinger, KH1
Kruger, MC1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Open-label, Single-arm Study to Evaluate the Effects of a Marine Lipid Oil Concentrate Formulation on Inflammation/Discomfort in Individuals Who Are Generally Healthy[NCT04819646]31 participants (Actual)Interventional2021-01-07Completed
A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of a Specialized Pro-Resolving Mediator Formulation on Inflammation in Individuals Who Are Overweight to Mildly Obese and Otherwise Generally Healthy[NCT04269876]8 participants (Actual)Interventional2019-10-31Terminated (stopped due to COVID-19 pandemic)
A Double Blind Comparison of Omacor and Placebo in Patients Awaiting Endarterectomy to Investigate the Effect on Carotid Plaque Stability[NCT00294216]Phase 3121 participants Interventional2003-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for eicosapentaenoic acid ethyl ester and Inflammation

ArticleYear
Icosapent ethyl in cardiovascular prevention: Resolution of inflammation through the eicosapentaenoic acid - resolvin E1 - ChemR23 axis.
    Pharmacology & therapeutics, 2023, Volume: 247

    Topics: Atherosclerosis; Eicosapentaenoic Acid; Humans; Inflammation

2023
The case for adding eicosapentaenoic acid (icosapent ethyl) to the ABCs of cardiovascular disease prevention.
    Postgraduate medicine, 2021, Volume: 133, Issue:1

    Topics: Cardiovascular Diseases; Clinical Trials as Topic; Comorbidity; Cost-Benefit Analysis; Cytokines; Ei

2021
Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders.
    Journal of inherited metabolic disease, 2018, Volume: 41, Issue:4

    Topics: Eicosapentaenoic Acid; Fatty Acids; Humans; Hypothalamo-Hypophyseal System; Inflammation; Mental Dis

2018
Can Yellow Stripe Scad Compete with Salmon on Its Role in Platelet Phospholipid Membrane and Its Cardiovascular Benefits?
    Journal of obesity, 2019, Volume: 2019

    Topics: Adult; Animals; Anti-Inflammatory Agents; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids,

2019

Trials

2 trials available for eicosapentaenoic acid ethyl ester and Inflammation

ArticleYear
Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation.
    Scientific reports, 2018, 12-21, Volume: 8, Issue:1

    Topics: Administration, Intravenous; Adult; Chromatography, Liquid; Dietary Supplements; Docosahexaenoic Aci

2018
Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation.
    Scientific reports, 2018, 12-21, Volume: 8, Issue:1

    Topics: Administration, Intravenous; Adult; Chromatography, Liquid; Dietary Supplements; Docosahexaenoic Aci

2018
Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation.
    Scientific reports, 2018, 12-21, Volume: 8, Issue:1

    Topics: Administration, Intravenous; Adult; Chromatography, Liquid; Dietary Supplements; Docosahexaenoic Aci

2018
Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation.
    Scientific reports, 2018, 12-21, Volume: 8, Issue:1

    Topics: Administration, Intravenous; Adult; Chromatography, Liquid; Dietary Supplements; Docosahexaenoic Aci

2018
Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability.
    Atherosclerosis, 2010, Volume: 212, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Capsules; Carotid Artery Diseases; Chi-Square

2010

Other Studies

8 other studies available for eicosapentaenoic acid ethyl ester and Inflammation

ArticleYear
The need for precision nutrition, genetic variation and resolution in Covid-19 patients.
    Molecular aspects of medicine, 2021, Volume: 77

    Topics: COVID-19; Docosahexaenoic Acids; Eicosanoids; Eicosapentaenoic Acid; Fatty Acids, Essential; Fatty A

2021
Consumption of Monounsaturated Fatty Acids Is Associated with Improved Cardiometabolic Outcomes in Four African-Origin Populations Spanning the Epidemiologic Transition.
    Nutrients, 2021, Jul-16, Volume: 13, Issue:7

    Topics: Adult; Black People; Cardiometabolic Risk Factors; Dietary Fats; Dietary Fiber; Docosahexaenoic Acid

2021
Differential and shared effects of eicosapentaenoic acid and docosahexaenoic acid on serum metabolome in subjects with chronic inflammation.
    Scientific reports, 2021, 08-11, Volume: 11, Issue:1

    Topics: Cross-Over Studies; Dietary Supplements; Docosahexaenoic Acids; Double-Blind Method; Eicosapentaenoi

2021
Immunoregulatory role of 15-lipoxygenase in the pathogenesis of bacterial keratitis.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018, Volume: 32, Issue:9

    Topics: Animals; Arachidonate 15-Lipoxygenase; Eicosapentaenoic Acid; Inflammation; Inflammation Mediators;

2018
Maternal eicosapentaenoic acid feeding promotes placental angiogenesis through a Sirtuin-1 independent inflammatory pathway.
    Biochimica et biophysica acta. Molecular and cell biology of lipids, 2019, Volume: 1864, Issue:2

    Topics: Angiogenesis Inducing Agents; Animals; Diet, High-Fat; Dietary Supplements; Eicosapentaenoic Acid; F

2019
Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability.
    Atherosclerosis, 2010, Volume: 212, Issue:1

    Topics: Administration, Oral; Capsules; Carotid Artery Diseases; Dietary Supplements; Docosahexaenoic Acids;

2010
Ethyl-eicosapentaenoate (E-EPA) attenuates motor impairments and inflammation in the MPTP-probenecid mouse model of Parkinson's disease.
    Behavioural brain research, 2012, Jan-15, Volume: 226, Issue:2

    Topics: Animals; Biogenic Monoamines; Brain; Cyclooxygenase 2; Cytokines; Eicosapentaenoic Acid; Exploratory

2012
Identification of inflammatory and proresolving lipid mediators in bone marrow and their lipidomic profiles with ovariectomy and omega-3 intake.
    American journal of hematology, 2008, Volume: 83, Issue:6

    Topics: Animals; Bone Marrow; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Female; In

2008