egg-white and Edema

Anesthetized mice or rats received intravenously 6%, 10%, 20%, 40%, 60%, 80%, and 90% dextran and/or white egg (1ml/rat or 0.15ml/mouse) into their tails. Medication (/kg b.w., 5ml/kg) was given intraperitoneally (BPC 157 10µg, 1µg, 10ng, and 10pg/kg, chloropyramine 20mg/kg, and cimetidine 10mg/kg intraperitoneally, alone or in combination while controls received an equivolume of saline), immediately after challenge or, alternatively, at 5min after or 24 or 48h before challenge. The effect was assessed at 5, 10, 20 and 30min after dextran and/or white egg challenge. We commonly noted prominent edema involving the face, upper and lower lip, snout, paws and scrotum (presented with extreme cyanosis), poor respiration and the number of fatalities after dextran and/or white egg application. Contrary, BPC 157 regimens (10µg, 1µg, 10ng, and 10pg/kg) effectively, may both prevent anaphylactoid reactions that may arise from dextran and/or white egg application and furthermore, rescue already advanced reactions when given after the challenge. Chloropyramine and cimetidine given alone were only moderately effective. When given together with BPC 157, the observed effect correlates with the strong effect of BPC 157 given alone.

Topics: Administration, Intravenous; Anaphylaxis; Animals; Anti-Allergic Agents; Cimetidine; Dextrans; Disease Models, Animal; Edema; Egg White; Ethylenediamines; Histamine H1 Antagonists; Histamine H2 Antagonists; Male; Mice; Peptide Fragments; Proteins; Rats, Wistar; Time Factors

The effect of n6 and n3 polyunsaturated fatty acids (PUFA) on development of acute inflammation in rats has been studied. During 4 weeks male Wistar rats (initial weight 140-150 g) were on feed containing as lipid component 6% butter and 3% fish oil obtained from Sardinops sagax melanosticta (n3 PUFA-diet). The development of paw oedema induced by subplantar injection of dextran or carrageenan inhibited when the animals were on diet where prevailed n3 PUFA. In contrast, the state of paw oedema, caused by intraperitoneal administration of egg white was similarly high in rats given both n6 and n3 PUFA.

Topics: Acute Disease; Animals; Butter; Carrageenan; Dextrans; Dietary Fats, Unsaturated; Disease Models, Animal; Edema; Egg White; Fish Oils; Foot; Helianthus; Male; Plant Oils; Rats; Rats, Wistar; Sunflower Oil

Topics: Animals; Anti-Inflammatory Agents; Antimetabolites; Edema; Egg White; Granuloma; Histamine; Histamine Release; In Vitro Techniques; Inflammation; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Rats; Skin

Topics: Adrenal Glands; Adrenocorticotropic Hormone; Anhydrides; Animals; Carrageenan; Corticosterone; Croton Oil; Dexamethasone; Dextrans; Dibenzylchlorethamine; Edema; Egg White; Hexamethonium Compounds; Inflammation; Male; Pentobarbital; Physostigmine; Polycyclic Compounds; Rats; Terpenes; Turpentine

Topics: Anaphylaxis; Animals; Calcinosis; Calciphylaxis; Calcium; Calcium Chloride; Cerium; Connective Tissue; Dextrans; Dihydrotachysterol; Edema; Egg White; Female; Iron-Dextran Complex; Lead; Mast Cells; Polymyxins; Potassium Permanganate; Rats; Triamcinolone

Topics: Adrenal Glands; Adrenalectomy; Animals; Capillaries; Chlorpromazine; Cortisone; Edema; Egg White; Epinephrine; Ganglionic Blockers; Hydrocortisone; Hypophysectomy; Inflammation; Ischemia; Lymph Nodes; Male; Mast Cells; Microscopy, Electron; Pituitary Gland; Rats; Shock; Tourniquets; Veins

Topics: Animals; Anti-Inflammatory Agents; Bacillus subtilis; Carrageenan; Edema; Egg White; Female; Male; Mice; Peptide Hydrolases

Topics: Amines; Anaphylaxis; Animals; Edema; Egg White; Extremities; Foot Diseases; Histamine Release; Male; Mouth; Mouth Diseases; p-Methoxy-N-methylphenethylamine; Rats

Topics: Anaphylaxis; Animals; Dextrans; Edema; Egg White; Genetics; Histamine; Inflammation; Injections, Intradermal; Injections, Subcutaneous; p-Methoxy-N-methylphenethylamine; Polysaccharides; Rats; Serotonin; Yeast, Dried; Zymosan

Topics: Adrenalectomy; Anaphylaxis; Blood Glucose; Chlorpropamide; Dextrans; Drug Hypersensitivity; Drug Synergism; Edema; Egg White; Genetics; Histamine; Hypersensitivity; Insulin; Pharmacogenetics; Pharmacology; Rats; Research; Toxicology; Triiodothyronine

Topics: Body Weight; Body Weights and Measures; Chymotrypsin; Edema; Egg White; Peptide Hydrolases; Pharmacology; Rats; Research

Topics: Albumins; Body Temperature; Dextrans; Edema; Egg White; Hypersensitivity; Hypothermia; Immune System Diseases

Topics: Edema; Egg White; Iodides; Iodine; Iodine Radioisotopes; Sodium; Sodium Iodide

Topics: Edema; Egg White; Hypersensitivity; Tuberculosis

Topics: Animals; Blood; Dextrans; Edema; Egg White; Heart Failure; Hypersensitivity; Immune System Diseases; Procainamide; Rats

Topics: Animals; Dextrans; Edema; Egg White; Histamine; Histamine Release; Hypersensitivity; Immune System Diseases; p-Methoxy-N-methylphenethylamine; Rats; Skin

Topics: Animals; Antihypertensive Agents; Edema; Egg White; Rats; Reserpine; Secologanin Tryptamine Alkaloids

Topics: Anti-Inflammatory Agents; Edema; Egg White; Humans; Trypsin

Topics: Animals; Benzoquinones; Capillaries; Catechols; Edema; Egg White; Organophosphates; Phosphates; Quinones; Rats

Topics: Animals; Calcium; Calcium, Dietary; Edema; Egg White; Rats; Strontium

Topics: Animals; Anions; Edema; Egg White; Rats; Salts

Topics: Animals; Diabetes Mellitus, Experimental; Edema; Egg White; Ovalbumin; Rats

Topics: Animals; Cysteamine; Cysteine; Edema; Egg White; Ethylamines; Rats

Topics: Animals; Ascorbic Acid; Carbohydrate Metabolism; Edema; Egg White; Rats

Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Cortisone; Edema; Egg White; Hypersensitivity; Pituitary Diseases; Pituitary Gland; Rats; Salicylates

Topics: Albumins; Animals; Ascorbic Acid; Edema; Egg White; Hypersensitivity; Rats; Vitamins

Topics: Anti-Allergic Agents; Anti-Inflammatory Agents; Edema; Egg White; Histamine H1 Antagonists; Humans; Reproducibility of Results

Topics: Animals; Edema; Egg White; Rats

Topics: Animals; Carboxylic Acids; Edema; Egg White; Epinephrine; Pulmonary Edema; Quinolines; Rats

Topics: Animals; Edema; Egg White; Rats

Topics: Adrenocorticotropic Hormone; Animals; Cortisone; Edema; Egg White; Hormones; Hypersensitivity; Pituitary Gland; Pituitary Gland, Anterior; Pituitary Hormones, Anterior; Rats

Topics: Animals; Blood Vessels; Edema; Egg White; Hypersensitivity; Immune System Diseases; Rats

Topics: Animals; Dihydroergotamine; Edema; Egg White; Ergoloid Mesylates; Ergotamine; Hypersensitivity; Immune System Diseases; Rats

Topics: Animals; Edema; Egg White; Inflammation; Injections; Rats

Topics: Adrenal Glands; Adrenergic Agents; Animals; Anti-Allergic Agents; Edema; Egg White; Epinephrine; Histamine; Nervous System; Rats; Sympathetic Nervous System; Tissue Extracts

Topics: Amino Acids; Animals; Chromatography; Edema; Egg White; Epinephrine; Norepinephrine; Rats

Topics: Animals; Edema; Egg White; Rats