egg-white and Periodontal-Diseases

Lysozyme has a bactericidal activity for some strains of Gram-positive bacteria, by enzymatic cleavage of peptidoglycans that constitute the cell wall. Hen egg-white lysozyme (HEL) was tested in vitro for effects on biological activities of lipopolysaccharides from periodontopathic Gram-negative bacteria. Actinobacillus actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis. HEL inhibited a wide range of activities of these lipopolysaccharides, including activation of Limulus amoebocyte lysate, stimulation of human leukocytes to secrete tumour necrosis factor-alpha, polyclonal activation of mouse B cells, and promotion of osteoclastic differentiation in mouse bone marrow cultures. The anti-endotoxic activity of HEL may be worthy of being intended for periodontal therapy.

Topics: Aggregatibacter actinomycetemcomitans; Animals; Antitoxins; Cell Differentiation; Chickens; Egg Proteins; Egg White; Gram-Negative Bacteria; Humans; Limulus Test; Lipopolysaccharides; Lymphocyte Activation; Mice; Muramidase; Osteoclasts; Periodontal Diseases; Porphyromonas gingivalis; Prevotella intermedia; Protein Binding