egg-white and Kidney-Diseases

Pigeon and dove eggwhite exhibit high level P1 antigenic activity and are potent and specific inhibitors of adherence mediated by P fimbriae of uropathogenic Escherichia coli. To evaluate pigeon and dove eggwhite as P fimbrial receptor analogues in the prevention of ascending renal infection, mice were challenged with a P fimbriated E. coli urosepsis isolate suspended in saline alone or in saline plus various inhibitors of adherence, including D-mannose, globoside, and chicken, dove, and pigeon eggwhite. D-mannose inhibited mannose-sensitive adherence but not P fimbrial adherence, and failed to prevent renal infection. Globoside and chicken eggwhite also failed to inhibit P fimbrial adherence; chicken eggwhite had little and globoside had no impact on renal infection. In contrast, dove and pigeon eggwhite eliminated P fimbrial adherence and significantly reduced the incidence and intensity of renal infection. These findings suggest that pigeon and dove eggwhite provide P1-antigen-specific protection against ascending renal infection in mice due to P fimbriated uropathogenic E. coli.

Topics: Aged; Agglutination; Animals; Chickens; Columbidae; Egg White; Escherichia coli; Escherichia coli Infections; Female; Fimbriae, Bacterial; Humans; Kidney Diseases; Male; Mice; Mice, Inbred BALB C; Urinary Tract Infections

Topics: Diet; Egg White; Feeding Behavior; Humans; Kidney Diseases; Renal Insufficiency, Chronic; Sodium Chloride