Compounds > eglumetad
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eglumetad and Schizophrenia

eglumetad has been researched along with Schizophrenia in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (13.33)18.2507
2000's9 (60.00)29.6817
2010's4 (26.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chaki, S; Ito, H; Kumagai, T; Nakanishi, S; Nakazato, A; Okuyama, S; Sakagami, K; Suzuki, Y; Taguchi, T; Yoshikawa, R1
Candler, J; Doran, AC; Duplantier, AJ; Efremov, I; Ganong, AH; Haas, JA; Hanks, AN; Kraus, KG; Lazzaro, JT; Lu, J; Maklad, N; McCarthy, SA; O'Sullivan, TJ; Rogers, BN; Siuciak, JA; Spracklin, DK; Zhang, L1
Borro, M; Caraci, F; Caruso, A; di Nuzzo, L; Mairesse, J; Matrisciano, F; Molinaro, G; Monn, JA; Motolese, M; Nicoletti, F; Nisticò, R; Orlando, R; Pittaluga, A; Scaccianoce, S; Simmaco, M1
Barberi, C; Danysz, W; Morè, L; Nagel, J; Pietraszek, M; Schäfer, D; Schlumberger, C; Schmidt, WJ1
Danysz, W; Gravius, A; Greco, S; Klein, KU; Morè, L; Pietraszek, M; Schlumberger, C1
Fujita, Y; Hashimoto, K; Slusher, BS; Takatsu, Y; Tsukamoto, T1
Krolikowski, KA; Neale, JH; Olszewski, RT; Profaci, CP1
Frank, E; Huang, XF; Newell, KA1
Holden, C1
Guo, N; Huang, Y; Hwang, DR; Kegeles, LS; Laruelle, M; Narendran, R; van Berckel, BN; Van Heertum, R; Waterhouse, R1
Fokkema, DS; Imre, G; Ter Horst, GJ1
Seeman, P1
Adams, BW; Moghaddam, B1
Wickelgren, I1
Carfagno, ML; Hoskins, LA; Pinto, ME; Raffa, RB; Yeh, JC1

Reviews

1 review(s) available for eglumetad and Schizophrenia

ArticleYear
Indirect modulation of dopamine D2 receptors as potential pharmacotherapy for schizophrenia: II. Glutamate (Ant)agonists.
    The Annals of pharmacotherapy, 2000, Volume: 34, Issue:6

    Topics: Animals; Bridged Bicyclo Compounds; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Receptors, Dopamine D2; Receptors, Glutamate; Schizophrenia

2000

Other Studies

14 other study(ies) available for eglumetad and Schizophrenia

ArticleYear
Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists.
    Journal of medicinal chemistry, 2000, Dec-14, Volume: 43, Issue:25

    Topics: Administration, Oral; Animals; Antipsychotic Agents; Bridged Bicyclo Compounds; Calcium; CHO Cells; Cricetinae; Crystallography, X-Ray; Cyclic AMP; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Inositol 1,4,5-Trisphosphate; Radioligand Assay; Rats; Receptors, Metabotropic Glutamate; Schizophrenia; Stereoisomerism; Structure-Activity Relationship

2000
3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization.
    Bioorganic & medicinal chemistry letters, 2009, May-01, Volume: 19, Issue:9

    Topics: Administration, Oral; Allosteric Regulation; Allosteric Site; Carbamates; Chemistry, Pharmaceutical; Drug Design; Humans; Inhibitory Concentration 50; Ligands; Microsomes; Models, Chemical; Molecular Structure; Oxazolidinones; Receptors, Metabotropic Glutamate; Schizophrenia

2009
Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740.
    Neuropharmacology, 2014, Volume: 86

    Topics: Amino Acids; Animals; Antipsychotic Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; D-Aspartic Acid; Disease Models, Animal; Epigenesis, Genetic; Female; Guanine Nucleotide Dissociation Inhibitors; Hippocampus; Male; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Proteomics; Receptors, Metabotropic Glutamate; Restraint, Physical; Schizophrenia

2014
Effects of a metabotropic glutamate receptor group II agonist LY354740 in animal models of positive schizophrenia symptoms and cognition.
    Behavioural pharmacology, 2009, Volume: 20, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Behavior, Animal; Bridged Bicyclo Compounds; Cognition; Disease Models, Animal; Drug Evaluation, Preclinical; Excitatory Amino Acid Agonists; Exploratory Behavior; Male; Maze Learning; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reflex, Startle; Schizophrenia; Schizophrenic Psychology

2009
Comparison of the mGlu(5) receptor positive allosteric modulator ADX47273 and the mGlu(2/3) receptor agonist LY354740 in tests for antipsychotic-like activity.
    European journal of pharmacology, 2009, Nov-25, Volume: 623, Issue:1-3

    Topics: Allosteric Regulation; Animals; Antipsychotic Agents; Behavior, Animal; Bridged Bicyclo Compounds; Dopamine Agents; Dose-Response Relationship, Drug; Excitatory Amino Acid Agents; Excitatory Amino Acid Agonists; Male; Motor Activity; Neural Inhibition; Oxadiazoles; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reflex, Startle; Schizophrenia; Treatment Outcome

2009
Orally active glutamate carboxypeptidase II inhibitor 2-MPPA attenuates dizocilpine-induced prepulse inhibition deficits in mice.
    Brain research, 2011, Jan-31, Volume: 1371

    Topics: Administration, Oral; Amino Acids; Animals; Antipsychotic Agents; Bridged Bicyclo Compounds; Dipeptides; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamate Carboxypeptidase II; Glutarates; Male; Mice; Neural Inhibition; Schizophrenia; Sensory Gating; Sulfhydryl Compounds; Xanthenes

2011
Group II mGluR agonist LY354740 and NAAG peptidase inhibitor effects on prepulse inhibition in PCP and D-amphetamine models of schizophrenia.
    Psychopharmacology, 2011, Volume: 216, Issue:2

    Topics: Animals; Bridged Bicyclo Compounds; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamate Carboxypeptidase II; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Organophosphorus Compounds; Phencyclidine; Receptors, Metabotropic Glutamate; Reflex, Startle; Schizophrenia; Species Specificity; Urea

2011
Density of metabotropic glutamate receptors 2 and 3 (mGluR2/3) in the dorsolateral prefrontal cortex does not differ with schizophrenia diagnosis but decreases with age.
    Schizophrenia research, 2011, Volume: 128, Issue:1-3

    Topics: Adolescent; Adult; Aged; Aging; Bridged Bicyclo Compounds; Excitatory Amino Acid Agonists; Female; Humans; Male; Middle Aged; Postmortem Changes; Prefrontal Cortex; Protein Binding; Radiography; Radioligand Assay; Receptors, Metabotropic Glutamate; Schizophrenia; Statistics as Topic; Tritium; Young Adult

2011
Psychiatric drugs. Excited by glutamate.
    Science (New York, N.Y.), 2003, Jun-20, Volume: 300, Issue:5627

    Topics: Animals; Anxiety Disorders; Brain; Brain Diseases; Bridged Bicyclo Compounds; Clinical Trials as Topic; Depressive Disorder; Dopamine; Excitatory Amino Acid Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Mental Disorders; Neurons; Pain; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Substance-Related Disorders; Synaptic Transmission

2003
Modulation of amphetamine-induced dopamine release by group II metabotropic glutamate receptor agonist LY354740 in non-human primates studied with positron emission tomography.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:5

    Topics: Amphetamine; Animals; Brain; Bridged Bicyclo Compounds; Dopamine; Dopamine Agents; Dopamine Antagonists; Excitatory Amino Acid Agonists; Female; Male; Papio anubis; Positron-Emission Tomography; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia

2006
Subchronic administration of LY354740 does not modify ketamine-evoked behavior and neuronal activity in rats.
    European journal of pharmacology, 2006, Aug-21, Volume: 544, Issue:1-3

    Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Behavior, Animal; Bridged Bicyclo Compounds; Excitatory Amino Acid Antagonists; Immunohistochemistry; Ketamine; Male; Movement; Neurons; Rats; Rats, Wistar; Schizophrenia

2006
Glutamate agonists for schizophrenia stimulate dopamine D2High receptors.
    Schizophrenia research, 2008, Volume: 99, Issue:1-3

    Topics: Amino Acids; Antipsychotic Agents; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclic S-Oxides; Dopamine Agonists; Excitatory Amino Acid Agonists; Humans; Receptors, Dopamine D2; Schizophrenia

2008
Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats.
    Science (New York, N.Y.), 1998, Aug-28, Volume: 281, Issue:5381

    Topics: Animals; Bridged Bicyclo Compounds; Disease Models, Animal; Dopamine; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Memory; Motor Activity; Nucleus Accumbens; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Schizophrenia; Stereotyped Behavior; Synaptic Transmission

1998
A new route to treating schizophrenia?
    Science (New York, N.Y.), 1998, Aug-28, Volume: 281, Issue:5381

    Topics: Animals; Bridged Bicyclo Compounds; Dopamine; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Maze Learning; Memory; Phencyclidine; Prefrontal Cortex; Rats; Receptors, Metabotropic Glutamate; Schizophrenia

1998